EACPT_A5.indd 1 1.9.2010 10:06:54 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, , www.eacpt2011.org

Welcome message

Dear Colleagues,

On behalf of the European Association for Clinical Pharmacology and Therapeutics (EACPT) and the Hungarian Society for Experimental and Clinical Pharmacology it is my pleasure to invite you to the 10th Congress of EACPT.

The Congress will take place between 26-29 June 2011 in Budapest, the capital of Hungary.

Budapest, “The Pearl of the Danube” is a multilingual, international metropole in the heart of Central Europe with nearly two million inhabitants, lively cultural and social life, plenty of spas and green areas to relax. The venue is the Budapest Congress & World Trade Center where experienced staff will host and serve the attendees.

Our title “From Drug Research to Therapy for the Benefit of Patients” is symbolising the close connection of the principle of clinical pharmacology to basic research as well as to the everyday patient care. The Congress will focus on key research and therapeutic areas and their related problems and latest achievements with the help of distinguished invited speakers, opinion leaders, experts and the upcoming future generation of clinical pharmacologists.

Come to Budapest to make the 10th Congress of EACPT a real success and to enjoy life and the hospitality of the capital of Hungary and its people.

With best regards on behalf of the organizers

Adam Vas MD PhD Congress President 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

Honorary President Prof. Sylvester E. Vizi, Budapest

Congress President Prof. Adam Vas, Budapest

International Advisory Board National Organizing Committee Prof. Ingolf Cascorbi, Germany Prof. György Blaskó, Debrecen Prof. Gunnar Alvan, Sweden Prof. János Borvendég, Budapest Prof. Kim Brosen, Denmark Prof. Zsuzsanna Fürst, Budapest Prof. John R. Cockcroft, United Kingdom Dr. Zoltán Kaló, Budapest Prof. Igor Francetic, Croatia Dr. Judit Kapocsi, Budapest Prof. Emil Gatchev, Bulgaria Prof. Sándor Kerpel-Fronius, Budapest Prof. Pierangelo Geppetti, Italy Dr. Péter Klivényi, Szeged Prof. Simon R. J. Maxwell, United Kingdom Prof. László Korányi, Balatonfüred Prof. Nicholas Moore, France Prof. Péter Kovács, Debrecen Prof. Michael Orme, United Kingdom Prof. Gyöngyvér Soós, Szeged Prof. Gonzalo Calvo Rojas, Spain Dr. Gábor Szepesi, Budapest Prof. Ana Sabo, Serbia Dr. Zsuzsanna Szepezdi, Budapest Prof. Jan Schellens, The Netherlands Prof. Kornélia Tekes, Budapest Prof. Milos P. Stojiljkovic, Serbia Prof. András Varró, Szeged Prof. Dmitri Sychev, Russia Prof. Tibor Wittmann, Szeged Prof. Giampaolo Velo, Italy Prof. Theo de Vries, The Netherlands Prof. David Webb, United Kingdom

Scientific Advisory Committee Financial and Sponsoring Committee Prof. Csaba Farsang, Budapest Dr. Gábor Szepesi, Budapest Prof. Kálmán Magyar, Budapest Prof. Adam Vas, Budapest Prof. Tamás Paál, Budapest Prof. László Vereczkey, Budapest Prof. Julius Papp, Szeged Prof. János Szolcsányi, Pécs

Congress Office MOTESZ Congress and Travel Agency H-1051 Budapest, Nádor u. 36. Information: Alice Sipos Tel.: 00 36 1 311 66 87 Fax: 00 36 1 383 79 18 E-mail: [email protected] Website: www.motesz.hu 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org Venue

Budapest Congress & World Trade Center H-1123 Budapest Jagelló út 1-3.

APPROACH of the Congress venue

By public transport: by tram No. 61 from Móricz Zsigmond körtér or Déli pályaudvar (South Railway Station), or by bus No. 8 or Nr. 112 from (4 stops).

By car: at the junction of M1 and M7 highways coming from the West, on Hegyalja út until the BAH junction.

By train: the distance is about 1 km from the South Railway Station, from the train station by tram No. 61 (4 stops).

From the airport: the distance by car is cca. one hour from Ferihegy Airport. From the airport by public transport: by bus Nr. 200E until Kõbánya-Kispest metro end station, than by metro (line Blue, Nr. 3) until Ferenciek tere, than by bus No. 8 or Nr. 112 from Ferenciek tere (4 stops).

WEBSITES FOR FURTHER INFORMATION www.eacpt2011.org The final programme will be available on the website as of 1 May 2011

IMPORTANT DEADLINES Deadline for sending abstracts 28 February 2011 Confirmation of abstract selection 1 April 2011 Deadline for early registration 15 April 2011 Deadline for accommodation booking 22 April 2011 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

CONGRESS LANGUAGE English

TECHNICAL EQUIPMENT Technical equipment will be available: PC, projection with Microsoft XP programme. In case of using other software, please provide your own computer.

EXHIBITION A Commercial Exhibition is being organised during the Congress. An Exhibition Kit will be sent to all the interested companies and industries. If you are interested in it and require further information please contact the Congress Secretariat.

CERTIFICATE OF ATTENDANCE

A Certificate of Attendance will be issued at the time of registration to delegates who are pre-registered. For on-site registrants, a Certificate of Attendance will be available at the end of the Congress. No certificate will be issued after the Congress.

BADGE Your badge will be provided with the registration material, at the registration desk. Participants, accompanying persons and exhibitors are requested to wear the congress badges at all times. Cost of replacing a lost or misplaced badge: 20 Euro.

DISABLED PERSONS The Congress Venue is fully accessible for disabled persons.

