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SUPPLEMENTAL TABLE 1: Gene Expression Changes Induced by TRF2 Over- Expression

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SUPPLEMENTAL TABLE 1: Gene Expression Changes Induced by TRF2 Over- Expression SUPPLEMENTAL TABLE 1: Gene Expression Changes Induced by TRF2 Over- Expression Probe ave fold ave adju set ID Acc # Symbol Description M change A t.stat st.p FDR B telomeric repeat 1555185 7014 TERF binding factor 2 0.87 1.83 6.36 8.65 0.444 0.026 3.67 204926 3624 INHBA Activin A 0.86 1.81 5.87 12.58 0.016 0.016 5.88 239336 7057 THBS1 Thrombospondin 1 0.78 1.72 6.19 7.63 1 0.033 2.85 Stress 70 protein chaperone, microsome- 202558 6782 STCH associated 0.72 1.65 7.54 7.41 1 0.038 2.66 206343 3084 NRG1 Neuregulin 1 0.62 1.53 9.22 7.15 1 0.041 2.42 Chromosome 21 orf 228908 257103 C21orf86 86 0.61 1.53 5.83 9.8 0.15 0.021 4.46 1556499 1277 COL1A1 Collagen, type I 0.59 1.51 6.42 8.48 0.523 0.026 3.55 steriod sulfatase, arylsulfatase C, 203767 412 STS isozymeS 0.58 1.5 5.88 8.01 0.851 0.026 3.17 solute carrier family 228181 7779 SLC30A1 30 (zinc transporter) 0.58 1.5 7.99 6.02 1 0.081 1.26 interleukin 1 receptor accessory 210233 3556 IL1RAP protein 0.57 1.49 7.11 8.58 0.473 0.026 3.62 Tripartite motif- 1554250 375593 TRIM50B containing 50B 0.57 1.48 5.27 10.25 0.101 0.02 4.73 Chromosome 1 orf 241908 148362 C1orf58 58 0.52 1.44 6.1 8.45 0.54 0.026 3.52 239043 0.51 1.42 4.73 6.89 1 0.049 2.17 heat shock protein 5 70kDa (glucose- regulated protein 230031 3309 HSPA5 78kDa) -0.5 0.71 7.4 -7.35 1 0.038 2.6 Exosome 227696 118460 EXOSC6 component 6 -0.5 0.71 7.99 -7.54 1 0.035 2.77 Cysteine-rich secretory protein CRISPLD LCCL domain 223475 83690 1 containing 1 -0.5 0.71 5.19 -5.77 1 0.095 0.98 latent transforming growth factor beta - 223690 4053 LTBP2 binding protein 2 0.51 0.7 8.97 -6.44 1 0.062 1.72 MAM domain - 228885 256691 MAMDC2 containing 2 0.51 0.7 7.47 -6.35 1 0.066 1.62 IMAGE:4520143 - 232790 mRNA 0.52 0.7 6.12 -8.14 0.739 0.026 3.28 UDP- gal:betaG1cNAc beta 1,3- galactosyltransferas - 211379 8706 B3GALT e, polypeptide 3 0.52 0.7 5.67 -6.81 1 0.05 2.09 Neurofilament light - 221801 4747 NEFL polypeptide 68kDa 0.53 0.69 6.55 -9 0.314 0.026 3.93 - 223493 26272 FBXO4 F-box protein 4 0.53 0.69 6.9 -6.1 1 0.076 1.35 Microfibrillar - 213765 8076 MFAP5 associated protein 5 0.54 0.69 6.04 -9.49 0.199 0.025 4.26 Chromosome 1 orf - 219476 79098 C1orf116 116 0.54 0.69 8.89 -6.55 1 0.059 1.83 Nudix (nucleoside diphosphate linked moiety X)-type motif - 228341 131870 NUDT16 16 0.55 0.69 5.75 -6.8 1 0.05 2.08 - 235086 7057 THBS1 Thrombospondin 1 0.55 0.68 8.61 -6.86 1 0.049 2.14 - 214599 2713 IVL involucrin 0.55 0.68 7.85 -8.33 0.61 