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2007 Ciências Básicas Moleculares XV Congresso de Iniciação Científica da UNIFESP – 2007 Ciências Básicas Moleculares UNIVERSIDADE FEDERAL DE SÃO PAULO ESCOLA PAULISTA DE MEDICINA XV CONGRESSO DE INICIAÇÃO CIENTÍFICA REITOR Prof. Dr. Ulysses Fagundes Neto VICE-REITOR Prof. Dr. Sergio Tufik PRÓ-REITORIAS Graduação Prof. Dr. Luiz Eugênio Araújo de Moraes Mello Pós-Graduação e Pesquisa Prof. Dr. Nestor Schor Extensão Prof. Dr. Walter Manna Albertoni Administração Prof. Dr. Sérgio Antonio Draibe 1 XV Congresso de Iniciação Científica da UNIFESP – 2007 Ciências Básicas Moleculares COMISSÃO ORGANIZADORA COORDENAÇÃO DO PIBIC - CONGRESSO Profa. Dra. Helena Bonciani Nader Profa. Dra. Lucia de Oliveira Sampaio Prof. Dr. Luiz Eugênio Araújo de Moraes Mello COMISSÃO INSTITUCIONAL DE INICIAÇÃO CIENTÍFICA Comitê Institucional Profa. Dra. Adriana Karaoglanovic Carmona Prof. Dr. Angelo Amato Vincenzo de Paola Profa. Dra. Anita Hilda Straus Takahashi Profa. Dra. Brasília Maria Chiari Profa. Dra. Clara Lucia Barbieri Mestriner Profa. Dra. Clara Regina Brandão de Ávila Profa. Dra. Eliane Beraldi Ribeiro Profa. Dra. Emília Inoue Sato Profa. Dra. Heimar de Fátima Marin Profa. Dra. Ieda Maria Longo Maugeri Profa. Dra. Janete Maria Cerutti Profa. Dra. Janine Schirmer Prof. Dr. José Carlos Costa Baptista Silva Prof. Dr. José Maria Soares Júnior Prof. Dr. Luiz Roberto Ramos Prof. Dr. Manuel de Jesus Simões Profa. Dra. Mara Helena de Andréa Gomes Profa. Dra. Maria Gerbase de Lima Profa. Dra. Marília de Arruda Cardoso Smith Profa. Dra. Neusa Pereira da Silva Prof. Dr. Reynaldo Jesus Garcia Filho Prof. Dr. Roberto Frussa Filho Profa. Dra. Rosana Fiorini Puccini Prof. Dr. Sang Won Han Profa. Dra. Sima Godosevicius Katz Comitê Externo Prof. Dr. Eder Carlos Rocha Quintão Prof. Dr. Ivan França Junior Prof. Dr. José Eduardo Krieger 2 XV Congresso de Iniciação Científica da UNIFESP – 2007 Ciências Básicas Moleculares Profa. Dra. Miriam Aparecida Barbosa Merighi Prof. Dr. Paulo Lee Ho Profa. Dra. Telma Maria Tenório Zorn SECRETÁRIA DO PIBIC E CONGRESSO Cristiane Regina da Silva SISTEMA DE COLETA DE DADOS DESENVOLVIMENTO Centro de Avaliação e Integração de Dados Institucionais André Alberto do Prado Kátia da Silva Diana Marcello Di Pietro COLETA DE DADOS Kátia da Silva Diana Marcello Di Pietro SITE E CD ROM Setor de Tecnologia da Informação – PROGRAD Fábio Luís Falchi de Magalhães (Simpson) Lidiane Cristina da Silva Marcelo Antônio Meirinho Walfran Carvalho De Araujo Yuri Bittar ASSESSORIA DE EVENTOS Pró-Reitoria de Extensão 3 XV Congresso de Iniciação Científica da UNIFESP – 2007 Ciências Básicas Moleculares XV CONGRESSO ANUAL DE INICIAÇÃO CIENTÍFICA A Universidade Federal de São Paulo (UNIFESP) tem por objetivo desenvolver, em nível de excelência, atividades inter-relacionadas de ensino, pesquisa e extensão. As atividades de ensino compreendem as áreas de graduação, pós-graduação e de extensão. A UNIFESP criada em 15 de dezembro de 1994, resulta da transformação da Escola Paulista de Medicina, fundada em junho de 1933, federalizada em janeiro de 1956 e transformada em estabelecimento isolado de ensino superior de natureza autárquica em setembro de 1964. O curso de