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New Developments in Viral Vaccine Technologies Guest Editors Rainer Ulrich, Berlin George P. Lomonossoff, Norwich Detlev H. Krüger, Berlin 73 figures and 39 tables, 2002 Basel Ⴇ Freiburg Ⴇ Paris Ⴇ London Ⴇ New York Ⴇ Bangalore Ⴇ Bangkok Ⴇ Singapore Ⴇ Tokyo Ⴇ Sydney S. Karger Drug Dosage All rights reserved. Medical and Scientific Publishers The authors and the publisher have exerted every effort to en- No part of this publication may be translated into other Basel Ⴇ Freiburg Ⴇ Paris Ⴇ London sure that drug selection and dosage set forth in this text are in languages, reproduced or utilized in any form or by any means, Ⴇ Ⴇ accord with current recommendations and practice at the time electronic or mechanical, including photocopying, recording, New York Bangalore Bangkok of publication. However, in view of ongoing research, changes microcopying, or by any information storage and retrieval Ⴇ Ⴇ Singapore Tokyo Sydney in government regulations, and the constant flow of informa- system, without permission in writing from the publisher or, in tion relating to drug therapy and drug reactions, the reader is the case of photocopying, direct payment of a specified fee to urged to check the package insert for each drug for any change the Copyright Clearance Center (see ‘General Information’). in indications and dosage and for added warnings and precau- tions. This is particularly important when the recommended © Copyright 2002 by S. Karger AG, agent is a new and/or infrequently employed drug. P.O. Box, CH–4009 Basel (Switzerland) Printed in Switzerland on acid-free paper by Reinhardt Druck, Basel ISBN 3–8055–7505–X Fax + 41 61 306 12 34 E-Mail [email protected] www.karger.com Contents Vol. 45, 2002 No. 1 No. 2 1 Some Thoughts from Your Publisher Original Papers Karger, T.; Karger, S. (Basel) 67 Superoxide Anion Production by Granulocytes Incubated with HeLa 229 Cells Persistently Infected with Influenza Virus Mini Review B/Lee/40 Hayase, Y.; Tobita, K. (Tochigi) 2 Genital Herpes Simplex Virus Type 1 Infection: New Fields for an Old Acquaintance? 71 Influence of Hepatitis C Virus Subtype on Hepatocellular Lippelt, L. (Münster); Braun, R.W. (Stuttgart); Kühn, J.E. (Münster) Carcinogenesis: A Multivariate Analysis of a Retrospective Cohort of 593 Patients with Cirrhosis Ikeda, K.; Kobayashi, M.; Someya, T.; Saitoh, S.; Tsubota, A.; Akuta, N.; Original Papers Suzuki, F.; Suzuki, Y.; Arase, Y.; Kumada, H. (Tokyo) 6 Liver Transplantation-Associated de novo Hepatitis B Virus 79 A New Indicator Cell Line to Monitor Human Foamy Virus Infection: Application of Molecular Evolutionary Analysis Infection and Stability in vitro Sugauchi, F.; Orito, E.; Ohno, T.; Kato, H.; Suzuki, T.; Hashimoto, T.; Li, Z.; Yang, P.; Liu, H.; Li, W-x. (Wuhan) Manabe, T.; Ueda, R.; Mizokami, M. (Nagoya) 85 Induction of Apoptosis in Rabbit Kidney Cell under High-Level 11 Analysis of Background Factors Influencing Long-Term Expression of Bovine Herpesvirus 1 Us ORF8 Product Prognosis of Patients with Chronic Hepatitis C Treated with Nakamichi, K.; Matsumoto, Y.; Tohya, Y.; Otsuka, H. (Tokyo) Interferon Yoneyama, K.; Yamaguchi, M.; Kiuchi, Y. (Tokyo); Morizane, T. (Kanagawa); Short