Research Publications by DISTINCTIONS Any Scientist of Pakistan in Last 10 Year and SERVICES Secretary General, the Chemical Society of Pakistan
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Progestogens and Venous Thromboembolism Among Postmenopausal Women Using Hormone Therapy. Marianne Canonico, Geneviève Plu-Bureau, Pierre-Yves Scarabin
Progestogens and venous thromboembolism among postmenopausal women using hormone therapy. Marianne Canonico, Geneviève Plu-Bureau, Pierre-Yves Scarabin To cite this version: Marianne Canonico, Geneviève Plu-Bureau, Pierre-Yves Scarabin. Progestogens and venous throm- boembolism among postmenopausal women using hormone therapy.. Maturitas, Elsevier, 2011, 70 (4), pp.354-60. 10.1016/j.maturitas.2011.10.002. inserm-01148705 HAL Id: inserm-01148705 https://www.hal.inserm.fr/inserm-01148705 Submitted on 5 May 2015 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Progestogens and VTE Finale version Progestogens and venous thromboembolism among postmenopausal women using hormone therapy Marianne Canonico1,2, Geneviève Plu-Bureau1,3 and Pierre-Yves Scarabin1,2 1 Centre for Research in Epidemiology and Population Health, U1018, Hormones and Cardiovascular Disease 2 University Paris-Sud, UMR-S 1018, Villejuif, France 3 University Paris Descartes and Hôtel-Dieu Hospital, Paris, France Adresse: 16 av. Paul Vaillant Couturier 94807 Villejuif Cedex Tel: +33 1 45 59 51 66 Fax: +33 1 45 59 51 70 Corresponding author: Marianne Canonico ([email protected]) 1/21 Progestogens and VTE Finale version Abstract Hormone therapy (HT) is the most effective treatment for correcting menopausal symptoms after menopause. -
Governance Structure of the State Bank of Pakistan
Governance Structure of the State Bank of Pakistan The State Bank of Pakistan (SBP) is incorporated under the State Bank of Pakistan Act, 1956, which gives the Bank the authority to function as the central bank of the country. The Act mandates the Bank to regulate the monetary and credit system of Pakistan and to foster its growth in the best national interest with a view to securing monetary stability and fuller utilization of the country’s productive resources. Central Board of Directors The State Bank of Pakistan is governed by an independent Board of Directors, which is responsible for the general superintendence and direction of the affairs of the Bank. The Board is chaired by the Governor SBP and comprises of 8 non-executive Directors and Secretary Finance to the Federal Government. The Governor SBP is also the Chief Executive Officer of the Bank and manages the affairs of the Bank on behalf of the Central Board. The SBP Act, 1956 (as amended) stipulates that the Board members should be eminent professionals from the fields of economics, finance, banking and accountancy and shall have no conflict of interest with the business of the Bank. During FY13, all 7 vacant positions on the Board were filled through appointment of Directors by the Federal Government. Out of these 7 newly appointed Directors, 5 were appointed on February 26, 2013 followed by 2 appointments in March, 2013. Brief profile of the members of the Board is given on pages 9-10. The current composition of the Board brings a diverse range of professional expertise, adding value to the deliberations. -
Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs That Modulate Farnesoid X Receptor
OPEN Quantitative High-Throughput Profiling of SUBJECT AREAS: Environmental Chemicals and Drugs that SCREENING SMALL MOLECULES Modulate Farnesoid X Receptor Chia-Wen Hsu1, Jinghua Zhao1, Ruili Huang1, Jui-Hua Hsieh2, Jon Hamm3, Xiaoqing Chang3, Keith Houck4 Received & Menghang Xia1 27 June 2014 Accepted 1National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, 2Division of the National 29 August 2014 Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 3Integrated Laboratory Systems, Inc., Morrisville, NC, 4U.S. Environmental Protection Agency, Research Triangle Park, NC. Published 26 September 2014 The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids, and glucose. Because endogenous chemicals bind