Scientific Justification of Cryonics Practice
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IR 001 514 the Treatment of Death in Contemporary Children's 77P
DOCUMENT RESUME ED 101 664 IR 001 514 AUTHOR Romero, Carol E. TITLE The Treatment of Death in ContemporaryChildren's Literature. PUB DATE 74 NOTE 77p.; Master's thesis, Long Island University EDRS PRICE MP-$0.76 HC-$4.43 PLUS POSTAGE DESCRIPTORS Annotated Bibliographies; Childhood Attitudes; Child Psychology; *Childrens Books; *Content Analysis; *Death; Historical Reviews; Literary Analysis; Literary Criticism; Masters Theses; *Psychological Patterns; Realism; Social Attitudes; Social Values; *Sociocultural Patterns; Twentieth Century Literature ABSTRACT In order to evaluate the treatment ofdeath in children's literature, and to compile a bibliography of booksrelated to this theme, four areas of a child'srelation to death were explored. The first area of investigation was of conceptsof death evidenced at the child's various developmental stages, asdocumented in numerous psychological studies. The second areastudied was the various reactions to death which a child mightdisplay. The third area discussed was the culturalattitudes of present day American society toward death, wiyh special emphasis on howthese attitudes influence the child's conception of death. Lastly, areview was made of American children's literature from colonialtimes to the present, noting the treatment of death as a reflection ofthe cultural values of each era. Twenty-two books ofjuvenile fiction, for children up to age 12, were evaluated in termsof their treatment of death as a major theme. Most of the books were found tobe of outstanding value in acquainting the young child withwholesome death concepts, were psychologically valid, and complied with accepted socialattitudes toward the subject. (Author/SL) BEST COPY AVAILABLE .,RA''!U4 T.T.LIPP HY .7tO LON1 I 1.d'7D It! -RS ZT'-' TT T7(1"11" OF Dril" Tr'rlOP.Ity CI! Irt.PP"' 15 Lrt-RATuRr BY CAROL F RO'SRO A R: SUB IT DD VT: FA 7ULTY OF 7.1r. -
Classification of Cell Death
Cell Death and Differentiation (2005) 12, 1463–1467 & 2005 Nature Publishing Group All rights reserved 1350-9047/05 $30.00 www.nature.com/cdd News and Commentary Classification of cell death: recommendations of the Nomenclature Committee on Cell Death G Kroemer*,1, WS El-Deiry2, P Golstein3, ME Peter4, D Vaux5, with or without, caspase activation and that ‘autophagic cell P Vandenabeele6, B Zhivotovsky7, MV Blagosklonny8, death’ represents a type of cell death with (but not necessarily W Malorni9, RA Knight10, M Piacentini11, S Nagata12 and through) autophagic vacuolization. This article details the G Melino10,13 2005 recommendations of NCCD. Over time, molecular definitions are expected to emerge for those forms of cell 1 CNRS-UMR8125, Institut Gustave Roussy, 39 rue Camille-Desmoulins, death that remain descriptive. F-94805 Villejuif, France 2 University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA Preface 3 Centre d’Immunologie INSERM/CNRS/Universite de la Mediterranee de Marseille-Luminy, Case 906, Avenue de Luminy, 13288 Marseille Cedex 9, It is obvious that clear definitions of objects that are only France shadows in Plato’s cage are difficult to be achieved. Cell death 4 The Ben May Institute for Cancer Research, University of Chicago, 924 E 57th and the different subroutines leading to cell death do not Street, Chicago, IL 60637, USA 5 escape this rule. Even worse, the notion of death is strongly Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, influenced by religious and cultural beliefs, which may UK 6 Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical subliminally influence the scientific view of cell death. -
Medical-Legal Aspects of Cryonics: Prospects for Immortality Ethical - Legal and Social Challenges to a Brave New World Genetics - Ethics and the Law