Communications Shibata, M.; Mitamura, K. (Tokyo) 20 Clinical and Subclinical Reactivation of Genital Herpes Virus 94 Detection of JC Virus Type 1 in Peripheral Lymphocytes, Wolff, M.H.; Schmitt, J.; Rahaus, M.; Dudda, H.; Hatzmann, W. (Witten) Brain and Cerebrospinal Fluid from Two Korean AIDS Patients with Progressive Multifocal Leukoencephalopathy 24 Evaluation of HBs, HBc, and frCP Virus-Like Particles for Expression of Human Papillomavirus 16 E7 Oncoprotein Jeong, B.-H.; Jin, J.-K. (Chunchon); Choi, E.-K. (Charlestown, Mass.); Kim, K.-H. (Chunchon); Choi, K.-W.; Oh, M.-D.; Shin, K.-C. (Seoul); Epitopes Kim, Y.-S. (Chunchon) Pumpens, P. (Riga); Razanskas, R. (Vilnius); Pushko, P.; Renhof, R.; Gusars, I.; Skrastina, D.; Ose, V.; Borisova, G.; Sominskaya, I.; Petrovskis, I.; 101 Genotyping of Hepatitis E Virus from Vietnam Jansons, J. (Riga); Sasnauskas, K. (Vilnius) Hijikata, M.; Hayashi, S. (Tokyo); Trinh, N.T.; Ha, L.D. (Hanoi); Ohara, H.; Shimizu, Y.K.; Keicho, N.; Yoshikura, H. (Tokyo) 33 Viral Dynamics and Pharmacokinetics in Combined Interferon Alfa-2b and Ribavirin Therapy for Patients Infected with 105 Accurate Prediction of Response to Interferon Therapy by Hepatitis C Virus of Genotype 1b and High Pretreatment Viral Repeated Measurement of Hepatitis C Virus Core Protein in Load Patients with Chronic Hepatitis C Tsubota, A.; Akuta, N.; Suzuki, F.; Suzuki, Y.; Someya, T.; Kobayashi, M.; Nishiguchi, S.; Enomoto, M.; Tanaka, M.; Fukuda, K.; Tamori, A.; Habu, D.; Arase, Y.; Saitoh, S.; Ikeda, K.; Kumada, H. (Tokyo) Takeda, T.; Shiomi, S.; Tanaka, T.; Yano, Y.; Otani, S. (Osaka) 43 Respiratory Syncytial Virus Enhances the Expression of CD 11b 111 Molecular Evaluation of the Prevalence of Oncogenic Human Molecules and the Generation of Superoxide Anion by Human Papillomavirus Genotypes in Cervical Acetowhite Lesions Eosinophils Primed with Platelet-Activating Factor Rocha-Zavaleta, L.; Garcia-Carranca, A.; Lira de la Cruz, A.L.; Barrios, T.; Tachibana, A.; Kimura, H.; Kato, M.; Nako, Y.; Kozawa, K.; Morikawa, A. Valdespino, V.; Cruz-Talonia, F. (Mexico) (Gunma) 115 Interaction of Adeno-Associated Virus Rep78 with SV40 T Antigen: Implications in Rep Protein Expression Leading to the Short Communications Inhibition of SV40-Mediated Cell Proliferation Batchu, R.B. (Little Rock, Ark.); Shammas, M.A. (Boston, Mass.); Wang, J.Y.; 52 Distinct Mutational Drug Resistance Profiles of HIV-1 RNA in Shmookler Reis, R.J. (Little Rock, Ark.); Munshi, N.C. (Boston, Mass.) Plasma and Culture Isolates of Patients Receiving Antiretroviral 119 Cyclophosphamide-Immunodepressed FVB/N Mice: Therapy Potentiating the Effects of Testicular Cytomegalovirus Infection Debiaggi, M.; Bruno, R.; Sacchi, P.; Achilli, G.; Romero, E.; Filice, G. (Pavia) Tebourbi, L. (Clamart); Emile, J.F.; Cerutti, I. (Villejuif) 56 Profound Sex-Specific Effects on Incubation Times for Transmission of Bovine Spongiform Encephalopathy to Mice Abiola, O.O.; Iyegbe, C.; Lantos, P.; Plomin, R.; Anderton, B.H.; Whatley, S.A. (London) 59 Mapping of Epitopes on the Fiber Knobs of Human Adenovirus Serotypes 8 and 15 Liebermann, H.; Lotz, K.; Seidel, W. (Greifswald) 58 Addendum © 2002 