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COVID-19: Make It the Last Pandemic
COVID-19: Make it the Last Pandemic Disclaimer: The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Independent Panel for Pandemic Preparedness and Response concerning the legal status of any country, territory, city of area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Report Design: Michelle Hopgood, Toronto, Canada Icon Illustrator: Janet McLeod Wortel Maps: Taylor Blake COVID-19: Make it the Last Pandemic by The Independent Panel for Pandemic Preparedness & Response 2 of 86 Contents Preface 4 Abbreviations 6 1. Introduction 8 2. The devastating reality of the COVID-19 pandemic 10 3. The Panel’s call for immediate actions to stop the COVID-19 pandemic 12 4. What happened, what we’ve learned and what needs to change 15 4.1 Before the pandemic — the failure to take preparation seriously 15 4.2 A virus moving faster than the surveillance and alert system 21 4.2.1 The first reported cases 22 4.2.2 The declaration of a public health emergency of international concern 24 4.2.3 Two worlds at different speeds 26 4.3 Early responses lacked urgency and effectiveness 28 4.3.1 Successful countries were proactive, unsuccessful ones denied and delayed 31 4.3.2 The crisis in supplies 33 4.3.3 Lessons to be learnt from the early response 36 4.4 The failure to sustain the response in the face of the crisis 38 4.4.1 National health systems under enormous stress 38 4.4.2 Jobs at risk 38 4.4.3 Vaccine nationalism 41 5. -
The Companion Test to SARS-Cov-2 Vaccination Innovating Rapid Testing to Preserve and Improve Life
TM The companion test to SARS-CoV-2 vaccination Innovating rapid testing to preserve and improve life Innovating rapid testing to preserve and improve life Leading the UK RTC Contents Introduction Page 03 The nature of SARS-CoV-2 testing has changed. Where Currently available tests detect antibodies targeting antibody tests were once chiefly used for charting the two different proteins on the SARS-CoV-2 virus: Introduction spread of infection within communities, today it is the Nucleocapsid or the Spike protein. However, almost 04 emerging as a key pillar of large-scale immunisation without exception, vaccine formulations are based on campaigns. the Spike protein. Vaccines and antibody tests converge on the same target However, there are stark differences between currently Testing for Nucleocapsid protein antibodies alone is 05 available antibody tests in both function and form. therefore of limited value. Though they may seem technical, these factors have Emerging evidence links prior infection with SARS-CoV-2 with immunity This short paper explains how rapid antibody testing significant implications for immunisation policy going focused on detecting the antibody response to the Spike 06 forward. protein, working hand in hand with vaccination, can help AbC-19™ Rapid Test The crucial difference is the antibody response that populations accelerate to herd immunity to SARS-CoV-2.. 06 the tests are evaluating. Trial of AbC-19™ Rapid Test with Vaccines 08 Summary 10 Contact 12 References 02 The companion test to SARS-CoV-2 vaccination 03 Vaccines and antibody tests Emerging evidence links prior infection converge on the same target with SARS-CoV-2 with immunity The SARS-CoV-2 virus comprises a single strand of RNA As a result, vaccine research has focused overwhelmingly on Two questions have dogged researchers since the outbreak of enveloped within four structural proteins. -
Pandemic Planning , File Type: PDF, File Size
July 2021 Dear ATISN 15194 – Pandemic Planning Thank you for your request to the Welsh Government for information under the Freedom of Information Act (2000) received on 03 June 2021. I have interpreted your requested information regarding pandemic planning as follows: 1. What plans were in place for a potential future pandemic before the COVID19 crisis began? 2. What conversations were had at ministerial level, before COVID19, about the potential of a future pandemic? 3. What plans are now in place for a future pandemic, if any? Our Response What plans were in place for a potential future pandemic before the COVID-19 crisis began? Wales, together with the rest of the UK, has been preparing its response to an influenza pandemic for many years. In 2007, Wales participated in the UK level (Tier 1) pandemic flu exercise Winter Willow, which led to the development of the 2007 National Framework for Responding to an Influenza Pandemic. This framework was used to support our Welsh Government response to the 2009 H1N1 Swine Flu pandemic. Although the H1N1 pandemic was not as severe as initially predicted, it did identify areas for further planning and Wales worked with the other UK governments to put in place the UK Influenza Preparedness Strategy 2011. This UK Strategy was agreed by the Health Ministers of all four nations. In 2016, our pandemic influenza plans were tested during Exercise Cygnus. The subsequent lessons identified were taken forward into an ongoing review of pandemic preparedness led by the UK Cabinet Office and Department of Health and Social Care. -
