Title MEMOIRS of the Institute of Scientific and Industrial Research, University Volume 76

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MEMOIRS of the Institute of Scientific and Citation Industrial Research, Osaka University. 76 P.1- P.221

Issue Date 2019

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URL http://hdl.handle.net/11094/77456

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Osaka University Knowledge Archive : OUKA

https://ir.library.osaka-u.ac.jp/

Osaka University

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································································ 135 Foreword Katsuaki Suganuma Director of the Institute of Scientific and Industrial Research

The Institute of Scientific and Industrial Research (ISIR) was founded in 1939 as a part of Osaka University with the aim of promoting basic science for the development of industry. Since then, ISIR has conducted interdisciplinary research in the fields of materials, information, and biological sciences. We play a leading role in the nanoscience and nanotechnology research through our Nanotechnology Center, which was established in 2002 and is ’s first such center attached to a university. As a nationwide research collaboration system, ISIR established the Network Joint Research Center for Materials and Devices and works in conjunction with five university-attached research institutes: Research Institute for Electronic Science (Hokkaido University), Institute of Multidisciplinary Research for Advanced Materials (Tohoku University), Chemical Resources Laboratory (Tokyo Inst. Tech.), ISIR (Osaka University), and Institute. for Materials Chemistry and Engineering (Kyushu University). The Japan’s first nationwide network research center provides a new framework for facilitating the inter-institute collaboration. For industrial applications of innovative achievements, we have promoted cooperation between academia and industry through Industry-On-Campus in the newly constructed Incubation Building. To promote the globalization of basic innovative research, a research-collaboration agreement was reached between the Interuniversity Microelectronics Center ( imec )— one of the world’s largest nanotechnology research institutes—and ISIR in 2011. This publication “Memoirs of the Institute of Scientific and Industrial Research (ISIR)” is our annual publication summarizing the scientific activities of ISIR.We hope this annual publication will be useful and stimulating for all researchers and young scientists outside as well as inside our institute. Our world-level innovative basic research efforts address problems related to the environment, energy, medicine, and security and safety on studies in the fields of materials, information, and medical sciences along with those in nanotechnology and nanoscience. ISIR pursues a target-driven basic research leading to real innovation and inspire the future.

― 1 ― Outline of ISIR 1. Research Activities

1) History and Organization The Institute of Scientific and Industrial Research (ISIR) was founded in 1939 as a part of Osaka University, based on the strong desire of the business leaders of private enterprises in Osaka area. The purpose of the Institute is to study science necessary for industry and their applications. Since then, the institute had developed into one of the leading research organizations for science and engineering in Japan. In 1939 ISIR had only 3 departments, however it had increased research areas and laboratories in the fields of electronic engineering, computer science, metallurgy and inorganic chemistry, organic chemistry, biochemistry, and beam science. Modern industry in this country is, however, coming to a major turning point. There is a strong requirement to develop interdisciplinary sciences, or new fields which are away from conventional area in order to advance basic and applied sciences coping with social changes. Since this Institute has researchers in a wide variety of fields and is suitable for making a new organization for interdisciplinary areas, it was restructured in 1995 to an Institute with 6 divisions with 24 departments for the purpose of promoting sciences on materials, information and biology. For solving problems related to energy, earth ecology, aging and advanced information technology, interdisciplinary and comprehensive studies have been conducted in the Institute. From 2002 through 2006, we have awarded as the best group in 21st Century COE program that is originally the top 20 group plan in Japan. This involves the positive exchange between different laboratories which yield results of the global level with respect to material, information and biotechnology. In 2002, Nanoscience and Nanotechnology Center has started after restructuring Research Center for Intermaterials and Radiation Laboratory. The new Center focuses its research on nanomaterials and devices, beam science for nanotechnology and industrial nanotechnology. In 2003, the Center Building was constructed. In the new Center Building, there is a Nanotechnology Process Foundry for supporting the nationwide research in the nanotechnology field. In 2006, Materials Science &Technology Research Center for Industrial Creation between ISIR and IMRAM (Tagenken) in Tohoku Univ. has started and then expanded to the Post-Silicon Materials and Devices Research Alliance including RIES

― 2 ― (Denshiken) in Hokkaido Univ. and LCLS (Former Shigenken) in TIT next year. In 2006, Academia Industry Relation Office (AIR-Office) has been settled in order to strengthen cooperation between the institute and industries. In 2008, Division of special project has been founded for promotion of research by young faculties. In 2009, we have made a great restructuring since 1995 in order to develop the novel interdisciplinary research fields and exercise leadership in nanotechnology research field into 3 great divisions (Division of Information and Quantum Sciences, Division of Material and Beam Sciences, and Division of Biological and Molecular Sciences) and expanded Nanoscience and Nanotechnology Center. We newly established the Center for Research Education and Training and the Center for International Collaboration. Former Materials Analysis Center was joined with Electron Microscope Laboratory and restricted into the Comprehensive Analysis Center. Research Laboratory for Quantum Beam Science was separated from Nanoscience and Nanotechnology Center for facilitating the collaboration in the beam science field. In order to establish a core for academia-industry collaboration and open innovation, we constructed the SANKEN Incubation Building including Osaka University’s first on-campus rental laboratories for private corporations (Company Research Park) in 2010. ISIR Manufacturing Factory has been moved into the building. In addition, Nanoscience Techno-Core, Company Research Park and Osaka University Renovation Center was settled in the building. In 2010, the Network Joint Research Center for Materials and Devices including ISIR, IMRAM, RIES, LCLS and IMCE (Sendoken) in Kyushu Univ. has been started. ISIR is a headquarters of this 5 institutes network. In 2011, research-collaboration agreement was reached between the Interuniversity Microelectronics Center (imec)-one of the world’s largest nanotechnology research institutes- and ISIR.

