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I.C.FARBEN" INDUSTRIE AKTIEN" GESELLSCHAFT FRANKFURT (MAIN) 1 9 3 8 I. G. Farbenindustrie Aktiengesellschaft Frankfurt am Main Bericht des Vorstands und des Aufsichtsrats und Jahresabschluß für das Geschäftsjahr 1938. VORSTAN Geheimer Kommerzienrat Dr. HERMANN SCHMITZ, Ludwigshafen a. Rh./Heidelberg, Vorsitzer, Dr. FRITZ GAJEWSKI, Leipzig, Professor Dr. HEINRICH HäRLEIN, Wuppertal-Elberfeld, Dr. AUGUST v. KNIERIEM, Mannheim, Zentralausschuß Dr. CARL KRAUCH, Heidelberg-Schlierbach, Dr. FRITZ TER MEER, Kronberg (Taunus), Dr. CHRISTIAN SCHNEIDER, Leuna, Dr. GEORG von SCHNITZLER, Frankfurt (Main), Dr. OTTO AMBROS, Ludwigshafen a. Rh., Dr. MAX BRÜGGEMANN, Leverkusen-Wiesdorf, Dr. ERNST BÜRGIN, Bitterfeld, Dr. HEINRICH BÜTEFISCH, Leuna, Ministerialrat a. D. Dr. BERNHARD BUHL, Frankfurt (Main), PAUL HAEFLIGER, Frankfurt (Main), Dr. MAX JLGNER, Berlin-Steglitz, Dr. CONSTANTIN JACOBI, Frankfurt (Main), Dipl. Ing. FRIEDRICH JÄHNE, Frankfurt (Main), Dr. HANS KÜHNE, Leverkusen-Wiesdorf, Professor Dr. CARL LUDWIG LAUTENSCHLÄGER, Frankfurt (Main), Generalkonsul WILHELM RUDOLF MANN, Leverkusen-Wiesdorf. Dr. HEINRICH OSTER, Berlin-Charlottenburg, Kommerzialrat WILHELM OTTO, Berlin-Zehlendorf-West, Dr. OTTO SCHARF, Halle (Saale), Kommerzienrat HERMANN WAIBEL, Wiesbaden, Dr. HANS WALTHER, Frankfurt (Main), EDUARD WEBER-ANDREAE, Frankfurt (Main), Dr. CARL WURSTER, Ludwigshafen a. Rh. Im Geschäftsjahr oder nachher ausgeschieden: Kommerzienrat Dr. LUDWIG HERMANN, Frankfurt (Main) t 31. 5. 1938. AUFSICHTSRAT. Geheimer Kommerzienrat Professor Dr. CARL BOSCH, Heidelberg, Vorsitzer, Dr. WALTHER vom RATH, Kronberg (Taunus), stellvertretender Vorsitzer, Dr. WILHELM FERDINAND KALLE, Tutzing (Oberbayern), stellvertretender Vorsitzer, Dr. AXEL AUBERT, Oslo, Dr. RICHARD BAYER, Haus Falkenberg, Trills über Wuppertal-Vohwinkel, W ALDEMAR von BÖTTINGER, Landwirt, Schloß Arensdorf i. d. Neumark, Dr. WALTER von BRÜNING, Polizeipräsident a. D., Semper a. Rügen, Kommerzienrat LOTHAR BRUNCK, Kirchheimbolanden (Pfalz), Dr. CARL LUDWIG DUISBERG, Berlin-Zehlendorf-MiUe, Kommerzienrat Dr. -
Intelligent Produzieren Gute Chemie Ist Die Basis Für Vollständiges Und Qualitativ Hochwertiges Recycling
19/2013 22. Jahrgang · 10. – 23. Oktober 2013 DIE ZEITUNG FÜR DIE MÄRKTE DER CHEMIE UND LIFE SCIENCES Chemiekonjunktur Logistik Chemikalien Wachstumsdynamik Automatisierte Transportab- Nachhaltigkeitskonzepte in den BRIC-Staaten wicklung beschleunigt Prozesse und eine hohe Produktsicherheit lässt nach und bringt Sicherheit gewinnen an Bedeutung Seite 4 Seite 18 Seiten 19 – 24 Intelligent produzieren Gute Chemie ist die Basis für vollständiges und qualitativ hochwertiges Recycling oderne Nachhaltigkeits- oder Ökoeffizienzanalysen betrachten die Auswirkungen eines Produkts auf seine Umwelt über den gesamten Lebenszyklus hinweg, sozusagen von der „Wiege bis zu Bahre“. Dem M Chemiker und wissenschaftlichen Leiter des Hamburger Umweltinstituts, Prof. Michael Braungart, ist dies nicht genug: Er fordert mehr Ökoeffektivität statt Öko- effizienz bei der Entwicklung von Produkten. Mit seinem Umweltforschungs- und Beratungsinstitut EPEA berät er Unternehmen aus