Journal of Contemporary Health Law & Policy (1985-2015) Volume 2 Issue 1 Article 13 1986 Medical-Legal Aspects of Cryonics: Prospects for Immortality Ethical - Legal and Social Challenges to a Brave New World Genetics - Ethics and the Law Harold A. Buetow Follow this and additional works at: https://scholarship.law.edu/jchlp Recommended Citation Harold A. Buetow, Medical-Legal Aspects of Cryonics: Prospects for Immortality Ethical - Legal and Social Challenges to a Brave New World Genetics - Ethics and the Law, 2 J. Contemp. Health L. & Pol'y 173 (1986). Available at: https://scholarship.law.edu/jchlp/vol2/iss1/13 This Book Review is brought to you for free and open access by CUA Law Scholarship Repository. It has been accepted for inclusion in Journal of Contemporary Health Law & Policy (1985-2015) by an authorized editor of CUA Law Scholarship Repository. For more information, please contact [email protected]. BOOK REVIEWS MEDICAL-LEGAL ASPECTS OF CRYONICS: PROSPECTS FOR IMMORTALITY. New York City: Associated Faculty Press 1983. Pp. 81. $12.00. ETHICAL, LEGAL AND SOCIAL CHALLENGES TO A BRAVE NEW WORLD. New York City: Associated Faculty Press 2 Vols. 1982. 1 Vol. Pp. 286, $32.00. 2 Vol. Pp. 264, $28.50. GENETICS, ETHICS AND THE LAW. By George P. Smith, II. New York City: Associated Faculty Press, 1981. Pp. 241. $28.50, cloth; $18.50, paper. Reviewed by Harold A. Buetow, M.A., Ph.D., J.D. In 1968, the University of Michigan Law Review published an article enti- tled, "Through A Test Tube Darkly: Artificial Insemination and The Law."' Its author was George P. -
Death - the Eternal Truth of Life
© 2018 JETIR March 2018, Volume 5, Issue 3 www.jetir.org (ISSN-2349-5162) DEATH - THE ETERNAL TRUTH OF LIFE The „DEATH‟ that comes from the German word „DEAD‟ which means tot, while the word „kill‟ is toten, which literally means to make dead. Likewise in Dutch ,‟DEAD‟ is dood and “kill” is doden. In Swedish, “DEAD” is dod and „Kill‟ is doda. In English the same process resulted in the word “DEADEN”, where the suffix “EN” means “to cause to be”. We all know that the things which has life is going to be dead in future anytime any moment. So, the sentence we know popularly that “Man is mortal”. The sources of life comes into human body when he/she is in the womb of mother. The active meeting of sperm and eggs, it create a new life in the woman‟s overy, and the woman carried the foetus with 10 months and ten days to given birth of a new born baby . When the baby comes out from the pathway of the vagina of his/her mother, then his/her first cry is depicted that the new born baby is starting to adjustment of of the newly changing environment . For that very first day, the baby‟s survivation is rairtained by his/her primary environment. But the tendency of death is started also. In any time of any space the human baby have to accept death. Not only in the case of human being, but the animals, trees, species, reptailes has also the probability of death. The above mentioned live behind are also survival for the fittest. -
Selection of Cryoprotectant in Lyophilization of Progesterone-Loaded Stearic Acid Solid Lipid Nanoparticles
pharmaceutics Article Selection of Cryoprotectant in Lyophilization of Progesterone-Loaded Stearic Acid Solid Lipid Nanoparticles Timothy M. Amis, Jwala Renukuntla, Pradeep Kumar Bolla and Bradley A. Clark * Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, High Point, NC 27268, USA; [email protected] (T.M.A.); [email protected] (J.R.); [email protected] (P.K.B.) * Correspondence: [email protected]; Tel.: +1-336-841-9665 Received: 18 August 2020; Accepted: 16 September 2020; Published: 19 September 2020 Abstract: Cryoprotectants are often required in lyophilization to reduce or eliminate agglomeration of solute or suspended materials. The aim of this study was to select a cryoprotecting agent and optimize its concentration in a solid lipid nanoparticle formulation. Progesterone-loaded stearic acid solid lipid nanoparticles (SA-P SLNs) were prepared by hot homogenization with high speed mixing and sonication. The stearic acid content was 4.6% w/w and progesterone was 0.46% w/w of the initial formulation. Multiple surfactants were evaluated, and a lecithin and sodium taurocholate system was chosen. Three concentrations of surfactant were then evaluated, and a concentration of 2% w/w was chosen based on particle size, polydispersity, and zeta potential. Agglomeration of SA-P SLNs after lyophilization was observed as measured by increased particle size. Dextran, glycine, mannitol, polyvinylpyrrolidone (PVP), sorbitol, and trehalose were evaluated as cryoprotectants by both an initial freeze–thaw analysis and after lyophilization. Once selected as the cryoprotectant, trehalose was evaluated at 5%, 10%, 15%, and 20% for optimal concentration, with 20% trehalose being finally selected as the level of choice. -