S. Karger AG, Basel Fax + 41 61 306 12 34 Access to full text and tables of contents, E-Mail [email protected] including tentative ones for forthcoming issues: www.karger.com www.karger.com/int_issues No. 3 No. 4–6 Original Papers New Developments in Viral Vaccine Technologies Guest Editors: Rainer Ulrich (Berlin); George P. Lomonossoff (Norwich); 125 Temperature-Sensitive Viral Infection: Inhibition of Detlev H. Krüger (Berlin) Hemagglutinating Virus of Japan (Sendai Virus) Infection at 41° Ishida, Y.-i.; Hiraki, A.; Hirayama, E.; Koga, Y.; Kim, J. (Kyoto) 197 Editorial 136 Human Rhinovirus 87 Identified as Human Enterovirus 68 by Ulrich, R. (Berlin); Lomonossoff, G.P. (Norwich); Krüger, D.H. (Berlin) VP4-Based Molecular Diagnosis Ishiko, H.; Miura, R.; Shimada, Y.; Hayashi, A.; Nakajima, H.; Yamazaki, S.; Takeda, N. (Tokyo) Overviews 142 Large Hepatitis Delta Antigen Is Phosphorylated at Multiple 199 Overview of the Needs and Realities for Developing New and Sites and Phosphorylation Is Associated with Protein Improved Vaccines in the 21st Century Conformational Change Hilleman, M.R. (West Point, Pa.) Choi, S.-H.; Park, K.-J.; Hwang, S.B. (Anyang) 212 Virus-Like Particles as a Modular System for Novel Vaccines 150 Experimental Infection of Lacertids with Lizard Erythrocytic Lechner, F.; Jegerlehner, A.; Tissot, A.C.; Maurer, P.; Sebbel, P.; Viruses Renner, W.A.; Jennings, G.T.; Bachmann, M.F. (Zürich) Alves de Matos, A.P. (Lisbon); Paperna, I. (Rehovot); Crespo, E. (Lisbon) 160 The Genome Organization of Pea Stem Necrosis Virus and Its Hepatitis B Virus Assignment to the Genus Carmovirus Suzuki, S.; Hase, S.; Takahashi, H.; Ikegami, M. (Sendai) 218 Molecular Epidemiology and Immunology of Hepatitis B Virus 164 Detection of Human T-Lymphotropic Virus Type I (HTLV-I) Infection – An Update Infection during Coculture of HTLV-I Infected and Uninfected Pumpens, P.; Grens, E. (Riga); Nassal, M. (Freiburg) Cells Using Inverse Long PCR 233 In vitro Expression of Human Hepatitis B Virus Genomes Ishizaki, J.; Okayama, A.; Kuroki, M.; Tsubouchi, H. (Kiyotake) Carrying Woodchuck Hepatitis Virus Pre-S1 Sequences 172 Efficient Haemodialysis Improves the Response to Hepatitis B Hourioux, C.; Kneser, J.; Bruss, V. (Göttingen) Virus Vaccination 237 Immunogenic Effects of Woodchuck Hepatitis Virus Surface Kovacic, V.; Sain, M.; Vukman, V. (Trogir) Antigen Vaccine in Combination with Antiviral Therapy: Breaking of Humoral and Cellular Immune Tolerance in Chronic Short Communications Woodchuck Hepatitis Virus Infection Menne, S.; Roneker, C.A.; Tennant, B.C. (Ithaca, N.Y.); Korba, B.E.; 177 Production of Monospecific Antibody to Immunodominant Gerin, J.L.; Cote, P.J. (Rockville, Md.) Epitopes of the Caprine Arthritis Encephalitis Virus 251 Selective Expression of Immunogenic, Virus-Like Particle- Transmembrane Glycoprotein and Analysis of Their Activity Derived Antibody-Binding Epitopes in vitro El Kholy, S.; Riedl, P.; Kwissa, M.; Reimann, J.; Schirmbeck, R. (Ulm) Dufour, S.; Zahno, M.-L.; Vogt, H.-R.; Peterhans, E.; Bertoni, G. (Bern) 183 Upregulation of Ku Expression in Human Neuroectodermal Human Immunodefiency Virus Tumor Cells after Retroviral DNA Integration Liu, X.; Lin, J.;