Imports of Benzenoid Chemicals and Products 1978
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Table S1: Sensitivity, Specificity, PPV, NPV, and F1 Score of NLP Vs. ICD for Identification of Symptoms for (A) Biome Developm
Table S1: Sensitivity, specificity, PPV, NPV, and F1 score of NLP vs. ICD for identification of symptoms for (A) BioMe development cohort; (B) BioMe validation cohort; (C) MIMIC-III; (D) 1 year of notes from patients in BioMe calculated using manual chart review. A) Fatigue Nausea and/or vomiting Anxiety Depression NLP (95% ICD (95% CI) P NLP (95% CI) ICD (95% CI) P NLP (95% CI) ICD (95% CI) P NLP (95% CI) ICD (95% CI) P CI) 0.99 (0.93- 0.59 (0.43- <0.00 0.25 (0.12- <0.00 <0.00 0.54 (0.33- Sensitivity 0.99 (0.9 – 1) 0.98 (0.88 -1) 0.3 (0.15-0.5) 0.85 (0.65-96) 0.02 1) 0.73) 1 0.42) 1 1 0.73) 0.57 (0.29- 0.9 (0.68- Specificity 0.89 (0.4-1) 0.75 (0.19-1) 0.68 0.97 (0.77-1) 0.03 0.98 (0.83-1) 0.22 0.81 (0.53-0.9) 0.96 (0.79-1) 0.06 0.82) 0.99) 0.99 (0.92- 0.86 (0.71- 0.94 (0.79- 0.79 (0.59- PPV 0.96 (0.82-1) 0.3 0.95 (0.66-1) 0.02 0.95 (0.66-1) 0.16 0.93 (0.68-1) 0.12 1) 0.95) 0.99) 0.92) 0.13 (0.03- <0.00 0.49 (0.33- <0.00 0.66 (0.48- NPV 0.89 (0.4-1) 0.007 0.94 (0.63-1) 0.34 (0.2-0.51) 0.97 (0.81-1) 0.86 (0.6-0.95) 0.04 0.35) 1 0.65) 1 0.81) <0.00 <0.00 <0.00 F1 Score 0.99 0.83 0.88 0.57 0.95 0.63 0.82 0.79 0.002 1 1 1 Itching Cramp Pain NLP (95% ICD (95% CI) P NLP (95% CI) ICD (95% CI) P NLP (95% CI) ICD (95% CI) P CI) 0.98 (0.86- 0.24 (0.09- <0.00 0.09 (0.01- <0.00 0.52 (0.37- <0.00 Sensitivity 0.98 (0.85-1) 0.99 (0.93-1) 1) 0.45) 1 0.29) 1 0.66) 1 0.89 (0.72- 0.5 (0.37- Specificity 0.96 (0.8-1) 0.98 (0.86-1) 0.68 0.98 (0.88-1) 0.18 0.5 (0-1) 1 0.98) 0.66) 0.88 (0.69- PPV 0.96 (0.8-1) 0.8 (0.54-1) 0.32 0.8 (0.16-1) 0.22 0.99 (0.93-1) 0.98 (0.87-1) NA* 0.97) 0.98 (0.85- 0.57 (0.41- <0.00 0.58 (0.43- <0.00 NPV 0.98 (0.86-1) 0.5 (0-1) 0.02 (0-0.08) NA* 1) 0.72) 1 0.72) 1 <0.00 <0.00 <0.00 F1 Score 0.97 0.56 0.91 0.28 0.99 0.68 1 1 1 *Denotes 95% confidence intervals and P values that could not be calculated due to insufficient cells in 2x2 tables. -
Safety Assessment of Benzyl Salicylate As Used in Cosmetics
Safety Assessment of Benzyl Salicylate As Used in Cosmetics Status: Draft Report for Panel Review Release Date: November 9, 2018 Panel Meeting Date: December 3-4, 2018 The 2018 Cosmetic Ingredient Review Expert Panel members are: Chair, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Ronald A. Hill, Ph.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; James G. Marks, Jr., M.D., Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Executive Director is Bart Heldreth, Ph.D. This safety assessment was prepared by Alice Akinsulie, Scientific Writer/Analyst. © Cosmetic Ingredient Review 1620 L Street, NW, Suite 1200 ♢ Washington, DC 20036-4702 ♢ ph 202.331.0651 ♢ fax 202.331.0088 ♢ [email protected] Commitment & Credibility since 1976 Memorandum To: CIR Expert Panel Members and Liaisons From: Alice Akinsulie, Scientific Analyst/Writer Date: November 9, 2018 Subject: Draft Safety Assessment of Benzyl Salicylate as Used in Cosmetics Enclosed is the Draft Report of the Safety Assessment of Benzyl Salicylate as Used in Cosmetics. (It is identified as bensal122018rep in the pdf document.) On October 9, 2018, CIR issued the Scientific Literature Review (SLR) for this ingredient. According to the Dictionary, Benzyl Salicylate is reported to function mainly as a fragrance ingredient and light stabilizer. The Personal Care Products Council (Council) provided concentration of use survey data for the light stabilizer function (only) of Benzyl Salicylate. The results indicate that the light stabilizer concentrations of use for Benzyl Salicylate falls in the IFRA Standards for use of Benzyl Salicylate as a fragrance ingredient (identified as bensal122018data). -