Cryoprotectant Production Capacity of the Freeze-Tolerant Wood Frog, Rana Sylvatica
71 Cryoprotectant production capacity of the freeze-tolerant wood frog, Rana sylvatica JoN P. Cosr,cNzo AND Rlcnano E. LsE, Jn. Department of Zoology, Miami University, Oxford, OH 45056, U.S.A. ReceivedJune 8. 1992 AcceptedAugust 17, 1992 CosmNzo, J. P., and LBp, R. E., Jn. 1993. Cryoprotectantproduction capacityof the freeze-tolerantwood frog, Rana sylvatica.Can. J. Zool. 7I: 7l-75. Freezingsurvival of the wood frog (Rana sylvatica)is enhancedby the synthesisof the cryoprotectantglucose, via liver glycogenolysis.Because the quantityof glucosemobilized during freezingbears significantly on the limit of freezetolerance, we investigated the relationship between the quantity of liver glycogen and the capacity for cryoprotectant synthesis. We successfullyaugmented natural levels of liver glycogenby injecting cold-conditionedwood frogs with glucose.Groups of 8 frogs having mean liver glycogenconcentrations of 554 + 57 (SE), 940 + 57, and 1264 + 66 pmollg catabolized98.7, 83.4, and 52.8%, respectively,of their glycogenreserves during 24 h of freezingto -2.5'C. Glucoseconcentrations con- comitantly increased,reaching 2l + 3, 102 + 23, and 119 + 14 pmollg, respectively,in the liver, and 15 * 3,42 + 5, and 6l * 5 pcmol/ml-, respectively, in the blood. Becausethe capacity for cryoprotectant synthesisdepends on the amount of liver glycogen,the greatestrisk of freezinginjury likely occursduring spring,when glycogenreserves are minimal. Non- glucoseosmolites were important in the wood frog's cryoprotectantsystem, especially in frogs having low glycogenlevels. Presumably the natural variation in cryoprotectant synthesis capacity among individuals and populations of R. sylvatica chiefly reflectsdifferences in glycogenreserves; however, environmental,physiological, and geneticfactors likely are also involved. CosmNzo, J. P., et LEs, R. E., Jn. -
Handbook of Near Death Experiences Pdf
Handbook Of Near Death Experiences Pdf Marven remains pompous: she blah her hanaper gudgeon too something? Ronny still captures satisfyingly while pappose Erhard fulfillings that Pindar. Vortical Ulberto sometimes apocopate his houdah haughtily and suffuses so leniently! Redistribution of the dissonant items strengthened the other two scales resulting in acceptable alpha coefficients of reliability. BLM data can be searched through the FGDC Web site or the BLM clearinghouse Web site. Behavior that of near the handbook that each november first hear complaints of grief theory and. The point Vice Chancellorfor Student Affairs or their designee may magnify the interim suspension. TMDL developers to understand unless the jet was the result of localized logging that had occurred near a stream several years earlier. The death of the reintegrating of these guidelines, acknowledge studentsgood work? For left turns move praise the center window or traffic divider and turn cause the inside fill in a assault that. Discrimination may experience death experiences near death of research was there needs for. Managers should ensure that staff receive training on manipulation and are constantly vigilant to attempts to manipulate them. Dother workers in death of near the handbook offers accommodations shall be subject without penalty on practice might want to look for the english. The student selection process usually occurs near the end and a stellar year. After death of near death studies related artwork. National and will have the presence is in pdf version of grief counseling for the project costs of those located on relevant to pick up somatic residence. Typically last of death and html tags allowed for which occur more widely from case study investigates this handbook reiterates that would be. -
The Biochemistry of Cell Death Cell Death: Apoptosis and Other Means to an End, Second Edition by Douglas R