enfermagem teve início em 1939, com a criação da Escola Paulista de Enfermagem. A pesquisa inicia-se em 1948, com a instalação do laboratório de farmacologia e bioquímica. Novos cursos de graduação são iniciados em meados da década de 60: Ciências Biomédicas, 1966; Fonoaudiologia, 1968 e Tecnologia Oftálmica, 1970. Em 2003, a universidade cria, depois de mais de 35 anos, novos cursos de graduação. Inicialmente, foram implementados 5 cursos da área da saúde (Educação Física, Fisioterapia, Nutrição, Psicologia, Terapia Ocupacional) no campus da Baixada Santista. Em 2006, no campus de Diadema são criados 4 cursos da área de exatas e biológicas (Ciências Biológicas, Engenharia Química, Farmácia/Bioquímica, Química), em São José dos Campos na área das exatas (Ciências da Computação) e no campus de Guarulhos 4 cursos de humanidades (Ciências Sociais, Filosofia, História, Pedagogia). Deixamos de ser uma universidade temática, integrando em nossas atividades as três grandes áreas do saber. O ensino de graduação na UNIFESP, universidade dedicada ao ensino e à pesquisa é fortemente influenciado por algumas características da Instituição que evidenciam a importância de programa institucional de iniciação científica: integração científica e geográfica entre os Departamentos das áreas básicas e profissionais; corpo docente com titulação pós-graduada em porcentagem superior a 90%; grupos de excelência em pesquisa e significativo envolvimento de alunos em programa de iniciação. O PIBIC (Programa Institucional de Bolsas de Iniciação Científica) completa, em 2007, quinze anos na UNIFESP. Esta importante ação indutora do CNPq ampliou de maneira considerável a iniciação científica na Instituição. No período de agosto/2006 à julho/2007, duzentos e noventa e sete (297) alunos de graduação receberam bolsa de IC e apresentarão seus trabalhos durante o XV Congresso de Iniciação Científica, seja na forma de painéis ou de apresentação oral. Ainda, deverão participar deste Congresso alunos de IC bolsistas da FAPESP, e de outras agências de fomento que desenvolvem projetos na nossa Instituição, bem como em outras universidades. O Congresso de Iniciação Científica da UNIFESP tem como objetivos a divulgação dos resultados de projetos de pesquisa que vem sendo desenvolvidos pelos estudantes de graduação, bem como o treinamento na apresentação e discussão dos trabalhos. Todos os estudantes, bolsistas ou não do PIBIC, apresentam seus resultados tanto em sessões temáticas, seja sob a forma de cartazes como apresentação oral. Ainda, os estudantes são os responsáveis pela coordenação dos trabalhos orais, atuando como presidentes de sessão. Com isso, pretende-se estimular: o treinamento do estudante de graduação na análise e na interpretação dos dados de sua pesquisa, bem como na divulgação de seus resultados; 4 XV Congresso de Iniciação Científica da UNIFESP – 2007 Ciências Básicas Moleculares o treinamento na elaboração dos dados para divulgação oral e de cartaz; a troca de experiência entre pesquisadores de grupos de pesquisa já consagrados e emergentes; o apoio e a oferta de subsídios teóricos, visando ao aperfeiçoamento daqueles que se qualificam para a investigação científica; a vocação e os talentos potenciais para o pensar