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Randal Koene Page 3
CRYONICS 4th Quarter 2019 | Vol 40, Issue 4 www.alcor.org Scholar Profile: Randal Koene page 3 Cryonics in China and Australia Cryonics and Public Skepticism: page 19 Meeting The Challenges to Our Credibility page 24 CRYONICS Editorial Board Contents Saul Kent Ralph C. Merkle, Ph.D. R. Michael Perry, Ph.D. 3 Scholar Profile: Randal Koene Accomplished neuroscientist and founder of the only dedicated Editor whole brain emulation nonprofit in existence, Dr. Randal Koene Aschwin de Wolf is no stranger to standing out. Responsible for coining the term Contributing Writers that put this niche but growing field on the map, Koene is working Ben Best hard to make humans more adaptable than ever before. In his Randal Koene R. Michael Perry, Ph.D. vision of the future, minds will be substrate-independent, with Nicole Weinstock full or even enhanced functioning on a limitless and changing Aschwin de Wolf menu of platforms. Copyright 2019 by Alcor Life Extension Foundation 19 Cryonics in China and Australia All rights reserved. Ben Reports on the emerging cryonics industry in China and the plans to create a Reproduction, in whole or part, new cryonics organization in Australia. without permission is prohibited. 24 FOR THE RECORD Cryonics magazine is published Cryonics and Public Skepticism: Meeting the Challenges to Our quarterly. Credibility Cryonics has been viewed with skepticism or hostility by some, including some Please note: If you change your scientists, ever since it started in the 1960s, even though (we like to remind the address less than a month before the naysayers) its intended basis is strictly scientific. -
Antinatalism and Moral Particularism Gerald K
Essays in Philosophy Volume 20 Article 5 Issue 1 Is Procreation Immoral? 1-22-2019 Antinatalism and Moral Particularism Gerald K. Harrison Massey University, [email protected] Follow this and additional works at: https://commons.pacificu.edu/eip Recommended Citation Harrison, Gerald K. () "Antinatalism and Moral Particularism," Essays in Philosophy: Vol. 20: Iss. 1, Article 5. https://doi.org/10.7710/ 1526-0569.1629 Essays in Philosophy is a biannual journal published by Pacific nivU ersity Library | ISSN 1526-0569 | http://commons.pacificu.edu/eip/ Essays in Philosophy ISSN 1526-0569 | Essays in Philosophy is published by the Pacific University Libraries Volume 20, Issue 1 (2019) Antinatalism and Moral Particularism Gerald K. Harrison Massey University Abstract I believe most acts of human procreation are immoral, and I believe this despite also believing in the truth of moral particularism. In this paper I explain why. I argue that procreative acts possess numerous features that, in other contexts, seem typically to operate with negative moral valences. Other things being equal this gives us reason to believe they will operate negatively in the context of procreative acts as well. However, most people’s intuitions represent procreative acts to be morally permissible in most circumstances. Given moral particularism, this would normally be good evidence that procreative acts are indeed morally permissible and that the features that operate negatively elsewhere, simply do not do so in the context of procreative acts in particular. But I argue that we have no good reason to think our intuitions about the ethics of human procreation are accurate. -
Documenting Apollo on The
NASA HISTORY DIVISION Office of External Relations volume 27, number 1 Fourth Quarter 2009/First Quarter 2010 FROM HOMESPUN HISTORY: THE CHIEF DOCUMENTING APOLLO HISTORIAN ON THE WEB By David Woods, editor, The Apollo Flight Journal Bearsden, Scotland In 1994 I got access to the Internet via a 0.014 Mbps modem through my One aspect of my job that continues to amaze phone line. As happens with all who access the Web, I immediately gravi- and engage me is the sheer variety of the work tated towards the sites that interested me, and in my case, it was astronomy we do at NASA and in the NASA History and spaceflight. As soon as I stumbled upon Eric Jones’s burgeoning Division. As a former colleague used to say, Apollo Lunar Surface Journal (ALSJ), then hosted by the Los Alamos NASA is engaged not just in human space- National Laboratory, I almost shook with excitement. flight