― 3 ― ࠙Organizationࠚ㸦31-March , 2019㸧 Divisions Departments

Division 1 Information & Quantum Sciences Quantum System Electronics Interface Quantum Science Advanced Electron Devices Intelligent Media Reasoning for Intelligence Knowledge Science Architecture for Intelligence Divison 2 Advanced Materials & Functionalized Natural Materials Beam Science  Semiconductor Materials and Processes Advanced Hard Materials   Advanced Interconnection Materials Excited Solid-State Dynamics Accelerator Science Beam Materials Science Division 3 Biological & Molecular Sciences Molecular Excitation Chemistry Synthetic Organic Chemistry Regulatory Bioorganic Chemistry Biological and Molecular Sciences Biomolecular Science and Research  Biomolecular Science and Regulation Biomolecular Science and Engineering

Next Industry Generation Translational Datability New Industry Generation Systems Intellectual Property Research Laboratories of 3rd Project Laboratory of Cell Membrane Structural Biology

Specially Appointed Laboratory Innovative Nanobiodevice based on Single Molecule Analysis

㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃 Research Centers Nanoscience and Nanotechnology Center Functional Nanomaterials and Nanodevices Advanced Nanofabrication Nanocharacterization for Nanostructures and Functions Theoretical Nanotechnology Soft Nanomaterials Bio-Nanotechnology

― 4 ― ࠙ࠚ㸦㸧 Nanotechnology Environmental and Energy Applications Nano-Inteligent Systems Nanodevices for Medical Applications Nanosystem Design Nanodevice Characterization Nanotechnology for Industrial Applications Simulation for Nanotechnology Nanoelectronics Nano-Function Characterization Nano-Medicine Nano-Biology Nano Information Technology Nanofabrication Shop Advance Nanotechnology Instrument Laboratory  Nanotechnology Open Facilities Mitsubishi Electric Collaborative Research Division for Wide-area Security Technology Screen-Single-Molecule Analysis Nano-Lithography Research Comprehensive Analysis Center Research Laboratory for Quantum Beam Science Center for Research Education and Training International Collaborative Research Center

㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃 Service Facilities Workshop Laboratory for Radio-Isotope Experiments Electronic Processing Laboratory Academia Industry Relations Office Office of Information Network Public Relations Office Library Planning Office Facilities Management Office Technical Machine Group Measurement Group Administrative Office General Affairs Division 㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃㺃 Research Cooperation Division

― 5 ― Staffs’ Age (years old) –As of Mar.31.2019

Professors Associate Professors Assistant Professors

Staffs’ Alma Master –As of Mar.31.2019 Professors Associate Professors Assistant Professors

2) Administration Administration and management of ISIR are conducted by the Director selected from full professors of ISIR. The term of the Director is two years. Reappointment is possible, but the Director can’t be in the position for more than 4 years.

Important matters of ISIR are discussed and determined by the Faculty Council, which consists of the Director and all professors of ISIR. Various committees such as International Exchange, Self-Review, Circumstances and so on are working for each purpose. Administration of the Institute-associated Centers is conducted by Director of each Center and its Executive Committee. Evaluation Committee composed of outside experts in academic societies was established and the committee evaluated several items such as management, budget, facilities and research activities. The new organization was highly evaluated, but with change of their structure to National University Agencies in April 2004, our management system needs reshaping. A Board of Directors

― 6 ― under the Director has been formed, and Advisory Board has been set up to introduce opinions from outside into the Institute. 3) Research Budget The budget of ISIR is mainly composed of Subsidy for operating expenses, Grants-in-Aid for Scientific Research of Ministry of Education, Sports, Culture, Science and Technology, Donations for Research, and Budget of Joint Research. The recent trend in the expenditure of ISIR is as follows. ࣭Grants-in Aid for Scientific Research Personnel Budget(Unit : million yen) Expenditure of Ministry of Education, Culture, Non personnel Year Expenditure Sports, Science and Technology are Gran t s Aid fo r  Scientific Research delivered to researchers and the Donation for Research total budget in 2018 is  Joint Research 769,296,000yen. Contract Research  ࣭Donation for Research is accepted Others after the Judgement of Committee       and the amount are as follows. (Unit : kilo yen , ( ) Number) Division Information and Advanced Biological and Nanoscience and Quantum Materials and Molecular Nanotechnology Year Sciences Beam Science Sciences Center

51,100 42,080 6,789 10,500 2018 㸦9㸧 㸦21㸧 㸦10㸧 㸦7㸧 Division Year Special Projects Others Total

0 2,500 112,969 2018 㸦0㸧 㸦2㸧 㸦49㸧 ࣭Cooperative Researches and Contract Researches in the fiscal year 2018 are as follows: Cooperative Researches are carried out with 131 organizations and the budget for the fiscal year 2018 is 289,888,000 yen. The number of Contract Researches is 60 and the budget for the fiscal year 2018 is 999,296,000 yen.