Safety Assessment of Benzyl Salicylate As Used in Cosmetics
Safety Assessment of Benzyl Salicylate As Used in Cosmetics Status: Scientific Literature Review for Public Comment Release Date: October 9, 2018 Panel Meeting Date: December 3-4, 2018 All interested persons are provided 60 days from the above release date to comment on this safety assessment and to identify additional published data that should be included or provide unpublished data which can be made public and included. Information may be submitted without identifying the source or the trade name of the cosmetic product containing the ingredient. All unpublished data submitted to CIR will be discussed in open meetings, will be available at the CIR office for review by any interested party and may be cited in a peer-reviewed scientific journal. Please submit data, comments, or requests to the CIR Executive Director, Dr. Bart Heldreth. The 2018 Cosmetic Ingredient Review Expert Panel members are: Chair, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Ronald A. Hill, Ph.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; James G. Marks, Jr., M.D., Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Executive Director is Bart Heldreth, Ph.D. This safety assessment was prepared by Alice Akinsulie, Scientific Writer/Analyst. © Cosmetic Ingredient Review 1620 L Street, NW, Suite 1200 ♢ Washington, DC 20036-4702 ♢ ph 202.331.0651 ♢ fax 202.331.0088 ♢ [email protected] INTRODUCTION This scientific literature review is the initial step in preparing a safety assessment of Benzyl Salicylate as used in cosmetic formulations. -
WO 2010/099522 Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 2 September 2010 (02.09.2010) WO 2010/099522 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 45/06 (2006.01) A61K 31/4164 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/4045 (2006.01) A61K 31/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2010/025725 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 1 March 2010 (01 .03.2010) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (25) Filing Language: English SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (26) Publication Language: English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 61/156,129 27 February 2009 (27.02.2009) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, (71) Applicant (for all designated States except US): ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, HELSINN THERAPEUTICS (U.S.), INC. -
Multiple Targets of Salicylic Acid and Its Derivatives in Plants and Animals
REVIEW published: 26 May 2016 doi: 10.3389/fimmu.2016.00206 Multiple Targets of Salicylic Acid and Its Derivatives in Plants and Animals Daniel F. Klessig1*, Miaoying Tian2 and Hyong Woo Choi1 1 Boyce Thompson Institute, Cornell University, Ithaca, NY, USA, 2 Department of Plant and Environmental Protection Sciences, University of Hawaii at Manoa, Honolulu, HI, USA Salicylic acid (SA) is a critical plant hormone that is involved in many processes, includ- ing seed germination, root initiation, stomatal closure, floral induction, thermogenesis, and response to abiotic and biotic stresses. Its central role in plant immunity, although extensively studied, is still only partially understood. Classical biochemical approaches and, more recently, genome-wide high-throughput screens have identified more than two dozen plant SA-binding proteins (SABPs), as well as multiple candidates that have yet to be characterized. Some of these proteins bind SA with high affinity, while the affinity of others exhibit is low. Given that SA levels vary greatly even within a particular plant species depending on subcellular location, tissue type, developmental stage, and with respect to both time and location after an environmental stimulus such as infection, the presence of SABPs exhibiting a