U.S. Department of Health and Human Services

Total Page:16

File Type:pdf, Size:1020Kb

U.S. Department of Health and Human Services U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES SECRETARY'S ADVISORY COMMITTEE ON GENETICS, HEALTH, AND SOCIETY Eighth Meeting Friday, October 20, 2005 Brookside Room A/B Marriott Bethesda North Hotel and Montgomery County Conference Center 5701 Marinelli Road North Bethesda, Maryland IN ATTENDANCE: Acting Chair Cynthia E. Berry, J.D. Partner Powell Goldstein LLP 901 New York Avenue, N.W., 3rd Floor Washington, D.C. 20001 Members Sylvia Mann Au, M.S., C.G.C. State Genetics Coordinator Hawaii Department of Health Genetics Program 741 Sunset Avenue Honolulu, HI 96816 Chira Chen Staff Research Associate Comprehensive Cancer Center University of California, San Francisco 2340 Sutter Street, Suite N171 San Francisco, CA 94115 James P. Evans, M.D., Ph.D. Director of Clinical Genetics and the Bryson Program in Human Genetics University of North Carolina, Chapel Hill Medical Bioinformatics Research Building, Suite 4200 CB# 7264 103 Mason Farm Road Chapel Hill, NC 27599-7624 Kevin T. FitzGerald, S.J., Ph.D. Dr. David P. Lauler Chair in Catholic Health Care Ethics Research Associate Professor Department of Oncology Georgetown University Medical Center Building D, Suite 236 4000 Reservoir Road, N.W. Washington, D.C. 20057 IN ATTENDANCE: Julio Licinio, M.D. Professor of Psychiatry and Medicine/Endocrinology Neuropsychiatric Institute David Geffen School of Medicine at UCLA University of California, Los Angeles Gonda Center, Room 3357A 695 Charles Young Drive South Los Angeles, CA 90095-1761 Agnes Masny, R.N., M.P.H., M.S.N. Adjunct Assistant Professor of Nursing Temple University College of Allied Health Professionals Research Assistant and Nurse Practitioner Family Risk Assessment Program Fox Chase Cancer Center Prevention Pavilion 7701 Burholme Avenue Philadelphia, PA 19111 Joseph Telfair, Dr.P.H., M.S.W., M.P.H. Associate Professor Department of Maternal and Child Health School of Public Health University of Alabama at Birmingham 1665 University Boulevard, Room 320 Birmingham, AL 35294-0022 Emily S. Winn-Deen, Ph.D. Vice President Strategic Planning and Business Development Cepheid 904 Caribbean Drive Sunnyvale, CA 94089 IN ATTENDANCE: Ex Officio Members Agency for Healthcare Research and Quality Francis D. Chesley, Jr., M.D. Director Office of Extramural Research, Education, and Priority Populations Agency for Healthcare Research and Quality 540 Gaither Road Rockville, MD 20850 Centers for Disease Control and Prevention Muin J. Khoury, M.D., Ph.D. Director Office of Genomics and Disease Prevention Centers for Disease Control and Prevention 4770 Buford Highway, MS K-89 Atlanta, GA 30341 Centers for Medicare and Medicaid Services James Rollins, M.D. Centers for Medicare and Medicaid Services 7500 Security Boulevard Baltimore, MD 21244-1850 Department of Energy Daniel Drell, Ph.D. Biologist Life Sciences Division Office of Biological and Environmental Research Department of Energy 1000 Independence Avenue, S.W. Washington, D.C. 20585-1290 Department of Labor Amy Turner U.S. Department of Labor 200 Constitution Avenue, N.W. Washington, D.C. 20210 IN ATTENDANCE: Department of Veteran Affairs Sherrie Hans, M.D. U.S. Department of Veteran Affairs 810 Vermont Avenue, N.W. Washington, D.C. 20420 Equal Employment Opportunity Commission Peter Gray, J.D. Senior Attorney Advisor Office of Legal Counsel Equal Employment Opportunity Commission 1801 L Street, N.W. Washington, D.C. 20507 Food and Drug Administration Steven Gutman, M.D., M.B.A. Director Office for In Vitro Diagnostic Device Evaluation and Safety Food and Drug Administration 2098 Gaither Road, MSC HFZ 440 Rockville, MD 20850 Health Resources and Services Administration Suzanne Feetham, Ph.D., R.N., FAAN Senior Program Manager Center for Quality Health Resources and Services Administration