and aeronautics; its employees engage in virtually every engineering and natural Eric was trying to understand what had been learned about working on science discipline in some way and often at the Moon by closely studying the time that 12 Apollo astronauts had spent the cutting edge. This breadth of activities is, there. To achieve this, he took dusty, old transcripts of the air-to-ground of course, reflected in the history we record communication, corrected them, added commentary and, best of all, man- and preserve. Thus it shouldn’t be surprising aged to get most of the men who had explored the surface to sit with him that our books and monographs cover such a and add their recollections. -
ARCHITECTS of INTELLIGENCE for Xiaoxiao, Elaine, Colin, and Tristan ARCHITECTS of INTELLIGENCE
MARTIN FORD ARCHITECTS OF INTELLIGENCE For Xiaoxiao, Elaine, Colin, and Tristan ARCHITECTS OF INTELLIGENCE THE TRUTH ABOUT AI FROM THE PEOPLE BUILDING IT MARTIN FORD ARCHITECTS OF INTELLIGENCE Copyright © 2018 Packt Publishing All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without the prior written permission of the publisher, except in the case of brief quotations embedded in critical articles or reviews. Every effort has been made in the preparation of this book to ensure the accuracy of the information presented. However, the information contained in this book is sold without warranty, either express or implied. Neither the author, nor Packt Publishing or its dealers and distributors, will be held liable for any damages caused or alleged to have been caused directly or indirectly by this book. Packt Publishing has endeavored to provide trademark information about all of the companies and products mentioned in this book by the appropriate use of capitals. However, Packt Publishing cannot guarantee the accuracy of this information. Acquisition Editors: Ben Renow-Clarke Project Editor: Radhika Atitkar Content Development Editor: Alex Sorrentino Proofreader: Safis Editing Presentation Designer: Sandip Tadge Cover Designer: Clare Bowyer Production Editor: Amit Ramadas Marketing Manager: Rajveer Samra Editorial Director: Dominic Shakeshaft First published: November 2018 Production reference: 2201118 Published by Packt Publishing Ltd. Livery Place 35 Livery Street Birmingham B3 2PB, UK ISBN 978-1-78913-151-2 www.packt.com Contents Introduction ........................................................................ 1 A Brief Introduction to the Vocabulary of Artificial Intelligence .......10 How AI Systems Learn ........................................................11 Yoshua Bengio .....................................................................17 Stuart J. -
Hell on Earth
Welcome to Hell on Earth Artificial Intelligence, Babies, Bitcoin, Cartels, China, Democracy, Diversity, Dysgenics, Equality, Hackers, Human Rights, Islam, Liberalism, Prosperity, The Web Michael Starks The saddest day in US history. President Johnson, with two Kennedy’s and ex-President Hoover, gives America to Mexico - Oct 3rd 1965 Reality Press Las Vegas Copyright © 2020 by Michael Starks All rights reserved. No part of this publication may be reproduced, distributed, or transmitted without the express consent of the author. Printed and bound in the United States of America. ISBN 978-1-951440-81-7 “At what point is the approach of danger to be expected? I answer, if it ever reach us it must spring up amongst us; it cannot come from abroad. If destruction be our lot, we must ourselves be its author and finisher. As a nation of freemen we must live through all time or die by suicide.” Abraham Lincoln Heaven and Earth are inhumane--they view the myriad creatures as straw dogs TaoTe Ching This very body the Buddha, this very earth the lotus paradise Osho I can well imagine a religion in which there are no doctrines, so that nothing is spoken. Clearly, then, the essence of religion can have nothing to do with what is sayable. Wittgenstein What we are supplying are really remarks on the natural history of man, not curiosities; however, but rather observations on facts which no one has doubted and which have only gone unremarked because they are always before our eyes. Wittgenstein RFM I p142 Philosophers constantly see the method of science before their eyes and are irresistibly tempted to ask and answer questions in the way science does. -