wide range of affinities for SA may provide great Edited by: flexibility and multiple mechanisms through which SA can act. SA and its derivatives, Brigitte Mauch-Mani, Université de Neuchâtel, Switzerland both natural and synthetic, also have multiple targets in animals/humans. Interestingly, Reviewed by: many of these proteins, like their plant counterparts, are associated with immunity or Robin Katrina Cameron, disease development. Two recently identified SABPs, high mobility group box protein McMaster University, Canada and glyceraldehyde 3-phosphate dehydrogenase, are critical proteins that not only serve Taras P. -
Imports of Benzenoid Chemicals and Products in 1977
IMPORTS OF BENZENOID CHEMICALS, AND PRODUCTS 1977 United States General Imports of Intermediates, Dyes, Medicinals, Flavor and Perfume Materials, and Other Finished Benzenoid Products Entered in 1977 Under Schedule 4, Part 1, of the . Tariff Schedules of the United States USITC PUBLICATION 900 . JULY 1978 United States International Trade Commission I Washington, D.C. 20436 UNITED ST ATES INTERNATIONAL· TRADE. COMMISSION COMMISSIONERS Joseph 0. Parker, Chairman Bill Alberger, Vice Chairman George M. Moore Catherine Bedell ltalo H. Ablondi Daniel Minchew Kenneth R. Mason, Secretary to the Commission OFFICE OF INDUSTRIES Norris A. Lynch, Director This report was principally prepared by Frances Battle, Virginia Bailey, Judy Bryant, Ralph Gray, Sharon Greenfield, Mildred Higgs, Kenneth Kozel, Ross Lewis, Linda Mudd, and Loretta Willis of the Energy and Chemical Division. Antomatic Data Processing imput was provided by James Gill and Dean Stout. Address all communications to Office of the Secretary United States International Trade Commission Washington, D.C. 20436 For Release Contact: Mr. James O'Connor July 21, 1978 (202) 523-0496 USITC 78-076 UNITED STATES INTERNATIONAL TRADE COMMISSION RELEASES FIGURES ON IMPORTS OF BENZENOID CHEMICALS AND PRODUCTS IN 1977 The U.S. International Trade Commission today issued a re~ port on U.S. imports of benzenoid chemicals and products in 1977. The report includes data on articles entered under schedule 4, parts lB and lC, of the Tariff Schedules of the United States. It provides detailed statistics on imports of 2,670 products, including benzenoid intermediates, dyes, organic pigments, medic inals and pharmaceuticals, flavor and pe~fume materials, and other benzenoid products. -
Opinion on Salicylic Acid (CAS 69-72-7) - Submission I - Corrigendum of 20-21 June 2019
SCCS/1601/18 Final Opinion Corrigendum of 20-21 June 2019 Scientific Committee on Consumer Safety SCCS OPINION ON salicylic acid (CAS 69-72-7) Submission I The SCCS adopted the final Opinion by written procedure on 21 December 2018 Corrigendum of 20-21 June 2019 SCCS/1601/18 Final Opinion Opinion on salicylic acid (CAS 69-72-7) - Submission I - Corrigendum of 20-21 June 2019 ___________________________________________________________________________________________ ACKNOWLEDGMENTS Members of the Working Group are acknowledged for their valuable contribution to this Opinion. The members of the Working Group are: For the preliminary and the final Opinion The SCCS members: Dr U. Bernauer Dr L. Bodin Prof. Q. Chaudhry (SCCS Chair) Prof. P.J. Coenraads (SCCS Vice-Chair and Chairperson of the WG) Prof. M. Dusinska Dr J. Ezendam Dr E. Gaffet Prof. C. L. Galli Dr B. Granum Prof. E. Panteri (Rapporteur) Prof. V. Rogiers (SCCS Vice-Chair) Dr Ch. Rousselle Dr M. Stepnik Prof. T. Vanhaecke Dr S. Wijnhoven External experts: Dr A. Simonnard Dr A. Koutsodimou Prof. W. Uter The additional contribution of the following external expert is gratefully acknowledged: Dr. N. von Goetz All Declarations of Working Group members are available on the following webpage: http://ec.europa.eu/health/scientific_committees/experts/declarations/sccs_en.htm This Opinion has been subject to a commenting period of a minimum eight weeks after its initial publication (from 10 September until 14 November 2018). Comments received during this time were considered by the SCCS. For this Opinion, comments received resulted in the following main changes: sections 3.3.1.1. -