― 7 ―

4) International Research

Quantum System Research on photon-electron spin Ruhr University Bochum Germany Electronics conversion

Research on SiGe self-assembled University of Regensburg Germany quantum dots Quantum System Research on photon-electron Max Planck Institute Electronics Germany conversioni transition metal Stuttgart dichalchogenide Semiconductor Liquid-AFM measurementsof Oxford University UK Electronics glyco-functionalizedgraphene Advanced Belgium Electronic imec Flexible Electronics The Netherlands Devices Intelligent Media Peking University Drexel University USA University of Rajshahi Bangladesh Hanoi University of Vietnam Science and Technology Computer vision Vietnam National Vietnam University of Agriculture Chonnam National Korea University Reasoning for Max-Planck-Institute Germany Statistical Causal Inference Intelligence Nanyang Technological Representative selection with structured Singapore University sparsity Federation University Australia Machine Learning Australia Knowledge Honda Research Adaptive Information Presentation in USA Science InstituteUSA, Inc. Cars Automatic Tailor-made Spoken Carnegie Mellon University USA Dialogue System for Individual Users Architecture for imec Belgium Brain signal analysis Intelligence Chulalongkorn University Thailand Machine Learning

― 8 ― University of the Philippines Philippines Manila

University of Leuven Belgium

Thammasat University Thailand Introductive Logic Programing De La Salle Philippines Empathic Computing University-Manila Architecture for University of California, Intelligence USA Brain signal analysis San Diego

Functionalized Development of paper photodetector by Chinese academy of Natural Materials China using perovskite nanowires and sciences nanocellulose

Semiconductor Control of Si surface properties by the Materials and chemical methods and improvement of Slovak Academy of Science Slovakia Processes conversion efficiencies of crystalline Si solar cells Fabrication of ultralow reflectivity Si Zilina University Slovakia surfaces by surface structure chemical transfer method and their properties Defect elimination in IGZO thin films Hangyang University Korea by cyanide method and improvement of electrical properties Improvement of Si device Inner Mongolia Normal China characteristics by nitric acid oxidation University method Reaction of hydrogen molecules with Università di Perugia Italy hydroxyl radicals Advanced Hard Academic Exchange in the field of Materials Hanyang University Korea Nanochemical Engineered New Functional Materials Korea Institute of Ceramic Low-powered (<15 mW) smart sensors Engineering and Korea for multiple gas detection by Technology functionalized nano-structured materials Sun Moon University Korea Development of Multifunctional

― 9 ― Nanomaterials and Processing Technology for Eco-friendly Applications

Bulk Fluorescent Ceramic Fabrication Korea Institute of Industrial Korea Technology and Application with Rare Technology Earth

Advanced Or anic/inor anic Nanoh brid Platforms Donghua University China Interconnection for Precision 1¥1mor Ima in and Ewha Womans University Korea Materials Therapy Excited Peter Grünberg Institut Phonon physics of graphene and related Solid-State (PGI-3), materials by using newly developed Germany Dynamics Forschungszentrum Jülich, high-resolution electron energy loss Germany spectroscopy Ecole Polytechnique, Laboratoire des Solides Ultrafast carrier dynamics in Irradies, -Saclay semiconductors University Accelerator Study using THz-far infrared La Sapienzza Univ, INFN Italy Science enlectromagnetic wave from SR Beam Materials Study the reaction between a hydrated Science Paris-Sud University France electron and hydronium ion at elevated temperatures Study on thermalization process of University of Notre-Dame USA electron in polar liquids produced by ionizing radiation Study on modeing of radiolysis of high University of Science and China temperature water under mixed Technology of China radiation field. Molecular Pohang University of Korea photoresponsible materials research Excitation Science and Technology Chemistry Shanghai University China Environmental science research Chungnam National Korea Advanced materials research University Korea Atomic Energy Korea Quantum Beam Science Research

― 10 ― Research Institute Synthetic Organic Development of novel asymmetric RWTH Aachen University Germany Chemistry Brønsted Acid Catalyzed Substitution Development of combination process of Bielefeld University Germany organocatalysis and biocatalysis development of organocatalyzed [4+2] Paris-Sud University France annulation development of chiral phosphine University of Burgundy France catalyst and its application to asymmetric catalysis Synthetic Organic development of chiral vanadium Chung-Ang University Korea Chemistry catalyst Regulatory Regulation of repeat instability using University of Toronto Canada Bioorganic small molecules Chemistry Adam Mickiewicz Binding analysis of CUG repeat-binding Poland University molecules Polish Academy of Structural analysis of small Poland Sciences molecule-nucleic acid complex Weizmann Institute of Regulation of microRNA function using Israel Science small molecules Organic Fine Department of Medical Development of PNA device for dengue Thailand Chemicals Sciences, Thailand virus infection Eindhoven University of Regulation of 14-3-3 functions by use The Netherlands Technology of fusicoccin derivatives McGill university Canada neurite outgrowth effect of fusiccocin Biomolecular Science and Application of ZZ-BNC for novel SPR Academia Sinica Reaction sensor

Biomolecular The University of Hong Hong Kong Function of drug efflux systems Science and Kong Regulation French National Institute for Agricultural Research France Regulation of drug efflux systems 䠄INRA䠅 Emory University USA Noninvasive autonomous control of

― 11 ― neuronal activity deep inside brain with cell ular activity-dependent chemiluminogenetic probes Maintaining and differentiating iPS cells to cardiomyocytes. pH imaging in University of Oxford UK lysosomes in cardiomyocytes with genetically encoded indicator. Development of a technology for an NanoScope Technologies, USA optical control and imaging of in vivo LLC brain function with high time resolution Biomolecular DRVision Technologies Live-cell fluorescent probes for USA Science and LLC neurological diseases Engineering Albert Einstein College of Development of near-infrared USA Medicine chemiluminescent protein Measurement of Mg2+ dynamics in Vanderbilt University USA cyanobacteria with MARIO Development of genetically encoded University of Alberta Canada FRET-based Ca2+ indicators using novel red chrom-oprotein Functional Indian Institue of India Sn oxide-based gas sensors Nanomaterials Technology, Hyderabard and Genova University Italy Functional Oxide-MEMS Nanotechnology 䠏D correlated oxide nano-structures for Purdue University USA nano-scaling phenomena and electronic phase change memory application. Nanocharacteri- ETEM observation of nanomaterials University of Kansas USA zation for under catalytic reaction conditions Nanostructures ETEM observation of Fischer-Tropsch Utrecht University The Netherlands and Functions synthesis catalysts Lawrence Berkeley In situ surface analyses of supported USA National Laboratory metal catalysts Analysis and characterization of Harvard University USA molecular materials using electron microscopy FEI Company USA Development of a high resolution

