INDEX

III-In autologous WBC in 33 scintigraphy 179 in typhoid 52 biodistribution 179 brucellosis 45-50 clinical indications 181 manifestation 45 labelling 179 nuclear medicine radiation effects 180 bone scintigraphy 46-50 uptake mechanisms 180 67-Ga scintigraphy 48-50 avidin-biotin system 216 bone disease 46-50 bartonellosis sacro-ileitis 46-50 (see Cat-scratch disease) candidiasis 83-84 blastomycosis 97-100 bone scintigraphy 84 incidence 97 in drug addicts 84 bone disease 97-100 manifestation 83 lung disease 97 colloid scintigraphy 83 nuclear medicine 98-100 67-Ga scintigraphy 83 bone scintigraphy 98-100 18-F fluconazole 84 67-Ga scintigraphy 98-100 labelled peptide scan 84 X-Ray findings 97 labelled WBC scan 83 bone scintigraphy monoclonal antibodies 84 in blastomycosis 98 septic arthritis due to 84 in brucellosis 46 201-TI SPECT 83 in candidiasis 84 carditis in cat-scratch disease 53 in Chagas' disease 120 in coccidioidomycosis 77-82 in Coxsackie disease 143 in hydatid disease 147 in diphtheria 56 in leprosy 23-25 in Lyme's disease 40 in Lyme's disease 42 in measles 142 in maduromycosis 101 cat-scratch disease 53 in paracoccidioidomyc. 85-89 bone scintigraphy 53 in pyomyositis 51 bone marrow scan 53 in salmonellosis 52 Chagas' disease in sporotrichosis 74 (digestive tract) 123-127 in syphilis 31-33 epidemiology 123 in tuberculosis 12-14 gallbladder 127 in 38 gastrointestinal borreliosis disorders 124 (see Lyme' disease) nuclear medicine 124-127 brain SPECT oesophagus in encephalitis 138 emptying 124-126 in Lyme's disease 39, drug effect in 124-126 43-44 pharynx 124-126 in malaria 129 small bowel transit 126 in neurocysticercosis 162 stomach 126 in sodoku 54 Chagas' disease (heart) 111-122 254 INDEX

epidemiology III OTP A renal study clinical forms 112 in leprosy 25,26 122 in schistosomiasis 158, 159 natural history 112 in tuberculosis 16, 17 nuclear medicine 114-122 encephalitis 137-140 apex aneurysm 116-117 causes 137 autonomic nuclear medicine 138-140 denervation 121 chronic fatigue 67-Ga scan 122 syndrome and gated blood pool 114-119 encephalitis 140 heart perfusion 120 diaschisis-cerebellum 138 L V dysfunction 114 Epstein Barr virus 138-140 123-1 MIBG scan 121-122 Herpes simplex 138-140 RV dysfunction 119 Japanese encephalitis 138-140 stress gated imaging 115 SPECT 138-140 201-Tl 120 tick-borne related 138-140 pathological findings 113 unilateral hyper- pathophysiology and perfusion 138-140 pathogenic Varicella zooster 138-140 mechanisms 113 endothelium 212 chromomycosis 104 antibodies and AB 67-Ga 104 fragments against coccidioidomycosis 75-82 adhesion molecules 213 bone disease 77-82 histology 212 disseminated disease 77 Ig super family 212 incidence 75 integrins 212 lung disease 76-77 radiopharmaceuticals to manifestation 75 image activated 213 nuclear medicine 76 selectins 212 bone scintigraphy 77-82 Enterobacter aerogenes depreotide 79 WBC scan in 53 67-Ga scintigraphy 76-82 extracellular matrix 215 cistemography 76,81 avidin-biotin system 216 X-ray findings 75 extravasation 216 Coxsackie virus 143 molecular weight and 216 pyrophosphate scan 143 histology 215 201-Tl scintigraphy 143 labelled liposomes 218 dengue 141 radiopharmaceuticals gated blood pool in 141 for imaging 215 diphtheria 56-57 fascioliasis 167 PYP scintigraphy 56 67-Ga scan 167 DISIDA scintigraphy liver scintigraphy 167 (see hepato-biliary scintigraphy) 18-FOG 186 OMSA renal scintigraphy in candidiasis 84 in schistosomiasis 159 clinical indications in tuberculosis 17 in infection 187 INDEX 255