aller Welt bei der Umsetzung sei- nes Prinzips „Cradle-to-Cradle“ (von der Wiege zur Wiege). Dr. Andrea Gruß sprach mit Prof. Braungart darüber, warum „gute“ Chemie mehr als nachhaltig sein muss. CHEManager: Herr Braungart, auf Qualität und Schönheit setzen immer mehr Unternehmen ent- und nicht auf Nachhaltigkeit. Dann wickeln Produkte nach Prinzipien entstehen Innovationen. der „grünen“ Chemie. Führt dies Der Begriff Nachhaltigkeit ist zu einer höheren Produktqualität? auch langweilig. Es geht dabei im- mer nur darum, zu reduzieren, zu Prof. M. Braungart: Es gibt keine ‚grü- minimieren und zu sparen. Das ne‘ Chemie, es gibt nur gute oder heißt, alles wie bisher zu machen, N EWSFLOW schlechte Chemie. Chemie, die sich nur eben weniger schlecht. Doch in Lebewesen anreichert, hat ein weniger schlecht ist noch lange - Fotolia.com © aleciccotelli Unternehmen Qualitätsproblem. Chemie, die Abfäl- nicht gut. -
I.G. Farben's Petro-Chemical Plant and Concentration Camp at Auschwitz Robert Simon Yavner Old Dominion University
Old Dominion University ODU Digital Commons History Theses & Dissertations History Summer 1984 I.G. Farben's Petro-Chemical Plant and Concentration Camp at Auschwitz Robert Simon Yavner Old Dominion University Follow this and additional works at: https://digitalcommons.odu.edu/history_etds Part of the Economic History Commons, and the European History Commons Recommended Citation Yavner, Robert S.. "I.G. Farben's Petro-Chemical Plant and Concentration Camp at Auschwitz" (1984). Master of Arts (MA), thesis, History, Old Dominion University, DOI: 10.25777/7cqx-5d23 https://digitalcommons.odu.edu/history_etds/27 This Thesis is brought to you for free and open access by the History at ODU Digital Commons. It has been accepted for inclusion in History Theses & Dissertations by an authorized administrator of ODU Digital Commons. For more information, please contact [email protected]. 1.6. FARBEN'S PETRO-CHEMICAL PLANT AND CONCENTRATION CAMP AT AUSCHWITZ by Robert Simon Yavner B.A. May 1976, Gardner-Webb College A Thesis Submitted to the Faculty of Old Dominion University in Partial Fulfillment of the Requirements for the Degree of MASTER OF ARTS HISTORY OLD DOMINION UNIVERSITY August 1984 Approved by: )arw±n Bostick (Director) Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Copyright by Robert Simon Yavner 1984 All Rights Reserved Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. ABSTRACT I.G. FARBEN’S PETRO-CHEMICAL PLANT AND CONCENTRATION CAMP AT AUSCHWITZ Robert Simon Yavner Old Dominion University, 1984 Director: Dr. Darwin Bostick This study examines the history of the petro chemical plant and concentration camp run by I.G. -
The Persistence of Elites and the Legacy of I.G. Farben, A.G