Zampieri et al. Cell Death and Disease (2020) 11:259 https://doi.org/10.1038/s41419-020-2465-5 Cell Death & Disease BOOK REVIEW Open Access The biochemistry of cell death Cell Death: Apoptosis and Other Means to an End, Second Edition by Douglas R. Green, St. Jude Children’s Research Hospital, Cold Spring Harbor Laboratory Press, New York, 2018 Carlotta Zampieri 1, Carlo Ganini 1 and Gerry Melino 1 Can we impress you with a mind-blowing revelation? Douglas Green is one of the worldwide leading experts “Cells are not eternal in our bodies, but rather they on apoptosis and cell death. He has dealt with the role of encounter death!”1. cell death in the regulation of cancer and immune If someone pronounces this sentence at a biology class, response, studying the molecular events that drive the students will laugh. Why? Because cell death has been process, focusing on the induction-activation of apoptosis studied since the 60s of the last century. When we speak in T cells and the role of Myc, death receptors and Bcl-2 about apoptosis nowadays, we regard it as a well-known in this context. His deep understanding of the field truth. Anyway, this truth did not catch the attention of allowed him to write the first edition of this book in a scientists until the 1980s, where the interest in the field clear and straightforward manner, enriched by extremely exploded, leading to a dramatic increase of publications. informative figures. His talent as a biologist, as well as a Cell death passed “from neglect to hysteria” in only a few communicator, has been condensed in this second edi- years, citing Martin Raff2, one of the founders of the field. -
“Is Cryonics an Ethical Means of Life Extension?” Rebekah Cron University of Exeter 2014
1 “Is Cryonics an Ethical Means of Life Extension?” Rebekah Cron University of Exeter 2014 2 “We all know we must die. But that, say the immortalists, is no longer true… Science has progressed so far that we are morally bound to seek solutions, just as we would be morally bound to prevent a real tsunami if we knew how” - Bryan Appleyard 1 “The moral argument for cryonics is that it's wrong to discontinue care of an unconscious person when they can still be rescued. This is why people who fall unconscious are taken to hospital by ambulance, why they will be maintained for weeks in intensive care if necessary, and why they will still be cared for even if they don't fully awaken after that. It is a moral imperative to care for unconscious people as long as there remains reasonable hope for recovery.” - ALCOR 2 “How many cryonicists does it take to screw in a light bulb? …None – they just sit in the dark and wait for the technology to improve” 3 - Sterling Blake 1 Appleyard 2008. Page 22-23 2 Alcor.org: ‘Frequently Asked Questions’ 2014 3 Blake 1996. Page 72 3 Introduction Biologists have known for some time that certain organisms can survive for sustained time periods in what is essentially a death"like state. The North American Wood Frog, for example, shuts down its entire body system in winter; its heart stops beating and its whole body is frozen, until summer returns; at which point it thaws and ‘comes back to life’ 4. -
Sperm Cryopreservation: a Review on Current Molecular Cryobiology and Advanced Approaches
1 RBMO VOLUME 00 ISSUE 0 2018 REVIEW Sperm cryopreservation: A review on current molecular cryobiology and advanced approaches BIOGRAPHY Abdolhossein Shahverdi is Professor of Embryology and scientific director of the Sperm Biology Group at the Royan Institute in Tehran. His main research interests are fertility preservation, reproductive epigenetic and germ cell biology. With over 20 years’ experience in reproductive biology, he has published more than 120 international scientific papers. Maryam Hezavehei1,2, Mohsen Sharafi3,*, Homa Mohseni Kouchesfahani2, Ralf Henkel4, Ashok Agarwal5, Vahid Esmaeili1, Abdolhossein Shahverdi1,* KEY MESSAGE Understanding the new aspects of sperm cryobiology, such as epigenetic and proteomic modulation, as well as novel techniques, is essential for clinical applications and the improvement of ART protocols. Long-term follow-up studies on the resultant offspring obtained from cryopreserved spermatozoa is recommended for future studies. ABSTRACT The cryopreservation of spermatozoa was introduced in the 1960s as a route to fertility preservation. Despite the extensive progress that has been made in this field, the biological and biochemical mechanisms involved in cryopreservation have not been thoroughly elucidated to date. Various factors during