LIABILITY The Organising Committee and the MOTESZ Congress and Travel Agency do not accept liability for personal medical expenses, travel expenses, losses of whatever nature incurred by delegates and/or accompanying persons.

SPECIAL REQUIREMENTS For participants who have special requirements with respect to diet or other matters, arrangements can be made, provided that applications with special request will have been received by the secretariat before 31 May 2011. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

REGISTRATION On-line registration is available on the website: www.eacpt2011.org In case of having difficulties with the on-line registration, please complete the attached registration form and return it to the address given on the form.

REGISTRATION INFORMATION

Registration deadlines Deadline for early registration fee is 15 April 2011. Please use the on-line registration or fill in the enclosed registration form and send or fax it to the Congress Office.

Travel Bursaries EACPT offers a limited number of travel bursaries to young scientists, actively taking part in the congress. The successful candidate will receive 500 € for support of travel and accommodation. If you wish to apply for a travel bursary, please tick the relevant box when submitting your abstract.

Registration fees Early registration fee Registration fee from until 15 April 2011 15 April 2011 and on-site Regular participant 650 € 750 € Student 300 € 350 € Accompanying person 250 € Gala dinner 70 €

Registration fee for regular participants and students includes • Access to scientific presentations, abstract book, congress material • Access to exhibition • Opening ceremony • Daily lunches at congress venue 3 times • Cultural programme on Monday evening

Registration fee for accompanying persons includes • Opening ceremony • Cultural programme on Monday evening • Access to exhibition

Please note that the deadline to benefit from the early registration fee is 15 April 2011. Registration forms received without payment cannot be processed. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

PAYMENT Payments should preferably be made in advance and paid in EURO by one of the following methods: – by bank transfer – by credit card

No registration will be confirmed until payment is received by the MOTESZ Congress and Travel Agency. Only registered participants can attend the Congress.

CONFIRMATION Only upon receipt of the total registration fee, will the registration be confirmed. The letter of confirmation should be presented at the registration desk to receive all the congress materials. MODIFICATIONS The Congress Secretariat (MOTESZ Congress and Travel Agency) must be notified of any change or cancellation of hotel reservation by fax or by e-mail. In such case please do not contact the hotel directly. All modifications are subject to a 20 Euro administration fee.

CANCELLATION Cancellations should be submitted to the MOTESZ Congress and Travel Agency (H-1051 Budapest, Nádor u. 36., fax: 00 36 1 383 79 18, e-mail: [email protected]) In case of cancellations received before 15 April 2011 a 20% administrative fee will be charged, the rest of the fee paid will be refunded. Cancellations received after this date are not eligible for a refund. You may designate a substitute participant at any time for an extra charge of 30 EUR.

INVITATION LETTER An invitation letter will be sent upon request. This letter, however, does not constitute any obligation for the Organising Secretariat to cover registration fee, accommodation, travel expenses and any other cost related to the participation at the Congress.

ACCREDITATION Application for EACCME Credit Points will be made once the scientific programme is finalized. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org SPONSORS AND EXHIBITORS

MAJOR SPONSOR

SPONSORS 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org PRELIMINARY SCIENTIFIC PROGRAMME TIME SCHEDULE

Room A Room B Room C Room D 26 June, New developments in organspecific clinical Sunday Translational clinical pharmacology Future trends in clinical pharmacology pharmacology I Cascorbi (D) / Cardiovascular diseases: S Erdine (T) / B Flamion (B) / Session 1 Systems biology Clinical Trial Design A Falus (H) Hypertension Cs Farsang (H) J Borvendég (H) New ways in the Systems biology: perspectives in Clin. trial designs of new 09.00 - 09.30 A Falus (H) pharmacotherapy of S Erdine (TR) B Flamion (B) personalized medicine applications hypertension Arterial stiffness measurement as a powerful tool in the Deep sequencing in complex Role of pharmacists in clinical 09.30 - 10.00 P Rosenstiel (D) assesment of the M Illyés (H) G Laekemann (B) diseases trials: no pain, no gain hemodynamic actions of different drugs 10.00 - 10.15 free presentation free presentation free presentation 10.15 - 10.45 Coffee Break Coffee Break Coffee Break TBD / Cardiovascular diseases: M Vos (NL) / Pharmacovigilance (in G Velo (I) / Session 2 Use of biomarkers in clinical trials J Timár (H) Heart A Varró (H) collaboration with ISoP) J Pallos (H) Biomarkers of target therapies in CV and GI safety of NSAIDs: 10.45 - 11.15 J Tímár (H) Biology of QT prolongation M Vos (NL) F Salvo (I) lung cancer evidences from clinical studies European and global 11.15 - 11.45 TBD TBD Drug induced arrhythmias H Bonnemeir (D) pharmacovigilance as seen by a G Sjölin-Forsberg (S) clinical pharmacologist 11.45 - 12.00 free presentation free presentation free presentation 12.00 - 12.15 free presentation free presentation free presentation EACPT Executive 12.15 - 13.15 Lunch Lunch Lunch Committee Meeting E Vasar (I) / J Fareed (USA) / D Fialova (CZ) / Session 3 Transgenic models Hemostaseology Vulnerable populations G Szabó (H) Gy Blaskó (H) J Kapocsi (H) Anxiety/depression transgenic Problematics of pediatric clinical 13.15 - 13.45 E Vasar (I) New oral anticoagulants S Harder (D) K Hoppu (SF) models studies The novel platelet inhibitors Medication errors in elderly 13.45 - 14.15 Transgenic models in drug research L Hein (D) J Fareed (USA) D Fialova (CZ) and their clinical significance population 14.15 - 14.30 free presentation free presentation free presentation 14.30 - 14.45 free presentation free presentation free presentation 14.45 - 15.15 Coffee Break Coffee Break Coffee Break ASCPT symposium: Personalized I CascorbiI (D) / Session 4 medicine: academic, regulatory RJ Hohl (US) and industry perspectives Academics, drug discovery and 15.15 - 15.45 RJ Hohl personalized medicine Personalised medicine in drug 15.45 - 16.15 RL Lalonde development Precompetitive collaboration 16.15 - 16.45 J Wagner driving personalized medicine 16.45 - 17.00 Break Plenary Lecture: Industrial Drug 17.00 - 18.45 Erik Bogsch (H) R&D: Perspectives 18.00 - 18.45 Opening Ceremony A Vas (H) 18.45 - 21.00 Welcome Reception in the BCWTC 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