in Herpes infection 143 in histoplasmosis 94 in histoplasmosis 195 in hydatid disease 147 in hydatid disease 147 in keloidean in neurocysticercosis 163 paracoccidioidomyc. 104 in oxyuriasis 168 in leishmaniasis 131 in plague 55 in leprosy 22 in syphilis 35 in Lyme's disease 40-42 in tuberculosis 6-10 in maduromycosis 101-103 uptake mechanisms 186 in measles 142 59-Fe in paracoccidioidomyc. 85-89 in leprosy 27 in plague 55-56 fever of unknown origin in pyomyositis 51 (see FUO) in salmonellosis 52 FUO 191-198 in sporotrichosis 74 in AIDS 196, 198 in tuberculosis 6-20 causes 192 uptake mechanisms 177 classical FUO 198 gated blood pool Durak's definition 192 scintigraphy 18-FDG PET in 195-198 in Chagas' disease 114 67-Ga scan in 194, 195 in dengue 141 labelled IgG in 194 in Lyme's disease 40 labelled WBC in 194 Haemophilus injluenzae neutropenic FUO 198 WBC scan in arthritis 53 nosocomial FUO 198 hepato-biliary scintigraphy PDCs 193 in hydatid disease 147 Petersdorrs definition 191 in 55 diagnostic strategy 192 in paracoccidioidomyc. 89 filariasis 149-151 in schistosomiasis 157 manifestation 149 Herpes simplex 138-140, nuclear medicine 150-151 143 lympho- encephalitis 138-140 scintigraphy 150-151 in the skin 143 67-Ga citrate scintigraphy 67-Ga 143 biodistribution 177 18-FDG 143 in blastomycosis 98 HIDAs scintigraphy in brucellosis 48 (see hepato-biliary scintigraphy) in candidiasis 83 histoplasmosis 93-95 in Chagas' myocarditis 122 fibrosing mediastinitis 94 characteristics 177 incidence 93 in chromomycosis 104 manifestation 93 clinical indications mimicking pulmonary in infection 177 embolism 94-95 in coccidioidomycosis 76-82 nuclear medicine 94-95 in fascioliasis 167 18-FDG 95 inFUO 194-195 67-Ga 94 in Herpes infection 143 radionuclide 256 INDEX

angiography 94-95 67-Ga scan 104 V -Qimaging 94-95 klebsiella 53 99mTc-HMPAO labelled WBC scan in WBC 181-182 Klebsiella septicemia 53 biodistribution 182 labelled antibiotics 227-232 clinical indications 182 biodistribution 231 hydatid disease 145-149 ceftizoxime derived incidence 145 compounds (CDCs) 231 nuclear medicine 146-149 labelled ceftizoxime 231 bone scintigraphy 147 labelled ciprofloxacin 228-230 colloid scintigraphy 146 labelling method 228 liver SPECT 146-147 labelled antibodies 233 DISIDA imaging 147 AB structure 234 18-FDG 147 anti- L. amazonensis 235 201-TI perfusion 147-148 labelling methods 234 infiltrating lymphocytes 218 99mTc labelled histology 218 anti granulocyte antibodies 182 radiofarmaceuticals biodistribution 182 for imaging 219 clinical indications 183 infiltrating macrophages 223 uptake mechanisms 183 histology 223 III-In labelled HIG 184 radiopharmaceuticals biodistribution 