Parklawn Building, Room 7-100 Rockville, MD 20857 National Institutes of Health Alan E. Guttmacher, M.D. Deputy Director National Human Genome Research Institute National Institutes of Health Building 31, Room 4B09 31 Center Drive, MSC 2152 Bethesda, MD 20982 IN ATTENDANCE: Office for Civil Rights Robinsue Frohboese, J.D., Ph.D. Principal Deputy Director Office for Civil Rights 200 Independence Avenue, S.W., Room 515F Washington, D.C. 20201 Office for Human Research Protections Michael A. Carome, M.D. Associate Director for Regulatory Affairs Office for Human Research Protections 1101 Wootton Parkway, Suite 200 Rockville, MD 20852 Executive Secretary Sarah Carr Secretary's Advisory Committee on Genetics, Health, and Society NIH Office of Biotechnology Activities 6705 Rockledge Drive, Suite 750, MSC 7985 Bethesda, MD 20892-7985 C O N T E N T S PAGE Call to Order Cynthia E. Berry, J.D. Acting SACGHS Chair 10 Vote on Coverage and Reimbursement Report 10 Genetic Discrimination Session Update on the Status of the Genetic Information Nondiscrimination Act of 2005 (S. 306/H.R. 1227) Frank Swain Coalition for Genetic Fairness 15 Public Attitudes Toward Advances in Genetics, Genetic Privacy, and the Misuse of Genetic Information Christy White Cogent Research 20 Q&A and Committee Discussion 31 Pharmacogenomics Session Update from the SACGHS Task Force on Pharmacogenomics Emily S. Winn-Deen, Ph.D. SACGHS Task Force Chair 41 Update from the Food and Drug Administration Steven I. Gutman, M.D., M.B.A. Director Office of In Vitro Diagnostics, FDA 45 Allen Rudman, Ph.D. Associate Director Office of Clinical Pharmacology and Biopharmaceutics Center for Drug Evaluation and Research, FDA 51 Q&A and Committee Discussion Facilitator: Emily S. Winn-Deen, Ph.D. 59 Public Comments Jean F. Jenkins, Ph.D., R.N., FAAN International Society of Nurses in Genetics 66 Pharmacogenomics Session Feasibility of Integrating Pharmacogenomics into Drug Development from an Economic Perspective Thomas A. Metcalfe Head of Biomarker Program F. Hoffman-La Roche, Ltd. 70 Economic Challenges of Integrating Pharmacogenomics into Clinical Practice Kathryn Phillips, Ph.D. Professor of Health Economics and Health Services Research Director, Program in Pharmacogenomics and Population Screening University of California, San Francisco 85 Q&A and Committee Discussion Facilitator: Emily S. Winn-Deen, Ph.D. 92 Ethical and Social Issues Associated with Using Race and Genetics in the Study of Differential Drug Response Wylie Burke, M.D., Ph.D. Professor and Chair Department of Medical History and Ethics University of Washington 102 Q&A and Committee Discussion Facilitator: Emily S. Winn-Deen, Ph.D. 116 Discussion of Next Steps, Work Plan, and Final Work Product for Pharmacogenomics Facilitators: Emily S. Winn-Deen, Ph.D., and Cynthia E. Berry, J.D. 124 Planning for March, 2006 SACGHS Meeting and Concluding Remarks Cynthia E. Berry, J.D. 136 P R O C E E D I N G S (8:33 a.m.) MS. BERRY: Good morning. In keeping with our new tradition of reviewing military history, I'll tell you that today, on this day in 1944, keeping his "I shall return" pledge to the people of the Philippines, General Douglas MacArthur waded ashore, and just like General MacArthur, the SACGHS has returned on its second day of our October meeting. (Laughter.) DR. EVANS: Hopefully there will be less carnage. (Laughter.) MS. BERRY: Yes, a lot less carnage. Sort of a clean-up item to begin with. Yesterday we mentioned the coverage and reimbursement report and the recommendations that were edited and distributed to you. There was the original version, and then the edited version, members of the committee were supposed to take a look at those. What we're going to do is not have a protracted discussion and try to edit and reedit, because that just takes too long. What we'll have is essentially an up or down vote. Will we accept the staff recommendations