0.026 3.43 - 203158 2744 GLS glutaminase 0.56 0.68 6.4 -6.29 1 0.068 1.56 - 203159 2744 GLS glutaminase 0.56 0.68 8.77 -9.96 0.131 0.021 4.55 Zinc finger DAZ - 213186 9666 DZIP3 interacting protein 3 0.57 0.67 6.77 -5.49 1 0.106 0.65 trophoblast-derived - 234989 283131 TncRNA noncoding RNA 0.57 0.67 9.63 -5.74 1 0.095 0.95 DNA helicase - 228736 113510 HEL308 HEL308 0.58 0.67 5.22 -5.67 1 0.097 0.86 gap junction protein 226701 2702 GJA5 (connexin 40) -0.6 0.66 6.85 -5.44 1 0.107 0.59 mRNA, cDNA - 229544 DKFZp5640762 0.63 0.65 7.73 -8.71 0.416 0.026 3.72 full length insert cDNA clone - 231033 YI40A07 0.65 0.64 6.26 -8.98 0.321 0.026 3.91 - 208607 6288 SAA1 Serum amyloid A1 0.66 0.63 8.84 -10.3 0.097 0.02 4.76 Microfibrillar - 213764 8076 MFAP5 associated protein 5 0.67 0.63 5.4 -8.78 0.39 0.026 3.77 pleckstrin homology- - 217999 22822 PHLDA1 like domain 0.67 0.63 9.48 -6.34 1 0.067 1.61 full length cDNA clone of - - 216247 neuroblastoma 0.69 0.62 4.95 10.49 0.082 0.02 4.87 ribosomal L1 212019 26156 RSL1D1 domain containing 1 -0.7 0.62 5.95 -8.37 0.588 0.026 3.46 Hypothetical protein 1554067 144577 FLJ32549 FLJ32549 -0.7 0.62 4.87 -5.04 1 0.135 0.1 Troponin I type 2 - 206393 7136 TNNI2 (skeletal, fast) 0.71 0.61 6.73 -8.18 0.711 0.026 3.31 - 209792 5655 KLK10 kallikrein 10 0.74 0.6 9.66 -6.92 1 0.049 2.2 S100 calcium - 206027 6274 S100A4 binding protein A3 0.75 0.59 7.98 -8.26 0.653 0.026 3.38 ribosomal L1 - - 213750 26156 RSL1D1 domain containing 1 0.77 0.59 7.11 10.73 0.068 0.02 5 Transcribed locus, moderately similar - 230383 230383 to NP_060190.1 0.79 0.58 6.96 -7.95 0.906 0.026 3.12 Hypothetical protein - 226756 168455 FLJ36031 FLJ36031 0.95 0.52 6.73 -8.47 0.531 0.026 3.54 pleckstrin homology- 10.1 225842 22822 PHLDA1 like domain -1 0.5 5 -7.1 1 0.042 2.38 - 237435 Transcribed locus 1.21 0.43 5.69 -6.54 1 0.059 1.82 Microarrays were performed using the Affymetrix HG-U133 2.0 arrays at the Gladstone Institute. Data represents expression changes in vHMEC from three RMs expressing either vector control (pWP) or TRF2. Column headings are described below. Probe set ID: Affymetrix probe set ID Acc #: accession number listed in Entrez gene database Symbol: gene symbol Description: description of transcribed product Ave M: log-ratio for the comparison of interest Fold change: fold increase in expression level Ave A: average log intensity values of the arrays t.stat: moderated t-statistic adjust p: adjusted p values controlling for multiple-testing errors, usually threshold at 0.05 for significance FDR: false discovery rate, usually threshold at 0.05 for significance B: log-odds ratio, usually select >0 for significance .
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