and activate FXR, it is important to examine which xenobiotic compounds Correspondence and would disrupt normal receptor function. We used a cell-based human FXR b-lactamase (Bla) reporter gene assay to profile the Tox21 10K compound collection of environmental chemicals and drugs. requests for materials Structure-activity relationships of FXR-active compounds revealed by this screening were then compared should be addressed to against the androgen receptor, estrogen receptor a, peroxisome proliferator-activated receptors d and c, and M.X. ([email protected]. the vitamin D receptor. We identified several FXR-active structural classes including anthracyclines, gov) benzimidazoles, dihydropyridines, pyrethroids, retinoic acids, and vinca alkaloids. Microtubule inhibitors potently decreased FXR reporter gene activity. Pyrethroids specifically antagonized FXR transactivation. Anthracyclines affected reporter activity in all tested assays, suggesting non-specific activity. These results provide important information to prioritize chemicals for further investigation, and suggest possible modes of action of compounds in FXR signaling. -
Role of Androgens, Progestins and Tibolone in the Treatment of Menopausal Symptoms: a Review of the Clinical Evidence
REVIEW Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence Maria Garefalakis Abstract: Estrogen-containing hormone therapy (HT) is the most widely prescribed and well- Martha Hickey established treatment for menopausal symptoms. High quality evidence confi rms that estrogen effectively treats hot fl ushes, night sweats and vaginal dryness. Progestins are combined with School of Women’s and Infants’ Health The University of Western Australia, estrogen to prevent endometrial hyperplasia and are sometimes used alone for hot fl ushes, King Edward Memorial Hospital, but are less effective than estrogen for this purpose. Data are confl icting regarding the role of Subiaco, Western Australia, Australia androgens for improving libido and well-being. The synthetic steroid tibolone is widely used in Europe and Australasia and effectively treats hot fl ushes and vaginal dryness. Tibolone may improve libido more effectively than estrogen containing HT in some women. We summarize the data from studies addressing the effi cacy, benefi ts, and risks of androgens, progestins and tibolone in the treatment of menopausal symptoms. Keywords: androgens, testosterone, progestins, tibolone, menopause, therapeutic Introduction Therapeutic estrogens include conjugated equine estrogens, synthetically derived piperazine estrone sulphate, estriol, dienoestrol, micronized estradiol and estradiol valerate. Estradiol may also be given transdermally as a patch or gel, as a slow release percutaneous implant, and more recently as an intranasal spray. Intravaginal estrogens include topical estradiol in the form of a ring or pessary, estriol in pessary or cream form, dienoestrol and conjugated estrogens in the form of creams. In some countries there is increasing prescribing of a combination of estradiol, estrone, and estriol as buccal lozenges or ‘troches’, which are formulated by private compounding pharmacists. -
USP Reference Standards Catalog
Last Updated On: January 6, 2016 USP Reference Standards Catalog Catalog # Description Current Lot Previous Lot CAS # NDC # Unit Price Special Restriction 1000408 Abacavir Sulfate R028L0 F1L487 (12/16) 188062-50-2 $222.00 (200 mg) 1000419 Abacavir Sulfate F0G248 188062-50-2 $692.00 Racemic (20 mg) (4-[2-amino-6-(cyclo propylamino)-9H-pur in-9yl]-2-cyclopenten e-1-methanol sulfate (2:1)) 1000420 Abacavir Related F1L311 F0H284 (10/13) 124752-25-6 $692.00 Compound A (20 mg) ([4-(2,6-diamino-9H- purin-9-yl)cyclopent- 2-enyl]methanol) 1000437 Abacavir Related F0M143 N/A $692.00 Compound D (20 mg) (N6-Cyclopropyl-9-{( 1R,4S)-4-[(2,5-diami no-6-chlorpyrimidin- 4-yloxy)methyl] cyclopent-2-enyl}-9H -purine-2,6-diamine) 1000441 Abacavir Related F1L318 F0H283 (10/13) N/A $692.00 Compound B (20 mg) ([4-(2,5-diamino-6-c Page 1 Last Updated On: January 6, 2016 USP Reference Standards Catalog Catalog # Description