― 12 ― environmental TEM Theoretical Materials Design toward Environmental Uppsala University Sweden Nanotechnology and Energy Issues The density functional theory and its University of Jember Indonesia computational applications Electronic states of transition-metal Pusan National University Korea oxides Theoretical Electronic structure in transition-metal CNR Italy Nanotechnology oxides Theoretical Materials design by first-principles Forschungszentrum Jülich Germany Nanotechnology calculations Soft Indian Institute of Chemical Cheical Biology Applications of India Nanomaterials Biology Organic Electron Acceptors Max Plank Institute (Mainz Printable Organic Semiconductors and Germany Laboratory) Flexible Devices Bio-Nanotechnol Huazhong University of China Microfludics ogy Science and Technology Comprehensive Carnegie Institution of Structure transition of dielectric Analysis Center Washington Geophysical USA substance Laboratory, Photochemistry of Sichuan University China supramacromolecular complex

5) Symposia, Seminars, Workshops and Lectures

2017/4/14 Seminar on the research of the bacterial drug efflux systems 2017/5/25-5/26 Symposium on Photovoltaic Materials and Technologies 2017/6/1 Lecture on Functional AlN Thin Films and Their Physica Properties 2017/6/12/-6/13 QTech2017 2017/6/15 Research Forum on development of small-molecule drug targeting nucleic acids 2017/6/19 6th imec-Handai international symposium 2017/6/22 Core to core seminar 2017/7/1 45th Kansai Joint Speech Seminar Workshop of "Development of beam chemistry using accelerator and elucidation of 2017/7/21 radiation induced chemical reaction"

― 13 ― 2017/8/8 Research Forum on development of small-molecule drug targeting nucleic acids 2017/8/18 Seminar on the Design and Advanced Function of Novel Materials 2017/9/11-9/12 Workshop on Nano Spin Conversion Science 2018 2017/9/29 Joint research meeting: Okada Group (Tokyo Tech) and Komatani Lab (Osaka U) Satellite Workshop of Kanamori Memorial Symposium — Recent Progress in 2017/10/2-2017/10/3 Materials Science for Spintronics and Energy Applications 2017/10/12 Research Forum on development of small-molecule drug targeting nucleic acids 2017/10/17 JST-TU Delft Quantum Technology Workshop 2017/10/27-10/29 12th Korea-Japan Symposium on Frontier Photoscience 2017/11/16-17 The 14th Japan Catechinology 2017/11/26-12/1 Workshop on Innovative Nanodevice and Systems 2017 2017/11/30 H29 Printed Electronics Sympojium/3rd Workshop 22nd Physics and Applications of Spin-related Phenomena in Semiconductors 2017/12/4-12/5 (PASPS-22) 2017/12/15 Research Forum on development of small-molecule drug targeting nucleic acids 2017/12/23 ᪥ᮏ≀⌮Ꮫ఍኱㜰ᨭ㒊බ㛤䝅䞁䝫䝆䜴䝮䛂㔞ᏊຊᏛ 90 ᖺ䛃 1st SANKEN JSPS Symposium for the Circulation of Talented Researchers 2018/1/17 “Global Networking on Molecular Technology Research” 2018/1/26 Printed Electronics Association : Public Symposium 2018/2/2 ኱㜰኱Ꮫ≀㉁䞉ᮦᩱ⛉Ꮫ◊✲᥎㐍ᶵᵓㅮ₇఍ 2018/2/9 Seminar for Young Researchers on SANKEN Nanotechnology Center 2018/2/16 රᗜ┴䝬䝔䝸䜰䝹䝈䞉䜲䞁䝣䜷䝬䝔䜱䜽䝇ㅮ₇఍ 2018/3/9 Seminar on Photochemical Functions of Materials for Biorogical Viewoint 2018/3/16 4th Osaka University-KAERI Workshop on Radiation Research 2018/3/16 Symposium on Frontier Researches of Functional Oxide Devices and Materials The 2018 Annual Meeting of the Japan Society for Bioscience, Biotechnology, and 2018/3/18 Agrochemistry, Symposium 2018/3/19 Seminar on the research of the bacterial drug efflux systems 2018/3/19 The 65th JSAP Spring Meeting 2018/3/20 The 98th CSJ Annual Meeting

Other Lectures and Seminars

Kwansei Gakuin Molecular Graph and data 2017/4/10 Takashi Okada Emeritus Prof. University mining

