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Schizophrenia: Could It Be Prevented?
SCHIZOPHRENIA : COULD IT BE PREVENTED ? A SATELLITE MEETING OF THE 2014 ANNUAL MEETING OF THE SOCIETY OF BIOLOGICAL PSYCHIATRY MAY 7, 2014 NEW YORK HILTON MIDTOWN TABLE OF CONTENTS WELCOME MESSAGE 3 ACKNOWLEDGMENTS 4 PROGRAM 5 INTRODUCTION – PROF . MICHEL CUENOD 6 SESSION 1: CHAIRS & SPEAKERS 7 SESSION 2: CHAIRS & SPEAKERS 14 SESSION 3: CHAIRS & SPEAKERS 19 2 WELCOME MESSAGE Early detection of psychotic disorders has recently become a focus for research and clinical development, leading to a major conceptual shift in psychiatry, and to the development of a preventive approach to psychiatric disorders. Based on emerging evidence that treatment delay has a negative impact on outcome, specialized programs to reduce the duration of untreated psychosis and develop specifically adapted treatments have been initiated worldwide. To this effect, it is essential to understand the underlying causes and mechanisms in order to identify key biomarkers profiles, and to develop novel therapeutic and preventive measures based on the etio-pathophysiology. Our Symposium brings together a panel of distinguished leaders in the field, who will present the state of the art of schizophrenia research with focus on pathophysiological mechanisms, genetic and environmental risk factors and their interaction during neurodevelopment. Dialogs between academia and industry on innovative solutions to therapeutic targets will contribute to shape the perspectives on preventive measures. Details regarding the course of the Symposium as well as our speakers and chairs are listed below. We trust that they will meet with your interest, and that we will have an opportunity to share experience, expand our networks, discuss collaborations and cultivate friendships. We thank you for joining us and look forward to a fruitful event. -
381 Part 117—Drawbridge Operation
Coast Guard, DOT Pt. 117 c. Betterments llll $llll other than an order of apportionment, Expected savings in repair or maintenance nor relieve any bridge owner of any li- costs: ability or penalty under other provi- a. Repair llll $llll b. Maintenance llll $llll sions of that act. Costs attributable to requirements of rail- [CGD 91±063, 60 FR 20902, Apr. 28, 1995, as road and/or highway traffic llll amended by CGD 96±026, 61 FR 33663, June 28, $llll 1996; CGD 97±023, 62 FR 33363, June 19, 1997] Expenditure for increased carrying capacity llll $llll Expired service life of old bridge llll PART 117ÐDRAWBRIDGE $llll OPERATION REGULATIONS Subtotal llll $llll Share to be borne by the bridge owner Subpart AÐGeneral Requirements llll $llll Contingencies llll $llll Sec. Total llll $llll 117.1 Purpose. Share to be borne by the United States 117.3 Applicability. llll $llll 117.4 Definitions. Contingencies llll $llll 117.5 When the draw shall open. Total llll $llll 117.7 General duties of drawbridge owners and tenders. (d) The Order of Apportionment of 117.9 Delaying opening of a draw. Costs will include the guaranty of 117.11 Unnecessary opening of the draw. costs. 117.15 Signals. 117.17 Signalling for contiguous draw- § 116.55 Appeals. bridges. (a) Except for the decision to issue an 117.19 Signalling when two or more vessels are approaching a drawbridge. Order to Alter, if a complainant dis- 117.21 Signalling for an opened drawbridge. agrees with a recommendation regard- 117.23 Installation of radiotelephones. ing obstruction or eligibility made by a 117.24 Radiotelephone installation identi- District Commander, or the Chief, Of- fication. -
Acute Systemic Inflammation Up-Regulates Secretory Sphingomyelinase in Vivo: a Possible Link Between Inflammatory Cytokines and Atherogenesis
Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: A possible link between inflammatory cytokines and atherogenesis Ma-Li Wong*, Boxun Xie†, Nan Beatini†, Phan Phu‡, Sudhir Marathe†, Anthony Johns§, Philip W. Gold‡, Emmet Hirsch¶, Kevin Jon Williamsʈ, Julio Licinio*, and Ira Tabas†** *Department of Psychiatry and Biobehavioral Sciences, University of California, School of Medicine, Los Angeles, CA 90095-1761; Departments of †Medicine, Anatomy, and Cell Biology and ¶Obstetrics and Gynecology, Columbia University, New York, NY 10032; ‡Clinical Neuroendocrinology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1284; §Berlex Biosciences, Richmond, CA 94804; and ʈDorrance H. Hamilton Research Laboratories, Division of Endocrinology, Diabetes, and Metabolic Diseases, Thomas Jefferson University, Philadelphia, PA 19107 Edited by S. M. McCann, Pennington Biomedical Research Center, Baton Rouge, LA, and approved May 23, 2000 (received for review March 7, 2000) Inflammation plays a critical role in atherogenesis, yet the medi- sphingomyelinase (SMase) (20, 21). Ceramide generated from ators linking inflammation to specific atherogenic processes re- SMase activation has been reported to play roles in cytokine- main to be elucidated. One such mediator may be secretory mediated apoptosis, cellular differentiation, and cellular senes- sphingomyelinase (S-SMase), a product of the acid sphingomyeli- cence (20, 21), each of which may be important in the inflam- nase gene. The secretion of S-SMase by cultured endothelial cells matory response. Whereas studies in vitro have suggested roles is induced by inflammatory cytokines, and in vivo data have for several different mammalian SMase activities in various implicated S-SMase in subendothelial lipoprotein aggregation, ceramide signaling pathways (20, 21), a product of the acid macrophage foam cell formation, and possibly other atherogenic SMase (ASM) gene has been implicated in several specific processes. -
May 2012 [.Pdf]
CMU’S NEWS SOURCE FOR FACULTY & STAFF 5/12 ISSUE 2 S ILICON V ALLEY C AMPU S C ELEBRATE S D ECA D E OF S UCCE ss 4 QATAR ANNOUNCES CAMPUS SERVICE Hats Off! WINNERS 9 E A S T H ARLEM S TU D ENT S V I S IT CMU, P ITT 11 M EC H ANICAL E NGINEERING R ECOGNIZE D BY L EAGUE OF A MERICAN B ICYCLI S T S Breaking Ground Innovative Hub To House Biomedical, Nanotechnology, Energy Research n Bruce Gerson Carnegie Mellon’s recently approved 10-year master plan won’t be gathering dust anytime soon. The first building to be built under ELLON QATAR the new plan is a new research facility M that will house the Biomedical Engi- neering Department; an energy institute CARNEGIE focused on developing technologies to F Y O improve energy production, efficiency S and sustainability; and a nanotechnology fabrication lab, with space for approxi- HOTO COURTE mately 200 faculty members, researchers P and graduate students. Scheduled to break ground in the M EMBERS OF THE C A RNEGIE M ELLON IN Q A T A R C L A SS OF 2 0 1 2 RECEIVE D THEIR D IPLOM A S A T A M A Y 7 GR ad U A TION fall and to be completed in spring of CEREMONY A T THE Q A T A R N A TION A L C ONVENTION C ENTRE . W ITH 6 1 MEMBERS , THIS YE A R ’ S CL A SS W A S THE L A RGEST TO 2015, the 100,000-square-foot, GR ad U A TE FROM THE D OH A C A MPUS . -
The Queens Ribbon
The Queens Ribbon The proposed “Queens Ribbon” a bicycle-pedestrian bridge connecting Queens to Manhattan (rendering by T.Y. Lin International). A plan for three new car-free bridges to Manhattan’s Business District from Queens, Brooklyn, and New Jersey June 24, 2020 Table of Contents 1. Introduction 2. Background 3. The Need for Bicycle-Pedestrian Bridges 4. Three New Bridges – Alignment Options 5. Queens-Roosevelt Island-Midtown Manhattan Ribbon Bridge Case Study 6. Conclusion Appendices A. Worldwide Bicycle-Pedestrian Bridges B. Bicycling Growth in New York City C. Level of Service on East River Bridges D. Our Team 2 1. Introduction At the start of the Covid-19 crisis a group of transportation engineers began working together, on a pro bono basis, to develop a transportation system that would provide an almost risk-free method of travel to Manhattan’s Central Business District (CBD – Manhattan south of Central Park). The impetus for this grouping was the realization that the city may face similar epidemics, a severe flu season, or other man-made or natural disasters in the future. Experience told the group that the two forms of transportation that are most risk-free from both infections and crashes are walking and bicycling. These “active transportation” options are also healthy modes that burn calories, and build muscle, bone, heart, and lung strength while improving mental and emotional health. From this discussion, the idea of a bicycle-pedestrian bridge was born. Importantly, these facilities would be equitable. Costs to use them would be a pair of shoes or a bicycle. The group included teams from the Institute of Design & Each bridge could handle Construction (IDC) Innovation Hub of the NYU Tandon School approximately 20,000 people of Engineering, T.Y. -
