PATHOLOGY AND MOLECULAR MEDICINE Fields of Research Greer, P. A. Pathology is a study of disease and the mechanisms Professor leading to injury. It involves a wide range of biochemical, Cole, S.P.C., Collier, C.P., Deeley, R.G., Elliott, B.E., Greer, P.A., molecular, cellular and clinical approaches. Fields of LeBrun, D., Lillicrap, D.P., Manley, P.N., Mulligan, L., SenGupta, interest in the department include: cancer biology, drug S., Shepherd, L.E., Tron, V., Yang, X.,Young, I.D. resistance, metastasis, programmed cell death and cell cycle regulation, transgenic mouse models of gene function, cell Associate Professor differentiation and gene regulation, hemostasis/thrombosis, Berman, D., Boag, A.H., Davey, S., Feilotter, H., Hurlbut, D.J., amyloidosis and Alzheimer's disease, disturbances in protein Rossiter, J.P. synthesis, and human genetics (including human gene Assistant Professor mapping). Detailed information on faculty research interests Chen, J.C.-H., Childs, T., Davidson, C.M., Farmer, P., Good, D., is presented in a brochure which is available on request. Isotalo, P., Manduch, M., Nicol, C., Rauh, M. See also the Department of Pathology WEB Page: http:// www.path.queensu.ca/. Professor Emeritus Kisilevsky, R., Ludwin, S.K. Departmental Facilities Adjunct Professor Excellent facilities are available for training in experimental Zoutman, D. pathology and basic research in cell and molecular biology. Facilities and techniques include hemtological analysis, Adjunct Associate Professor electron microscopy, histochemistry, immunohistology, flow Chan, M. cytometry, two-photo confocal fluorescence microscopy, microinjection with fluorescence image analysis and time Adjunct Assistant Professor lapse capability, transgenic mice facilities for production Crocker, S., Hough, C., Sangrar, W., Tam, S-P. of transgenic over-expressing and gene-knock out models, Cross-Appointed cell fractionation, tissue culture; column chromatography, Evans, G.A., Farmer, J., James, P., Lee, D., MacKenzie, J., DNA, RNA and protein electrophoresis; gene cloning and Matthews, J., Maurice, D.H., Mueller, C.R., Petkovich, P.M., sequencing, using of isotopes and microarray-based global Raptis, L.H., Ropeleski, M.J.,Tayade, C., Tomalty, L.L., Young, gene expression profiling. P.G. Financial Assistance Programs Graduate students are encouraged to apply for financial • Pathology and Molecular Medicine - Doctor of Philosophy support in the form of fellowships and studentships from (https://queensu-ca-public.courseleaf.com/graduate- external granting agencies. Graduate research assistantships, studies/programs-study/pathology-molecular-medicine/ funded from grants to staff members, and teaching pathology-molecular-medicine-phd/) assistantships, funded by the University, are also available. Departmental policy ensures a minimum stipend support for • Pathology and Molecular Medicine - Master of Science graduate students. (https://queensu-ca-public.courseleaf.com/graduate- studies/programs-study/pathology-molecular-medicine/ Postgraduate Activities pathology-molecular-medicine-ms/) Postgraduate training programs leading to certification and fellowship in the Royal College of Physicians and Surgeons Courses of Canada and the American Board of Pathology are offered All courses are 3.0 credit units except PATH 899 and 999, through the Faculty of Medicine to medical graduates. which are 6.0 credit units. Faculty PATH 822 Experimental Cancer Therapeutics Intended for students engaged or interested in pre-clinical Head cancer research. Both medical and basic science trainees Boag, A.H. are encouraged to take this course. Specific areas to be covered include introduction to new drug development, Coordinator of Graduate Studies queensu.ca/academic-calendar Pathology and Molecular Medicine 1 molecular basis of oncogenic transformation and signalling Research projects in the physiological, biological, genetic and pathways, challenges with current cancer therapeutics, molecular basis of disease. Students will review the literature molecular approaches to profiling human cancers as tools related to their proposed graduate research thesis project for identifying biochemical and genetic abnormalities and write a series of essays on topics selected in consultation and developing criteria for reliable prognostic indicators; with a supervisory committee consisting of their supervisor strategies for novel target and drug discovery, as well as and two other faculty. They will also develop a written draft experimental drug delivery; novel imaging approaches to research proposal that will be presented to their supervisory enhance the sensitivity of preclinical testing and