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(12) Patent Application Publication (10) Pub. No.: US 2006/0008537 A1 Wu Et Al

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US 20060008537A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0008537 A1 Wu et al. (43) Pub. Date: Jan. 12, 2006 (54) METHOD OF TREATING ACNE (22) Filed: Jul. 7, 2004 (76) Inventors: Jeffrey M. Wu, Warrington, PA (US); Publication Classification Jue-Chen Liu, Belle Mead, NJ (US); Jeannette Chantalat, Princeton, NJ (51) Int. Cl. (US); Ying Sun, Belle Mead, NJ (US) A61K 33/04 (2006.01) (52) U.S. Cl. .............................................................. 424/705 Correspondence Address: PHILIP S. JOHNSON JOHNSON & JOHNSON (57) ABSTRACT ONE JOHNSON & JOHNSON PLAZA NEW BRUNSWICK, NJ 08933-7003 (US) The invention features a composition including an anti-acne agent, an antimicrobial agent, and a lactate, and the use (21) Appl. No.: 10/886,314 thereof in the treatment of acne. US 2006/0008537 A1 Jan. 12, 2006 METHOD OF TREATING ACNE made on the product containing the composition or in Stores, magazines, newspaper, radio, television, internet, and the BACKGROUND OF THE INVENTION like. 0001 Acne is a skin disorder that is often accompanied 0010. The compositions of the present invention are by pimples that Sometimes cause acne Sufferers embarrass useful for treating follicular diseases, Such as acne, Sebor ment. Consumers have utilized topical anti-acne agents, rhea, follicular rash, follicular infections Such as folliculitis Such as Salicylic acid and benzoyl peroxide to treat acne for and pSudofolliculitis barbe, follicular ketarosis, keratosis many years. Topical anti-acne agents typically function by pilaris, phrynoderma, ichthyosis follicularis, alopecia, folli exfoliating skin and/or killing bacteria on the Surface of the cular dysplasia, hirsutism, and hypertrichosis. AS used skin. Although Such anti-acne agents are often effective at herein, the term “treating” or “treatment” means the treat treating acne pimples, they tend to take a long time, typically ment (e.g., alleviation or elimination of Symptoms and/or days or weeks, to abate acne symptoms. They are also often cure) and/or prevention or inhibition of the condition (e.g., ineffective at treating pre-emergent pimples. a skin condition). 0011. In one embodiment, the composition is for the SUMMARY OF THE INVENTION treatment of acne, including but not limited to the treatment or prevention of acne blemishes, acne pimples, pre-emergent 0002 The present invention features a composition pimples, blackheads, and/or whiteheads. What is meant by a including an anti-acne agent, an antimicrobial agent, and a “pre-emergent pimple' is an inflamed follicle that are not lactate. The present invention also features a method of Visually apparent on the Surface of the skin with the naked treating a follicular disease, Such as acne, by applying a eye (e.g., as a lesion). In one embodiment, the appearance of composition to an area of skin in need of Such treatment. The acne (e.g., the size and/or appearance of the acne lesion present invention also features a method of promoting a and/or blackhead) is reduced within about eight hours, Such composition by promoting the composition for the treatment as within about four hours. of a follicular disease, Such as acne. 0012. In one embodiment, the present invention relates to 0003. Other features and advantages of the present inven topical compositions including an anti-acne agent. What is tion will be apparent from the detailed description of the meant by an anti-acne agent is an compound that has been invention and from the claims. approved by the U.S. Food and Drug Administration for the topical treatment of acne. Examples of anti-acne agents DETAILED DESCRIPTION OF THE include, but are not limited to, Salicylic acid, benzoyl INVENTION peroxide, Sulphur, retinoic acid, candida bombicola?glucose/ 0004. It is believed that one skilled in the art can, based methyl rapeseedate ferment, peat water, resorcinol, Silt, peat, upon the description herein, utilize the present invention to permethin, azaleic acid, clindamycin, adapalene, erythromy its fullest extent. The following specific embodiments are to cin, Sodium Sulfacetamide, and combinations thereof. In one be construed as merely illustrative, and not limitative of the embodiment, the amount of anti-acne agent in the compo remainder of the disclosure in any way whatsoever. sition is from about 0.01% to about 10%, for example from about 0.1% to about 5%, or from about 0.5% to about 2% by 0005. Unless defined otherwise, all technical and scien weight, based on the total weight of the composition. tific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the 0013 In one embodiment, the compositions of the invention belongs. Also, all publications, patent applica present invention include a hair growth agent. What is meant tions, patents, and other references mentioned herein are by a hair growth agent is a compound that induces hair incorporated by reference. Whenever used, any percentage growth. Examples of hair growth agents include, but are not is weight by weight (w/w) unless otherwise indicated. limited to, minoxadil, Spironolactone, cyproterone acetate, aZeleic acid, buSerelin, bicalutamide, cromakalim, 0006 AS used herein, “topically applying” means cyclosporin, aminoglutethimide, cyproterone acetate, diaz directly laying on or spreading on Outer skin, e.g., by use of oxide, phenytoin, estradiols, flutamide, prezatide copper, the hands or an applicator Such as a wipe, puff, roller, or inocoterone, leuprolide acetate, ketoconazole, pinacidil, Spray. progesterone, finasteride, retinoic acid, turosteride, Vitamins 0007 AS used herein, "cosmetically-acceptable” means and minerals Such as Vitamin E, niacin (vitamin B3), pan that the compound(s) or composition(s) which the term tothenic acid (vitamin B5), pyridoxine (vitamin B6), vitamin describes are Suitable for use in contact with tissues (e.g., the C, biotin, inositol, Zinc, copper, cysteine, methionine, coen skin) without undue toxicity, incompatibility, instability, Zyme Q10, essential fatty acids Such as flaxseed oil, prim irritation, allergic response, and the like. This term is not rose oil, and fish oil, herbal extracts Such as ginko biloba, intended to limit the compound/composition to which it and combinations thereof. describes for use Solely as a cosmetic (e.g., the ingredient/ 0014. In one embodiment, the compositions of the product may be used as a pharmaceutical). present invention include a hair retardation agent. What is meant by a hair retardation agent is a compound that reduces 0008 AS used herein, “safe and effective amount” means the appearance and/or growth of hair. Examples of hair an amount of compound(s) or composition(s) sufficient to retardation agents include, but are not limited to eflornithine treat acne, but low enough to avoid Serious Side effects. hydrochloride, Soy extracts, antiandrogenic Sterols from 0009 What is meant by “promoting” is promoting, Serenoa (Serenoa repens) and/or from Cucurbita Seeds advertising, or marketing. Examples of promoting include, (Cucurbita pepo), dipeptide N-(Carboxymethyl)phenylala but are not limited to, written, Visual, or verbal Statements nyl-B-alanine compounds, 3-deaZaneplanocin, inhibitors of US 2006/0008537 A1 Jan. 12, 2006 nitric oxide Synthetase Such as NG-methyl-L-arginine, drenolide, mometasone furoate, and methylprednisolone inhibitors of glutamine metabolism Such as 6-diazo-5-ox acetate), methotrexate, cyclosporine, calcipotriene, anthra onorleucine (I), and combinations thereof. line, Shale oil, elubiol, ketoconazole, coal tar, Salicylic acid, 0.015. In one embodiment, the compositions of the Zinc pyrithione, Selenium Sulfide, hydrocortisone, Sulfur, present invention include an antimicrobial agent. What is menthol, and pramoxine hydrochloride, and combinations meant by an antimicrobial agent is a compound that kills thereof. microorganisms or prevents or inhibits their growth or 0020. In one embodiment, the compositions of the reproduction. Examples of antimicrobial agents include, but present invention include an anti-Viral agent. Examples of are not limited to: ethanol, propanol, benzalkonium chloride, anti-viral agents include, but are not limited to, imiquimod, benzethonium chloride, methyl benzethonium chloride, podofilox, podophyllin, interferon alpha, acyclovir, famcy cetypyridiunium chloride, 2,4,4-trichloro-2-hydroxy diphe clovir, Valcyclovir, reticulos and cidofovir. nyl ether (Triclosan), parachlorometa Xylenol (PCMX), lodopropynyl butylcarbamate, diazolidinyl urea, chlorhex 0021. In one embodiment, the compositions of the idene digluconate, chlorhexidene acetate, chlorhexidene present invention include an anti-inflammatory agent. isethionate, chlorhexidene hydrochloride, heXetidine, Examples of anti-inflammatory agents, include, but are not Quaternium 15, triclocarbon, polyhexamethylene biguanide, limited to, non-Steroidal and Steroidal anti-inflammatory cetylpyridium chloride, imidazolidinyl urea, diazolidinyl agents Such as corticosteroids Such as hydrocortisone, urea, 3-iodo-2-propynyl-N-butylcarbamate, 2-methyl-4- hydroxyltriamcinolone alphamethyl dexamethasone, dex isothiazolin-3-one, dimethyl dimethyl hydantoin,(5-chloro amethasone-phosphate, beclomethasone dipropionate, clo 2-(2,4-dichlorophenoxy)phenol, monolaurin glyceryl lau betasol Valerate, desonide, desoxymethasone, desoxycorti rate, camelia Sinensis, candida bombicola?glucose/methyl costerone acetate, dexamethasone, dichlorisone, difloraSone rapeseedate ferment, hydrogen peroxide, phenol,
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  • CLINICAL REVIEW Management of Hirsutism