Great Mambo Chicken and the Transhuman Condition
Tf Freewheel simply a tour « // o é Z oon" ‘ , c AUS Figas - 3 8 tion = ~ Conds : 8O man | S. | —§R Transhu : QO the Great Mambo Chicken and the Transhuman Condition Science Slightly Over the Edge ED REGIS A VV Addison-Wesley Publishing Company, Inc. - Reading, Massachusetts Menlo Park, California New York Don Mills, Ontario Wokingham, England Amsterdam Bonn Sydney Singapore Tokyo Madrid San Juan Paris Seoul Milan Mexico City Taipei Acknowledgmentof permissions granted to reprint previously published material appears on page 301. Manyofthe designations used by manufacturers andsellers to distinguish their products are claimed as trademarks. Where those designations appear in this book and Addison-Wesley was aware of a trademark claim, the designations have been printed in initial capital letters (e.g., Silly Putty). .Library of Congress Cataloging-in-Publication Data Regis, Edward, 1944— Great mambo chicken and the transhuman condition : science slightly over the edge / Ed Regis. p- cm. Includes bibliographical references. ISBN 0-201-09258-1 ISBN 0-201-56751-2 (pbk.) 1. Science—Miscellanea. 2. Engineering—Miscellanea. 3. Forecasting—Miscellanea. I. Title. Q173.R44 1990 500—dc20 90-382 CIP Copyright © 1990 by Ed Regis All rights reserved. No part ofthis publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher. Printed in the United States of America. Text design by Joyce C. Weston Set in 11-point Galliard by DEKR Corporation, Woburn, MA - 12345678 9-MW-9594939291 Second printing, October 1990 First paperback printing, August 1991 For William Patrick Contents The Mania.. -
Selection of Cryoprotectant in Lyophilization of Progesterone-Loaded Stearic Acid Solid Lipid Nanoparticles
pharmaceutics Article Selection of Cryoprotectant in Lyophilization of Progesterone-Loaded Stearic Acid Solid Lipid Nanoparticles Timothy M. Amis, Jwala Renukuntla, Pradeep Kumar Bolla and Bradley A. Clark * Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, High Point, NC 27268, USA; [email protected] (T.M.A.); [email protected] (J.R.); [email protected] (P.K.B.) * Correspondence: [email protected]; Tel.: +1-336-841-9665 Received: 18 August 2020; Accepted: 16 September 2020; Published: 19 September 2020 Abstract: Cryoprotectants are often required in lyophilization to reduce or eliminate agglomeration of solute or suspended materials. The aim of this study was to select a cryoprotecting agent and optimize its concentration in a solid lipid nanoparticle formulation. Progesterone-loaded stearic acid solid lipid nanoparticles (SA-P SLNs) were prepared by hot homogenization with high speed mixing and sonication. The stearic acid content was 4.6% w/w and progesterone was 0.46% w/w of the initial formulation. Multiple surfactants were evaluated, and a lecithin and sodium taurocholate system was chosen. Three concentrations of surfactant were then evaluated, and a concentration of 2% w/w was chosen based on particle size, polydispersity, and zeta potential. Agglomeration of SA-P SLNs after lyophilization was observed as measured by increased particle size. Dextran, glycine, mannitol, polyvinylpyrrolidone (PVP), sorbitol, and trehalose were evaluated as cryoprotectants by both an initial freeze–thaw analysis and after lyophilization. Once selected as the cryoprotectant, trehalose was evaluated at 5%, 10%, 15%, and 20% for optimal concentration, with 20% trehalose being finally selected as the level of choice. -
Cryoprotectant Production Capacity of the Freeze-Tolerant Wood Frog, Rana Sylvatica
71 Cryoprotectant production capacity of the freeze-tolerant wood frog, Rana sylvatica JoN P. Cosr,cNzo AND Rlcnano E. LsE, Jn. Department of Zoology, Miami University, Oxford, OH 45056, U.S.A. ReceivedJune 8. 