Room A Room B Room C Room D 27 June, New developments in organspecific clinical Monday Translational clinical pharmacology Future trends in clincal pharmacolgy pharmacology J Mayer (CZ) / R Stockley (UK) / TBA / Session 1 Targeted therapy in oncology Respiratory diseases Hematology I Bodrogi (H) A Somfay (H) J Demeter (H) Role of steroids and bronchodil. 08.00 - 08.30 Angiogenesis inhibition in solid tumors H-J Schmoll (D) R Stockley (UK) Targeted therapy of CML J Mayer (CZ) COPD phenotypes 08.30 - 09.00 New drugs in asthma M Cazzola (I) Therapy of CNS lymphomas AJM Ferreri (I) 09.00 - 09.15 free presentation free presentation free presentation 09.15 - 09.30 free presentation free presentation free presentation 09.30 - 09.45 free presentation free presentation free presentation 09.45 - 10.15 Coffee Break Coffee Break Coffee Break M Pirmohamed (UK) / Metabolic syndromes: Lipid N D Wong (USA) / M Pascual (E) / Session 2 Translational medicine Spin-off and biotech B Melegh (H) disorders A Császár (H) Gy Dormán (H) 10.15 - 10.45 Biobanks E Wichmann (D) TBD TBD TBD M Pascual ( E ) Dyslipidemia, Metabolic Prevention of adverse drug events Syndrome and Cardiovascular 10.45 - 11.15 M Pirmohamed (UK) N D Wong (USA) TBD TBD using genetic information Disease: Evidence, Evaluation and Management 11.15 - 11.30 free presentation free presentation free presentation 11.30 - 11.45 free presentation free presentation free presentation Plenary lecture: 11.45 - 12.30 H-G Eichler (A) Roadmap of the EMA 12.30 - 13.45 Lunch and Guided Poster Tour / Poster prize Lunch and Guided Poster Tour / Poster prize Lunch and Guided Poster Tour / Poster prize 13.00 - 13.45 General Assembly J Dulak (PL) / Metabolic syndromes: Diabetes L Groop (S) / Impact of clinical trials on the D Vitezic (HRV) / Session 3 Advanced therapies I Édes (H) mellitus L Korányi (H) health system Z Kaló (H) Genetics and pharmacogenetics Economic impact of clinical trials on 13.45 - 14.15 Stem cell therapy J Dulak (PL) L Groop (S) D Vitezic (HRV) of type 2 diabetes the health care system Stem cell therapy in acute coronary Genetics and new therapies of Economic impact of clinical trials on 14.15 - 14.45 I Édes (H) H Beck-Nielsen (DK) Z Kaló (H) syndrome type1 DM the GDP 14.45 - 15.00 free presentation free presentation free presentation 15.00 - 15.15 free presentation free presentation free presentation 15.15 - 15.30 free presentation free presentation free presentation 15.30 - 16.00 Coffee Break Coffee Break Coffee Break B Gulyás (S) / P Riederer (D) / European competitivness in G Szepesi (H) / Session 4 Imaging techniques Neurodegeneration A Vas (H) P Klivényi (H) clinical trials M Stojiljkovic (SER) TSPO and cell death, implications for Why have we failed to find cures Trends in globalization of clin. trials. 16.00 - 16.30 M Gavish (IL) A Korczyn (IL) J Ravuelta (E) cancer and degenerative diseases for dementia An Europ. perspective Drug development in Parkinson's P Riederer (D) Clinical trials-competitiveness of Eu A Fernandez (E) Role of modern imaging disease 16.30 - 17.00 techniques in drug and biomarker B Gulyás (S) Novel therapeutic strategies in R&D the treatment of neurodegen. L Vécsei (H) free presentation disorders: kynurenines IFAPP Symposium Symposium on Clinical Clinical Pharmacology and rational The role of IFAPP in G Nell (A) / Pharmacology- vital role in FC Tulunay (TR) / 17.00 - 19.00 BPS Symposium medicines use pharmaceutical medicine S Kerpel-Fronius (H) optimising valuable resources in LL Gustafsson (S) education programs Europe in the future? Is there evidence based The Role of The Clinical Pharmacologist The role of IFAPP in education EACPT Council 17.15-18.45 D Webb (UK ) G Nell (A) pharmacotherapy in practice: ways FC Tulunay (TR) in Health Technology Appraisal programs Meeting to address this?