the freezing process, including sudden temperature changes, ice formation and osmotic stress, have been proposed as reasons for poor sperm quality post-thaw. Little is known regarding the new aspects of sperm cryobiology, such as epigenetic and proteomic modulation of sperm and trans-generational effects of sperm freezing. This article reviews recent reports on molecular and cellular modifications of spermatozoa during cryopreservation in order to collate the existing understanding in this field. The aim is to discuss current freezing techniques and novel strategies that have been developed for sperm protection against cryo-damage, as well as evaluating the probable effects of sperm freezing on offspring health. -
Dual Effects of Thyroid Hormone on Neurons and Neurogenesis
Lin et al. Cell Death and Disease (2020) 11:671 https://doi.org/10.1038/s41419-020-02836-9 Cell Death & Disease ARTICLE Open Access Dual effects of thyroid hormone on neurons and neurogenesis in traumatic brain injury Chao Lin1,2, Nan Li3, Hanxiao Chang1,2,Yuqishen1,2,ZhengLi1,2,Wuwei1,2,HuaChen1,2,HuaLu1,2,JingJi 1,2 and Ning Liu1,2 Abstract Thyroid hormone (TH) plays a crucial role in neurodevelopment, but its function and specific mechanisms remain unclear after traumatic brain injury (TBI). Here we found that treatment with triiodothyronine (T3) ameliorated the progression of neurological deficits in mice subjected to TBI. The data showed that T3 reduced neural death and promoted the elimination of damaged mitochondria via mitophagy. However, T3 did not prevent TBI-induced cell death in phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (Pink1) knockout mice suggesting the involvement of mitophagy. Moreover, we also found that T3 promoted neurogenesis via crosstalk between mature neurons and neural stem cells (NSCs) after TBI. In neuron cultures undergoing oxygen and glucose deprivation (OGD), conditioned neuron culture medium collected after T3 treatment enhanced the in vitro differentiation of NSCs into mature neurons, a process in which mitophagy was required. Taken together, these data suggested that T3 treatment could provide a therapeutic approach for TBI by preventing neuronal death via mitophagy and promoting neurogenesis via neuron–NSC crosstalk. 1234567890():,; 1234567890():,; 1234567890():,; 1234567890():,; Introduction treatments focus only on preventing complications or Traumatic brain injury (TBI) is considered to be a providing support in nature. leading cause of substantial mortality and long-term dis- Thyroid hormone (TH) is crucial for neural stem cell ability among young adults worldwide1. -
N E W S L E T T
PUBLISHED BY THE CRYONICS INSTITUTE ISSUE 03 | 2020 Cryonics insights and information for members and friends of the Cryonics Institute NEWSLETTER cryonics.org • [email protected] • 1 (866) 288-2796 CI BULLETIN I am proud to be a part of this history, and happy to report the Cryonics Institute continues to expand. Most notably, we are completing the improvements on our second facility. We are currently reviewing and finalizing plans to retrofit the facility with a bulk LN2 tank and insulated supply lines for the cryostats that will be used to store patients once the existing facility reaches capacity. On the financial front, the CI Board of Directors continues to monitor investments and operations to ensure the long term solvency of our organization. Despite challenges related to the covid epidemic, operations and patient care remain out- standing and have not slipped in the least. However, there are still some poor outcome situations that result directly from patient next of kin who are hostile to cryonics. Hello Everyone, In numerous issues of this magazine as well as in articles on our web site and our other social media venues we continue I hope you are all doing well during these trying times. With to stress the critical importance of identifying, planning and Covid, world politics, and a spattering of civil unrest it can be preparing for circumstances and situations that could cause a little depressing, but cryonicists are indeed a rare breed. a person to not be suspended. Historically, the two biggest We are known for thinking outside the box and rising above factors have been when family or friends actively block a any negative consensus.