for some of the editorial comments, the green- line version that you have? Yes or no? If it's no, we will go back to the original language that the committee approved at our last meeting. So we'll just go around the room. Do we have everybody here? Yes, I think so. So the question will be on approval of the edited version of the recommendations for the Coverage and Reimbursement Task Force, the green-line version that you all have. I guess we'll start with Jim. DR. EVANS: I vote for approving the edited version. MS. BERRY: Chira? MS. CHEN: I would do the same. DR. FITZGERALD: Yes to the edited. MS. BERRY: Agnes? MS. MASNY: I would say yes to the edited. The only thing is I do have a question, sort of a concern that came up to me, especially in view of yesterday's discussion. That is for item number seven, just a clarification point where we say genetic counseling to be able to provide full access of genetic counseling services for all Americans, and then it goes on to identify a body who would oversee to determine who is appropriate to provide this kind of counseling. I think that, and I don't know if the committee would like to look at using the word not just "genomic," but "genetic counseling." I think that if we leave just genetic counseling, I think genetic counseling implies specifically genetic counseling for single-gene disorders, and I think the information that we heard, specific profession and a specific specialty. I think with the information that we heard yesterday, that we need to have prepared health professionals who will be able to provide and possibly bill for genetic, genomic counseling, and education services. So I just think that we should have a little bit of foresight. I don't know if the task force would want to address that, or if in fact this was just intended for genetic counseling. MS. BERRY: Suzanne? MS. GOODWIN: You guys don't have a full copy of the report, but at the beginning, we had, at your request, added some definitions of some of the terminology used throughout the report.
Recommended publications
  • Schizophrenia: Could It Be Prevented?
    SCHIZOPHRENIA : COULD IT BE PREVENTED ? A SATELLITE MEETING OF THE 2014 ANNUAL MEETING OF THE SOCIETY OF BIOLOGICAL PSYCHIATRY MAY 7, 2014 NEW YORK HILTON MIDTOWN TABLE OF CONTENTS WELCOME MESSAGE 3 ACKNOWLEDGMENTS 4 PROGRAM 5 INTRODUCTION – PROF . MICHEL CUENOD 6 SESSION 1: CHAIRS & SPEAKERS 7 SESSION 2: CHAIRS & SPEAKERS 14 SESSION 3: CHAIRS & SPEAKERS 19 2 WELCOME MESSAGE Early detection of psychotic disorders has recently become a focus for research and clinical development, leading to a major conceptual shift in psychiatry, and to the development of a preventive approach to psychiatric disorders. Based on emerging evidence that treatment delay has a negative impact on outcome, specialized programs to reduce the duration of untreated psychosis and develop specifically adapted treatments have been initiated worldwide. To this effect, it is essential to understand the underlying causes and mechanisms in order to identify key biomarkers profiles, and to develop novel therapeutic and preventive measures based on the etio-pathophysiology. Our Symposium brings together a panel of distinguished leaders in the field, who will present the state of the art of schizophrenia research with focus on pathophysiological mechanisms, genetic and environmental risk factors and their interaction during neurodevelopment. Dialogs between academia and industry on innovative solutions to therapeutic targets will contribute to shape the perspectives on preventive measures. Details regarding the course of the Symposium as well as our speakers and chairs are listed below. We trust that they will meet with your interest, and that we will have an opportunity to share experience, expand our networks, discuss collaborations and cultivate friendships. We thank you for joining us and look forward to a fruitful event.