1992 AcceptedAugust 17, 1992 CosmNzo, J. P., and LBp, R. E., Jn. 1993. Cryoprotectantproduction capacityof the freeze-tolerantwood frog, Rana sylvatica.Can. J. Zool. 7I: 7l-75. Freezingsurvival of the wood frog (Rana sylvatica)is enhancedby the synthesisof the cryoprotectantglucose, via liver glycogenolysis.Because the quantityof glucosemobilized during freezingbears significantly on the limit of freezetolerance, we investigated the relationship between the quantity of liver glycogen and the capacity for cryoprotectant synthesis. We successfullyaugmented natural levels of liver glycogenby injecting cold-conditionedwood frogs with glucose.Groups of 8 frogs having mean liver glycogenconcentrations of 554 + 57 (SE), 940 + 57, and 1264 + 66 pmollg catabolized98.7, 83.4, and 52.8%, respectively,of their glycogenreserves during 24 h of freezingto -2.5'C. Glucoseconcentrations con- comitantly increased,reaching 2l + 3, 102 + 23, and 119 + 14 pmollg, respectively,in the liver, and 15 * 3,42 + 5, and 6l * 5 pcmol/ml-, respectively, in the blood. Becausethe capacity for cryoprotectant synthesisdepends on the amount of liver glycogen,the greatestrisk of freezinginjury likely occursduring spring,when glycogenreserves are minimal. Non- glucoseosmolites were important in the wood frog's cryoprotectantsystem, especially in frogs having low glycogenlevels. Presumably the natural variation in cryoprotectant synthesis capacity among individuals and populations of R. sylvatica chiefly reflectsdifferences in glycogenreserves; however, environmental,physiological, and geneticfactors likely are also involved. CosmNzo, J. P., et LEs, R. E., Jn. -
Sperm Cryopreservation: a Review on Current Molecular Cryobiology and Advanced Approaches
1 RBMO VOLUME 00 ISSUE 0 2018 REVIEW Sperm cryopreservation: A review on current molecular cryobiology and advanced approaches BIOGRAPHY Abdolhossein Shahverdi is Professor of Embryology and scientific director of the Sperm Biology Group at the Royan Institute in Tehran. His main research interests are fertility preservation, reproductive epigenetic and germ cell biology. With over 20 years’ experience in reproductive biology, he has published more than 120 international scientific papers. Maryam Hezavehei1,2, Mohsen Sharafi3,*, Homa Mohseni Kouchesfahani2, Ralf Henkel4, Ashok Agarwal5, Vahid Esmaeili1, Abdolhossein Shahverdi1,* KEY MESSAGE Understanding the new aspects of sperm cryobiology, such as epigenetic and proteomic modulation, as well as novel techniques, is essential for clinical applications and the improvement of ART protocols. Long-term follow-up studies on the resultant offspring obtained from cryopreserved spermatozoa is recommended for future studies. ABSTRACT The cryopreservation of spermatozoa was introduced in the 1960s as a route to fertility preservation. Despite the extensive progress that has been made in this field, the biological and biochemical mechanisms involved in cryopreservation have not been thoroughly elucidated to date. Various factors during the freezing process, including sudden temperature changes, ice formation and osmotic stress, have been proposed as reasons for poor sperm quality post-thaw. Little is known regarding the new aspects of sperm cryobiology, such as epigenetic and proteomic modulation of sperm and trans-generational effects of sperm freezing. This article reviews recent reports on molecular and cellular modifications of spermatozoa during cryopreservation in order to collate the existing understanding in this field. The aim is to discuss current freezing techniques and novel strategies that have been developed for sperm protection against cryo-damage, as well as evaluating the probable effects of sperm freezing on offspring health. -
To Intercontinental to Interplanetary to Intersolar
Why Editorials? Why some, not all? In compiling the MMM Classics volumes, with precious few exceptions, editorials were not included. Why? Yes, some addressed temporary conditions, and are of no lasting interest. But indeed, many MMM editorials through the years have addressed concerns that remain pertinent today, if indeed they are not timeless. So we have taken another look and here reprint those “In Focus” editorials that, we think, speak to conditions and issues still very relevant today. These pieces represent the editor’s opinions alone, and have never been presented as the opin- ions or policies of the Lunar Reclamation Society, the National Space Society, the Artemis Society, or the Moon Society. There are none for the first year, as we didn’t start writing editorials until MMM #11. The Topics: The relation between the Moon and Mars in Manned Space Exploration Policy is clearly the num- ber one issue addressed. What we mean by “space” difers widely among “space proponents.” This is a critical issue. Space is more than the boundary layer of Earth, a place for space stations and satellites. This is a realm already part of Earth’s “econosphere” and will take care of itself. It is the endless fron- tier, beyond that needs our attention. The endless hiatus between Apollo 17 and what we all want to come next is a key topic. There is much we can do to make the next human lunar opening a stronger and more lasting one. Asteroids, promise and threat, are looked at and put in perspective with a nearer term threat: space debris, which could end up confining humans forever on our home world. -