― 14 ― Masayuki Introduction to the Machine 2017/4/14 Tohoku Univ. Assoc. Prof. Ohzeki Learning Takeo Institute of Chemistry, ୙ᩧཬࡧ఩⨨㑅ᢥⓗศᏊኚ 2017/4/20 Professor Kawabata Kyoto University ᥮ࡢ᪂ᶵ㍈ Towards Operando and real time 3D analysis of 2017/5/12 Thierry Epicier University of Lyon Professor Nanocatalysts in Environmental TEM Graduate School and Faculty of ࢥࣉࢩ࢔࢔ࣝ࢝ࣟ࢖ࢻࡢ඲ 2017/5/29 Shigeru Arai Pharmaceutical Assoc.Prof. ྜᡂ◊✲ Sciences, Chiba University Indira Gandhi Centre for Deep UV region usable pure Padmalochan 2017/6/1 Atomic Research Ph.D,Student and doped AlN thin films and Panda (IGCAR) its physical properties Radu Senior Presales Recent topics on computer 2017/6/2 NTTData Romania Orghidan Consultant visions and robotics ๰⸆ࢆᚿྥࡋࠊࣚ࢘⣲ཎᏊࡢ 2017/6/5 Yasuyuki Kita Ritsumeikan University Professor ≉ᛶࢆά⏝ࡋࡓ࣓ࢱࣝࣇࣜ ࣮࢝ࢵࣉࣜࣥࢢ཯ᛂࡢ㛤ᣅ Drug development toward Gifu Pharmaceutical 2017/6/22 N. Shioda Assoc. Prof. neurological disorders based on University G-Qplex Hiroki Dept. of Physics, Kobe Research Thermoelectric chalcogenide 2017/7/6 Funashima University Lecturer thermoelectric mineral Inuzuka Nagoya Institute of ࡘ࡞ࡀࡾ࡜ㄽ⌮ࢆ㔜どࡋࡓ▱ 2017/7/13 Professor Nobuhiro Technology ㆑Ⓨぢ࢔ࣝࢦࣜࢬ࣒ CNR-SPIN and VO2: a solid state actuator for 2017/7/14 Luca Pellegrino Researcher University of Genova micro/nanorobotics Accademia Nazionale Orienting molecules: dei Lincei, Roma Vincenzo Stereodirectional and Chiral 2017/8/8 Accademia Nazionale Emeritus Prof. Aquilanti Features of Photo- and Reaction delle Scienze, Università Dynamics di Perugia

― 15 ― Random lasing in Toshihiro 2017/8/18 Hosei University Assoc. Prof. semiconductor NAKAMURA micro/nano-structures Faculty of ࣊ࢸࣟཎᏊࢆ᭷ࡍࡿⰾ㤶᪘໬ Koji Pharmaceutical 2017/9/20 Assis. Prof. ྜ≀㢮ࡢ㠉᪂ⓗ࡞࣓ࢱࣝࣇࣜ MORIMOTO Sciences, Ritsumeikan ࣮㓟໬ⓗ⤖ྜᙧᡂ University Graduate School of ࣌ࣉࢳࢻ⤖ྜ➼౯య࡟ࡼࡿ࢔ Tetsuo Integrated Science and 2017/9/20 Assoc.Pprof. ࣑ࣟ࢖ࢻ࣌ࣉࢳࢻࡢจ㞟ᶵᵓ NARUMI Technology, Shizuoka ゎ᫂ University Nanyang Technological RNA Technology, Basic and 2017/9/29 Gang Chen Assis. Prof. (PI) University Application Timothy John SLAC National Research Longitudinal Beam Dynamics 2017/10/25 Maxwell Accelerator Laboratory Associate and Diagnostics at the LCLS Perspectives of VO2 for new CNR-SPIN and 2017/12/5 Luca Pellegrino Researcher applications in micro/nano University of Genova actuators Study of Liquid Lead Corrosion Artoto of Fast Nuclear Reactor 2017/12/7 University of Jember Lecturer Arkundato and Its Mitigation by Using Molecular Dynamics Method Palladium-catalyzed Aromatic Fumitoshi Faculty of Science, Keio C-H Functionalization by 2017/12/11 Professor KAKIUCHI University Means of Electrochemical Oxidation Toward Ultrahigh Precision of Yasukazu Electron Holography: Imaging 2018/1/16 Kyushu Univ. Professor Murakami of Electromagnetic Field in Nanostructure Materials Dimitrios Multifunctional RF Frontends 2018/1/17 Purdue Univ. Professor Peroulis for High-Frequency AI Sensors Center for Emergent Cluster multipole theory for Michi-To 2018/1/18 Matter Science (CEMS), Research Scientistmacroscopic phenomena in Suzuki RIKEN antiferromagnets

― 16 ― Gustav Forschungszentrum 2018/1/18 Scientist Magnetic topological materials Bihlmayer Jülich Institute of Observation of crystal and Daisuke Multidisciplinary 2018/1/18 Assis. Prof. magnetic structures on Okuyama Research for Advanced noncentrosymmetric magnets Materials, Tohoku Univ. Institute of Ferro- and antiferromagnetic Johannes Daniel Multidisciplinary skyrmions from a neutron 2018/1/18 Assis. Prof. Reim Research for Advanced scattering perspective: Two Materials, Tohoku Univ. case studies Jean-Jacques RNA aptamer, Basic and 2018/1/18 University of Bordeaux Prof. (PI) Toulmé Application Transparent oxide Tokyo Institute of 2018/1/26 Hideo Hosono Professor semiconductor technologies for Technology organic electronics Organic integrated circuits and 2018/1/26 Junichi Takeya University of Tokyo Professor printed electronics Prof. Dr. Eindhoven University of Small-molecule stabilization of 2018/2/1 Christian Assoc. Professor Technology Protein-Protein Interactions Ottmann Clinical application of optical Towada Municipal Chief Manager of 2018/3/9 Taito Itabashi function and long term Central Hospital Orthopedics antimicrobial expression Mechanism of photo Yukihiro 2018/3/9 Ushio Inc. Project Manager functionalization inducing MORIMOTO Osseo integration An overview on the activities at CNR-SPIN and CNR-SPIN and University of 2018/7/14 Daniele Marre Professor University of Genova Genova in condensed matter physics.