    [Show full text]
  • Acute Systemic Inflammation Up-Regulates Secretory Sphingomyelinase in Vivo: a Possible Link Between Inflammatory Cytokines and Atherogenesis
    Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: A possible link between inflammatory cytokines and atherogenesis Ma-Li Wong*, Boxun Xie†, Nan Beatini†, Phan Phu‡, Sudhir Marathe†, Anthony Johns§, Philip W. Gold‡, Emmet Hirsch¶, Kevin Jon Williamsʈ, Julio Licinio*, and Ira Tabas†** *Department of Psychiatry and Biobehavioral Sciences, University of California, School of Medicine, Los Angeles, CA 90095-1761; Departments of †Medicine, Anatomy, and Cell Biology and ¶Obstetrics and Gynecology, Columbia University, New York, NY 10032; ‡Clinical Neuroendocrinology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1284; §Berlex Biosciences, Richmond, CA 94804; and ʈDorrance H. Hamilton Research Laboratories, Division of Endocrinology, Diabetes, and Metabolic Diseases, Thomas Jefferson University, Philadelphia, PA 19107 Edited by S. M. McCann, Pennington Biomedical Research Center, Baton Rouge, LA, and approved May 23, 2000 (received for review March 7, 2000) Inflammation plays a critical role in atherogenesis, yet the medi- sphingomyelinase (SMase) (20, 21). Ceramide generated from ators linking inflammation to specific atherogenic processes re- SMase activation has been reported to play roles in cytokine- main to be elucidated. One such mediator may be secretory mediated apoptosis, cellular differentiation, and cellular senes- sphingomyelinase (S-SMase), a product of the acid sphingomyeli- cence (20, 21), each of which may be important in the inflam- nase gene. The secretion of S-SMase by cultured endothelial cells matory response. Whereas studies in vitro have suggested roles is induced by inflammatory cytokines, and in vivo data have for several different mammalian SMase activities in various implicated S-SMase in subendothelial lipoprotein aggregation, ceramide signaling pathways (20, 21), a product of the acid macrophage foam cell formation, and possibly other atherogenic SMase (ASM) gene has been implicated in several specific processes.
    [Show full text]
  • Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gamma
    Molecular Neurobiology https://doi.org/10.1007/s12035-018-1359-3 Neuroimmunomodulation in Major Depressive Disorder: Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gamma Antonio Inserra1,2,3 & Claudio Alberto Mastronardi4,5 & Geraint Rogers6,7 & Julio Licinio8,9 & Ma-Li Wong1,2,9 Received: 29 April 2018 /Accepted: 19 September 2018 # The Author(s) 2018 Abstract Major depressive disorder (MDD) is one of the leading causes of disability worldwide, and its incidence is expected to increase. Despite tremendous efforts to understand its underlying biological mechanisms, MDD pathophysiology remains elusive and pharmacotherapy outcomes are still far from ideal. Low-grade chronic inflammation seems to play a key role in mediating the interface between psychological stress, depressive symptomatology, altered intestinal microbiology, and MDD onset. We review the available pre-clinical and clinical evidence of an involvement of pro-inflammatory pathways in the pathogenesis, treatment, and remission of MDD. We focus on caspase 1, inducible nitric oxide synthase, and interferon gamma, three inflammatory systems dysregulated in MDD. Treatment strategies aiming at targeting such pathways alone or in combination with classical therapies could prove valuable in MDD. Further studies are needed to assess the safety and efficacy of immune modulation in MDD and other psychiatric disorders with neuroinflammatory components. Keywords Major depressive disorder . MDD . Inflammation . Neuroinflammation . Caspase 1 . Inflammasome . T-helper 1 (Th1) . Interleukin 1 . Inducible nitric oxide synthase . Interferon gamma . Gut microbiome Introduction describe the elusive pathophysiology of MDD, including the monoamine hypothesis, the neurotrophic hypothesis, the gluta- Major depressive disorder (MDD) is a psychiatric disorder with mate hypothesis, the cytokine (or macrophage) hypothesis, and significant morbidity, mortality, disability, and economic bur- the microbiota-inflammasome hypothesis [8–13].