Eric Drexler: Une Porte Ouverte Sur L'avenir (Hache)
Eric Drexler: Une porte ouverte sur l’avenir (Hache) http://editions-hache.com/essais/drexler/drexler1.html?nu=oui Une porte ouverte sur l’avenir Eric Drexler, mars 2003 (écrit en 1986) Adresse originale : http://editions-hache.com/essais/drexler/drexler1.html Éditions Hache : http://editions-hache.com/essais/ Ce texte est la traduction par Marc Macé du chapitre 9, consacré à la cryonie (appelée ici du terme plus général « biostase »), du livre Engines of Creation de K. Eric Drexler (Anchor Books, 1986) consacré aux nanotechnologies. La traduction complète de Marc Macé a depuis été publiée par Vuibert . Le texte original (en anglais) complet est disponible sur le site d’ Eric Drexler . Londres, avril 1773. A Jacques Dubourg 146 . Vos observations sur les causes de la mort et les expériences que vous proposez pour rappeler à la vie ceux qui semblent avoir été tués par la foudre démontrent à la fois votre sagacité et votre humanité. Mais la doctrine de la vie et de la mort est encore peu comprise… J’aimerais qu’il soit possible […] d’inventer une méthode pour embaumer les noyés de manière à ce qu’ils puissent être ramenés à la vie à une époque donnée, même éloignée. J’ai un très ardent désir de voir et d’observer l’état de l’Amérique dans une centaine d’années. A une mort naturelle je préférerais être immergé dans une barrique de Madère, avec quelques amis, pour être ramené à la vie cent ans plus tard par la chaleur du soleil de ma chère patrie ! Mais […] selon toute probabilité, nous vivons dans un siècle trop peu avancé et trop proche de la naissance de la science pour qu’un tel art soit porté à sa perfection de notre vivant… Veuillez… Benjamin Franklin Benjamin Franklin voulait un procédé pour stopper et faire repartir le métabolisme mais il n’y en avait alors aucun de connu. -
Effects of Sample Treatments on Genome Recovery Via Single-Cell Genomics
The ISME Journal (2014) 8, 2546–2549 & 2014 International Society for Microbial Ecology All rights reserved 1751-7362/14 www.nature.com/ismej SHORT COMMUNICATION Effects of sample treatments on genome recovery via single-cell genomics Scott Clingenpeel1, Patrick Schwientek1, Philip Hugenholtz2 and Tanja Woyke1 1DOE Joint Genome Institute, Walnut Creek, CA, USA and 2Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia Single-cell genomics is a powerful tool for accessing genetic information from uncultivated microorganisms. Methods of handling samples before single-cell genomic amplification may affect the quality of the genomes obtained. Using three bacterial strains we show that, compared to cryopreservation, lower-quality single-cell genomes are recovered when the sample is preserved in ethanol or if the sample undergoes fluorescence in situ hybridization, while sample preservation in paraformaldehyde renders it completely unsuitable for sequencing. The ISME Journal (2014) 8, 2546–2549; doi:10.1038/ismej.2014.92; published online 13 June 2014 Relatively little is known about the functioning of genomes from single cells. Three methods of sample complex microbial communities, largely due to the preservation were tested: cryopreservation with difficulty in culturing most microbes (Rappe and 20% glycerol as a cryoprotectant, preservation in Giovannoni, 2003). Although metagenomics can 70% ethanol, and preservation in 4% paraformalde- provide information on the genetic capabilities of hyde. Because paraformaldehyde treatment causes the entire community, it is difficult to connect crosslinks between nucleic acids and proteins, we predicted gene functions to specific organisms using tested cells exposed to 4% paraformaldehyde with metagenomics (Morales and Holben, 2011).