Monitoring medicines use, the role of Critical drug evaluation to optimise D Williams (IRL) The German experience N Clemens R Malmstrom (S) the clinical pharmacologist the managed entry of new drugs

Pharmacoeconomic aspects of rational Assessing the value of new drugs D Hughes (UK) The Italian Experience D Criscuolo (I) K Paterson (UK) medicines use and providing prescribing guidance The clinical pharmacologist and the Innitiatives across Europe to The Central European development of evidence-based P Jackson (UK) S Kerpel-Fronius (H) enhance prescribing efficiency of B Godman (UK) Cooperative Training Concept treatment guidelines existing drugs in a class 20.00-21.00 Organ Music in the Basilica of Pest 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

Room A Room B Room C Room D 28 June, New developments in organspecific clinical Tuesday New developments in basic disciplines Future trends in clinical pharmacology pharmacology Chronic inflammatory I Francetic (HRV) / Z Szekanecz (H) / A Korczyn (IL) / Session 1 Rational drug prescribing diseases: Rheumatoid The placebo question G Falkay (H) L Cirják (H) L Vécsei (H) arthritis New developments in targeted Placebo in clinical practice and 08.00 - 08.30 Consumption of drugs in Slovenia J Furst (SLO) therapy of autoimmune P Gergely (CH) M Davidson (IL) research diseases V Vlahovic-Palcevski How to overcome the placebo 08.30 - 09.00 Outcome measures in drug prescribing Rheumatoid arthritis Z Szekanecz (H) R Anand (CH) (HRV) hurdles in clinical trials 09.00 - 09.15 free presentation free presentation free presentation 09.15 - 09.30 free presentation free presentation free presentation 09.30 - 09.45 free presentation free presentation free presentation 09.45 - 10.15 Coffee Break Coffee Break Coffee Break R Gomeni (I) / Chronic inflammatory Gy Soós(H) / A Sabo (SER) / Session 2 PK/PD relationship Bioequivalence studies L Tóthfalusi (H) diseases: dermatology T Ruzicka (D) P Kovács (H) New perspectives in chronic Application of PK/PD in drug New bioeqv. guidelines; first year Education sub 10.15 - 10.45 R Gomeni (I) inflammatory diseases: T Ruzicka (D) H Potthast (D) development: an industrial perspective experience Committee meeting renaissance of retinoids

Bioequivalence pros and cons of 10.45 - 11.15 PK/PD modeling in pain J Lötsch (D) free presentation Markus Zimmer (D) everyday regulatory decisions 11.15 - 11.30 free presentation free presentation Bioequivalence studies - the 25 M. Mikov (SER) 11.30 - 11.45 free presentation free presentation year experience of Novi Sad Plenary lecture: Development of 11.45 - 12.30 Innovative and Follow-up Biological Christian Schneider (D) Agents 12.30 - 13.45 Lunch and Guided Poster Tour / Poster prize Lunch and Guided Poster Tour / Poster prize Lunch and Guided Poster Tour / Poster prize U Schellekens (NL) / TBA / I Klingman(D) / Session 3 Innovative and Biosimilar products Pediatrics/neonatology Ethical aspects S Kerpel-Fronius (H) A Arató (H) Zs Fürst (H)

The impact of Directive Biological treatment in 2001/83/EC on the harmonisation 13.45 - 14.15 Erythropoetine H Schellekens (NL) L deRidder (NL) J Borvendég (H) pediatric Crohn disease of ethical approval of clinical trials in Europe. How far have we come?

Obesity and metabolic 14.15- 14.45 LMWH biosimilars controversy E Corretge (F) D Molnar (H) EU GCP Committee I Klingman (D) syndromes in children 14.45 - 15.00 free presentation free presentation free presentation 15.00 - 15.15 free presentation free presentation free presentation 15.15 - 15.45 Coffee Break Coffee Break Coffee Break F De Ridder (B) / M Davidson (UK) / European network of Gy Blaskó (H) / Session 4 Biostatistics Psychiatric disorders J Singer (H) I Bitter (H) excellence: ECRIN and ENSAT G Calvo ( E ) Pharmacogenetic predictors of ECRIN: new perspective for 15.45 - 16.15 Adaptive designs in early development F De Ridder (B) A Serretti (I) J DeMotes (F) Education sub antidepressant response European clinical research Committee meeting Cognitive function in Hungarian Network of Clinical 16.15 - 16.45 Handling of missing data F Torres (E) M Davidson (IL) Gy Blaskó (H) schizophrenia Pharmacology 16.45 - 17.00 free presentation free presentation free presentation 17.00 - 17.15 free presentation free presentation free presentation Symposium on Computerized Clinical Pharmacological 17.15- 18.45 Gedeon Richter Symposium Drug Prescribing in Europe: LL Gustafsson (S) G Alvan (S) Services in Health Care. Today and Tomorrow Knowledge databases for The role of clinical EACPT Executive rational drug therapy: Y Böttiger, B C Asker-Hagelberg 17.15-17.40 pharmacology in reviewing Committee Meeting decvelopment, usage and Eiermann (S) (S) effects drug treatment Strategies to reduce over Toxicological services 17.40-18.00 alerting in electronic decision W Haefeli (D) provided by clinical O Spigset (N) support: a German perspective pharmacology

Integrating international The convergence of pharmacological sources with R van der Stichele conventional therapeutic drug 18.00-18.20 E Eliasson (S) national therapeutic arsenals: (B) monitoring and the experience of Belgium pharmacogenetic services Services in 18.20-18.45 General discussion pharmacoepidemiology and M Andersen (DK) drug utilization 19.15: Departure to Gala Dinner Gala Dinner: Lázár Equestrian Park in 20.00-23.00 Domonyvölgy 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

