Universal Folding Pathways of Polyhedron Nets
Universal folding pathways of polyhedron nets Paul M. Dodda, Pablo F. Damascenob, and Sharon C. Glotzera,b,c,d,1 aChemical Engineering Department, University of Michigan, Ann Arbor, MI 48109; bApplied Physics Program, University of Michigan, Ann Arbor, MI 48109; cDepartment of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109; and dBiointerfaces Institute, University of Michigan, Ann Arbor, MI 48109 Contributed by Sharon C. Glotzer, June 6, 2018 (sent for review January 17, 2018; reviewed by Nuno Araujo and Andrew L. Ferguson) Low-dimensional objects such as molecular strands, ladders, and navigate, thermodynamically, from a denatured (unfolded) state sheets have intrinsic features that affect their propensity to fold to a natured (folded) one. Even after many decades of study, into 3D objects. Understanding this relationship remains a chal- however, a universal relationship between molecular sequence lenge for de novo design of functional structures. Using molecular and folded state—which could provide crucial insight into the dynamics simulations, we investigate the refolding of the 24 causes and potential treatments of many diseases—remains out possible 2D unfoldings (“nets”) of the three simplest Platonic of reach (11–13). shapes and demonstrate that attributes of a net’s topology— In this work, we study the thermodynamic foldability of 2D net compactness and leaves on the cutting graph—correlate nets for all five Platonic solids. Despite being the simplest and with thermodynamic folding propensity. To
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