Current Lot Previous Lot CAS # NDC # Unit Price Special Restriction hloropyrimidin-4-yla mino)cyclopent-2-en yl]methanol) 1000452 Abacavir Related F1L322 F0H285 (09/13) 172015-79-1 $692.00 Compound C (20 mg) ([(1S,4R)-4-(2-amino -6-chloro-9H-purin-9 -yl)cyclopent-2-enyl] methanol hydrochloride) 1000485 Abacavir Related R039P0 F0J094 (11/16) N/A $692.00 Compounds Mixture (15 mg) 1000496 Abacavir F0J102 N/A $692.00 Stereoisomers Mixture (15 mg) 1000500 Abacavir System F0J097 N/A $692.00 Suitability Mixture (15 mg) 1000521 Acarbose (200 mg) F0M160 56180-94-0 $222.00 (COLD SHIPMENT REQUIRED) 1000532 Acarbose System F0L204 N/A $692.00 Suitability -
Small Molecules in Solution Has Rarely Been Reported, However, As a General Guide We Recommend Storage in DMSO at -20°C
(Z)-Guggulsterone Small Molecules Retinoic acid receptor (RAR) pathway inhibitor; Inhibits farnesoid X receptor (FXR) Catalog # 73702 1 mg Product Description (Z)-Guggulsterone is a plant steroid found in the resin of the guggul plant Commiphora mukul that acts as a selective antagonist of farnesoid X receptor (FXR; Cui et al.). It decreases chenodeoxycholic acid (CDCA)-induced FXR activation (IC ₅₀ = 10 µM) in the presence of 100 µM CDCA (Urizar et al.; Cui et al.). Molecular Name: (Z)-Guggulsterone Alternative Names: Not applicable CAS Number: 39025-23-5 Chemical Formula: C₂₁H₂₈O₂ Molecular Weight: 312.5 g/mol Purity: ≥ 95% Chemical Name: (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15- decahydrocyclopenta[a]phenanthrene-3,16-dione Structure: Properties Physical Appearance: A crystalline solid Storage: Product stable at -20°C as supplied. Protect product from prolonged exposure to light. For long-term storage store with a desiccant. For product expiry date, please contact [email protected]. Solubility: · DMSO ≤ 800 µM · Absolute ethanol ≤ 3.2 µM · DMF ≤ 30 mM For example, to prepare a 10 mM stock solution in DMF, resuspend 1 mg in 320 μL of DMF. Prepare stock solution fresh before use. Information regarding stability of small molecules in solution has rarely been reported, however, as a general guide we recommend storage in DMSO at -20°C. Aliquot into working volumes to avoid repeated freeze-thaw cycles. The effect of storage of stock solution on compound performance should be tested for each application. Compound has low solubility in aqueous media. -
Guggulsterones and Levels
Cholesterol, Guggulsterones and levels. Because normal levels of serum lipids, Bile Production including cholesterol, are supported by increased circulating thyroid hormones, it is believed guggul Much of the cholesterol made by your liver is uti- Guggulsterones works by stimulating the thyroid gland, in addition lized to create bile, a substance used in digestion to its effects on bile production. to emulsify fats. Because excess cholesterol and triglycerides are excreted from our bodies in the Clinically Effective Dosage form of bile, it is important to support the liver’s bile-producing mechanism. According to several clinical studies, the amount of guggulsterones used to maintain Natural Support for Research shows that certain guggul compounds— normal cholesterol levels is 75 mg per day, guggulsterones—help maintain cholesterol levels when taken with a diet low in saturated fats. Cholesterol Health in the normal range and act at the farnesoid X This is the daily dose delivered by SOURCE receptor (FXR) to promote bile production. NATURALS GUGGULSTERONES. Guggulsterones appear to be farnesoid X receptor (FXR) antagonists. FXR is a bile acid receptor. If A Wellness Revolution in FXR is activated, this results in down-regulation Cardiovascular Care of the amount of bile acids produced by the liver. Bile is made out of cholesterol, which gets used up At a time when our cardiovascular health faces when bile is produced. When bile levels are high, numerous lifestyle challenges, research into the the production of more bile is slowed through remarkable heart-supportive properties of the oday’s lifestyle, with its high-fat, processed food diet, lack of exercise, and negative feedback of the FXR pathway. -