Portland State University PDXScholar Dissertations and Theses Dissertations and Theses 5-7-1997 The Persistence of Elites and the Legacy of I.G. Farben, A.G. Robert Arthur Reinert Portland State University Follow this and additional works at: https://pdxscholar.library.pdx.edu/open_access_etds Part of the History Commons Let us know how access to this document benefits ou.y Recommended Citation Reinert, Robert Arthur, "The Persistence of Elites and the Legacy of I.G. Farben, A.G." (1997). Dissertations and Theses. Paper 5302. https://doi.org/10.15760/etd.7175 This Thesis is brought to you for free and open access. It has been accepted for inclusion in Dissertations and Theses by an authorized administrator of PDXScholar. Please contact us if we can make this document more accessible: [email protected]. THESIS APPROVAL The abstract and thesis of Robert Arthur Reinert for the Master of Arts in History were presented May 7, 1997, and accepted by the thesis committee and department. COMMITTEE APPROVALS: Sean Dobson, Chair ~IReard~n Louis Elteto Representative of the Office of Graduate Studies DEPARTMENT APPROVAL: [)fl Dodds Department of History * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ACCEPTED FOR PORTLAND STATE UNIVERSITY BY THE LIBRARY by on ct</ ~~ /997 ABSTRACT An abstract of the thesis of Robert Arthur Reinert for the Master of Arts in History presented May 7, 1997. Title: The Persistence of Elites and the Legacy of LG. Farben, A.G .. On a massive scale, German business elites linked their professional ambitions to the affairs of the Nazi State. By 1937, the chemical giant, l.G. Farben, became completely "Nazified" and provided Hitler with materials which were essential to conduct war. -
Scheduling Order
Case 2:16-cv-12943-SSV-JCW Document 1 Filed 07/19/16 Page 1 of 36 IN THE UNITED STATES DISTRICT COURT FOR THE EASTERN DISTRICT OF LOUISIANA VERONICA A. SMITH Plaintiff, v. Civil Action No.______________ SANOFI S.A., AVENTIS PHARMA S.A., and Section: __________ SANOFI-AVENTIS U.S. LLC, separately, and doing business as WINTHROP U.S. Defendants. COMPLAINT AND JURY DEMAND Plaintiff, Veronica A. Smith, by and through her attorneys, respectfully submits the following Complaint and Jury Demand against Defendants Sanofi S.A.; Aventis Pharma S.A.; and Sanofi-Aventis U.S. LLC, separately, and doing business as Winthrop U.S. (“Defendants”), and alleges the following: NATURE OF THE ACTION 1. This action seeks to recover damages for injuries sustained by Plaintiff as the direct and proximate result of the wrongful conduct of Defendants, Sanofi S.A., Aventis Pharma S.A., and Sanofi-Aventis U.S. LLC, in connection with the designing, developing, manufacturing, distributing, labeling, advertising, marketing, promoting, and selling of TAXOTERE®, a prescription medication used in the treatment of breast cancer. Case 2:16-cv-12943-SSV-JCW Document 1 Filed 07/19/16 Page 2 of 36 JURISDICTION AND VENUE 2. This Court has subject matter jurisdiction pursuant to 28. U.S.C. § 1332 (diversity jurisdiction). The amount in controversy exceeds $75,000.00 exclusive of interest and costs. There is complete diversity of citizenship between Plaintiff and Defendants. Plaintiff is a resident and citizen of and is domiciled in the State of Louisiana, within St. John the Baptist Parish. As set forth more fully below, all Defendants are entities organized in states other than the State of Louisiana, all Defendants have their principal place of business in a state other than the State of Louisiana, and none of the Defendants is a citizen or resident of the State of Louisiana. -
Military Tribunal, Indictments