7) Public Information Activity

Public information activity of ISIR in 2018 is as follows: • Bulletin of ISIR (in both Japanese and English) • Memoirs of the Institute of Scientific and Industrial Research, Osaka University (in English)

― 17 ― • Annual Report of ISIR (in Japanese) • SANKEN News Letters(in Japanese) • Report on SANKEN Techno Salon (in Japanese) • WWW home-page ( http://www.sanken.osaka-u.ac.jp/ )

8) Research Reports

The number of scientific and technological papers published in 2018 is 259. The details are described in the part of activity of divisions and facilities.

9) Scientific Awards K.KISHI㻌 Best presentation award of 138th Annual Meeting of the 2018/3/28 S.TAKIZAWA㻌㻌 Pharmaceutical Society of Japan (AMPSJ) H.SASAI 2018/3/22 K.FUKUI Knowledge-based Systems Outstanding Reviewer Award 2018/3/14 T.SEKITANI JEITA Venture Award 2018/3/13 R.TAKEDA IPSJ Yamashita SIG Research Award 2018/3/12 K.HAYASHI ANLP Annual Meeting Excellent Paper T.ONO Y.KANAI 2018/2/16 Academic-industrial Alliance Award K.INOUE K.MATSUMOTO 2018/2/15 T.NAGAI The Photobiology Association of Japan award 2017/12/27 T.MATSUMOTO 2018 Albert Nelson Marquis Lifetime Achievement Award S.NAGAO 2017/12/25 T.SUGAHARA MES2017 best paper award K.SUGANUMA The 33rd International Korea-Japan Seminar on Ceramics, Young 2017/11/23 T.GOTO Ceramist Best Presentation Award 2017/11/23 Y.ONITSUKA 2nd prize in the Best Young Researcher Contribution Contest 2017/11/22 S.YAMASAKI Japan Science and Technology Agency, President Award 2017/11/8 K.KAIHATSU The 15th Award of Kansai Branch, Synthetic Organic Chemistry 2017/11/5 S.YAMASAKI The 2nd COI Young Innovation Pitch, Best Presenter Award 2017 National Tsing Hua University 2017/10/31 Z.XU -Osaka University Life Science Student Symposium,Outstanding

― 18 ― presentation 20th International Symposium on Calcium Binding Proteins and 2017/10/26 M. N.HOSSAIN Calcium Function in Health and Disease (CaBP20), Excellent Poster Award The 55th Annual Meeting of The Biophysical Society of Japan, 2017/10/23 H.SHINODA Student Presentation Award 16th Docomo Mobile Science Award, Basic Science, Excellence 2017/10/20 T.SEKITANI Award A.ARIMA M.TSUTSUI 2017/10/5 W.TONOMURA ໬Ꮫ࡜࣐࢖ࢡ࣭ࣟࢼࣀࢩࢫࢸ࣒Ꮫ఍➨  ᅇ◊✲఍ඃ⚽◊✲㈹ K.YOKOTA M.TANIGUCHI 2017/9/28 N.TAKEMURA VRSJ Outstanding Paper Award 2017/9/28 M,FUJITSUKA Japanese Society of Radiation Chemistry Award T.SEKINO 2017/9/20 T.GOTO Session Incentive Award, the 30th Fall Meeting S.CHO International Investigator Awards of the Japan Society for Molecular 2017/9/15 M.TANIGUCHI Science 2017/9/13 Y.MAKIHARA IEICE Contribution award H.KOBAYASHI 2017/9/7 Key Scientific Article T.MATSUMOTO 2017/9/1 M.SOMIYA 2017 JARI/JSEV Oral Presentation Award T.AOKI H.SASAKI Kansai blanch of The Society of Synthetic Organic Chemistry, Japan 2017/8/9 S.TAKIZAWA Poster Award M.SAKO 2017/8/9 I.MITSUGAMI MIRU Reviewer Award The31st Grand Prize for the Advanced Technology Award 2017/7/24 Y.Zhang The Fujisankei Business i Prize 2017/7/13 H.KOGA Young Scientist Award of the Cellulose Society of Japan M.SAKO 2017/7/4 H.SASAKI GSC Poster Award S.TAKIZAWA

― 19 ― M.SUGIYAMA T.UEMURA S.YOSHIMOTO 9th International Conference on Molecular Electronics and 2017/6/27 M.AKIYAMA Bioelectronics, Best Poster Award T.ARAKI T.SEKITANI M.NUMAO 2017/6/26 JSAI Incentive Award K.FUKUI 2017/5/29 M.TANE Honda Memorial Young Researcher Award S.YOSHIMOTO T.ARAKI 2017/5/16 T.UEMURA Workshop on LSIs and Systems 2017, Best Poster Award (General) S.NEZU T.SEKITANI M.SUGIYAMA T.UEMURA S.YOSHIMOTO Young Researchers Conference, The Institute of Electronics, 2017/5/16 M.AKIYAMA Information and Communication Engineers 2017, Best Poster Award T.ARAKI T.SEKITANI 2017/4/21 T.OKAJIMA Nagase Research Promotion Award

2. Education ISIR accepts graduate students from the Graduate Schools of Science, Engineering, Engineering Science, Pharmaceutical Science, Information Science and Technology, and Frontier Biosciences, and also researchers for special training, including those from industry and from abroad. Staff members also belong to various Faculties: Faculty of Science, Faculty of Engineering, Faculty of Engineering Science, Faculty of Pharmaceutical Science, Faculty of Information Science and Technology, and Faculty of Frontier Biosciences. Some members belong to two Faculties. They give lectures for graduate and undergraduate students in each Faculty.