USP Reference Standards Catalog
Last Updated On: November 7, 2020 USP Reference Standards Catalog Catalog Status RS Name Current Previous Lot CAS # NDC # Unit Co. Of Material UN # Net Unit Commodity Special Pkg. USMCA KORUS Base Base # Lot (VUD) Price Origin Origin Weight Of Codes Restriction Type Eligible Eligible Control Control Measur (HS Codes)* Drug Drug % e 1000408 Active Abacavir Sulfate (200 R108M0 R028L0 (30- 188062- N/A $245.00 GB Chemical 200 mg 2933595960 No No mg) JUN-2020) 50-2 Synthesis 1000419 Active Abacavir Sulfate F0G248 188062- N/A $760.00 IN Chemical 20 mg 2933595960 No No Racemic (20 mg) (4- 50-2 Synthesis [2-amino-6- (cyclopropylamino)- 9H-purin-9yl]-2- cyclopentene-1- methanol sulfate (2:1)) 1000420 Active Abacavir Related F1L311 F0H284 (31- 906626- N/A $877.00 IN Chemical 20 mg 2933599550 No No Compound A (20 mg) OCT-2013) 51-5 Synthesis ([4-(2,6-diamino-9H- purin-9-yl)cyclopent- 2-enyl]methanol) 1000437 Active Abacavir Related F0M143 N/A N/A $877.00 IN Chemical 20 mg 2933599550 No No Compound D (20 mg) Synthesis (N6-Cyclopropyl-9- {(1R,4S)-4-[(2,5- diamino-6- chlorpyrimidin-4- yloxy)methyl] cyclopent-2-enyl}-9H- purine-2,6-diamine) 1000441 Active Abacavir Related F1L318 F0H283 (31- N/A N/A $877.00 IN Chemical 20 mg 2933599550 No No Compound B (20 mg) OCT-2013) Synthesis ([4-(2,5-diamino-6- chloropyrimidin-4- ylamino)cyclopent-2- enyl]methanol) 1000452 Active Abacavir Related F1L322 F0H285 (30- 172015- N/A $960.00 IN Chemical 20 mg 2933599550 No No Compound C (20 mg) SEP-2013) 79-1 Synthesis ([(1S,4R)-4-(2-amino- 6-chloro-9H-purin-9- yl)cyclopent-2- -
Potential of Guggulsterone, a Farnesoid X Receptor Antagonist, In
Exploration of Targeted Anti-tumor Therapy Open Access Review Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer Sosmitha Girisa , Dey Parama , Choudhary Harsha , Kishore Banik , Ajaikumar B. Kunnumakkara* Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India *Correspondence: Ajaikumar B. Kunnumakkara, Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India. [email protected]; [email protected] Academic Editor: Gautam Sethi, National University of Singapore, Singapore Received: August 8, 2020 Accepted: September 14, 2020 Published: October 30, 2020 Cite this article: Girisa S, Parama D, Harsha C, Banik K, Kunnumakkara AB. Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer. Explor Target Antitumor Ther. 2020;1:313-42. https://doi.org/10.37349/ etat.2020.00019 Abstract Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. The importance of medicinal plants as primary healthcare has been well-known from time immemorial against various human diseases, including cancer. Commiphora wightii that belongs to Burseraceae family is one such plant which has been used to cure various ailments in traditional systems of medicine. -
A Pharmaceutical Product for Hormone Replacement Therapy Comprising Tibolone Or a Derivative Thereof and Estradiol Or a Derivative Thereof
Europäisches Patentamt *EP001522306A1* (19) European Patent Office Office européen des brevets (11) EP 1 522 306 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.7: A61K 31/567, A61K 31/565, 13.04.2005 Bulletin 2005/15 A61P 15/12 (21) Application number: 03103726.0 (22) Date of filing: 08.10.2003 (84) Designated Contracting States: • Perez, Francisco AT BE BG CH CY CZ DE DK EE ES FI FR GB GR 08970 Sant Joan Despi (Barcelona) (ES) HU IE IT LI LU MC NL PT RO SE SI SK TR • Banado M., Carlos Designated Extension States: 28033 Madrid (ES) AL LT LV MK (74) Representative: Markvardsen, Peter et al (71) Applicant: Liconsa, Liberacion Controlada de Markvardsen Patents, Sustancias Activas, S.A. Patent Department, 08028 Barcelona (ES) P.O. Box 114, Favrholmvaenget 40 (72) Inventors: 3400 Hilleroed (DK) • Palacios, Santiago 28001 Madrid (ES) (54) A pharmaceutical product for hormone replacement therapy comprising tibolone or a derivative thereof and estradiol or a derivative thereof (57) A pharmaceutical product comprising an effec- arate or sequential use in a method for hormone re- tive amount of tibolone or derivative thereof, an effective placement therapy or prevention of hypoestrogenism amount of estradiol or derivative thereof and a pharma- associated clinical symptoms in a human person, in par- ceutically acceptable carrier, wherein the product is pro- ticular wherein the human is a postmenopausal woman. vided as a combined preparation for simultaneous, sep- EP 1 522 306 A1 Printed by Jouve, 75001 PARIS (FR) 1 EP 1 522 306 A1 2 Description [0008] The review article of Journal of Steroid Bio- chemistry and Molecular Biology (2001), 76(1-5), FIELD OF THE INVENTION: 231-238 provides a review of some of these compara- tive studies. -