185 for imaging 224 clinical indications 185 invasive fungal infection 199-208 uptake mechanisms 185 aspergillosis 200-208 99mTc labelled IgG 185 beta glucan 206 biodistribution 186 chitin 206 clinical indications 186 epidemiology 200 uptake mechanisms 186 fungal cell wall 206 labelled interleukin-12p40 223 fungal structure 205 labelled interleukin-2 221 galactomannan 208 labelled liposomes 218 in immune- leishmaniasis 130-131 compromised hosts 201 incidence 130 diagnosis 202 67-Ga imaging 131 mannoproteins 207 leprosy 21-28 pathogen-specific bone leprosy 23 considerations 203 incidence-epidemiology21-22 pathogenesis 199 liver function in 27 specific imaging 204 mutilation in 23,24 Pseudomonas nuclear medicine 23-28 aeruginosa 204 bone scintigraphy 23-25 Candida 204 67-Ga scitnigraphy 22 targets in fungal renal function-DTPA 25, 26 structure 203 scintigraphic pattern 22 keloidean in vitro diagnosis 27 paracoccidioidomycosis 103 liver and spleen colloid INDEX 257 scintigraphy neurocysticercosis 161-166 in fascioliasis 167 classification 161 in hydatid disease 146 imaging 162 in malaria 129 incidence 161 in paracoccidioidomyc. 87 manifestation 160 in schistosomiasis 156 nuclear medicine 162-166 leptospirosis 54 brain SPECT 162-166 liver function in 54 18-FDG 163 HIDA scintigraphy in 55 osteomyelitis Lyme's disease 39-44 in blastomycosis 98 incidence-manifestation39-40 in brucellosis 46 nuclear medicine in candidiasis 84 bone scan 42 in coccidioidomycosis 77-82 67-Ga scintigraphy 40-42 in hydatid disease 147 heart perfusion 40 in leprosy 23-25 myositis 40-42 in Lyme's disease 42 39 in maduromycosis 101 SPECT in 39,43, in paracoccidioidomyc. 85-89 44 in pyomyositis 51 Iymphoscintigraphy in salmonellosis 52 in filariasis 150 in sporotrichosis 74 in paracoccidioidomyc. 86 in syphilis 31-33 maduromycosis 101-103 in tuberculosis 12-14 bone scintigraphy 101-103 in yaws 38 disseminated disease 102-103 oxyuriasis 167-168 67-Ga scan 101-103 18-FDG 168 malaria 129-130 paracoccidioidomycosis 85-91 incidence 129 incidence 85 nuclear medicine 129-130 liver function 89 brain SPECT 129-130 manifestation 85 colloid scintigraphy 129 nuclear medicine 85-91 measles 142 bone scintigraphy 85-89 67-Ga in myocarditis 142 soft tissue uptake 89 melioidosis 54 colloid scintigraphy 87 DTPA brain DISIDA scan 89,91 scintigraphy 54 67-Ga scintigraphy 85-89 mumps 143 glucoheptonate scan 90 salivary gland scan 143 Iymphoscintigraphy 87 monoclonal AB 222 RES scintigraphy 87,89,90 anti T. cruzi 237 X-ray findings 85 mycetoma (see maduromycosis) plague 55 99mTc-nanocolloids 178 67-Ga scintigraphy in 55-56 biodistribution 178 18-FDG 55-56 clinical indications 179 polycional AB in hydatid uptake mechanism 178 disease 237 258 INDEX pyrophosphate heart strongyloidiasis 168 scintigraphy 51-Cr EDTA test in 168 in coxsackie carditis 143 intestinal penneability 168 in diphtheria 56 substance P 214 radiophannaceuticals for syphilis inflammation-infection 18-FDG 35 imaging 175-189 HMPAO SPECT 33,34 biodistribution 176 123-IMP SPECT 34 radiation dose from 176 incidence-classification29, 30 radiophannaceuticals