― 20 ― Number of graduate students as of March 31, 2018 is as follows.

Field Pharma- Information Engineering Frontier Science Engineering ceutical Science and Science Biosciences Total Course Science Technology Master Course 42 61 15 1 18 - 137 Doctor Course 25 39 3 1 14 12 94 Total 67 100 18 2 32 12231

Number of students who had obtained Master's or Doctor's Degree in FY2018 is as follows.

Field Pharma- Information Frontier Science Engineering ceutical Science and Biosciences Total Degree Science Technology Master’s Degree 14 20 0 9 - 43 Doctor’s Degree 9 7 1 4 1 22 Total 23 23 1 13 1 65

3. International Exchange

1) Exchange Agreement

At Present, academic exchange agreements are concluded with the following 37 organizations.

Otto-von-Guericke University, Magdeburg (Faculty of Natural Science) Chonnam National University Pukyong National University (Basic Science Research Institute) Forschungszentrum Jülich GmbH Pusan National University(College of Natural Sciences) Hanyang University

National Taiwan University Centre National de la Recherche Scientifique Chungnam National University College of Natural Sciences RWTH Aachen University Peking University The School of Electronics Enginering and Computer Science Tammasat University University of Geneva(Faculty of Science)

― 21 ― Inner Mongolia Normal University University of Augsburg De La Salle University(College of Computer Studies) Assiut University Interuniversitair Micro-Electronica Centrum vzw (IMEC) University of Bordeaux Bielefeld University㸦Faculty of Chemistry㸧 Pacific Northwest National Laboratory Korea Institute of Ceramic Engineering and Technology Advanced Radiation Technology Institute/Korea Atomic Energy Research Institute Eindhoven University of Technology (Department of Mechanical Engineering) Chulalongkorn University (Department of Computer Engineering, Faculty of Engineering) Sun Moon University (College of Engineering) École polytechnique University of Paris-Saclay University of Science and Technology (School of Materials Science and Engineering) University of Genoa University of Cologne (Faculty of Mathematics and Natural Sciences) National Chiao Tung University(College of Science) Shenzhen University Uppsala University(Department of Physics and Astronoomy) Fraunhofer Institute For Integrated Systems and Device Technology IISB The Hebrew University of Jerusalem The University of Hong Kong(School of Biological Sciences)

2) Foreign Researchers and Students The Number of foreign researchers and students staying in ISIR as of March 31, 2019 is 118 in total. Details are, Assistant Professor(include of specially appointed staffs) (2), Specially Appointed Associate Professor(7), Specially Appointed Researcher(2), Part-time Employee (21), Graduate Students 62(Doctor Course,46, Master Course,16), Undergraduate Student(2), Special Auditor(2).,Research Students (19). Their nationalities are; China(54), Korea(16), Thailand(6), Viet Nam(8), Indonesia(2), Bangladesh(7), Egypt(1), The Netherland(3), Philippine(3), India(6), Iran(1), Costa

― 22 ― Rica(1),Sri Lanka(2), Germany(1), Syrian(2), Taiwan(1), Macau(1), Hungary(1), Brazil(1), Myanmar(1). The Number of visiting Research Scholar in 2018 is 36. Their nationalities are; China(12), Thailand(3), U.S.A.(5), Korea(1), Germany(3), Egypt(1), Sweden(1), Slovenia(1), Denmark(1), Bangladesh(6), Belgium(1).

3) International Conferences and Symposiums Number of presentations (plenary, invited, oral and poster in various international conferences and symposia) by staff of ISIR is 356 in total. Number of ISIR staffs who have been working as committee members of International Conferences or Editorial Board of international academic journals are 146 in total. For more details, see the part of activity of divisions and facilities.

4. Concluding Remarks (1) Organization and Management System After the reorganization in April 2009, ISIR has three major research divisions, Division of Information and Quantum Sciences, Division of Materials and Beam Sciences, and Division of Biological and Molecular Sciences, and one permanent research center “Nanoscience and Nanotechnology Research Center”. In addition, ISIR contains two divisions for special purposes named “Division of Next Industry Creation” and “Division of Special Project Research”. The latter division contains independent laboratories supervised by associate professors with limited terms selected from young assistant professors of ISIR for promotion of young scientists. ISIR also has two research supporting centers, “Comprehensive Analysis Center” and “Research Laboratory for Quantum Beam Science”. Inter-institute project research, “Materials Science & Technology Research Center for Industrial Creation” and “Post-Silicon Materials and Devices Research Alliance” has been successfully finished in 2009 and the new inter-institute collaboration named “Strategic Alliance Project for Creation of Nano-Materials, Nano-Devices and Nano-Systems” on the basis of the Network Joint Research Center for Materials and Devices has been started in 2010. In the ISIR, the following facilities are also installed; Workshop, Office of Information Network, Laboratory of Radio-isotope Experiments, Library, Academia-Industry Relation Office, Public Relations Office and Technical Division. Management of ISIR is performed by the Director and the Board of Directors supervised by the Faculty Council composed of all ISIR professors. Advisory Board has

― 23 ― been set up to introduce opinions from outside into the Institute. Advisory Board has been set up to introduce opinions from outside into the Institute.