MILITARY TRIBUNALS CASE No.6 THE UNITED STATES OK AMERICA -against- CARL KRAUCH, HERMANN SCHMITZ, GEORG VON SCHNITZLER, FRITZ GAJEWSKI, HEINRICH HOERLEIN, AUGUST VON KNIERIEM, FRITZ.a'ER MEER, CHRISTIAN SCHNEIDER, OTTO AMBROS, MAX BRUEGGEMANN, ERNST BUERGIN, HEINRICH BUETEFISCH, PAUL HAEFLIGER, MAX ILGNER, FRIEDRICH JAEHNE,. HANS KUEHNE, CARL LAUTENSCHLAEGER, WILHELM MANN, HEINRICH OSTER, KARL WURSTER, WALTER DUERR FELD, HEINRICH GATTINEAU, ERICH VON DER HEYDE, and HANS KUGLER, officialS of I. G. F ARBENINDUSTRIE AKTIENGESELLSCHAFT Defendants OFFICE OF MILITARY GOVERNMENT FOR GERMANY (US) NURNBERG 1947 PURL: https://www.legal-tools.org/doc/1e951a/ 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 PURL: https://www.legal-tools.org/doc/1e951a/ 1 TABLE OF CONTENTS INTRODUCTORY 5 COUNT ONE-PLANNING, PREPARATION, INITIATION AND WAGING OF WARS OF AGGRESSION AND INVASIONS OF OTHER COUNTRIES 9 STATEMENT OF THE OFFENSE 9 PARTICULARS OF DEFENDANTS' PARTICIPATION 9 A. The Alliance of FARBEN with Hitlet· and the Nazi Party 9 B. F ARBEN synchronized all of its activities with the military planning of the German High Command 13 C. FARBEN participated in preparing the Four Year Plan and in directing the economic mobilization of Germany for war 15 D. F ARBEN participated in creating and equipping the Nazi military machine for aggressive war. 20 E. F ARB EN procured and stockpiled critical war materials . for the Nazi offensive / 22 F. FARBEN participated in weakening Germany's potential enemies 23 G. FARBEN carried on propaganda, intelligence, and espionage activ:ities 25 H. With the approach of war and with each new act of aggression, F ARBEN intensified its preparation for, and participation in, the planning and execution of such aggressions and the reaping of spoils therefrom 27 I. -
PDF Viewing Archiving 300
I.C.FARBEN INDUSTRIE AKTIEN~ GESELLSCHAFT FRANKFURT(.MAIN) 1 9 3 2 L G. Farbenindustrie Aktiengesellschaft Frankfurt (Main) Bericht· des Vorstandes und des Aufsichtsrates über das Geschäftsjahr 1932. 8. ordentliche Generalversammlung Freitag, den 28. April 1933, vormittags 11 Uhr, in unserem Verwaltungsgebäude Frankfurt (Main) Grüneburgplatz. Tages-Ordnung: 1. Vorlage des Jahresabschlusses und des Geschäftsberichtes für 1932 und Beschlußfassung über den Jahresabschluß. 2. Gewinnverteilung. 3. Entlastung des Aufsichtsrates und des Vorstandes. 4. Wahlen zum Aufsichtsrat. 5. Wahl des Bilanzprüfers fUr das Geschäftsjahr 1933. Aufsi chtsrat. Geheimer Regierungsrat Professor Dr. CARL DUISBERG, Leverkusen, Vorsitzender, Dr. CARL von WEINBERG, Frankfurt (Main)-Niederrad, stellvertretender Vorsitzender, Dr. WTLHELM FERDINAND KALLE, Frankfurt (Main), Dr. RUDOLF MANN, Leverkusen, Verwaltungsrat Geheimer Kommerzienrat Dr. LUDWIG SCHUON, München, Staatssekretär z. D. Dr. ERNST von SIMSON, Berlin-Dahlem, Geheimer Regierungsrat Dr. ARTHUR von WEINBERG, Frankfurt (Main)-Niederrad. J Dr. WALTHER vom RATH, Cronberg (Taunus), Kommerzienrat ADOLF KÄCHELEN, Stuttgart, stellvertretender Vorsitzender, Wirkt. Geheimer Oberregierungsrat Dr. WILHELM von Dr. AXEL AUBERT, Oslo. MEISTER, Regierungspräsident a. D., Genf. Geheimer Hofrat Dr. GUST AV AUFSCHLÄGER, Hamburg, OTTO von