Cross-Presenting Human T Cells Induce Robust CD8 T Cell Responses
Cross-presenting human ␥␦ T cells induce robust CD8؉ ␣ T cell responses Marle` ne Brandesa,1, Katharina Willimanna, Gilles Bioleyb,2, Nicole Le´ vyc, Matthias Eberla,3, Ming Luod, Robert Tampe´ e, Fre´ de´ ric Le´ vyc,4, Pedro Romerob, and Bernhard Mosera,3,5 aInstitute of Cell Biology, University of Bern, CH-3000 Bern 9, Switzerland; bDivision of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, Lausanne Branch, University Hospital (Centre Hospitalier Universitare Vaudois), CH-1005 Lausanne, Switzerland; cLudwig Institute for Cancer Research, Lausanne Branch, CH-1066 Epalinges, Switzerland; dDepartment of Microbiology, University of Alabama, Birmingham, AL 35294; and eInstitute of Biochemistry, Biocenter, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany Edited by Peter Cresswell, Yale University School of Medicine, New Haven, CT, and approved December 18, 2008 (received for review October 7, 2008) ␥␦ T cells are implicated in host defense against microbes and receptors and the transformation of these cells into professional tumors but their mode of function remains largely unresolved. APCs, termed ␥␦ T-APCs, capable of inducing CD4ϩ T cell Here, we have investigated the ability of activated human responses (9, 10). Of note, antigen-presenting ␥␦ T cells have also .(V␥9V␦2؉ T cells (termed ␥␦ T-APCs) to cross-present microbial and been reported in cows (11); pigs (12); and, most recently, mice (13 tumor antigens to CD8؉ ␣ T cells. Although this process is thought Reactivity to HMB-PP-expressing microbes and certain tumors to be mediated best by DCs, adoptive transfer of ex vivo antigen- suggested to us a role for human ␥␦ T-APCs in the induction of ϩ loaded, human DCs during immunotherapy of cancer patients has pathogen/tumor-specific CD8 T effector cells.
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