to nuclear medicine in 30-35 image different phases of aorta aneurysm 34 inflammation 210 bone syphilis 31-33 salmonelloses 52 neurosyphilis 33-35 bone scintigraphy 52 201-Tl scintigraphy costochondritis 52 in Chagas' disease 120 67-Ga scintigraphy 52 in coxsackie carditis 143 I 23-iodoamphetamine in hydatid disease 147 SPECT 52 in Lyme's disease 40 schistosomiasis 155-159 in tuberculosis 8 classification (mansoni) 157 236 epidemoilogy 155-156 affinity for iron and haematobium schistos. 158-159 lactoferrin 236 nuclear medicine 156-159 tropical pyomyositis 51-52 DISIDA imaging 157 bone scintigraphy 51 DTP A imaging 158 67-Ga scintigraphy 51-52 DMSA imaging 159 WBCscan 52 liver scintigraphy 156-159 manifestation 51 sodoku 54 tuberculosis 1-20 brain SPECT in 54 aetiology 1 labelled somatostatin in AIDS 18-20 analogues 214 BACTEC 20 in Graves' disease 214 epidemiology 2-5 in sarcoidosis 214 extra-pulmonary South American disease 10-20 blastomycosis (see bone tuberculosis 12-14 paracoccidioidomycosis) breast 17 sporotrichosis 71-74 gastrointestinal 14 bone disease 72 cerebellum 15 bone scintigraphy 74 gyneacologic II 67-Ga scintigraphy 74 hepatic abscess 14 joint disease 72 lymph nodes 15 manifestation and mediastinum 15 transmission 71 meningitis 15 X-ray findings 73 salivary glands 14 Strongyloides direct serositis 14 labelling 237 spleen 17 INDEX 259

urinary tract 15-17 oleothorax 10 FUO and tuberculosis II primary infection 1 lung disease 8-10 pyothorax 10 miliary 10,20 social causes 2 nuclear medicine in 5-20 transmission 1 bone scintigraphy 12-14 in vitro diagnosis 20 DMSA 17 typhoid fever 52 DTPA 16, 17 123-iodoamphetamine 18-FDG 6,10,18 SPECT 52 67-Ga 6-20 ventriculography (see glucoheptonate scan 6, 7 gated blood pool scintigraphy) HMPAO 12 WBC scintigraphy Hippuran 16 in candidiasis 83 123-IMP 8 inFUO 194 81m-Kr 7 in infectious arthritis 53 MAG3 17 in Klebsiella sepsis 53 PET 10 in meningitis 53 radiopharmaceuticals 6 in pyomyositis 52 somatostatin recept. 127 in tuberculosis 10,13,14 tecnegas 7 yaws 37-38 201-TI 8 bone scintigraphy in 38 tetrofosmin 8 manifestation 37 V - Q scintigraphy 7,8 differences vs. syphilis 37 WBC 10,13,14 133-Xe 7 Developments in Nuclear Medicine

I. P.H. Cox (ed.): Cholescintigraphy. 1981 ISBN 90-247-2524-0 2. P.H. Cox (ed.): Progress in Radiopharmacology. Selected Topics. Proceedings of the 3rd European Symposium (Noordwijkerhout, The Netherlands, April 1982). 1982 ISBN 90-247-2768-5 3. M.H. Jonckheer and F. Deconinck (eds.): X-Ray Fluorescent Scanning ofthe Thyroid. 1983 ISBN 0-89838-561-X 4. K. Kristensen and E. Norbygaard (eds.): Safety and Efficacy ofRadio pharmaceuticals. 1983 ISBN 0-89838-609-8 5. A. Bossuyt and F. Deconinck: Amplitude/Phase Patterns in Dynamic Scintigraphic Imaging. With a Foreword by A. Bertrand Brill. 1984 ISBN 0-89838-641-1 6. M.R. Hardeman and Y. Najean (eds.): Blood Cells in Nuclear Medicine, Part I. Cell Kinetics and Bio-distribution. 1984 ISBN 0-89838-653-5 7. G.F. Fueger (ed.): Blood Cells in Nuclear Medicine, Part II. Migratory Blood Cells. 1984 ISBN 0-89838-654-3 8. HJ. Biersack and P.H. Cox (eds.): Radioisotope Studies in Cardiology. 