Safety Assessment of Alkanoyl Lactyl Lactate Salts as Used in Cosmetics Status: Draft Final Report for Panel Review Release Date: May 10, 2019 Panel Date: June 6-7, 2019 The 2019 Cosmetic Ingredient Review Expert Panel members are: Chair, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Ronald A. Hill, Ph.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; James G. Marks, Jr., M.D.; Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Executive Director is Bart Heldreth, Ph.D. This report was prepared by Wilbur Johnson, Jr., M.S., Senior Scientific Analyst. © Cosmetic Ingredient Review 1620 L STREET, NW, SUITE 1200 ◊ WASHINGTON, DC 20036-4702 ◊ PH 202.331.0651 ◊ FAX 202.331.0088 ◊
[email protected] Distributed for Comment Only -- Do Not Cite or Quote Commitment & Credibility since 1976 Memorandum To: CIR Expert Panel Members and Liaisons From: Wilbur Johnson, Jr. Senior Scientific Analyst Date: May 10, 2019 Subject: Draft Final Report on Alkanoyl Lactyl Lactate Salts Enclosed is a draft final report on 10 alkanoyl lactyl lactate salts (alkylL062019rep). This ingredient family comprises the carboxylic acid salts of diesters that are formed between a fatty acid group and two equivalents of lactic acid. A tentative report was issued at the December 2018 meeting, and the Panel’s conclusion therein states that the 10 alkanoyl lactyl lactate salts are safe in cosmetics in the present practices of use and concentration described in the safety assessment, when formulated to be non-irritating and non-sensitizing, which may be based on a QRA.