e o criar cientificamente; a divulgação de trabalhos de pesquisa desenvolvidos através dos Programas Institucionais da UNIFESP e de outras Instituições. Em nome dos docentes e funcionários técnico-administrativos da UNIFESP, em especial de todos da Pró-Reitoria de Graduação, damos as boas vindas aos participantes, desejando sucesso nesta reunião, e que as discussões dos resultados sejam de grande proveito no encaminhamento dos trabalhos de cada um. Helena Bonciani Nader Lucia de Oliveira Sampaio Luiz Eugênio Araújo de Moraes Mell o Pró-Reitoria de Graduação 5 XV Congresso de Iniciação Científica da UNIFESP – 2007 Ciências Básicas Moleculares PROGRAMAÇÃO DO XV CONGRESSO DE INICIAÇÃO 18/06 18:00 horas Abertura Palestra proferida pelo Prof. Dr. Ricardo Enzo Brentani Diretor Presidente do Conselho Técnico-Administrativo da FAPESP Presidente do Hospital A.C. Camargo Prof. Titular da disciplina de Oncologia da Universidade de São Paulo - USP Tema: “O valor da ciência” Local: Teatro Marcos Lindenberg 19/06 08:00 às 10:30 horas - Apresentação Oral Local : Prédio dos Anfiteatros - Edifício Costabile Galucci 11:00 às 12:00 horas - Apresentação Pôster Local: Cobertura Estacionamento C 13:00 às 15:30 horas - Apresentação Oral Local : Prédio dos Anfiteatros - Edifício Costabile Galucci 16:00 às 17:00 horas - Apresentação Pôster Local: Cobertura Estacionamento C 20/06 08:00 às 10:30 horas - Apresentação Oral Local : Prédio dos Anfiteatros - Edifício Costabile Galucci 11:00 às 12:00 horas - Apresentação Pôster Local: Cobertura Estacionamento C 13:00 às 15:30 horas - Apresentação Oral Local : Prédio dos Anfiteatros - Edifício Costabile Galucci 16:00 às 17:00 horas - Apresentação Pôster Local: Cobertura Estacionamento C 6 XV Congresso de Iniciação Científica da UNIFESP – 2007 Ciências Básicas Moleculares DISTRIBUIÇÃO DOS TRABALHOS POR ÁREA Área Total Ciências Básicas Moleculares 68 Ciências Básicas Morfológicas 21 Cirurgia Aplicada 12 Cirurgia Experimental 10 Distúrbios da Comunicação e Audição 31 Enfermagem 24 Medicina Aplicada 75 Medicina Experimental 33 Outra 45 Saúde Coletiva 31 Total geral 350 7 XV Congresso de Iniciação Científica da UNIFESP – 2007 Ciências Básicas Moleculares Título: ADESÃO DE NEUTRÓFILOS A CÉLULAS ENDOTELIAIS DE VEIA UMBILICAL HUMANA (HUVECs): PARTICIPAÇÃO DAS VIAS DE SINALIZAÇÃO CELULAR. Autores: Cardoso, A.S.C.; Nogueira Neto, J.; Pereira, E.M.; Gomes, L.F.; Simon -Giavarotti, K.A.; Junqueira, V.B.C. Bolsista: André dos Santos Carneiro Cardoso Orientador: Virgínia Berlanga Campos Junqueira Resumo: Os neutrófilos, ou PMNs (polimorfonucleares), compõem a maior fração de células da imunidade inata, sendo assim componentes importantes na resposta imune. A principal função dos neutrófilos é fagocitar e matar microorganismos invasores. Durante sua vida na circulação, os neutrófilos são submetidos a muitas situações que resultarão na ativação das vias de transdução de sinal. A ativação dos neutrófilos resulta na iniciação de uma resposta inflamatória, levando a quimiotaxia, adesão a células endoteliais, migração e desenvolvimento de funções efetoras, como também produção de radicais livres. Essa ativação ode se dar por diferentes
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