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Conscious Sedation of Children with Propofol Is Anything but Conscious

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Conscious Sedation of Children with Propofol Is Anything but Conscious Conscious Sedation of Children With Propofol Is Anything but Conscious Scott T. Reeves, MD; Jeana E. Havidich, MD; and D. Patrick Tobin, CRNA ABSTRACT. Objective. To determine the depth of se- taining adequate cardiopulmonary function and the dation required for bone marrow aspiration and intrathe- ability to respond purposefully to verbal command cal injection of chemotherapeutic agents in children us- and/or to tactile stimulation.”1 Recently, the Joint ing a bispectral (BIS) index monitor and clinical Commission on Accreditation of Healthcare Organi- assessment by an independent observer. zations (JCAHO) revised its standards for anesthesia Methods. Sixteen children who were undergoing 19 2 intrathecal chemotherapy and bone marrow aspirations and sedation. This revision was required by changes were enrolled in the study. Their ages ranged from 23 in anesthesia and sedation practices, which have months to 190 months with a mean of 79 months. The BIS moved from the operating room setting to peripheral index was recorded every 5 minutes by an independent sites such as ambulatory care clinics. In addition, observer. The patients received only intravenous propo- potent intravenous induction anesthetics, including fol for sedation. There were no complications during the propofol, have entered the mainstream of sedation procedures. practice. Results. The mean BIS score was 62.8 ؎ 9.6. The mean -low BIS score was 29.7 ؎ 13.7, indicating a level of deep The objective of this prospective study was to de sedation and/or general anesthesia was necessary to in- termine the level of sedation (conscious vs deep), duce the desired stated of consciousness that would per- using a bispectral (BIS) index monitor, provided by mit the practitioner to perform the procedure. The aver- experienced anesthesia personnel for bone marrow -age dose of propofol was 166 ؎ 47 ␮g/kg/min. Mean aspiration and intrathecal injection of chemothera Aldrete score for level of consciousness was 0.9 ؎ 0.4, peutic agents with propofol in children. Propofol indicating a depressed level of consciousness. The mean ,was chosen because of its rapid onset, short half-life ؎ activity level was 1.0 0.4, indicating impaired move- and antiemetic effect. ment. Conclusions. Children who undergo conscious seda- tion with propofol for intrathecal chemotherapy and METHODS bone marrow aspiration demonstrate BIS values and clinical assessments consistent with deep sedation. Be- This study was approved by the Medical University of South cause of an increased risk of adverse events when Carolina Institutional Review Board. Parental informed consent and child assent (when appropriate for age) were obtained for children undergo deep sedation, appropriate parental in- each subject. Sixteen children who were undergoing 19 intrathecal formed consent, age-appropriate resuscitative equip- chemotherapy and bone marrow aspirations were enrolled in the ment, and skilled anesthesia personnel should be present study. Their ages ranged from 23 months to 190 months with a for rescue in the event of cardiovascular and respiratory mean of 79 months. The majority of patients were connected to an complications from deep sedation. Pediatrics 2004; A2000 monitor (Aspect Medical Systems Inc, Newton, MA) before 114:e74–e76. URL: http://www.pediatrics.org/cgi/content/ initiation of sedation using a disposable BIS sensor attached to the full/114/1/e74; BIS index monitor, sedation, children. patient’s forehead according to the manufacturer’s specifications. An impedance test was performed before initiating data collec- tion. The impedance had to fall within the manufacturer’s deter- ABBREVIATIONS. JCAHO, Joint Commission on Accredita- mined threshold to generate a reliable signal quality and measure- tion of Healthcare Organizations; BIS, bispectral; EEG, electro- ment. Hemodynamic monitoring included an electrocardiogram, encephalogram. pulse oximeter, and noninvasive blood pressure cuff and was recorded every 5 minutes. Measurement of the patient’s level of consciousness and activity level was performed every 5 minutes onscious or moderate sedation has gained using a modification of the Aldrete scoring system (Table 1). wide acceptance as the primary mechanism to After confirmation of appropriate non per os status and normal expedite the conduct of procedures on chil- laboratory values, the patients received intravenous propofol for C sedation. One of the investigators was present as an independent dren. According to the American Society of Anesthe- siology task force on sedation and analgesia, con- observer to evaluate the BIS scores every 5 minutes (Table 2). Anesthesia personnel who administered