selection of committee and defended in a final oral examination. To be responsive patients; preclinical (in vitro and animal) models taken by all students in the first full term of the graduate for validating experimental targets; clinical drug development program. P. Greer (course coordinator). and testing of novel anti-cancer drugs; and the molecular basis for variability in tumour responses. Half course, lectures PATH 828 Bioinformatics for Cancer Research and seminars. Bioinformatics is an essential component of biological and PREREQUISITES: Recommended courses: ANAT 311, health science research given the ongoing developments BCHM 310, PHAR 340, MICR 360, PATH 310, CANC 440, or in generating large amounts of data in short periods of equivalents, or with permission of the department. The time. This course introduces tools and methods to manage number of students may be restricted. and analyze the results obtained in cancer research. Topics include study design, basic statistics for clinical and genetic PATH 823 Cancer Biology research, data-mining approaches and alternative methods The aim of this course is to introduce and discuss essential to statistics for data analysis, and signaling pathways analysis. questions in the basic science of oncology. Trainees with The course will cover the appropriate pre-processing and an interest in cancer research are encouraged to take this data analysis techniques for various genetic data types such course. Topics include pathology of cancer, cancer genetics, as microarray, tissue microarrays, methylation, NanoString, growth factors, signal transduction, oncogenes, suppressor RNAseq, miRNAseq, proteomics and qRT- PCR. Students genes, early stage tumorigenesis, tumor immunology with little computing background, but who are interested in and metastasis. A general theme for the course will be pursuing or collaborating with bioinformatic research, are mechanisms regulating neoplastic transformation and tumor encouraged to enroll. progression. In order to provide a balance and high profile in all areas, various staff members in the Cancer Research PATH 830 (MSc) Institute and associated departments have been selected PATH 930 (PhD) Pathology and Molecular Medicine as session leaders in this course. Half course, lectures and Research Seminar Series seminars; Fall term. L. Mulligan. This seminar series consists of weekly presentations by PREREQUISITES: Recommended courses: ANAT 311, visiting external speakers, Queen’s faculty, and Departmental BCHM 411 or BCHM 431, MICR 360 or equivalents, or with MSc and PhD students. Internal faculty and external permission of the department. The number of students may visiting speakers will be selected by the Graduate Program be restricted. coordinator with input from faculty and students. MSc students will give 1/2 hour seminars in their first PATH 826 The Molecular Basis of Disease year, and one hour seminars in their second year; PhD This course covers several diseases that highlight the students will give 1 hour seminars in their first and third genetic, biochemical, physiologic, anatomic, and general years, and an exit seminar in their final year. Attendance etiologic factors that play a role in the progression of each by all Departmental graduate students is compulsory and disease from its inception to death or recovery. Some of will be monitored by the Graduate Program Coordinator. the topics will be drawn from the ongoing research within Departmental faculty will provide evaluations of student the Department of Pathology and Molecular Medicine. presentations consisting of a mark and written comments The perspective will demonstrate that each disease is the relating to introduction and background, presentation of result of an evolving interplay of genetic and environmental results and response to questions. A final mark and summary factors. (Jointly with PATH 430. Additional work prescribed of faculty evaluations will be compiled by the coordinator for graduate students.) Half-course, lectures and seminars; and provided to the student and supervisor. Students Winter term. D. Lillicrap. are required to provide a written summary outlining their PREREQUISITE: PATH 410 or ANAT 309, BCHM 310, PHGY 212, research progress to their supervisory committee five days or equivalent. Class size will be limited to 12 students with prior to their seminar. Fall/Winter terms. P. Greer preference given to undergraduate students. PATH 899 Master's Thesis Research PATH 827 Research Project in Pathology

Pathology and Molecular Medicine 2 queensu.ca/academic-calendar

PATH 999 Ph.D. Thesis Research

queensu.ca/academic-calendar Pathology and Molecular Medicine 3