January 2016 the Future of NYC Real Estate
January 2016 http://therealdeal.com/issues_articles/the-future-of-nyc-real-estate-2/ The Future of NYC real estate Kinetic buildings and 2,000-foot skyscrapers are just around the corner By Kathryn Brenzel The Hudson Yards Culture Shed, a yet-to-be-built arts and performance space at 10 Hudson Yards, just might wind up being the Batmobile of buildings. Dormant, it’s a glassy fortress. Animated, it will be able to extend its wings so-to-speak by sliding out a retractable exterior as a canopy. The design is a window into the future of New York City construction — and the role technology will play. This isn’t to say that a fleet of moving buildings will invade New York anytime soon, but the projects of the future will be smarter, more adaptive and, of course, more awe-inspiring. “I think you’re going to start having more and more facades that are more kinetic, that react to the environment,” said Tom Scarangello, CEO of Thornton Tomasetti, a New York-based engineering firm that’s working on the Culture Shed. For example, Westfield’s Oculus, the World Trade Center’s new bird-like transit hub, features a retractable skylight whose function is more symbolic than practical: It opens only on Sept. 11. As a whole, developers are moving away from the shamelessly reflective glass boxes of the past, instead opting for transparent-yet-textured buildings as well as slender, soaring towers à la Billionaires’ Row. They are already beginning to experiment with different building materials, such as trading steel for wood in the city’s first “plyscraper,” which is being planned at 475 West 18th Street. -
Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gamma
Molecular Neurobiology https://doi.org/10.1007/s12035-018-1359-3 Neuroimmunomodulation in Major Depressive Disorder: Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gamma Antonio Inserra1,2,3 & Claudio Alberto Mastronardi4,5 & Geraint Rogers6,7 & Julio Licinio8,9 & Ma-Li Wong1,2,9 Received: 29 April 2018 /Accepted: 19 September 2018 # The Author(s) 2018 Abstract Major depressive disorder (MDD) is one of the leading causes of disability worldwide, and its incidence is expected to increase. Despite tremendous efforts to understand its underlying biological mechanisms, MDD pathophysiology remains elusive and pharmacotherapy outcomes are still far from ideal. Low-grade chronic inflammation seems to play a key role in mediating the interface between psychological stress, depressive symptomatology, altered intestinal microbiology, and MDD onset. We review the available pre-clinical and clinical evidence of an involvement of pro-inflammatory pathways in the pathogenesis, treatment, and remission of MDD. We focus on caspase 1, inducible nitric oxide synthase, and interferon gamma, three inflammatory systems dysregulated in MDD. Treatment strategies aiming at targeting such pathways alone or in combination with classical therapies could prove valuable in MDD. Further studies are needed to assess the safety and efficacy of immune modulation in MDD and other psychiatric disorders with neuroinflammatory components. Keywords Major depressive disorder . MDD . Inflammation . Neuroinflammation . Caspase 1 . Inflammasome . T-helper 1 (Th1) . Interleukin 1 . Inducible nitric oxide synthase . Interferon gamma . Gut microbiome Introduction describe the elusive pathophysiology of MDD, including the monoamine hypothesis, the neurotrophic hypothesis, the gluta- Major depressive disorder (MDD) is a psychiatric disorder with mate hypothesis, the cytokine (or macrophage) hypothesis, and significant morbidity, mortality, disability, and economic bur- the microbiota-inflammasome hypothesis [8–13]. -
Four Freedoms Park Conservancy 2017 & 2018