Dear Rook Irwin Sweeney Good Law Project Limited V Secretary of State
Rook Irwin Sweeney LLP Our ref: SS/335/10241.0086 107-111 Fleet Street Your ref: AMI:AIR;162 London EC4A 2AB 4 May 2021 By email: Dear Rook Irwin Sweeney Good Law Project Limited v Secretary of State for Health and Social Care v Abingdon Health Limited As you are aware, Abingdon Health plc (“Abingdon”) has not yet decided whether to participate in the judicial review proceedings that the Good Law Project (“GLP”) have brought against the Secretary of State for Health and Social Care, in which Abingdon is named as an Interested Party. Our client acknowledges the GLP’s right to challenge the Department of Health and Social Care’s (“DHSC’s”) processes, but is concerned about the basis on which the case is proceeding. Therefore, we would like to set out some points of clarification below, and have enclosed documents that we hope are useful. The test developed by Abingdon that is the subject of these proceedings is referred to as the “AbC-19TM Test”. Abingdon Health and its expertise 1. Throughout the proceedings to date, the GLP has made multiple disparaging statements about Abingdon’s expertise and its ability to develop a COVID-19 antibody test.1 Such statements have led the Court to conclude that “the extent to which Abingdon Health itself had any expertise is open to serious doubt”.2 In our view, there is no doubt at all as to Abingdon’s expertise, and it was eminently qualified for the task of developing a COVID-19 antibody test. On a full analysis of the facts, a Court would be likely to conclude the same. -
27Th APRIL 2020
27th APRIL 2020 19 COVID-19 REPORT SUMMARY • The number of confirmed deaths as a result of COVID-19 has now passed 200,000 with Johns Hopkins University confirming almost 2,980,053 cases worldwide. • On 25th April, the UK became the fifth country in the world to record 20,000 hospital deaths as a result of COVID- 19. The UK death toll currently stands at 20,732. • Several Muslim majority countries have now begun to soften COVID-19 measures in preparation for the holy month of Ramadan with Saudi Arabia, Egypt and Algeria all shortening curfews that had been in place. • Multiple US States and European countries have begun to ease lockdown restrictions having instituted plans to begin reopening shops. • The World Health Organisation has warned that Africa could see as many as 10 million cases of COVID-19 within three to six months. In the last 10 days alone, the continent has seen a 40% rise in new COVID-19 cases. • A second wave of locusts has descended on East Africa and the swarm is estimated to be 20 times bigger than the first invasion at the end of 2019. Amidst the COVID-19 global lockdown, pesticides and bio-pesticides usually sourced from countries such as Japan, Morocco and the Netherlands, have become more expensive and harder to obtain. Further to this, protective clothing worn when using pesticides have been taken for those combating this coronavirus outbreak. • The World Health Organisation has warned against introducing ‘immunity passports’ for people who have recovered from the COVID-19 virus, citing that ‘there is currently no evidence that people who have recovered from Covid-19 and have antibodies are protected from a second infection’. -
COVID-19/SARS-Cov2: an Exploration
COVID-19/SARS-CoV2: An Exploration How we act now INTERACTIVE DOWNLOADABLE PDF will build the future for our children An urgent invitation: • To question all that is happening before the chance is lost • To explore broader science, views and statistics • To research further A compilation of links to resources that will: • Help you to navigate the current situation • Help you to make informed decisions • Promote open debate and explore different views • Offer a starting point for further research • Introduce just the tip of the iceberg of the wealth of knowledge we can explore Photo by Monica Gozalo on Unsplash.com • June 2021 COVID-19/SARS-CoV2: An Exploration PLEASE NOTE: Any text you see coloured orange with an underline throughout this document, will be clickable live links to internal Sections or Pages within this document, or go to external reference websites. INTRODUCTION In response to the remarkable times we are living in, we have created this shareable, downloadable, interactive PDF Exploration document ( also found on-lineHERE ), a gathering of our extensive research into the covid pandemic and its effects on us all. We hope that it will enable and inspire you to research further if you choose to. We respect and appreciate that some of what you read and explore may challenge views you hold to be true at the moment, but we believe there are significant questions that need asking about the Covid19 narrative as it is. We all wish to make choices that will enable a full and healthy life for ourselves, our communities and our children, and that are right for now and for the future. -
How the Nations Should Gear up for Future Pandemics?
