UBQLN2 Polyclonal Antibody C-Terminal Ubiquitin-Associated Domain

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UBQLN2 polyclonal antibody C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, Catalog Number: PAB1699 and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein Regulatory Status: For research use only (RUO) degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. Product Description: Rabbit polyclonal antibody raised [provided by RefSeq] against synthetic peptide of UBQLN2. References: Immunogen: A synthetic peptide (conjugated with KLH) 1. Structural studies of the interaction between ubiquitin corresponding to C-terminus of human UBQLN2. family proteins and proteasome subunit S5a. Walters KJ, Kleijnen MF, Goh AM, Wagner G, Howley PM. Host: Rabbit Biochemistry. 2002 Feb 12;41(6):1767-77. 2. The hPLIC proteins may provide a link between the Reactivity: Human ubiquitination machinery and the proteasome. Kleijnen Applications: WB-Ce MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha (See our web site product page for detailed applications NL, Gill G, Howley PM. Mol Cell. 2000 Aug;6(2):409-19. information) 3. Selection system for genes encoding nuclear-targeted proteins. Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Protocols: See our web site at Muramatsu M. Nat Biotechnol. 1998 http://www.abnova.com/support/protocols.asp or product Dec;16(13):1338-42. page for detailed protocols Form: Liquid Purification: Protein G purification Recommend Usage: Western Blot (1:1000) The optimal working dilution should be determined by the end user. Storage Buffer: In PBS (0.09% sodium azide) Storage Instruction: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 29978 Gene Symbol: UBQLN2 Gene Alias: CHAP1, CHAP1/DSK2, Dsk2, HRIHFB2157, LIC-2, N4BP4, PLIC-2, PLIC2, RIHFB2157 Gene Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a Page 1/1 Powered by TCPDF (www.tcpdf.org).

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(Stch) Gene Reduces Prion Disease Incubation Time in Mice
Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice Julia Grizenkovaa,b, Shaheen Akhtara,b, Holger Hummericha,b, Andrew Tomlinsona,b, Emmanuel A. Asantea,b, Adam Wenborna,b, Jérémie Fizeta,b, Mark Poultera,b, Frances K. Wisemanb, Elizabeth M. C. Fisherb, Victor L. J. Tybulewiczc, Sebastian Brandnerb, John Collingea,b, and Sarah E. Lloyda,b,1 aMedical Research Council (MRC) Prion Unit and bDepartment of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and cDivision of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, United Kingdom Edited by Reed B. Wickner, National Institutes of Health, Bethesda, MD, and approved July 10, 2012 (received for review May 28, 2012) Prion diseases are fatal neurodegenerative disorders that include way crosses and a heterogeneous cross (12–14). In these studies, bovine spongiform encephalopathy (BSE) and scrapie in animals the underlying functional polymorphism is unknown but could be and Creutzfeldt-Jakob disease (CJD) in humans. They are character- an amino acid change within the coding region of a protein or ized by long incubation periods, variation in which is determined by splicing variant or may occur within noncoding sequences such as many factors including genetic background. In some cases it is pos- untranslated regions, promoters, or other regulatory regions sible that incubation time may be directly correlated to the level of thereby influencing the pattern or level of expression. Although gene expression. To test this hypothesis, we combined incubation incubation time is a polygenic trait, it is possible that in some cases, time data from five different inbred lines of mice with quantitative there may be a direct correlation between incubation time and gene expression profiling in normal brains and identified five genes individual gene expression level.
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PrimePCR™Assay Validation Report Gene Information Gene Name ubiquilin 2 Gene Symbol UBQLN2 Organism Human Gene Summary This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. Gene Aliases CHAP1, DSK2, FLJ10167, FLJ56541, N4BP4, PLIC2 RefSeq Accession No. NC_000023.10, NG_016249.1, NT_011630.14 UniGene ID Hs.179309 Ensembl Gene ID ENSG00000188021 Entrez Gene ID 29978 Assay Information Unique Assay ID qHsaCEP0055207 Assay Type Probe - Validation information is for the primer pair using SYBR® Green detection Detected Coding Transcript(s) ENST00000338222 Amplicon Context Sequence CATTTGCAGATTGACTGTATATGACCTTAATCTTTGTGCAGCCTGAAGGATCAGT GTAGTAATGCCAGGAAAGTGCTTTTTACCTAAGACTTCCTTCTCAGCTTCTCCCA TAAAGAGACCCTAATATGCAT Amplicon Length (bp) 101 Chromosome Location X:56593074-56593204 Assay Design Exonic Purification Desalted Validation Results Efficiency (%) 105 R2 0.9967 cDNA Cq 21.06 cDNA Tm (Celsius) 79.5 Page 1/5 PrimePCR™Assay Validation Report gDNA Cq 25.2 Specificity (%) 100 Information to assist with data interpretation is provided at the end of this report. Page 2/5 PrimePCR™Assay
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