Four Freedoms Park Conservancy 2017 & 2018 Four Freedoms Park Conservancy Board of Directors William J. vanden Heuvel, Founder & Chair Emeritus • Mrs. Franklin D. Roosevelt, Jr., Honorary Chair Barbara Shattuck Kohn, Chair • Sally Minard, Vice Chair • Alison M. von Klemperer, Secretary William R. Griffith, Treasurer • Clark Copelin • John S. Dyson • Barbara Georgescu • David Handler Donald B. Hilliker • Warren Hoge • Eduardo Jany • Jessica S. Lappin • Richard Lorenti • David A. Paterson James S. Polshek, Emeritus • Katrina vanden Heuvel • Chris Ward • William Whitaker, Ex Officio Four Freedoms Park Conservancy operates, maintains, and programs Franklin D. Roosevelt Four Freedoms State Park to the highest standard. As steward of this extraordinary civic space designed by Louis I. Kahn, the Conservancy advances President Roosevelt’s legacy and inspires, educates, and engages the public in the ideals of the Four Freedoms: freedom of speech and expression, freedom of worship, freedom from want, and freedom from fear. The Conservancy does this by: • safeguarding the memorial as a space for inspired use • fostering community and understanding • igniting conversation about human rights and freedoms today Connect with us and join the conversation: facebook.com/fdrfourfreedomspark | @4freedomspark | fdrfourfreedomspark.org New York State Office of Parks, Recreation and Historic Preservation, Rose Harvey, Commissioner Table of Contents A Message from Four Freedoms Park Conservancy Leadership 2 A Message from NY State Parks Commissioner Rose Harvey 3 Board Spotlight: Eduardo Jany 4 Park Visitorship 2013-2018: 1,000,000 & Counting 5 Planning for the Future: Preserving an Architectural 6 Masterpiece in the East River Inspiring the Next Generation Through FDR's Four Freedoms 8 Public Programs & Events at FDR Four Freedoms State Park 12 Four Freedoms Exemplars Lifetime Achievement Awards: 14 Honoring Tom Brokaw & William J. -
Franklin D. Roosevelt Four Freedoms Park Conservancy 133 East 62Nd Street New York, NY
Franklin D. Roosevelt Four Freedoms Park Conservancy 133 East 62nd Street New York, NY FRANKLIN D. ROOSEVELT FOUR FREEDOMS PARK UNVEILS DIGITAL EDUCATIONAL RESOURCE fdr4freedoms Provides Online Historical Component To Complement Four Freedoms Park And Extend Its Impact Into The Classroom New York, NY – October 24, 2012 – The Four Freedoms Park Conservancy unveiled today the first phase of fdr4freedoms, the comprehensive digital resource that chronicles the history of the Franklin D. Roosevelt era by using state-of-the-art digital technology to link Four Freedoms Park to classrooms in America and around the world. Four Freedoms Park in New York City is the stunning, new, public memorial to former President Franklin D. Roosevelt and the “Four Freedoms” that he outlined in his famous State of the Union Address in January of 1941. In that speech he articulated his vision of a more perfect world where Freedom of Speech and Expression, Freedom of Religion, Freedom from Want, and Freedom from Fear would exist for all, everywhere in the world. Four Freedoms Park opens this month, four decades after it was first conceived by Governor Nelson Rockefeller and Mayor John Lindsay and designed by world-renowned architect Louis Kahn. The Park is located spectacularly on the southern tip of Roosevelt Island, appropriately looking across the East River to the United Nations. Roosevelt Island was renamed in Franklin Roosevelt’s honor in 1973, but plans for the Park had to be put on hold at the time because the city was then on the verge of bankruptcy. Through the leadership of Ambassador William vanden Heuvel, the Park has now been realized, and New York City has added an extraordinarily beautiful and important, new, public space. -
SI Beagle Fall 2013.Indd
WELFARE FUND SI BEAGLE LEARNING CENTERS PROGRAM WWW.UFT.ORG VOLUME 28, NUMBER 1 FALL 2013 Any other questions, please call the main offi ce at 212-598- ❖ TO REGISTER HOW TO REGISTER 6879 from July 15, 2013-August 30, 2013. • Each registrant must complete a separate registration FALL LEARNING CENTER CLASS SCHEDULE ❖ ELIGIBILITY coupon with their name, last four digits of social security Start date: Monday, September 9, 2013 number, address, phone number and course information. End date: Tuesday, November 26, 2013 UFT retirees will be registered before spouses, registered • Provide the correct course/seminar/trip code(s) and domestic partners, AFT, NYSUT and PSC members. course/seminar/trip title(s) • Registration deadline: Monday, August 19, 2013 • Spouses, registered domestic partners, AFT, NYSUT and ❖ REGISTRATION FEES PSC members are wait-listed. Do not enclose a payment • Classes are 11 sessions, unless otherwise noted (See calen- ALL CHECKS/MONEY ORDERS MUST BE MADE dar below): for them. PAYABLE TO UFTWF RETIREE PROGRAMS • Each registrant must pay with his/her own checks/money WEEK Mondays Tuesdays Wednesdays Thursdays Fridays (NO CASH ACCEPTED). order made payable to UFTWF Retiree Programs. 