Electronic supplementary material: The online version of this article contains supplementary material. Cite as: Issac A, Vijay VR, Krishnan N, Jacob J, Stephen S, Radhakrishnan RV, Dhan- © 2021 THE AUTHOR(S) dapani M. How the nations should gear up for future pandemics? J Glob Health JOGH © 2021 ISGH 2021;11:03075. How the nations should gear up for future pandemics? VIEWPOINTS Alwin Issac1, VR Vijay1, Nadiya Krishnan1, Jaison Jacob1, Shine Stephen1, Rakesh Vadakkethil Radhakrishnan1, Manju Dhandapani2 1College of Nursing, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India 2National Institute of Nursing Education, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India ealth authorities from the city of Wuhan, China, informed World Health Organization (WHO) about an increase in pneumonia cases of unknown origin on December 31, 2019. Health authorities in China Hdetected novel coronavirus as the causative agent for the pneumonia cases and the virus was initially named “2019-nCoV”, which was later renamed as coronavirus disease 2019 (COVID-19). Owing to the virus virulence and its contagious nature, WHO declared novel coronavirus outbreak a public health emergency of international concern. With the steep rise in number of people infected with the virus outside China, WHO stated the eruption as a pandemic on March 11, 2020 [1]. Owing to the plight of wildlife habitat, poor health system, and global connectivity, COVID-19 wouldn’t be the last time a virus would jump from animal into humans To increase pandemic resil- and endanger humanity. The ever-rising trend of globalization and human migra- ience, nations must adhere to tion for trade, commerce, and tourism across the national borders has made it easy the fundamentals of universal for an outbreak to progress to a pandemic. -
Whole Blood-Based Measurement of SARS-Cov-2-Specific T Cell
medRxiv preprint doi: https://doi.org/10.1101/2021.06.02.21258218; this version posted June 3, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers Martin J. Scurr1,2, Wioleta M. Zelek3,4, George Lippiatt2, Michelle Somerville1, Stephanie E. A. Burnell1, Lorenzo Capitani1, Kate Davies5, Helen Lawton5, Thomas Tozer6, Tara Rees6, Kerry Roberts6, Mererid Evans7, Amanda Jackson7, Charlotte Young7, Lucy Fairclough8, Mark Wills9, Andrew D. Westwell10, B. Paul Morgan3,4, Awen Gallimore*1,3§ and Andrew Godkin*1,3,6§ 1 Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, UK. 2 ImmunoServ Ltd., Cardiff, UK 3 Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff, UK. 4 UK Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK. 5 Radyr Medical Centre, Cardiff, UK. 6 Dept. of Gastroenterology & Hepatology, University Hospital of Wales, Heath Park, Cardiff, UK. 7 Velindre Cancer Centre, Cardiff, UK. 8 School of Life Sciences, University of Nottingham, Nottingham, UK. 9 Department of Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, UK. 10 School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK. * Corresponding Authors: Prof Andrew Godkin Division of Infection and Immunity Henry Wellcome Building Health Park Cardiff CF14 4XN Email: [email protected] Authorship note: (§) Aw.G and An.G contributed equally to this work. -
Data Science and AI in the Age of COVID-19
Data science and AI in the age of COVID-19 Reflections on the response of the UK’s data science and AI community to the COVID-19 pandemic Executive summary Contents This report summarises the findings of a science activity during the pandemic. The Foreword 4 series of workshops carried out by The Alan message was clear: better data would Turing Institute, the UK’s national institute enable a better response. Preface 5 for data science and artificial intelligence (AI), in late 2020 following the 'AI and data Third, issues of inequality and exclusion related to data science and AI arose during 1. Spotlighting contributions from the data science 7 science in the age of COVID-19' conference. and AI community The aim of the workshops was to capture the pandemic. These included concerns about inadequate representation of minority the successes and challenges experienced + The Turing's response to COVID-19 10 by the UK’s data science and AI community groups in data, and low engagement with during the COVID-19 pandemic, and the these groups, which could bias research 2. Data access and standardisation 12 community’s suggestions for how these and policy decisions. Workshop participants challenges might be tackled. also raised concerns about inequalities 3. Inequality and exclusion 14 in the ease with which researchers could Four key themes emerged from the access data, and about a lack of diversity 4. Communication 17 workshops. within the research community (and the potential impacts of this). 5. Conclusions 20 First, the community made many contributions to the UK’s response to Fourth, communication difficulties Appendix A. -
Of the Royal College of Pathologists
