Myocardial Infarction in Irradiated Rats
Total Page：16
File Type：pdf, Size：1020Kb
Load more
Recommended publications
-
Research Publications by DISTINCTIONS Any Scientist of Pakistan in Last 10 Year and SERVICES Secretary General, the Chemical Society of Pakistan
CV and List of Publications PROF. DR. MUHAMMAD IQBAL CHOUDHARY (Hilal-e-Imtiaz, Sitara-e-Imtiaz, Tamgha-ei-Imtiaz) International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry, Dr. Panjwani Center for Molecular Medicine and Drug Research) University of Karachi, Karachi-75270 Pakistan Tel: (92-21) 34824924, 34824925 Fax: 34819018, 34819019 E-mail: [email protected] Web Page: www.iccs.edu Biodata and List of Publications Pag No. 2 MUHAMMAD IQBAL CHOUDHARY (Hilal-e-Imtiaz, Sitara-e-Imtiaz, Tamgha-e-Imtiaz) D-131, Phase II, D. O. H. S., Malir Cant., Karachi-75270, Pakistan Ph.: 92-21-4901110 MAILING INTERNATIONAL CENTER FOR CHEMICAL AND BIOLOGICAL SCIENCES ADDRESS (H. E. J. Research Institute of Chemistry Dr. Panjwani Center for Molecular Medicine and Drug Research) University of Karachi Karachi-74270, Pakistan Tel: (92-21) 34824924-5 Fax: (92-21) 34819018-9 Email: [email protected] Web: www.iccs.edu DATE OF BIRTH September 11, 1959 (Karachi, Pakistan) EDUCATION Doctor of Science (D.Sc.) (University of Karachi ) 2005 Ph.D. (Organic Chemistry) 1987 H. E. J. Research Institute of Chemistry University of Karachi, Karachi-75270, Pakistan Thesis Title: "The Isolation and Structural Studies on Some Medicinal Plants of Pakistan, Buxus papillosa, Catharanthus roseus, and Cissampelos pareira." M.Sc. (Organic Chemistry) 1983 University of Karachi, Karachi-75270, Pakistan B.Sc. (Chemistry, Biochemistry, Botany) 1980 University of Karachi, Karachi-75270, Pakistan AWARDS & Declared as the top most scientist (Number 1) among 1,650 HONORS scientists of Pakistan in all disciplines / fields of science and technology (year 2012) by the Pakistan Council for Science and Technology (Ministry of Science and Technology), Pakistan. -
Anabolic Steroids/Androgens Pa Summary
ANABOLIC STEROIDS/ANDROGENS PA SUMMARY PREFERRED Anadrol-50, Danazol, Fluoxymesterone, Methitest, Oxandrolone, Testosterone Cypionate Injection, Testosterone Enanthate Injection NON-PREFERRED Android, Testred LENGTH OF AUTHORIZATION: Varies NOTE: All preferred and non-preferred agents require prior authorization. See PA criteria labeled “Topical Testosterone” for Androderm, Androgel, Striant, and Testim. The criteria details below are for the outpatient pharmacy program. If an injectable medication is being administered in a physician’s office then the criteria information below does not apply. Instead, the physician’s office must bill this drug through the DCH physician’s injectable program and not the outpatient pharmacy program. Information regarding the physician’s injectable program can be located at www.mmis.georgia.gov. PA CRITERIA: For Anadrol-50 Approvable for the following diagnoses: anemia caused by deficient red blood cell production, acquired or congenital aplastic anemia, myelofibrosis, hypoplastic anemia due to administration of myelotoxic drugs Also approvable for HIV or AIDS wasting when significant weight loss is documented in members currently receiving nutritional support For Danazol Approvable for the following diagnoses: endometriosis, fibrocystic breast disease, hereditary angioedema For Fluoxymesterone, Methyltestosterone (Android, Methitest, Testred), Testosterone Cypionate or Enanthate Injection Approvable in male members 12 years of age or older for the following diagnoses: primary hypogonadism, secondary -
Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs That Modulate Farnesoid X Receptor