    [Show full text]
  • 2014 ADA Posters 1319-2206.Indd
    INTEGRATED PHYSIOLOGY—INSULINCATEGORY SECRETION IN VIVO 1738-P increase in tumor size and pulmonary metastasis is observed, compared Sustained Action of Ceramide on Insulin Signaling in Muscle Cells: to wild type mice. In this study, we aimed to determine the mechanisms Implication of the Double-Stranded RNA Activated Protein Kinase through which hyperinsulinemia and the canonical IR signaling pathway drive RIMA HAGE HASSAN, ISABELLE HAINAULT, AGNIESZKA BLACHNIO-ZABIELSKA, tumor growth and metastasis. 100,000 MVT-1 (c-myc/vegf overexpressing) RANA MAHFOUZ, OLIVIER BOURRON, PASCAL FERRÉ, FABIENNE FOUFELLE, ERIC cells were injected orthotopically into 8-10 week old MKR mice. MKR mice HAJDUCH, Paris, France, Białystok, Poland developed signifi cantly larger MVT-1 (353.29±44mm3) tumor volumes than Intramyocellular accumulation of fatty acid derivatives like ceramide plays control mice (183.21±47mm3), p<0.05 with more numerous pulmonary a crucial role in altering the insulin message. If short-term action of ceramide metastases. Western blot and immunofl uorescent staining of primary tumors inhibits the protein kinase B (PKB/Akt), long-term action of ceramide on insulin showed an increase in vimentin, an intermediate fi lament, typically expressed signaling is less documented. Short-term treatment of either the C2C12 cell in cells of mesenchymal origin, and c-myc, a known transcription factor. Both line or human myotubes with palmitate (ceramide precursor, 16h) or directly vimentin and c-myc are associated with cancer metastasis. To assess if insulin with ceramide (2h) induces a loss of the insulin signal through the inhibition and IR signaling directly affects the expression these markers, in vitro studies of PKB/Akt.
    [Show full text]
  • LEPTIN ENDOCRINE UPDATES Shlomo Melmed, M.D., Series Editor
    LEPTIN ENDOCRINE UPDATES Shlomo Melmed, M.D., Series Editor J.A. Fagin (ed.): Thyroid Cancer. 1998. ISBN: 0-7923-8326-5 J.S. Adams and B.P. Lukert (eds.): Osteoporosis: Genetics, Prevention and Treatment. 1998. ISBN: 0-7923-8366-4. B.-A. Bengtsson (ed.): Growth Hormone. 1999. ISBN: 0-7923-8478-4 C. Wang (ed.): Male Reproductive Function. 1999. ISBN: 0-7923-8520-9 B. Rapoport and S.M. McLachlan (eds.): Graves' Disease: Pathogenesis and Treatment. 2000. ISBN: 0-7923-7790-7. W. W. de Herder (ed.): Functional and Morphological Imaging of the Endocrine System. 2000. ISBN 0-7923-7923-9 H.G. Burger (ed.): Sex Hormone Replacement Therapy. 2001. ISBN 0-7923-7965-9 A. Giustina (ed.): Growth Hormone and the Heart. 2001. ISBN 0-7923-7212-3 W.L. Lowe, Jr. (ed.): Genetics of Diabetes Mellitus. 2001. ISBN 0-7923-7252-2 J.F. Habener and M.A. Hussain (eds.): Molecular Basis of Pancreas Development and Function. 2001. ISBN 0-7923-7271-9 N. Horseman (ed.): Prolactin. 2001. ISBN 0-7923-7290-5 M. Castro (ed.): Transgenic Models in Endocrinology. 2001 ISBN 0-7923-7344-8 R. Bahn (ed.): Thyroid Eye Disease. 2001. ISBN 0-7923-7380-4 M.D. Bronstein (ed.): Pituitary Tumors in Pregnancy ISBN 0-7923-7442-8 K. Sandberg and S.E. Mulroney (eds.): RNA Binding Proteins: New Concepts in Gene Regulation. 2001. ISBN 0-7923-7612-9 V. Goffin and P. A. Kelly (eds.): Hormone Signaling. 2002 ISBN 0-7923-7660-9 M. C. Sheppard and P. M. Stewart (eds.): Pituitary Disease. 2002 ISBN 1-4020-7122-1 N.