The Bulletin of the Royal College of Pathologists Number 191 July 2020 SPECIAL EDITION: Pathology and COVID-19 The role of genomics in shaping the response Cytology and the pandemic Experiences of NHS Nightingale Death certification Establishing convalescent plasma therapy Caring for the deceased Testing in the devolved nations Our COVID-19 seminars Also in this issue: The Royal College of Pathologists Haematology workforce challenges Pathology: the science behind the cure Going digital: training and exams Kate Gould: an appreciation The Royal College of Pathologists CONTENTS Pathology: the science behind the cure July 2020 NuMBER 191 EDITORIALS 114 INTERNATIONAL 150 From the Editor 114 Challenges for pathology laboratories during From the President 115 the pandemic: the view from Australia 150 PATHOLOGY AND COVID-19 117 Reorganisation of mobile blood collections in the age of social distancing 152 A new plague year 117 The role of viral genomics in shaping the TRAINING 154 response to the pandemic 118 FRCPath examinations during the COVID Nightingale tales 121 pandemic 154 The journey from Oxford medical school to Digital pathology and safe workplace the world’s largest ICU 124 station awareness 157 Cytology and the pandemic 125 Creating e-learning modules for undergraduate Establishing convalescent plasma as an medical students 159 effective therapy 126 Digital pathology validation for trainees: 160 Healthcare scientists in pathology: the CLINICAL EFFECTIVENESS 162 challenges of responding to the virus 128 What does patient safety in -
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ATISN 14601 16 December 2020 Dear ATISN 14601 – Covid-19 Thank you for your request to the Welsh Government for information under the Freedom of Information Act (2000) received on 29 November. You asked for: 1. Why are SARS-CoV-2 antibody levels flat or dropping across all age groups since May if the pandemic is still going? The Welsh Government does not hold information that shows levels of antibodies are flat or dropping across all age groups since May. The latest information the Welsh Government holds on levels of antibodies in the population is published here: https://gov.wales/coronavirus-covid-19-infection-survey This information is taken from the Coronavirus (COVID-19) Infection Survey (CIS) which is run across the whole of the UK and aims to estimate: how many people have the infection over a given time (positivity); how many new cases occur over a given period (incidence); and how many people have antibodies to COVID-19. This shows that antibody rates in those tested appear to have increased since the summer. 2. What percentage of the population is assumed to have had prior immunity to SARS-CoV-2 in the SAGE forecasting models? The Welsh Government does not hold information on the assumptions made in the SAGE forecasting models with regard to the percentage of the population and prior immunity. Information on how to make an FOI request to the Scientific Advisory Group for Emergencies can be found here: https://www.gov.uk/government/organisations/scientific-advisory-group-for-emergencies 3. Why do 50% of household members not catch SARS-CoV-2 from infected persons with whom they live? Parc Cathays ● Cathays Park Caerdydd ● Cardiff CF10 3NQ The Welsh Government does not hold recorded information on the percentage of household members that catch the virus from infected persons with whom they live. -
Data Flows of COVID-19
The data flows of COVID-19 Drawing on published documents, media reports and various individual and crowdsourced efforts listed in ‘Other references’ below, what do we know about the (health and social care) data flows of COVID-19? We all know there’s far more than just dodgy PPE contracts, Serco, Faculty AI and Palantir to be concerned about – but few seem to appreciate the full extent and very few the detail of what has been going on. N.B. This document covers what has been going on with health data in England in 2020, with occasional references to what has been happening in the other nations. Legal basis Firstly, in terms of the lawfulness of data flows, what changed? Much of what has been done with data during the pandemic has been enabled by the COPI Notices, first issued in March 2020, extended in July 2020, and extended again in February 2021. At the time of writing, the COPI Notices will expire on 30 September 2021. What is perhaps less well known is that on 30 January 2020, a “Level 4 National Incident” was declared by NHS England. This was six weeks before the Government was seen to act. In a crisis, the NHS operates at one of four different incident levels – described on page 11 of the National Incident Response Plan – that is decided according to the severity and impact of the incident on the health service. At Level 4, NHS England takes control of the overall coordination of the NHS's response. What this means in practice is that, in data terms, NHS England took operational control of care providing bodies such as hospitals, and so became a joint data controller of all of the data flowing through and around the NHS at the very beginning of the pandemic.