MENDELSSOHN-BARTHOLDY, Berlin, Dr. RICHARD BAYER, Leverkusen, Dr. ALFRED MERTON, Frankfurt (Main), WALDEMAR von BöTTINGER, Rittergutsbesitzer, WILHELM PELTZER, Fabrikant, Krefeld, Schloss Arensdorf i. d. Neumark, Dr. W ALTER von BRONING, Polizeipräsident a. D., JULIUS SCHARFF, Bad Liebenzell, Semper a. Rügen, Graf RUTGER JAN EUGEN SCHIMMELPENNINCK, Kommerzienrat LOTHAR BRUNCK, Kirchheimbolanden, Den Haag (Holland), Geheimer Kommerzienrat Dr. LEO GANS, Dr. OSCAR SCHLITTER, Berlin, Frankfurt (Main), Geheimer Regierungsrat Dr. ADOLF HAEUSER, Staatsminister Dr. FRIEDRICH SCHMIDT -OTT, Frankfurt (Main), Exzellenz, Berlin-Steglitz, Dr. JAKOB HASSLACHER, Duisburg-Ruhrort, LEOPOLD Freiherr von SCHRENCK-NOTZING, Berlin. -
TAXOTERE (DOCETAXEL) MDL No
Case 2:16-cv-17144 Document 1 Filed 12/12/16 Page 1 of 101 IN THE UNITED STATES DISTRICT COURT FOR THE EASTERN DISTRICT OF LOUISIANA IN RE: TAXOTERE (DOCETAXEL) MDL No. 2740 PRODUCTS LIABILITY LITIGATION SECTION “N” (5) HON. KURT D. ENGLELHARDT BARBARA EARNEST Plaintiff, MAG. JUDGE NORTH vs. COMPLAINT & JURY DEMAND SANOFI S.A., Civil Action No. __________ AVENTIS PHARMA S.A., and SANOFI-AVENTIS U.S. LLC, separately, and doing business as WINTHROP U.S HOSPIRA WORLDWIDE, INC.; and SUN PHARMA GLOBAL INC.; and McKESSON CORPORATION d/b/a McKESSON PACKAGING; and SANDOZ INC.; and ACCORD HEALTHCARE INC.; and APOTEX, INC.; and PFIZER, INC.; and ACTAVIS PHARMA, INC.; and NORTHSTAR RX LLC; and EAGLE PHARMACEUTICALS, INC. Defendants. COMPLAINT AND JURY DEMAND Plaintiff, Barbara Earnest, by and through her attorneys, Bachus & Schanker, LLC, respectfully submits the following Complaint and Jury Demand against Defendants Sanofi S.A.; Aventis Pharma S.A.; and Sanofi-Aventis U.S. LLC, separately,; and doing business as Winthrop Case 2:16-cv-17144 Document 1 Filed 12/12/16 Page 2 of 101 U.S and Hospira Worldwide, Inc.; and Sun Pharma Global Inc.; and McKesson Corporation d/b/a McKesson Packaging; and Sandoz Inc.; and Accord Healthcare Inc..; and Apotex, Inc.; and Pfizer, Inc.; and Actavis Pharma, Inc.; and Northstar Rx LLC; and Eagle Pharmaceuticals, Inc., and alleges the following upon personal knowledge, information and belief, and investigation of counsel. NATURE OF THE ACTION 1. This action seeks to recover damages for injuries sustained by Plaintiff as the direct and proximate result of the wrongful conduct of Defendants Sanofi S.A., Aventis Pharma S.A., and Sanofi-Aventis U.S. -
Complaint (PDF)
Case 2:16-cv-10763 Document 1 Filed 06/17/16 Page 1 of 36 IN THE UNITED STATES DISTRICT COURT FOR THE EASTERN DISTRICT OF LOUISIANA CAROL WEBB Plaintiff, v. Civil Action No.______________ SANOFI S.A., AVENTIS PHARMA S.A., and Section: __________ SANOFI-AVENTIS U.S. LLC, separately, and doing business as WINTHROP U.S. Defendants. COMPLAINT AND JURY DEMAND Plaintiff, Carol Webb, by and through her attorneys, respectfully submits the following Complaint and Jury Demand against Defendants Sanofi S.A.; Aventis Pharma S.A.; and Sanofi- Aventis U.S. LLC, separately, and doing business as Winthrop U.S. (“Defendants”), and alleges the following: NATURE OF THE ACTION 1. This action seeks to recover damages for injuries sustained by Plaintiff as the direct and proximate