OPEN Quantitative High-Throughput Profiling of SUBJECT AREAS: Environmental Chemicals and Drugs that SCREENING SMALL MOLECULES Modulate Farnesoid X Receptor Chia-Wen Hsu1, Jinghua Zhao1, Ruili Huang1, Jui-Hua Hsieh2, Jon Hamm3, Xiaoqing Chang3, Keith Houck4 Received & Menghang Xia1 27 June 2014 Accepted 1National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, 2Division of the National 29 August 2014 Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 3Integrated Laboratory Systems, Inc., Morrisville, NC, 4U.S. Environmental Protection Agency, Research Triangle Park, NC. Published 26 September 2014 The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids, and glucose. Because endogenous chemicals bind and activate FXR, it is important to examine which xenobiotic compounds Correspondence and would disrupt normal receptor function. We used a cell-based human FXR b-lactamase (Bla) reporter gene assay to profile the Tox21 10K compound collection of environmental chemicals and drugs. requests for materials Structure-activity relationships of FXR-active compounds revealed by this screening were then compared should be addressed to against the androgen receptor, estrogen receptor a, peroxisome proliferator-activated receptors d and c, and M.X. ([email protected]. the vitamin D receptor. We identified several FXR-active structural classes including anthracyclines, gov) benzimidazoles, dihydropyridines, pyrethroids, retinoic acids, and vinca alkaloids. Microtubule inhibitors potently decreased FXR reporter gene activity. Pyrethroids specifically antagonized FXR transactivation. Anthracyclines affected reporter activity in all tested assays, suggesting non-specific activity. These results provide important information to prioritize chemicals for further investigation, and suggest possible modes of action of compounds in FXR signaling. -
USP Reference Standards Catalog
Last Updated On: January 6, 2016 USP Reference Standards Catalog Catalog # Description Current Lot Previous Lot CAS # NDC # Unit Price Special Restriction 1000408 Abacavir Sulfate R028L0 F1L487 (12/16) 188062-50-2 $222.00 (200 mg) 1000419 Abacavir Sulfate F0G248 188062-50-2 $692.00 Racemic (20 mg) (4-[2-amino-6-(cyclo propylamino)-9H-pur in-9yl]-2-cyclopenten e-1-methanol sulfate (2:1)) 1000420 Abacavir Related F1L311 F0H284 (10/13) 124752-25-6 $692.00 Compound A (20 mg) ([4-(2,6-diamino-9H- purin-9-yl)cyclopent- 2-enyl]methanol) 1000437 Abacavir Related F0M143 N/A $692.00 Compound D (20 mg) (N6-Cyclopropyl-9-{( 1R,4S)-4-[(2,5-diami no-6-chlorpyrimidin- 4-yloxy)methyl] cyclopent-2-enyl}-9H -purine-2,6-diamine) 1000441 Abacavir Related F1L318 F0H283 (10/13) N/A $692.00 Compound B (20 mg) ([4-(2,5-diamino-6-c Page 1 Last Updated On: January 6, 2016 USP Reference Standards Catalog Catalog # Description Current Lot Previous Lot CAS # NDC # Unit Price Special Restriction hloropyrimidin-4-yla mino)cyclopent-2-en yl]methanol) 1000452 Abacavir Related F1L322 F0H285 (09/13) 172015-79-1 $692.00 Compound C (20 mg) ([(1S,4R)-4-(2-amino -6-chloro-9H-purin-9 -yl)cyclopent-2-enyl] methanol hydrochloride) 1000485 Abacavir Related R039P0 F0J094 (11/16) N/A $692.00 Compounds Mixture (15 mg) 1000496 Abacavir F0J102 N/A $692.00 Stereoisomers Mixture (15 mg) 1000500 Abacavir System F0J097 N/A $692.00 Suitability Mixture (15 mg) 1000521 Acarbose (200 mg) F0M160 56180-94-0 $222.00 (COLD SHIPMENT REQUIRED) 1000532 Acarbose System F0L204 N/A $692.00 Suitability -
Small Molecules in Solution Has Rarely Been Reported, However, As a General Guide We Recommend Storage in DMSO at -20°C
(Z)-Guggulsterone Small Molecules Retinoic acid receptor (RAR) pathway inhibitor; Inhibits farnesoid X receptor (FXR) Catalog # 73702 1 mg Product Description (Z)-Guggulsterone is a plant steroid found in the resin of the guggul plant Commiphora mukul that acts as a selective antagonist of farnesoid X receptor (FXR; Cui et al.). It decreases chenodeoxycholic acid (CDCA)-induced FXR activation (IC ₅₀ = 10 µM) in the presence of 100 µM CDCA (Urizar et al.; Cui et al.). Molecular Name: (Z)-Guggulsterone Alternative Names: Not applicable CAS Number: 39025-23-5 Chemical Formula: C₂₁H₂₈O₂ Molecular Weight: 312.5 g/mol Purity: ≥ 95% Chemical Name: (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15- decahydrocyclopenta[a]phenanthrene-3,16-dione Structure: Properties Physical Appearance: A crystalline solid Storage: Product stable at -20°C as supplied. Protect product from prolonged exposure to light. For long-term storage store with a desiccant. For product expiry date, please contact [email protected]. Solubility: · DMSO ≤ 800 µM · Absolute ethanol ≤ 3.2 µM · DMF ≤ 30 mM For example, to prepare a 10 mM stock solution in DMF, resuspend 1 mg in 320 μL of DMF. Prepare stock solution fresh before use. Information regarding stability of small molecules in solution has rarely been reported, however, as a general guide we recommend storage in DMSO at -20°C. Aliquot into working volumes to avoid repeated freeze-thaw cycles. The effect of storage of stock solution on compound performance should be tested for each application. Compound has low solubility in aqueous media. -
Guggulsterones and Levels
Cholesterol, Guggulsterones and levels. Because normal levels of serum lipids, Bile Production including cholesterol, are supported by increased circulating thyroid hormones, it is believed guggul Much of the cholesterol made by your liver is uti- Guggulsterones works by stimulating the thyroid gland, in addition lized to create bile, a substance used in digestion to its effects on bile production. to emulsify fats. Because excess cholesterol and triglycerides are excreted from our bodies in the Clinically Effective Dosage form of bile, it is important to support the liver’s bile-producing mechanism. According to several clinical studies, the amount of guggulsterones used to maintain Natural Support for Research shows that certain guggul compounds— normal cholesterol levels is 75 mg per day, guggulsterones—help maintain cholesterol levels when taken with a diet low in saturated fats. Cholesterol Health in the normal range and act at the farnesoid X This is the daily dose delivered by SOURCE receptor (FXR) to promote bile production. NATURALS GUGGULSTERONES. Guggulsterones appear to be farnesoid X receptor (FXR) antagonists. FXR is a bile acid receptor. If A Wellness Revolution in FXR is activated, this results in down-regulation Cardiovascular Care of the amount of bile acids produced by the liver. Bile is made out of cholesterol, which gets used up At a time when our cardiovascular health faces when bile is produced. When bile levels are high, numerous lifestyle challenges, research into the the production of more bile is slowed through remarkable heart-supportive properties of the oday’s lifestyle, with its high-fat, processed food diet, lack of exercise, and negative feedback of the FXR pathway. -
USP Reference Standards Catalog
Last Updated On: November 7, 2020 USP Reference Standards Catalog Catalog Status RS Name Current Previous Lot CAS # NDC # Unit Co. Of Material UN # Net Unit Commodity Special Pkg. USMCA KORUS Base Base # Lot (VUD) Price Origin Origin Weight Of Codes Restriction Type Eligible Eligible Control Control Measur (HS Codes)* Drug Drug % e 1000408 Active Abacavir Sulfate (200 R108M0 R028L0 (30- 188062- N/A $245.00 GB Chemical 200 mg 2933595960 No No mg) JUN-2020) 50-2 Synthesis 1000419 Active Abacavir Sulfate F0G248 188062- N/A $760.00 IN Chemical 20 mg 2933595960 No No Racemic (20 mg) (4- 50-2 Synthesis [2-amino-6- (cyclopropylamino)- 9H-purin-9yl]-2- cyclopentene-1- methanol sulfate (2:1)) 1000420 Active Abacavir Related F1L311 F0H284 (31- 906626- N/A $877.00 IN Chemical 20 mg 2933599550 No No Compound A (20 mg) OCT-2013) 51-5 Synthesis ([4-(2,6-diamino-9H- purin-9-yl)cyclopent- 2-enyl]methanol) 1000437 Active Abacavir Related F0M143 N/A N/A $877.00 IN Chemical 20 mg 2933599550 No No Compound D (20 mg) Synthesis (N6-Cyclopropyl-9- {(1R,4S)-4-[(2,5- diamino-6- chlorpyrimidin-4- yloxy)methyl] cyclopent-2-enyl}-9H- purine-2,6-diamine) 1000441 Active Abacavir Related F1L318 F0H283 (31- N/A N/A $877.00 IN Chemical 20 mg 2933599550 No No Compound B (20 mg) OCT-2013) Synthesis ([4-(2,5-diamino-6- chloropyrimidin-4- ylamino)cyclopent-2- enyl]methanol) 1000452 Active Abacavir Related F1L322 F0H285 (30- 172015- N/A $960.00 IN Chemical 20 mg 2933599550 No No Compound C (20 mg) SEP-2013) 79-1 Synthesis ([(1S,4R)-4-(2-amino- 6-chloro-9H-purin-9- yl)cyclopent-2- -