RISK PROFILE of Phenyl Salicylate
RISK PROFILE Phenyl salicylate C A S N o . 1 1 8 - 55- 8 Date of reporting 05.06.201 2 Content of document 1. Identification of substance .................................................................... p. 1 2. Uses and origin ................................................................................ p. 2 3. Regulation ............................................................................................. p. 3 4. Relevant toxicity studies .................................................................... p. 4 5. Exposure estimates and critical NOAEL/NOEL ........................................... p. 5 6. Other sources of exposure than cosmetic products .............................. p. 8 7. Assessment ............................................................................................. p. 9 8. Conclusion ............................................................................................. p. 10 9. References ............................................................................................. p. 11 10. Annexes ............................................................................................. p. 13 1. Identification of substance Chemical name (IUPAC): Phenyl -2-hydroxybenzoate INCI Phenyl salicylate Other name Salol CAS No. 118-55-8 EINECS No. 204-259-2 Molecular formula C13H10O3 Chemical structure Molecular weight 214.22 g/mol Contents (if relevant) Physiochemical properties Appearance: solid, white crystalline substance Density: 1.25 g/cm3 Risk profile Phenyl Salicylate Page 1 of -
Patch Test Concentrations and Vehicles for Testing Contact Allergens
49_907_928 05.11.2005 12:13 Uhr Seite 907 Chapter 49 Patch Test Concentrations 49 and Vehicles for Testing Contact Allergens Anton C. De Groot, Peter J. Frosch Patch testing is a relatively safe and reasonably reli- Guidelines for testing the patient’s own contact able method for identifying contact allergens in pa- materials are provided in Chap. 50. tients with contact dermatitis. It has been clearly Table 2 lists alphabetically all chemicals men- shown that patch testing is necessary in the majority tioned in this book with their test concentrations and of patients with eczema [1]. The technique of patch vehicles (sometimes two concentrations are suggest- testing is described in Chap. 22. ed when insufficient data are available) as suggested All patients are tested with the European standard by the various authors. All allergens commercially series,containing the most frequent contact allergens available are also listed with their supplier(s), their in European countries (Table 1). Often, standard se- test concentrations, and vehicles as supplied. It ries patch testing is not enough, and additional aller- should be appreciated that for a considerable num- gens or potential allergens need to be tested, based ber of allergens, the concentrations vary between on the patient’s history and clinical examination. Ex- suppliers. Table 3 provides a list of test concentra- amples are products and chemicals to which the pa- tions for groups of chemicals as suggested by various tient is exposed occupationally or in his or her home authors in this book. Table 4 finally is an alphabetical environment. Test series containing the most fre- listing of commonly used abbreviations and their full quent allergens in certain products (preservatives, chemical synonyms. -
