Anti-MMEL1 / Neprilysin 2 Antibody (ARG58000)

Product datasheet [email protected]

ARG58000 Package: 100 μl anti-MMEL1 / Neprilysin 2 antibody Store at: -20°C

Summary

Product Description Mouse Monoclonal antibody recognizes MMEL1 / Neprilysin 2

Tested Reactivity Hu

Tested Application FACS, IHC-P

Host Mouse

Clonality Monoclonal

Isotype IgG1

Target Name MMEL1 / Neprilysin 2

Antigen Species Human

Immunogen Purified recombinant fragment corresponding to aa. 1-107 of Human MMEL1.

Conjugation Un-conjugated

Alternate Names NL1; NEP2; NL2; SEP; s; Neprilysin II; m; Membrane metallo-endopeptidase-like 2; Membrane metallo- endopeptidase-like 1; MMEL2; EC 3.4.24.11; NEPII; Neprilysin-2 secreted; Neprilysin-2

Application Instructions

Application table Application Dilution

FACS 1:200 - 1:400

IHC-P 1:200 - 1:1000

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Calculated Mw 89 kDa

Properties

Form Liquid

Purification Affinity purified.

Buffer PBS and 0.05% Sodium azide.

Preservative 0.05% Sodium azide

Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.

Note For laboratory research only, not for drug, diagnostic or other use.

www.arigobio.com 1/3 Bioinformation

Gene Symbol MMEL1

Gene Full Name membrane metallo-endopeptidase-like 1

Background The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008]

Function Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). [UniProt]

Images

ARG58000 anti-MMEL1 / Neprilysin 2 antibody FACS image

Flow Cytometry: HeLa cells stained with ARG58000 anti-MMEL1 / Neprilysin 2 antibody (right histogram) and negative control (left histogram).

ARG58000 anti-MMEL1 / Neprilysin 2 antibody IHC-P image

Immunohistochemistry: Paraffin-embedded ovarian cancer tissue stained with ARG58000 anti-MMEL1 / Neprilysin 2 antibody.

www.arigobio.com 2/3 ARG58000 anti-MMEL1 / Neprilysin 2 antibody IHC-P image

Immunohistochemistry: Paraffin-embedded cervical cancer tissue stained with ARG58000 anti-MMEL1 / Neprilysin 2 antibody.