    [Show full text]
  • The Difference You Make
    THE DIFFERENCE YOU MAKE ANNUAL REPORT 2018–2019 TIME, TALENT, AND TREASURE This annual report affords me the chance to reflect on theT school’shis annual accomplishments report affords me over the chancethe past to yearreflect Center, and the Tata Innovation Center — that serve as withon thepride school’s and gratitude. accomplishments I am struck over by the what past we’ve year Johnson’s collective home. beenwith able pride to and achieve gratitude. together, I am stranduck so by grateful what we’ve Also in the vein of bringing people together, the forbeen the able community to achieve that together has built, and our so legacy grateful and for the Tata Innovation Center on Roosevelt Island now hosts continuescommunity to thatsupport has builtour ongoing our legacy growth. and continues numerous key Johnson programs: our Executive MBA/ to support our ongoing growth. MS in Healthcare Leadership, the Executive MBA Metro You are that community, and you are the reason NY, and, of course, the Cornell Tech MBA, as well as for Johnson’s success. supporting half-semester intensives and weekend As we all know, the people who make up courses that bring our Ithaca-based students to study Johnson are bright, driven, and accomplished, but what’s truly at the Cornell Tech campus. These significant developments help exceptional is their engagement and dedication. Members of the tie together different programs and student communities, allowing Johnson community have given so much of themselves to help students in executive MBA and residential MBA programs to work realize our success, and their ongoing dedication is inspiring.
    [Show full text]
  • The First International Conference on Translational Medicine
    Molecular Psychiatry (2010) 15, 878–879 & 2010 Macmillan Publishers Limited All rights reserved 1359-4184/10 www.nature.com/mp EDITORIAL The First International Conference on Translational Medicine Molecular Psychiatry (2010) 15, 878–879; doi:10.1038/ Table 1 First International Conference on Translational mp.2010.91 Medicine (The 13th Frank and Bobbie Fenner Conference), 1–4 November 2010, John Curtin School of Medical Research, As our mission to foster translational medicine ANU, Canberra, Australia continues to evolve, we have now conceptualized Participant leaders from the USA, Europe, China, and launched a new international conference to cover Singapore and Australia: the transition from discovery to healthcare and global Warwick Anderson, CEO, NHMRC, Australia health. The First International Conference on Transla- Juan Carlos Lopez, Chief Editor, Nature Medicine tional Medicine (the 13th Frank and Bobbie Fenner Anthony Hayward, Director, Clinical and Translational Conference) has a highly innovative mission of Program, NIH, USA bringing together into a global domain what have so Alan Schechter, Chief, Molecular Medicine, NIDDK, far been nationally focused efforts in translational NIH, USA medicine, such as the United States Clinical and Clay Johnston, Director, UCSF Clinical and Translational Translational Science Award (CTSA) mechanism and Science Institute the United Kingdom Academic Health Science Centre Anantha Shekhar, Director, Indiana Translational Institute, USA (AHSC) program. Initiatives from Ireland, which Dame Sally Davies, Director General of Research and created one academic health science center for the Development and Chief Scientific Adviser for the entire country, from China, Singapore and Australia Department of Health and NHS, London, UK will also be discussed and presented (see Table 1).