࠙ Management Organization of ISIRࠚ

Director

Faculty Council Board of Directors Advisory Board Network Joint Research Center for Materials and Devices Committees

(2) Research Activities In 1997, Harmonized Materials Research Group was designated as one of the Centers of Excellence (COE) of Ministry of Education, indicating the high research activity of the Institute. From 2002 through 2006, we have awarded as the best group in 21 Century COE program that is originally the top 20 group plan in Japan. This involves the positive exchange between different laboratories which yield results of the global level with respect to material, information and biotechnology. In 2005, Materials Science & Technology Research Center for Industrial Creation has launched as a joint center between ISIR and Institute of Multidisciplinary Research for Advanced Materials, Tohoku University. It was expanded to Post-Silicon Materials and Devices Research Alliance for collaboration with four university institutes in 2006. In 2010, nationwide Network Joint Research Center for Materials and Devices including five university institutes has been started. ISIR is a headquarters of the network. In 2011, Research Collaboration Agreement was reached between Interuniversity Microelectronics Center(imec) and ISIR. ISIR’s research environment as facilities and equipments has been becoming better. A new building was constructed in 2001 and 2003 to the increased number of scientists and the development of Nanotechnology, respectively and Nanoscience and Nanotechnology Center started in April 2002. In addition, the total repair of the old buildings into the earthquake-resistant structures has been completed in 2010. A new building named “SANKEN Incubation Building” has been completed in 2010 for open innovation by academia-industry collaboration.

― 24 ― (3) Education Considering objective of ISIR, supporting the graduate and undergraduate education is one of the important missions. ISIR has about 200 graduate students coming from 6 different graduate schools and faculties such as Science, Engineering, Engineering Science, Pharmaceutical Science, Frontier Biosciences and Information Science and Technology. In 2009, we have set up the Centre for Research Education and Training in order to promote the ISIR original education on research. We already have ISIR original lecture “Nano Engineering” in Graduate School of Engineering. We aim to expand the ISIR original lectures authorized by various graduate schools in Osaka University as a sub-program. The Sanken Techno-Salon is one of forums to exchange information between our staffs and the people from industries specializing in electronics, organic chemicals, semiconductors, drugs, etc. We have also seminars for providing seeds of new technologies to the industrial communities. We aim to grow researchers and students with the best humanity, capable of innovation of their specific fields of research from basic point of view.

(4) Contribution to Societies As the fast–paced advancement of science and technology and the rapid alteration of social and industrial structures, we must further recognize as the Institute open to society and industry. We consistently strive to deepen our cooperation with society through positively opening of facilities, intellectual properties and achievements to meetings (ex. Sanken Techno Salon),publications and website. Through them, we will be able to transfer our industrial seeds for new technology and exchange ideas for new materials. They have been highly evaluated that we have done joint researches with other university/industry. In April 2006, AIR-office (Academia Industry Relations Office) has been settled in order to strengthen cooperation between the Institute and industries. In 2008, Research Association of Industry and Science (RAIS) was reorganized, set up bureau office in ISIR and the bureau chief was adopted in order to promote and support the academia-industry cooperation. In 2010, “Company Research Park” opens in the new SANKEN Incubation Building as Osaka University’s first rental laboratories for business enterprises.

― 25 ― (5) International Exchange  㸦㸧  International Exchange is one of indispensable elements for our Institute. We are trying to open the door widely to invite more researchers and students from other countries, and we have 3 kind of international exchange, academic exchange, student exchange and branches in France and USA. International Conferences sponsored by our Institute have been held twice a year since 1998. It’s so important to release our results towards all over the world and have a chance to exchange opinions with foreign scientists. In 2009, International Center for Collaborative Research Education and Training was started for promoting the foreign exchange. It consists of several collaborative laboratories between foreign universities have been set up or in preparation as follows: ICT Collaborative Laboratory between the School of Electronics Engineering and Computer Science, Peking Univ. and ISIR, Collaborative Laboratory between College of Science and Technology. Korea Univ. and ISIR, and Collaborative Laboratory between Faculty of Mathematical and Physical Sciences, Univ. College of London and ISIR in Areas Relating to Excited Surface Science.

(6) Future Plan and Prospect In 2010, nationwide “Network Joint Research Center for Materials and Devices” has been started. It is a greatest collaboration network between university institutes in Japan. ISIR plays a leading role in the network as the headquarters. At the same time, our SANKEN Incubation Building was opened for the core of academia-industry collaboration. In 2011, the time has come to advance to the next step for ISIR. We promoted international collaboration with imec for open innovation.In order to respond with flexibility to our quickly changing society, along with the rapid development of science and technology, we must understand our role of society and in order to stay effective and relevant Institute for industries, we must make independent researches and release widely our intellectual properties and achievement. Keeping development of science and technology in Japan, we must cultivate researchers capable of producing academic and professional results that will benefit the people living on this planet. ISIR grow researchers and students who can active in the world. You can see about ISIR on the following URL (http://www.sanken.osaka-u.ac.jp/ index_e.html). The Institute of Scientific and Industrial Research keeps making efforts toward higher level contribution to science and industries, and keeps learning.

― 26 ― Administrative Office 㸦31-March , 2019㸧

Director : Yoshinobu Ishikura

General Affairs Division Staffs: Masahiro KOMAKI Satoshi KAJIURA Sachiko YAMAMOTO Tomoko SAWADA Mie SHIMOE Ritsuko Kitamura Supporting Staffs: Ayano KOMAI Akiko AKAMATSU Aki Kouno Research Cooperation Division Staffs: Kenji Nishikawa Natsuko Kitanohashi Takeshi NAKASHIMA Seiko Okamoto Yasuko MUTSUI Yasushi Matsuura Shingo TABATA Yusuke AKAO Yuka Konishi Momoko SAKAI Fumiko SHINJO Emi MIZUGUCHI Etsuko UNO Supporting Staffs: Yutaka Kurokui Kazune OTANI KOTO MIYAGOU Yumi AKUTSU

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