result of the wrongful conduct of Defendants, Sanofi S.A., Aventis Pharma S.A., and Sanofi-Aventis U.S. LLC, in connection with the designing, developing, manufacturing, distributing, labeling, advertising, marketing, promoting, and selling of TAXOTERE®, a prescription medication used in the treatment of breast cancer. Case 2:16-cv-10763 Document 1 Filed 06/17/16 Page 2 of 36 JURISDICTION AND VENUE 2. This Court has subject matter jurisdiction pursuant to 28. U.S.C. § 1332 (diversity jurisdiction). The amount in controversy exceeds $75,000.00 exclusive of interest and costs. There is complete diversity of citizenship between Plaintiff and Defendants. Plaintiff is a resident and citizen of and is domiciled in the State of Louisiana. As set forth more fully below, all Defendants are entities organized in states other than the State of Louisiana, all Defendants have their principal place of business in a state other than the State of Louisiana, and none of the Defendants is a citizen or resident of the State of Louisiana. -
Exploring Technological Change in the German Pharmaceutical Industry
Exploring technological change in the German pharmaceutical industry A history-friendly model of technological change and technology adoption in a science-based industry Zur Erlangung des akademischen Grades eines Doktors der Wirtschaftswissenschaften (Dr. rer. pol.) von der Fakultät für Wirtschaftswissenschaften der Universität Fridericiana zu Karlsruhe genehmigte Dissertation von lic. rer. pol. Iciar Dominguez Lacasa Tag der mündlichen Prüfung: 17. Juli 2005 Referent: Prof. Dr. Hariolf Grupp Koreferent: Prof. Dr. Hagen Lindstädt E R K L Ä R U N G (gemäß §4, Abs. 4 der Promotionsordnung vom 21. April 1989) Ich versichere wahrheitsgemäß, die Dissertation bis auf die in der Abhandlung angegebe Hilfe selbständig angefertigt, alle benutzten Hilfsmittel vollständig und genau angegeben und genau kenntlich gemacht zu haben, was aus Arbeiten anderer und aus eigenen Veröffentlichungen unverändert oder mit Abänderungen entnommen wurde. Acknowledgements The driving ideas for this project came from a working paper my supervisor gave me from the Danish Research Unit for Industrial Dynamics (DRUID). Already on the first pages I found a family of economic terms that were quite new for an economist with a strong neo-classical background like me: complex dynamics, behavioural patterns, invention, innovation, selection mechanisms, simulation model etc. Both, my curiosity to find out more about these terms and my interest for the economics of technological change motivated the learning process I have been involved in the last 4 years. This document is the result of this intellectual adventure. There are a number of people that have been important and I would like to thank here. First, I would like to express my special thanks to Hariolf Grupp for providing me with enough intellectual freedom and guidance when I needed it to complete this effort. -
Angewandte Chemie, 72,357,358,359,361 Ansco, 125, 133 452 INDEX