    CLINICAL REVIEW Management of Hirsutism

    For the full versions of these articles see bmj.com CLINICAL REVIEW Management of hirsutism Olympia Koulouri, Gerard S Conway Department of Endocrinology, Hirsutism is the presence of excess hair growth in that secrete androgens are rare and tend to cause severe University College London women, and the term usually refers to excessive hirsutism. Adrenal tumours usually co-secrete cortisol Hospitals, London NW1 2PQ growth of terminal hair in an androgen dependent dis- and the clinical picture is that of Cushing’s syndrome. Correspondence to: G S Conway [email protected] tribution. Although it is often thought to be a cosmetic At the time of the menopause, hair growth is pro- problem, unwanted hair growth adversely affects psy- moted by a fall in the production of ovarian oestradiol Cite this as: BMJ 2009;338:b847 chological wellbeing.1 It can have a similar effect on but relatively well maintained testosterone production. doi:10.1136/bmj.b847 quality of life scores to that of asthma, epilepsy, and In some instances, rising concentrations of luteinising diabetes,2 and effective treatments reverse these hormone lead to stromal hyperplasia, high testoster- adverse scores.3 one concentrations, and severe menopausal hirsutism. Several new treatments have emerged in recent years, including the wider availability of laser depilation, topi- What aspects of the history and examination are cal suppressors of hair growth (eflornithene), and a pro- important? gestogen with antiandrogenic properties (drospirenone). For research purposes, hair growth can be measured In this review, we assess the evidence base for new treat- using a scoring system established by Ferriman and ments in the context of established treatments, although Gallwey.5 In clinical practice, subjective assessment is the worldwide availability of these preparations varies usually adequate, although personal perception of greatly.