Room A Room B Room C 29 June, Clinical pharmacology: new developments in basic New developments in organspecific clinical Wednesday Future Trends in clinical pharmacology disciplines pharmacology D Webb (UK) / E Ludwig (H) / S Maxwell (UK) / Session 1 Pharmacooeconomics Infectious diseases Prescribing in Health Service Z Kaló (H) E Gatchev (BG) Z Járay (H) Will electronic prescribing Pharmacoeconomics: a reality Rational antibiotic 08.00- 08.30 M Rawlins (UK) E Gatchev (BG ) improve outcomes for J Coleman (UK) to physicians prophylaxis in surgery patients? Providing prescribing decision 08.30 - 09.00 TBD TBD Antimicrob. treat. IC setting F Scaglione (I) W Haefeli (D) support at the point of care 09.00 - 09.15 free presentation free presentation free presentation 09.15 - 09.30 free presentation free presentation free presentation 09.30 - 09.45 free presentation free presentation free presentation 09.45 - 10.15 Coffee Break Coffee Break Coffee Break

Plenary lecture: Targets of 10.15-11.00 drug treatment: nonsynaptic ES Vizi (H) receptors and transporters

Grad. and postgrad. teaching S Kerpel-Fronius (H) Rare diseases and orphan L Rägo (CH) / N Moore (F) / Session 2 Pharmacoepidemiology of clin. pharmacol. in Europe / T deVries (NL) drugs J Borvendég (H) Z Vokó (H)

Potentials of payers' databases Assessing new doctors for Orphan Drugs – state of the 11.00 - 11.30 S Maxwell (UK) K Westermark (S) for pharmacoepidemiological Z Vokó (H) competence to prescribe art investigations

Pharmacoepidemiologyband 11.30 - 12.00 TBD A Sabo (SER) TBD L Rägo (CH) A Khokhlov (RUS) practices: acceptable solutions 12.00 - 12.15 free presentation free presentation free presentation 12.15 - 12.30 free presentation free presentation free presentation 12.30 - 12.45 free presentation free presentation free presentation 12.45 - 13.30 Closing Ceremony 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org ABSTRACT INSTRUCTIONS

On-line abstract form is available on the www.eacpt2011.org website.

Deadline for abstract submission is 28 February 2011.

The EACPT2011 Congress offers the unique opportunity to present orally up-to-date data to the scientific community.

Up to 96 oral free presentations will be selected from the abstracts. This special format was successfully implemented into the series of EACPT congresses since 2007 and is in particular addressed to young research scientists. All abstracts will be evaluated by the Scientific Committee. Authors will receive confirmation before 1 April 2011. Accepted abstracts will be published in Basic and Clinical Pharmacology and Toxicology and on the conference web-site (see Abstract Form). All submitted abstracts should be accompanied by a registration from the first author (see Registration paragraph).

Best Abstract Awards: At the end of each poster discussion session a price will be given to the authors of the best poster. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org SOCIAL PROGRAMMES

Welcome reception 26 June 2011, 20.00 Venue: Budapest Congress & World Trade Center Included in the registration fee. Dress code: casual

Cultural programme 27 June 2011, 20.00 Organ concert in the St. Stephen Basilica Organ player: Organ Player – Professor János Borvendég Born in Budapest graduated at the Semmelweis Medical School Budapest as a MD. He worked as physician at the University Hospital (Szeged) as an internist and researcher of the Hungarian Academy of Science. 1970-82 he functioned as the Head of the Medical Dpt. of the Institute of Drug Research (Budapest). 1982 he was appointed Head of Biomedical Division of the National Institute of Pharmacy (Hungarian Drug Regulatory Agency), in 1991 Medical Deputy Director General of the Institute. 2002 Chief scientific counsellor of the same Institute. He is member of the CHMP (EMEA-London) since 1st May 2004. He was acting as a professor at the Budapest, and Kossuth Lajos University Debrecen (lecturer of pharmacology/ clinicopharmacology) and still delivering lectures on pharmacology at the Eötvös Loránd University Budapest. He is member of various scientific organisations, e.g. Co-chairman of the Central Ethical and Clinicopharmacologycal Committee. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

He began to play the organ at the age of eleven. He has been studying with professor Ferenc Gergely and professor József Kárpáthy at first as the guest pupil at the Béla Bartók music conservatoir and later as a student of the Budapest Music School. He gave his first organ recital at age of 16. János Borvendég acted as a church organist for several years. He has still given concerts regularly across the country and in Budapest. His favourite composers are J. S. Bach and the French romantic authors.

Gala Dinner Domonyvölgy – Lázár Equestrian Park 28 June 2011, 20.00 Dress code: casual Departure from the entrance of the congress venue at 19.00 Arrival: 19.45–20.00 The Lázár Equestrian Park, 35 km far from Budapest and close to the Gödöllõ Royal Palace was established in 1991 in Domonyvölgy. The driving world championship Lázár brothers brought their dreams to life by uniting the atmosphere of a Hungarian village and high quality Hungarian hospitality with the excitement of a high quality European horse stable. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

Arriving in the breath-taking nine-hectare Equestrian Park participants are welcomed with fresh scones topped with crackling, a fruit brandy, then they can admire a horse show, including four hand drive, pony driven carriage, display of nomad warrior archery, skills of the horsemen, cart pulled by four oxen, Puszta-five and horse display of „Queen Elizabeth” in costume, sitting side-saddle. At the end of the programme the guests are invited to take part in a pleasant coach trip through the woods as well as visit the Lázár Equestrian Park. Dinner will be served in one of the “Csárda” of the Park, Hungarian menu with unlimited wine and beer consumption. A folklore programme with gipsy band will take place during the dinner. Music and dance after all. Travel back to Budapest from 23.30.