INDEX A. Riebeck'schen Montanwerke, 371 Ach, Lorenz, 62, 66 Adams, Roger, 88 Adolf Baeyer Gesellschaft zur Forderung der chemischen Literatur, 32 AEG, 77, 105, 238, 370 Agfa (Aktien-Gesellschaft fur Anilin-Fabrikation), 19,25,26,36,68,69, 79,223,383, 103, 104, 109, 110, 115, 117, 120, 123-145,254,293,305 Agfa Photo GmbH, 133 Agfa Photo Oversees, 140 Agfa Products Inc, 125 Agfa-Ansco, 126, 137, 139, 140, 142, 143, 144, 308, 309, 311 Aktien-Gesellschaft fur Anilin-Fabrikation, See Agfa Akzo, 423 Albany Aniline & Chemical Works, 290 Alberts, Leonard, 165 Albright & Wilson, 419 Alien Property Custodian, 286,295,299,300, 304, 311, 320, 327, 328, 330, 332,334,335,337,338,339,341,342,344 alizarin, 418 Allied bombing, 169,207,374,376 Allied Chemical and Dye Corporation, 303,314 Allied Chemicals, 420 Allied Control Council, 379,386 Althoff, Friedrich, 63 Aluminum Company of America, 311 American Chemical Society, 330 American Glanzstoff, 312 American LG., 309,311,312,314,317 American LG. Chemical Company, 126, 308 American Magnesium Company, 311 ammonia, 22,24, 25, 32, 76, 79, 93, 99, 102, 105-110, 114-120, 172, 173, 175, 179, 182, 184, 230; 237, 239, 250, 303, 370, 374, 382, 392, 416, 420 Angewandte Chemie, 72,357,358,359,361 Ansco, 125, 133 452 INDEX Ansco Photo Products Inc., 125 Antipyrine, 297 anti-Semitism, 123-145, 347-366 ArbeitsausschuB, 255 Arbeitsgemeinschaft Chemische Industrie, 349 armistice, 235, 302, 328, 330 Arnold, Thurman, 318 Arora, Ashish, 447 artificial fibers, 38 Aryanization, 10,123-145,348 Asahi Bemberg, 13, 252 Asahi Chemical, -
(12) Patent Application Publication (10) Pub. No.: US 2003/0220312 A1 Schuh (43) Pub
US 2003O220312A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2003/0220312 A1 Schuh (43) Pub. Date: Nov. 27, 2003 (54) EPOXY-STEROIDAL ALDOSTERONE tinuation-in-part of application No. 09/854.264, filed ANTAGONST AND CALCIUM CHANNEL on May 11, 2001. BLOCKER COMBINATION THERAPY FOR TREATMENT OF CARDIOWASCULAR (60) Provisional application No. 60/221,359, filed on Jul. DSORDERS 27, 2000. Provisional application No. 60/203,637, filed on May 11, 2000. (75) Inventor: Joseph R. Schuh, St. Louis, MO (US) Publication Classification Correspondence Address: Pharmacia Corporation (51) Int. Cl." ........................ A61K 31/58; A61K 31/585 Corporate Patent Department (52) U.S. Cl. ............................................ 514/173; 514/175 Mail Zone O4E 800 N. Lindbergh Blvd. (57) ABSTRACT St. Louis, MO 63167 (US) A combination therapy comprising a therapeutically-effec tive amount of an epoxy-Steroidal aldosterone receptor (73) Assignee: G.D. Searle & Co., Chicago, IL antagonist and a therapeutically-effective amount of a cal Appl. No.: 10/324,330 cium channel blocker is described for treatment of circula (21) tory disorders, including cardiovascular disorderS Such as (22) Filed: Dec. 19, 2002 hypertension, angina and congestive heart failure. Preferred calcium channel blockers are those compounds having high Related U.S. Application Data potency and bioavailability. Preferred epoxy-steroidal aldos terone receptor antagonists are 20-Spiroxane Steroidal com (63) Continuation-in-part of application No. 10/126,134, pounds characterized by the presence of a 9C,11C.-Substi filed on Apr. 19, 2002, now abandoned, which is a tuted epoxy moiety. A preferred combination therapy continuation of application No.