2 12/ 35 74Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 22 March 2012 (22.03.2012) 2 12/ 35 74 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 9/16 (2006.01) A61K 9/51 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 9/14 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP201 1/065959 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 14 September 201 1 (14.09.201 1) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, (25) Filing Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (26) Publication Language: English TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 61/382,653 14 September 2010 (14.09.2010) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, NANOLOGICA AB [SE/SE]; P.O Box 8182, S-104 20 ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, Stockholm (SE). -
Prescription Medications, Drugs, Herbs & Chemicals Associated With
Prescription Medications, Drugs, Herbs & Chemicals Associated with Tinnitus American Tinnitus Association Prescription Medications, Drugs, Herbs & Chemicals Associated with Tinnitus All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form, or by any means, without the prior written permission of the American Tinnitus Association. ©2013 American Tinnitus Association Prescription Medications, Drugs, Herbs & Chemicals Associated with Tinnitus American Tinnitus Association This document is to be utilized as a conversation tool with your health care provider and is by no means a “complete” listing. Anyone reading this list of ototoxic drugs is strongly advised NOT to discontinue taking any prescribed medication without first contacting the prescribing physician. Just because a drug is listed does not mean that you will automatically get tinnitus, or exacerbate exisiting tinnitus, if you take it. A few will, but many will not. Whether or not you eperience tinnitus after taking one of the listed drugs or herbals, or after being exposed to one of the listed chemicals, depends on many factors ‐ such as your own body chemistry, your sensitivity to drugs, the dose you take, or the length of time you take the drug. It is important to note that there may be drugs NOT listed here that could still cause tinnitus. Although this list is one of the most complete listings of drugs associated with tinnitus, no list of this kind can ever be totally complete – therefore use it as a guide and resource, but do not take it as the final word. The drug brand name is italicized and is followed by the generic drug name in bold. -
Opinion on Methyl Salicylate (Methyl 2-Hydroxybenzoate)
SCCS/1633/21 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Scientific Committee on Consumer Safety 15 16 SCCS 17 18 19 20 21 OPINION 22 on Methyl salicylate 23 24 (methyl 2-hydroxybenzoate) 25 26 27 28 29 30 31 32 33 34 35 36 The SCCS adopted this document 37 at its plenary meeting on 24-25 June 2021 38 SCCS/1633/21 Preliminary version Opinion on methyl salicylate (methyl 2-hydroxybenzoate) 1 2 ACKNOWLEDGMENTS 3 4 Members of the Working Group are acknowledged for their valuable contribution to this Opinion. 5 The members of the Working Group are: 6 7 8 For the preliminary version 9 10 SCCS members 11 Dr U. Bernauer 12 Dr L. Bodin 13 Prof. Q. Chaudhry (SCCS Chair) 14 Prof. P.J. Coenraads (SCCS Vice-Chair and Chairperson of the WG) 15 Prof. M. Dusinska 16 Dr J. Ezendam 17 Dr E. Gaffet 18 Prof. C. L. Galli 19 Dr B. Granum 20 Prof. E. Panteri 21 Prof. V. Rogiers (SCCS Vice-Chair) 22 Dr Ch. Rousselle (Rapporteur) 23 Dr M. Stepnik 24 Prof. T. Vanhaecke 25 Dr S. Wijnhoven 26 27 SCCS external experts 28 Dr A. Koutsodimou 29 Prof. W. Uter 30 Dr N. von Goetz 31 32 33 34 35 36 37 38 39 40 41 42 All Declarations of Working Group members are available on the following webpage: 43 Register of Commission expert groups and other similar entities (europa.eu) 44 45 46 47 SCCS/1633/21 Preliminary version Opinion on methyl salicylate (methyl 2-hydroxybenzoate) 1 2 1.