OPTIONAL PROGRAMMES

CITY TOUR & OPERA HOUSE TOUR 26 June 2011, Sunday

During the City Tour you visit the top attractions of Budapest: On the Buda side: the Chain Bridge, the Castle District with the and the Fishermen’s Bastion, the Gellért Hill and the with the most spectacular view of Budapest. On the Pest side: the downtown with the Central Market Hall, the largest active Synagogue of Europe, the Heroes’Square at the , the Andrássy Avenue, the St. Stephen’s Basilica and the impressive House of Parliament. At the end you can discover the Opera House on a guided tour (interior visit, stage, Royal entrance and Royal Salon, etc.) and enjoy a surprise concert in the Main Staircase of the Opera House, performed by the artists of the Hungarian State Opera House. Departure time: 11.30 a.m. Price: 60€ / person Duration: 4,5 hours (min. 15 persons) 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

JEWISH HERITAGE TOUR 29 June 2011, Wednesday

Guided tour including the inside visit of Dohány Street Synagogue, the Jewish Museum, the Emanuel Memorial Tree, the Rumbach Synagogue and the outside visit of the Kazinczy street Synagogue and the Heroes’ Church. Presentation of the Jewish Quarter (ex-ghetto).

Departure time: 10.00 a.m. Price: 30€ / person Duration: 3 hours (min. 15 persons)

THE DANUBE BEND: ESZTERGOM-VISEGRÁD-SZENTENDRE 30 June 2011, Thursday

Let us invite you a full-day, all inclusive, cultural excursion to the north of Budapest to see four major sights on the Danube Bend:

Esztergom: The first stop will be in Esztergom. Here was the first royal seat of the Hungarian kings. The town is the ecclesiastical center for Catholicism in Hungary. The cathedral is the largest in the country and a monumental work of the 19th century architecture. In the Crypt you can find the tomb of cardinal Mindszenty who demonstrating against the soviet occupation spent 15 years in internal exile at the US embassy in Budapest. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

Visegrád: The second stop is superbly situated on a horseshoe bend of the Danube. In the 5th century after the Romans withdraw from the area, Slavs built a castle on the top of the hill calling it higher castle: Visegrád. In the 13th century the Hungarians built a mighty citadel on the top again, with a wall running down to a lower castle near the river. Lunch will be served in the Restaurant Sirály.

Szentendre: Open Air Folk Museum: The next stop after lunch is the largest museum of its type in the country. The museum presents you the traditional types of settlements and the vernacular architecture of Hungary. You can get an inside look how people lived, worked according to the social strata they belonged to in the first decades of the 20th century.

Szentendre Downtown: The final stop will be the ever-popular small village. In the 17th century Serbian merchants fleeing from the Balkan brought their cultural heritage. Later the Serbs left, but the Serbian appearance remained. In the early 20th century Szentendre became a favorite place of Hungarian artists and has been since then. So in your free time you can spend your savings in one of the thousand and one boutiques selling art and crafts, embroideries, leather wear. Departure time: 09.00 a.m. Price: 55€ / person Duration: 8,5 hours (min. 25 persons) 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org ACCOMMODATION

Novotel Budapest Congress & World Trade Center****

Location The completely renovated 4-star hotel was built directly together with Hungary’s largest conference center, which will be the congress venue. By public transport the city center can be easily reached, from where all railway stations can be approached by subway.

How to get to the congress venue The hotel is the congress venue.

Hotel services Wellness Center (Turkish bath, sauna, swimming pool, fitness centre), bowling alley, restaurant. The hotel disposes of 319 new Novation rooms.

Room services All rooms are equipped with bathroom, telephone, high-speed or wireless Internet access, LCD TV, number combination locked room safe, water heater machine. Non-smoking rooms are available too. Executive rooms offer the following services free of charge: WIFI, in-house movie, local telephone calls, large screen LCD TV, Nespresso coffee machine, dressing gown, slippers and mineral water prepared in the room.

Hilton Budapest Hotel*****

Location The hotel is situated in the heart of the historic Castle District that is a UNESCO World Heritage site and is accordingly strictly protected. In keeping with such traditions, the Hilton Budapest has certainly preserved the spirit of the Castle District. A perfect example would be the restored remains of a 13th century Dominican churchyard and cloisters that are now incorporated into the contemporary building. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

How to get to the congress venue (by public transport) By bus Nr. 16 until Moszkva tér (end station), than by tram Nr. 61.

Hotel services Restaurants, lobby bar, coffee shop, wine cellar, drink bar, business centre, central safe, function rooms, boutique, Wireless Internet access (surcharge), computer connection, baby-sitter (upon request), laundry, dry cleaning, gym, fitness, sauna, solarium, beauty parlour, beauty salon, hairdresser.

Parking The hotel has a garage and closed parking place. All hotel guests get a free “Castle District car-pass”, allowing them to use the parking places.

Room services Security key card system, three IDD telephones, Wireless Internet access (surcharge), modem point, voicemail, convenient working desk, Colour TV with remote control, satellite channels, on-demand movies, radio, safe, tea and coffee making facilities, minibar, air conditioning, iron and ironing board, bathrobe & slippers. The executive rooms offer Executive Lounge access with free breakfast and refreshments, from the Danube side rooms you can enjoy the marvelous view of the river.

Budapest Marriott Hotel*****

Location The 5-star hotel is strategically located in a prime position along the famous riverside promenade and affords spectacular view of the Danube River and the Castle Hill. Contemporary comfort, stylish decor and an enchanting view of the Danube from your private balcony are only a few of the stunning features to be enjoyed in air-conditioned guest rooms and suites. The city’s central point, Deák tér (underground station) is situated a few minutes walk from the hotel.