    [Show full text]
  • Acetyl-L-Carnitine Deficiency in Patients with Major Depressive Disorder
    Acetyl-L-carnitine deficiency in patients with major SEE COMMENTARY depressive disorder Carla Nascaa,1, Benedetta Bigioa,b, Francis S. Leec,d, Sarah P. Younge,f, Marin M. Kautzg, Ashly Albrightd, James Beasleyf, David S. Millingtone,f, Aleksander A. Mathéh, James H. Kocsisd, James W. Murroughg, Bruce S. McEwena,1, and Natalie Rasgona,i aHarold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065; bBiostatistics and Experimental Research Design, Center for Clinical and Translational Science, The Rockefeller University, New York, NY 10065; cSackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065; dDepartment of Psychiatry, Weill Cornell Medical College, New York, NY 10065; eDivision of Medical Genetics, Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710; fBiochemical Genetics Laboratory, Duke University Health System, Durham, NC 27710; gMood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029; hDepartment of Clinical Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden; and iCenter for Neuroscience in Women’s Health, Stanford University, Palo Alto, CA 94305 Contributed by Bruce S. McEwen, June 15, 2018 (sent for review February 2, 2018; reviewed by Julio Licinio, Robert M. Post, and Charles L. Raison) The lack of biomarkers to identify target populations greatly limits neurotrophic factor (BDNF) and a critical regulator of synaptic the promise of precision medicine for major depressive disorder glutamate release, the metabotropic glutamate receptor of class-2, (MDD), a primary cause of ill health and disability. The endoge- mGlu2 (10, 16–18). In several animal models, LAC supplementa- nously produced molecule acetyl-L-carnitine (LAC) is critical for hip- tion has been shown to ameliorate glutamatergic dysfunction and pocampal function and several behavioral domains.
    [Show full text]
  • Annual Meeting
    2018 Annual Meeting Preliminary Program and Registration Information Join the conversation: #APAAM18 psychiatry.org/annualmeeting ANNUAL MEETING May 5-9, 2018 • New York City 2 Table of Contents Building Well-Being Through Innovation 3 Frequently Asked Questions 39 Schedule-at-a-Glance 5 Getting to New York 45 General Information 7 Hotel Reservation Information 50 Program Format Descriptions 11 Hotel Descriptions 51 Learning Labs 14 Hotel Listings and Amenities 55 Master Course Listings 18 Hotel Map 57 Course Listings 20 Shuttle Bus Routes 58 Scientific Program Lecturers 35 Registration Information 59 APA Administration Meetings and Conventions Scientific Program Committee Consultants CEO and Medical Cathy L. Nash, CMP Linda L. M. Worley, M.D. Josepha Cheong, M.D. Director's Office Director Chairperson David F. Gitlin, M.D. Jacqueline Feldman, M.D. Saul Levin, M.D., M.P.A. Vernetta Copeland Margo Lauterbach, M.D. Iqbal Ahmed, M.D. Chief Executive Officer and Associate Director Susan V. McLeer, M.D. Medical Director Vice-Chairpersons Stephanie Dumey, CMP Sarah Oreck, M.D., M.S. Associate Director Division of Education APA President Eric R. Williams, M.D. Tristan Gorrindo, M.D. Chantalle Hinton Anita Everett, M.D. Corresponding Members Deputy Medical Director Associate Director Members Alvaro Camacho, M.D. Director, Education Division Traci Williams Lara J. Cox, M.D. J. Raymond DePaulo, M.D. Nina Taylor, M.A. Senior Meeting Planner Nancy Diazgranados, M.D. Maria I. Lapid, M.D. Deputy Director, Education Jamie Woodside, CEM Anna L. Dickerman, M.D. Division Exhibits & Meetings Manager Julio Licinio, M.D. Donald C. Goff, M.D.
    [Show full text]
  • Mind and Brain Theme Student Opportunities
    Mind and Brain Theme Student Opportunities Project 1: Chronic fatigue syndrome: Leptin, interleukin 6 and clinical symptoms Supervisors: Professor Julio Licinio, Dr Michael Musker Student: Honours Chronic fatigue syndrome (CFS) is characterised by a constellation of symptoms in previously healthy and active individuals. Because of these symptoms, quality of life of persons with CFS can be extremely compromised. While the search for a clear-cut cause remains elusive, we believe that we can make a major contribution to patient’s quality of life by elucidating the biological basis of their clinical symptoms. If the proximal biology underlying the disabling symptoms of CFS is elucidated, we will be able to target treatments aimed at symptomatic improvement. This project will involve assisting the research team in setting up human research study, interviewing participants, sampling and storage processes for bloods, collecting data from human participants in a mental health context, data collation and analysis. Mind & Brain: Laboratory Research The laboratory research group addresses the mechanisms of mind & brain disorders utilising molecular techniques and models in a laboratory environment. Project 2: The role of stress in cancer initiation and progression Supervisors: Professor Julio Licinio, Dr Martin Lewis, Mr Rhys Fogarty Student: Honours There is growing evidence that chronic psychosocial stress contributes to cancer initiation and progression, however the molecular mechanisms underlying this phenomenon are poorly understood. Chronic exposure of cells to hormones released during stress may activate pro- malignant pathways that increase the cell’s susceptibility to carcinogens and enhance malignant characteristics. The aim of this work is to use an in vitro model of chronic stress involving long-term exposure of cancer and normal cell lines to stress hormones.