propofol were blinded to scious sedation “describes a state that allows the the BIS index. There were no complications throughout the pro- child to tolerate unpleasant procedures while main- cedures. Propofol was titrated by intermittent intravenous bolus injec- tion to ensure adequate procedure conditions, still child during From the Department of Anesthesia and Perioperative Medicine, Medical lumbar puncture, and intrathecal chemotherapy injection. The University of South Carolina, Charleston, South Carolina. airway had to be supported with jaw lift and/or ventilation with Received for publication Jan 7, 2004; accepted Feb 4, 2004. a self-inflating bag and face mask intermittently in some of the Address correspondence to Scott T. Reeves, MD, Department of Anesthesia patients. and Perioperative Medicine, Medical University of South Carolina, 165 Ashley Ave, STE 525, PO Box 250912, Charleston, SC 29425. E-mail: [email protected] PEDIATRICS (ISSN 0031 4005). Copyright © 2004 by the American Acad- Statistical Analysis emy of Pediatrics. Data are reported as mean values with SDs. e74 PEDIATRICS Vol. 114Downloaded No. 1 July from 2004www.aappublications.org/news http://www.pediatrics.org/cgi/content/full/114/1/ by guest on September 29, 2021 e74 TABLE 1. Modified Aldrete Score alogram (EEG), a decrease in frequency and ampli- Level of Point Activity Level Point tude. The BIS index monitor was developed to mea- Consciousness Value Value sure the electrophysical state of the brain during Fully awake 2 No change from 2 anesthesia. This device uses advanced computer pro- preoperative level grams to analyze various aspects of the EEG to eval- Arousable on calling 1 Movement impaired 1 uate the effect of sedative and hypnotic agents.3,4 Not responsive 0 No movement 0 Numerous studies have demonstrated the effective- ness of the BIS monitors in both adults and children as an effective monitor of the depth of anesthesia.3,5–7 RESULTS McDermott and others8–13 recently validated the util- Sixteen children were enrolled in the study; their ity of the BIS monitor in children who undergo se- ages ranged from 23 to 190 months with a mean of 79 dation. A BIS value of 100 represents a fully awake months. The initial presedation BIS index was Ն97 in patient, values ranging from 70 to 90 are associated 15 of 19 sedation procedures. The remaining 4 pro- with diminished recall, and patients with values Ͻ70 cedure patients did not tolerate presedation elec- are unconscious. A value of 0 represents an isoelec- trode placement. BIS data collection started immedi- tric EEG.3,4 ately after the initiation of propofol and continued Frequently, the term “conscious sedation” or until the procedure had concluded and the child “moderate sedation” is used as the descriptive term regained consciousness. The mean BIS score was 62.8 to describe the level of sedation used in children. Ϯ 9.6 for the study. The lowest BIS score mean for all This implies that the child requires only a relatively of the patients was 29.7 Ϯ 13.7, indicating that a level small amount of sedative to achieve cooperation for of general anesthesia was necessary to induce the the procedure and that airway reflexes are intact and desired stated of consciousness that would permit respiratory and cardiovascular compromise does not the practitioner to perform the procedure. The data occur. Hence, there is minimal risk to the patient for the patients are tabulated in Table 2. undergoing the sedative procedure. Recently, Hoff- The mean cumulative dose of propofol received by man et al14 noted that 22% of children who are intermittent bolus was 166 Ϯ 47 ␮g/kg/min. All scheduled for conscious sedation using less potent patients were nonresponsive without movement sedatives (chloral hydrate, midazolam, fentanyl) ac- during needle insertion, indicative of an Aldrete tually achieve deep sedation. The complication rate score of 0 for level of consciousness and impaired (hypoxia, airway obstruction, aspiration, hypoten- movement. The mean Aldrete score for level of con- sion, bradycardia) was 3.8% in patients who re- sciousness was 0.9 Ϯ 0.4, indicating a depressed level mained conscious and 5.6% in patients who were of consciousness. The mean activity level was 1.0 Ϯ deeply sedated. 0.4, indicating impaired movement. Our results illustrate that levels of deep sedation and/or general anesthesia are necessary to prevent DISCUSSION movement during bone marrow aspiration and in- Recent technologic advances enable physicians trathecal chemotherapy administration. Our study and personnel who are administering sedation to differs from other studies in that propofol was the monitor subcortical brain waves to determine the sole agent used and trained anesthesia personnel level of consciousness. Sedative and anesthetic drugs monitored the patient. In our study, the lowest BIS produce changes in
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