How to get to the congress venue (by public transport) Ferenciek tere is located a few minutes walk, from there the congress venue can be reached by bus Nr. 8 or Nr. 112 (4 stops). 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

Hotel services All 364 hotel rooms were ergonomically developed and designed to ensure intense comfort and technological novelties for the guests. 24-hour room service, daily housekeeping, valet dry cleaning, guest laundry, AQVA Lounge Bar with cool vibes and chilled music, Lobby Lounge, Peppers! Mediterranean Grill, copy, fax messenger service, network/Internet printing, post/parcel, secretarial service, translator, babysitting, cash machine/ATM, newspaper delivered to room, newspaper in lobby, safe deposit boxes, high-speed Internet access.

Room services Air conditioning, alarm clock, complimentary service: tea and coffee making facilities, crib, electrical adapters, Internet browser/Web TV, iron and ironing board, luxurious bedding - down comforters, custom duvets, cotton-rich linens, pillows: foam, pull-out sofa bed, rollaway bed, safe, trouser press, hair dryer, cable/satellite TV, colour TV, minibar.

Mercure Budapest City Center****

Location The four-star hotel has a unique location, built in the pedestrian street called Váci utca, in the heart of Budapest’s tourist and business quarter. In the course of the hotel’s reconstruction the aim was to develop an environment visualizing the hotel’s themes, named as ’Budapest’s Essence’. The city’s central point, Deák tér (underground station) is situated a few minutes walk from the hotel, all railway stations can be reached easily.

How to get to the congress venue (by public transport) Ferenciek tere is located a few minutes walk, from there the congress venue can be reached by bus Nr. 8 or Nr. 112 (4 stops).

Hotel services The hotel has a restaurant, parking places, free Internet in the bar. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

Room services The hotel has 227 comfortable, light, renewed rooms. All rooms are equipped with bathroom, air-conditioning, telephone, minibar, radio, LCD TV with satellite channels, Pay TV, Wi-Fi for extra payment, in-room safe, smoke detector, hair-dryer. Non-smoking rooms are availabe too.

Danubius Hotel Budapest****

Location The hotel is located in a green residential area at the foot of the Buda Hills and near the Royal Castle district. It is a welcoming and pleasant hotel uniquely designed to offer a breathtaking 360º panorama over the city and Buda Hills.

How to get to the congress venue (by public transport): 5 stops by tram Nr. 61.

Hotel services Business centre, internet access, room service, sauna, souvenir shop, newspaper stand, hotel safe, parking for cars and coaches (for a fee). Restaurant Budapest serves international and . Coffee shop, summer terrace.

Room services The hotel comprises of 280 air-conditioned rooms and 9 suites with bath. The rooms are equipped with hairdryer, telephone, minibar, radio, Sat.-TV, Pay-TV. Some rooms have a safe. Rooms for smokers and connecting rooms are available.

Danubius Hotel Flamenco****

Location The hotel is located in the green belt of Buda, in the direct vicinity of the wonderful Feneketlen Tó (’Soundless Lake’). The hotel can be easily reached from the M1 and M7 highways, and the city center is accessible in 10 minutes as well. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

By public transport the city center and the main public transport centres can be reached by bus or by tram in 10 minutes from the hotel.

How to get to the congress venue (by public transport) 5 stops by tram Nr. 61.

Hotel services Restaurant, garage, Internet corner, gift shop can be found in the hotel. In the Danubius Premier Fitness Center swimming pool, sauna and well-equipped modern fitness room is awaiting the guests.

Room services In the 350 hotel rooms bathroom, air-conditioning, satellite TV, movie-channel for extra charge, minibar, telephone, radio, hair dryer, built-in safe, tea- and coffee making facilities and Internet-access are at the guests’ disposal. Non-smoking rooms are also available upon request.

Mercure Budapest Buda****

Location The hotel is located in the heart of Budapest, in immediate vicinity of the historical Castle- district and the Southern Railway Station, in pleasant surroundings, next to a nice park. The most important touristic sights and the Buda-side business quarter can be easily reached from the hotel, as well as all railway stations.

How to get to the congress venue (by public transport) 4 stops by tram Nr. 61.

Hotel services Fitness and wellness center, swimming pool, sauna, solarium, fitness and gym machines, restaurant, gift shop, parking - for extra payment - can be found in the hotel.

Room services The hotel comprises of 390 comfortable rooms. All rooms are equipped with bathroom, air- conditioning, telephone, minibar, colour TV – with international channels –, magnetic key-card system, Wi-Fi-system. Non-smoking rooms are available too. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

Hotel Mediterrán****

Location The hotel is located in the Buda-side, near to the downtown, with convenient public transportation to the entire city centre.

How to get to the congress venue The congress venue can be reached by a few minutes walk.

Hotel services Restaurant, drink bar, internet corner.

Room services 220/240 V AC, air-conditioning, soundproofed windows, minibar, safe, telephone, Wireless Internet access (complimentary), television with movie channels.

Jagello Business Hotel***

Location The hotel is located on the Buda side of the town, in quiet green surroundings, near to the congress venue. The city centre, from where all railway stations can be connected by subway, can be easily reached by public transport.

How to get to the congress venue The congress venue can be reached by a few minutes walk.

Hotel services Breakfast room, bar, green garden and terrace.

Room services The hotel disposes of 24 sound-proof, air-conditioned rooms. All rooms are non-smoking and have smoke-alarm. The rooms are equipped with bathroom with shower, colour TV with satellite channels, telephone, minibar, hair dryer. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

MAP WITH THE HOTELS

INFORMATION ABOUT HUNGARY AND BUDAPEST

Transport Because of the favourable geographical situation of the country, Hungary can be reached easily by any form of transport.