List of Category -I Members Registered in Membership Drive-Ii
LIST OF CATEGORY -I MEMBERS REGISTERED IN MEMBERSHIP DRIVE-II MEMBERSHIP CGN QUOTA CATEGORY NAME DOB BPS CNIC DESIGNATION PARENT OFFICE DATE MR. DAUD AHMAD OIL AND GAS DEVELOPMENT COMPANY 36772 AUTONOMOUS I 25-May-15 BUTT 01-Apr-56 20 3520279770503 MANAGER LIMITD MR. MUHAMMAD 38295 AUTONOMOUS I 26-Feb-16 SAGHIR 01-Apr-56 20 6110156993503 MANAGER SOP OIL AND GAS DEVELOPMENT CO LTD MR. MALIK 30647 AUTONOMOUS I 22-Jan-16 MUHAMMAD RAEES 01-Apr-57 20 3740518930267 DEPUTY CHIEF MANAGER DESTO DY CHEIF ENGINEER CO- PAKISTAN ATOMIC ENERGY 7543 AUTONOMOUS I 17-Apr-15 MR. SHAUKAT ALI 01-Apr-57 20 6110119081647 ORDINATOR COMMISSION 37349 AUTONOMOUS I 29-Jan-16 MR. ZAFAR IQBAL 01-Apr-58 20 3520222355873 ADD DIREC GENERAL WAPDA MR. MUHAMMA JAVED PAKISTAN BORDCASTING CORPORATION 88713 AUTONOMOUS I 14-Apr-17 KHAN JADOON 01-Apr-59 20 611011917875 CONTRALLER NCAC ISLAMABAD MR. SAIF UR REHMAN 3032 AUTONOMOUS I 07-Jul-15 KHAN 01-Apr-59 20 6110170172167 DIRECTOR GENRAL OVERS PAKISTAN FOUNDATION MR. MUHAMMAD 83637 AUTONOMOUS I 13-May-16 MASOOD UL HASAN 01-Apr-59 20 6110163877113 CHIEF SCIENTIST PROFESSOR PAKISTAN ATOMIC ENERGY COMMISION 60681 AUTONOMOUS I 08-Jun-15 MR. LIAQAT ALI DOLLA 01-Apr-59 20 3520225951143 ADDITIONAL REGISTRAR SECURITY EXCHENGE COMMISSION MR. MUHAMMAD CHIEF ENGINEER / PAKISTAN ATOMIC ENERGY 41706 AUTONOMOUS I 01-Feb-16 LATIF 01-Apr-59 21 6110120193443 DERECTOR TRAINING COMMISSION MR. MUHAMMAD 43584 AUTONOMOUS I 16-Jun-15 JAVED 01-Apr-59 20 3820112585605 DEPUTY CHIEF ENGINEER PAEC WASO MR. SAGHIR UL 36453 AUTONOMOUS I 23-May-15 HASSAN KHAN 01-Apr-59 21 3520227479165 SENOR GENERAL MANAGER M/O PETROLEUM ISLAMABAD MR. -
PROF. DR. ATTA-UR-RAHMAN, FRS Nishan-E-Imtiaz, Hilal-I-Lmtiaz, Sitara-I-Lmtiaz, Tamgha-I-Lmtiaz
List of Publications Atta-ur-Rahman Page 1 PROF. DR. ATTA-UR-RAHMAN, FRS Nishan-e-Imtiaz, Hilal-i-lmtiaz, Sitara-i-lmtiaz, Tamgha-i-lmtiaz PRESIDENT Network of Academies of Science in Countries of the Organization of Islamic Conference (NASIC) and Patron-in-Chief InternationalCenter for Chemical and Biological Sciences (H.E.J. Research Institute of Chemistry and Dr. PanjwaniCenter for Molecular Medicine and Drug Research) University of Karachi, Karachi Prof. Atta-ur-Rahman has over 1002 publications in the fields of organic chemistry including 37 patents, 173 books and 68 chapters in books published by major U.S. and European presses and 724 research publications in leading internatinal journals. BOOKS NAME OF BOOKS COUNTRY 1. “Biosynthesis of Indole Alkaloids”, Atta-ur-Rahman and A. Basha, Clarendon Press, UK Oxford(1983). 2. “Pakistan EncyclopaediaPlanta Medica,” Vol. I, Atta-ur-Rahman, H.M. Said and V.U. Pakistan Ahmad, Hamdard Foundation Press, Karachi (1986). 3. “Natural Product Chemistry”, Atta-ur-Rahman, Springer-Verlag, Heidelberg (1986). Germany 4. “New Trends in Natural Products Chemistry”, Atta-ur-Rahman and P.W. Le Quesne, The Elsevier Science Publishers, Amsterdam (1986). Netherlands 5. “Pakistan EncyclopaediaPlanta Medica”, Vol. 2, H.M. Said, V.U. Ahmad and Atta-ur- Pakistan Rahman, Hamdard Foundation Press, Karachi (1986). 6. “Nuclear Magnetic Resonance”, Atta-ur-Rahman, Springer-Verlag, New York(1986). USA Japanese Translation by Prof. Motoo Tori and Prof. Hiroshi Hirota published by Springer- Verlag, Tokyo (1988)]. 7. “Recent Advances in Natural Product Chemistry”, Atta-ur-Rahman, Shamim Printing Pakistan Press, Karachi (1987). Page 1 of 69 List of Publications Atta-ur-Rahman Page 2 8.