1985 ISBN 0-89838-733-7 9. P.H. Cox, G. Limouris and M.G. Woldring (eds.): Progress in Radiopharmacology 1985 ISBN 0-89838-745-0 10. P.H. Cox, SJ. Mather, C.S. Sampson and C.R. Lazarus (eds.): Progress in Radiophar- macy. 1986 ISBN 0-89838-823-6 1 I. H. Deckart and P.H. Cox (eds.): Principles ofRadio pharmacology. 1987 ISBN 0-89838-774-4 12. W.-D. Heiss, G. Pawlik, K. Herholz and K. Wienhard (eds.): Clinical Efficacy of Positron Emission Tomography. 1987 ISBN 0-89838-898-8 13. G.B. Gerber, H. Metivier and H. Smith (eds.): Age-Related Factors in Radionuclide Metabolism and Dosimetry. 1987 ISBN 0-89838-953-4 14. K. Kristensen and E. Norbygaard (eds.): Safety and Efficacy ofRadiopharmaceuticals 1987 ISBN 0-89838-986-0 15. C. Beckers, A. Goffmet and A. Bol (eds.): Positron Emission Tomography in Clinical Research and Clinical Diagnosis. Tracer Modelling and Radioreceptors. 1989 ISBN 0-7923-0254-0 16. M. De Schrijver: Scintigraphy ofInflammation with Nanometer-sized Colloidal Tracers. 1990 ISBN 0-7923-0272-9 17. Ch. Kessler, M.R. Hardeman, H. Henningsen and J.N. Petrovici (eds.): Clinical Application ofRadiolabelled Platelets. 1990 ISBN 0-7923-0729-1 18. H.J. Biersack and P.H. Cox (eds.): Nuclear Medicine in Gastroenterology. 1991 ISBN 0-7923-1074-8 19. R.P. Baum, P.H. Cox, G. Hor and G.L. Buraggi (eds.): Clinical Use ofAntibodies. Tumours, infection, infarction, rejection and in the diagnosis of AIDS. 1991 ISBN 0-7923-1424-7 20. J.C. Baron, D. Comar, L. Farde, 1.L. Martinot and B.M. Mazoyer (eds.): Brain Dopaminergic Systems: Imaging with Positron Tomography. 1991 ISBN 0-7923-1476-X 21. M.K. Dewanjee: Radioiodination. Theory, Practice, and Biomedical Application. 1991 ISBN 0-7923-1491-3 22. A.P. Schubiger and G. Westera (eds.): Progress in Radiopharmacy. 1992 ISBN 0-7923-1525-1 23. B.M. Mazoyer, W.-D. Heiss and D. Comar (eds.): PET Studies on Amino Acid Metabolism and Protein Synthesis. 1993 ISBN 0-7923-2076-X 24. G. StOcklin and V.W. Pike (eds.): Radiopharmaceuticalsfor Positron Emission Tomography. Methodological Aspects. 1993 ISBN 0-7923-2340-8 Developments in Nuclear Medicine

25. P.H. Cox and M. Pillay (eds.): The Clinical Applications ofSPET 1995 ISBN 0-7923-3187-7 26. D. Comar (ed.): PETfor Drug Development and Evaluation. 1995 ISBN 0-7923-3716-6 27. R.M. Lambrecht: Biological Models in Radiopharmaceutical Development. 1995 ISBN 0-7923-3836-7 28. R. Bares and G. Lucignani (eds.): Clinical PET 1996 ISBN 0-7923-4160-0 29. R. Duncan (ed.): SPECTImaging ofthe Brain. 1997 ISBN 0-7923-4186-4 30. SJ. Mather (ed.): Current Directions in Radiopharmaceutical Research and Development. 1996 ISBN 0-7923-4254-2 31. P.H. Cox and J.R. Buscombe (eds.): The Imaging ofInfection and Inflammation 1998 ISBN 0-7923-5087-1 32. B. Bendriem, D.W. Townsend (eds.): The Theory and Practice of3D PET 1998 ISBN 0-7923-5108-8 33. H.-J. Machulla (ed.): Imaging ofHypoxia. 1999 ISBN 0-7923-5529-6 34. FJ.H.N. Braga (ed.): Nuclear Medicine in Tropical and Infectious Diseases. 2002 ISBN 1-4020-7191-4

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