    [Show full text]
  • Depression and Obesity Treatments Are Life Saving
    LETTERS TO THE EDITOR Depression and obesity treatments are life saving To the editor—I was disappointed to read United States3. When causes of death are University of California, Los Angeles in your September 2002 issue a classifica- examined by age group, the importance Los Angeles, California, USA tion of antidepressants and antiobesity of suicide as a cause of death is self-evi- Email: [email protected] drugs as “lifestyle drugs”1. Depression is dent (Table 1)3. Moreover, depression is not a lifestyle; it is a severe medical disor- an independent risk factor for heart dis- We reply—We certainly agree that depres- der that has been recognized as such ease, which is the leading cause of mor- sion and obesity are potentially life-threat- 2 since antiquity . Melancholia (black bile tality in the US. In this context, ening conditions, and regret the in Greek) is a subtype of depression that antidepressant treatment is not a characterization of these in our news story was named by Hippocrates 2,500 years lifestyle option, it is a life-saving neces- as mere “lifestyles”. However, we stand by ago. It is the only disease category to sity. the main part of the piece, which focused have survived in its original name from Obesity is also a key contributor to not only on these conditions, but on other the Hippocratic classification of disease morbidity and mortality and can have a afflictions currently the focus of pharma- 2 based on the four humors . Moreover, profound negative impact on health and ceutical development, including hair loss, people die of depression, and do so in life expectancy.
    [Show full text]
  • Chadi Abdallah, M.D. Associate Member Baylor College of Medicine
    Chadi Abdallah, M.D. Ted Abel, Ph.D. James Abelson, M.D.,Ph.D. Associate Member Fellow Member Emeritus Baylor College of Medicine University of Iowa, Carver College of University of Michigan Health System Medicine Anissa Abi-Dargham, M.D. Megumi Adachi, Ph.D. R. Alison Adcock, M.D.,Ph.D. Fellow Associate Member Associate Member Stony Brook University Astellas Research Institute of America Duke University LLC Nii Addy, Ph.D. Nika Adham, B.Sc.,M.Sc.,Ph.D. Bryon Adinoff, M.D. Associate Member Member Fellow Emeritus Yale University School of Medicine Abbvie University of Colorado Medical School Caleb Adler, M.D. Martin Adler, Ph.D. George Aghajanian, M.D. Member Fellow Emeritus Fellow Emeritus University of Cincinnati College of Temple University School of Medicine Yale University School of Medicine Medicine Bernard Agranoff, B.S.,M.D. Susanne Ahmari, M.D.,Ph.D. Katherine Aitchison, Fellow Emeritus Member B.A.,FRCPsych,Ph.D. University of Michigan University of Pittsburgh Member University of Alberta Howard Aizenstein, M.D.,Ph.D. Olusola Ajilore, M.D.,Ph.D. Schahram Akbarian, M.D.,Ph.D. Member Member Member University of Pittsburgh University of Illinois at Chicago Icahn School of Medicine At Mount Sinai Huda Akil, Ph.D. Martin Alda, FRCPC,M.D. Robert Alexander, M.D. Fellow Member Member University of Michigan Dalhousie University Takeda George Alexopoulos, M.D. Tanya Alim, M.D. Murray Alpert, Ph.D. Fellow Emeritus Member Fellow Emeritus Weill Cornell Medical College Howard University Larry Alphs, M.D.,Ph.D. C. Anthony Altar, Ph.D. Susan Amara, Ph.D.
    [Show full text]