Potential of Guggulsterone, a Farnesoid X Receptor Antagonist, In
Exploration of Targeted Anti-tumor Therapy Open Access Review Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer Sosmitha Girisa , Dey Parama , Choudhary Harsha , Kishore Banik , Ajaikumar B. Kunnumakkara* Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India *Correspondence: Ajaikumar B. Kunnumakkara, Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India. [email protected]; [email protected] Academic Editor: Gautam Sethi, National University of Singapore, Singapore Received: August 8, 2020 Accepted: September 14, 2020 Published: October 30, 2020 Cite this article: Girisa S, Parama D, Harsha C, Banik K, Kunnumakkara AB. Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer. Explor Target Antitumor Ther. 2020;1:313-42. https://doi.org/10.37349/ etat.2020.00019 Abstract Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. The importance of medicinal plants as primary healthcare has been well-known from time immemorial against various human diseases, including cancer. Commiphora wightii that belongs to Burseraceae family is one such plant which has been used to cure various ailments in traditional systems of medicine. -
Ep 2446888 A2
(19) & (11) EP 2 446 888 A2 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 02.05.2012 Bulletin 2012/18 A61K 31/569 (2006.01) (21) Application number: 11010272.0 (22) Date of filing: 12.07.2006 (84) Designated Contracting States: (71) Applicant: DMI Biosciences, Inc. AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Englewood, CO 80110-3948 (US) HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (72) Inventor: Bar-Or, David Designated Extension States: Englewood, Colorado 80110 (US) AL BA HR MK RS (74) Representative: Schaeberle, Steffen (30) Priority: 12.07.2005 US 69872305 P Hoefer & Partner 24.08.2005 US 71115705 P Patentanwälte 24.08.2005 US 71115805 P Pilgersheimer Strasse 20 81543 München (DE) (62) Document number(s) of the earlier application(s) in accordance with Art. 76 EPC: Remarks: 06787393.5 / 1 919 290 This application was filed on 29-12-2011 as a divisional application to the application mentioned under INID code 62. (54) Use of danazol for the treatment of uveitis (57) The present invention relates to the treatment of an inflammatory disease or condition of the eye such as uveitis with danazof or a pharmacologically-acceptable salt or ester thereof. EP 2 446 888 A2 Printed by Jouve, 75001 PARIS (FR) EP 2 446 888 A2 Description FIELD OF THE INVENTION 5 [0001] The present invention relates to the treatment of diseases and conditions with an effective amount of a steroid having those formulas given below, or a pharmacologically-acceptable salt or ester thereof. -
Hirsutism and Polycystic Ovary Syndrome (PCOS)
Hirsutism and Polycystic Ovary Syndrome (PCOS) A Guide for Patients PATIENT INFORMATION SERIES Published by the American Society for Reproductive Medicine under the direction of the Patient Education Committee and the Publications Committee. No portion herein may be reproduced in any form without written permission. This booklet is in no way intended to replace, dictate or fully define evaluation and treatment by a qualified physician. It is intended solely as an aid for patients seeking general information on issues in reproductive medicine. Copyright © 2016 by the American Society for Reproductive Medicine AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE Hirsutism and Polycystic Ovary Syndrome (PCOS) A Guide for Patients Revised 2016 A glossary of italicized words is located at the end of this booklet. INTRODUCTION Hirsutism is the excessive growth of facial or body hair on women. Hirsutism can be seen as coarse, dark hair that may appear on the face, chest, abdomen, back, upper arms, or upper legs. Hirsutism is a symptom of medical disorders associated