Product datasheet Anti-KCNA5 Antibody Catalog Number: PB0693

BOSTER BIOLOGICAL TECHNOLOGY Special NO.1, International Enterprise Center, 2nd Guanshan Road, Wuhan, China

Web: www.boster.com.cn Phone: +86 27 67845390 Fax: +86 27 67845390 Email: [email protected]

Basic Information Product Name Anti-KCNA5 Antibody Name KCNA5 Source Rabbit IgG Species Reactivity human,mouse,rat Tested Application WB Contents 500ug/ml antibody with PBS ，0.02% NaN3 , 1mg BSA and 50% glycerol. Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human KCNA5 (583-613aa LEKCNVKAKSNVDLRRSLYALCLDTSRETDL), different from the related mouse and rat sequences by two amino acids. Purification Immunogen affinity purified. Observed MW 67KD Dilution Ratios Western blot: 1:500-2000

Storage 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing

Background Information Potassium voltage-gated channel, -related subfamily, member 5, also known as KCNA5 or Kv1.5, is a that in humans is encoded by the KCNA5 gene. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the , voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with KCNA1 and KCNA6 on 12. Mutations in this gene have been related to both atrial fibrillation and sudden cardiac death. KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.

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FOR RESEARCH USE ONLY. NOT FOR DIAGNOSTIC AND CLINICAL USE. 1 Product datasheet Anti-KCNA5 Antibody Catalog Number: PB0693

BOSTER BIOLOGICAL TECHNOLOGY Special NO.1, International Enterprise Center, 2nd Guanshan Road, Wuhan, China

Web: www.boster.com.cn Phone: +86 27 67845390 Fax: +86 27 67845390 Email: [email protected]

Selected Validation Data

Figure 1. Western blot analysis of Anti-KCNA5 antibody (PB0693). The sample well of each lane was loaded with 50ug of sample under reducing conditions.Lane 1: 293T whole cell lysates,Lane 2: A549 whole cell lysates,Lane 3: PANC whole cell lysates,Use rabbit Anti-KCNA5 1:1000, probed with a goat Anti-rabbit IgG-HRP secondary antibody. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002). A specific band was detected for KCNA5 at approximately 67KD. The expected band size for KCNA5 is at 67KD.

FOR RESEARCH USE ONLY. NOT FOR DIAGNOSTIC AND CLINICAL USE. 2

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