1 9/9/13 9/10/13 9/11/13 9/12/13 9/13/13 Include on the checks/money orders the course number 2 9/23/13 9/24/13 9/25/13 9/26/13 9/27/13 Use the registration coupon for all courses, seminars, trips exactly as it appears in the course description. Enclose 9/23/13 9/24/13 9/25/13 9/26/13 9/27/13 3 and Defensive Driving. -
2014 ADA Posters 1319-2206.Indd
INTEGRATED PHYSIOLOGY—INSULINCATEGORY SECRETION IN VIVO 1738-P increase in tumor size and pulmonary metastasis is observed, compared Sustained Action of Ceramide on Insulin Signaling in Muscle Cells: to wild type mice. In this study, we aimed to determine the mechanisms Implication of the Double-Stranded RNA Activated Protein Kinase through which hyperinsulinemia and the canonical IR signaling pathway drive RIMA HAGE HASSAN, ISABELLE HAINAULT, AGNIESZKA BLACHNIO-ZABIELSKA, tumor growth and metastasis. 100,000 MVT-1 (c-myc/vegf overexpressing) RANA MAHFOUZ, OLIVIER BOURRON, PASCAL FERRÉ, FABIENNE FOUFELLE, ERIC cells were injected orthotopically into 8-10 week old MKR mice. MKR mice HAJDUCH, Paris, France, Białystok, Poland developed signifi cantly larger MVT-1 (353.29±44mm3) tumor volumes than Intramyocellular accumulation of fatty acid derivatives like ceramide plays control mice (183.21±47mm3), p<0.05 with more numerous pulmonary a crucial role in altering the insulin message. If short-term action of ceramide metastases. Western blot and immunofl uorescent staining of primary tumors inhibits the protein kinase B (PKB/Akt), long-term action of ceramide on insulin showed an increase in vimentin, an intermediate fi lament, typically expressed signaling is less documented. Short-term treatment of either the C2C12 cell in cells of mesenchymal origin, and c-myc, a known transcription factor. Both line or human myotubes with palmitate (ceramide precursor, 16h) or directly vimentin and c-myc are associated with cancer metastasis. To assess if insulin with ceramide (2h) induces a loss of the insulin signal through the inhibition and IR signaling directly affects the expression these markers, in vitro studies of PKB/Akt. -
BPCA-FY2020-Annual-Report.Pdf
Table of Contents 2020 Highlights .............................................................................................................................. 4 Mandatory Operational Reporting ............................................................................................. 9 1. Mission Statement and Performance Measures .............................................................. 9 2. Assessment of the Effectiveness of Internal Controls ................................................... 14 3. Material Changes in Operations ..................................................................................... 15 4. Property Acquisition and Disposal Summary ............................................................... 16 5. Material Pending Litigation ............................................................................................ 17 Financials ..................................................................................................................................... 19 1. Financial Reports ............................................................................................................. 20 2. Debt Administration ........................................................................................................ 30 3. Four Year Financial Plan .............................................................................................. 39 4. Assets and Services Procured Without Competitive Bidding ...................................... 40 Historical Information ...............................................................................................................