Arrival to Budapest

By Air The Airport minibus service is popular and relatively cheap: for 9 Euro it will drop passengers anywhere within the city limits. A return ticket (18 Euro) is valid for six months. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

Airport information: www.malev.hu Central number: (+36-1) 296-9696 Flight information: (+36-1) 296-7000 Luggage search service: – Ferihegy 2A: (+36-1) 296-8108 (+36-1) 296-7217 – Ferihegy 2B: (+36-1) 295-3480 (+36-1) 296-7948 Telephone reservations for Malév flights: (+36-1) 235-3888 Airport minibus service: (+36-1) 296-8555

By Train Budapest has direct rail links to 25 capitals. There are more than 50 international connections each day. Trains depart every three hours between Budapest-Vienna, with a travel time of less than two and a half hours. Intercity links running between the capital and the major towns around Hungary are extremely popular and comfortable. There are three major international railway stations in Budapest: • Eastern Railway Station Budapest (Keleti pályaudvar) (VII. Baross tér) • Western Railway Station Budapest (Nyugati pályaudvar) (VI. Nyugati tér) • Southern Railway Station Budapest (Déli pályaudvar) (I. Krisztina krt. 37/a) Information on international rail links: (36+1) 461-5500, www.elvira.hu

All railway stations can be accessed by the metro (“Keleti pu.”, “Déli pu.” stop on Metro line 2, “Nyugati pu.” stop on Metro line 3).

By Passenger Car Of the four motorways and four highways in Hungary, seven depart from Budapest. Drivers are obliged to purchase a motorway sticker for the motorways M1, M3, M5 and M7 (obtainable at border crossing points and major petrol stations). The Hungarian Highway Code (KRESZ) is based on the Vienna and Geneva Convention, and as such, traffic signs and road markings are similar to those found in other European countries. However, it is important to highlight a few key traffic regulations that tourists visiting Hungary must observe at all times: use of seatbelts in the font and rear seats is compulsory; only mobile phones built-in or fitted with headset may be used in cars, and it is recommended that drivers making or receiving a call pull over to the side of the road in a safe area; drivers may not consume any alcohol before driving, and drunk drivers can be fined; the speed limit in built-up areas is 50 kph, outside built-up areas 90 kph, on the roads 110 kph and on motorways 130 kph; use of the horn in towns is only permitted in moments of danger. Hungarian Automobile Club (Magyar Autóklub) 24 hour helpline: (+36-1) 345-1755 Roadside breakdown service: 188 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

Transportation from/to the airport How to reach your hotel? From the airport – by Airport minibus or taxis In case of arriving by train – please get in contact with the Congress Secretariat in order to find the best solution ([email protected])

Public transportation Budapest has an efficient public transport network made up more than 180 bus, 14 trolleybus, 29 tram, and three metro lines. In general buses, trams and trolleybuses operate between 4.30 a.m. and 11 p.m. The three metro lines intersect at Deák Square in the centre of town. Metros run at 2-15 minutes intervals from 4.30 a.m. to 11.10 p.m. The local suburban train (HÉV) can be used to travel out to island in the south of the city, and to nearby Szentendre, Gödöllõ and Ráckeve. Maps sited at the entrances to metro stations give a comprehensive overview of the entire public transport network in Budapest. Conditions of travel are also included in German and English.

For more information see: www.bkv.hu, English version

Climate The climate is continental. At the time of the congress, it is early summer in Hungary. Usually the weather is warm with daily temperatures between 20-23 Co. Rain is possible, so a raincoat is recommended. For more information: www.weather.yahoo.com

Time Central European Summer Time (CEST) Greenwich mean time +1 hour; U.S. (EAST) +6 hours

Health requirements No vaccinations are required.

Entering the country Hungary is member of the Schengen area. In order to enter the country it is necessary to have a valid passport. If your country does not have a visa exemption agreement with Hungary, then it is wise to arrange an entry visa before leaving home.

Currency, credit cards, banking The currency in Hungary is the Forint (HUF). As at the beginning of November 2010 – 1 Euro ≈ 280 HUF 10th Congress of the European Association for Clinical Pharmacology and Therapeutics 26-29 June 2011, Budapest, Hungary www.eacpt2011.org

International credit cards are accepted for payment in most hotels, restaurants and shops. Exchange offices and machines are available throughout the town and at the Budapest Ferihegy Airport as well.

Opening hours Shops: food shops are open from 7 a.m. - 6 p.m., clothes shops between 10 a.m. - 6 p.m. Monday to Saturday. Shopping malls centres are also open on Sunday. Office hours: generally from 8 a.m. - 4 p.m. Monday to Friday Post offices: Monday - Friday 8 a.m. - 6 p.m., Saturday 8 a.m. - 1 p.m. Banks: Monday - Thursday 8 a.m. - 3 p.m., Friday 8 a.m. - 1 p.m.

Events / Programmes Hungary offers a stunning selection of programmes, and not only in the high season. Budapest has musical events every day of the year, while there is also a vigorous cultural life in all the major towns and cities. Major events are covered in the Event Calendar (published every year), while details of what’s on during the month are available in Budapest Panorama and Programmes in Hungary. For more information: www.budapestinfo.hu

Evening entertainment There are plenty of evening entertainment spots in the capital and countryside: besides the bars with shows, discos, jazz clubs and dance houses there are more than 20 casinos throughout the country.

Electricity 220 Volt, standard European 2 round-pin plugs are used.

For more information about Budapest www.budapest.hu, www.budapestinfo.hu