with the hormones called androgens. Polycystic ovary syndrome (PCOS), in which the ovaries produce excessive amounts of androgens, is the most common cause of hirsutism and may affect up to 10% of women. Hirsutism is very common and often improves with medical management. Prompt medical attention is important because delaying treatment makes the treatment more difficult and may have long-term health consequences. OVERVIEW OF NORMAL HAIR GROWTH Understanding the process of normal hair growth will help you understand hirsutism. Each hair grows from a follicle deep in your skin. As long as these follicles are not completely destroyed, hair will continue to grow even if the shaft, which is the part of the hair that appears above the skin, is plucked or removed. -
WO 2013/163758 Al 7 November 2013 (07.11.2013) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization I International Bureau (10) International Publication Number (43) International Publication Date WO 2013/163758 Al 7 November 2013 (07.11.2013) P O P C T (51) International Patent Classification: (72) Inventor; and A61K 31/416 (2006.01) C12Q 1/00 (2006.01) (71) Applicant : BOYD, Shelley Romayne [CA/CA]; Unit A61P 27/02 (2006.01) A61B 3/10 (2006.01) 2106, 112 George Street, Toronto, Ontario M5A 2M5 (CA). (21) International Application Number: PCT/CA2013/050335 (74) Agents: MARLES, Jennifer A. et al; 480-601 West Cor dova Street, Vancouver, British Columbia V6B 1G1 (CA). (22) International Filing Date: 30 April 2013 (30.04.2013) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (25) Filing Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (26) Publication Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (30) Priority Data: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 61/640,854 1 May 2012 (01.05.2012) US KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 61/641,393 2 May 2012 (02.05.2012) US ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 61/693,226 24 August 2012 (24.08.2012) us NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, 61/792,436 15 March 2013 (15.03.2013) us RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. -
Endometriosis
CLINICAL REVIEW Endometriosis Follow the link from the online version of this article to obtain certi ed continuing 1 2 3 medical education credits Martha Hickey, Karen Ballard, Cindy Farquhar 1 Endometriosis is a relatively common and potentially Department of Obstetrics and SOURCES AND SELECTION CRITERIA Gynaecology, University of debilitating condition affecting women of reproductive We searched Medline and Pubmed, used personal archives Melbourne and the Royal Women’s age. Prevalence is difficult to determine, firstly because of Hospital, Melbourne, Victoria, of references, and consulted with other experts to inform Australia 3052 variability in clinical presentation, and, secondly because this manuscript. When available, data from systematic 2Faculty of Health and Medical the only reliable diagnostic test is laparoscopy, when endo- reviews and randomised controlled trials were used. We Sciences, University of Surrey, metriotic deposits can be visualised and histologically also used expert guidelines such as the recent European Guildford, Surrey, UK Society of Human Reproduction and Embryology (ESHRE) 3 confirmed. Population based studies report a prevalence Department of Obstetrics and consensus.4 Gynaecology, University of of around 1.5% compared with 6-15% in hospital based 1 Auckland, Auckland, New Zealand studies. Endometriosis can be asymptomatic, but those Correspondence to: M Hickey with symptoms generally present early in reproductive What are the causes of endometriosis? [email protected] life and improve after menopause. Symptomatic endome- The pathogenesis of endometriosis is unknown, but lead- Cite this as: BMJ 2104;348:g1752 triosis can result in long term adverse effects on personal ing theories include retrograde menstruation, altered doi: 10.1136/bmj.g1752 relationships, quality of life, and work productivity.