NASA Technology Roadmaps TA 6: Human Health, Life Support, and Habitation Systems
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Guide for Oxygen Compatibility Assessments on Oxygen Components and Systems
NASA/TM-2007-213740 Guide for Oxygen Compatibility Assessments on Oxygen Components and Systems Keisa R. Rosales NASA Test and Evaluation Contract NASA Lyndon B. Johnson Space Center White Sands Test Facility Las Cruces, New Mexico Michael S. Shoffstall NASA Test and Evaluation Contract NASA Lyndon B. Johnson Space Center White Sands Test Facility Las Cruces, New Mexico Joel M. Stoltzfus NASA Lyndon B. Johnson Space Center White Sands Test Facility Las Cruces, New Mexico March 2007 NASA STI Program ... in Profile Since its founding, NASA has been dedicated • CONFERENCE PUBLICATION. Collected to the advancement of aeronautics and space papers from scientific and technical science. The NASA scientific and technical conferences, symposia, seminars, or other information (STI) program plays a key part in meetings sponsored or co-sponsored helping NASA maintain this important role. by NASA. The NASA STI program operates under the • SPECIAL PUBLICATION. Scientific, auspices of the Agency Chief Information technical, or historical information from Officer. It collects, organizes, provides for NASA programs, projects, and missions, archiving, and disseminates NASA’s STI. The often concerned with subjects having NASA STI program provides access to the NASA substantial public interest. Aeronautics and Space Database and its public interface, the NASA Technical Report Server, • TECHNICAL TRANSLATION. English- thus providing one of the largest collections of language translations of foreign scientific aeronautical and space science STI in the world. and technical material pertinent to Results are published in both non-NASA channels NASA’s mission. and by NASA in the NASA STI Report Series, which includes the following report types: Specialized services also include creating custom thesauri, building customized databases, • TECHNICAL PUBLICATION. -
Subject Index
MNL36-EB/Jan. 2007 Subject Index A safety inspection, 99 Chlorofluorocarbon (CFC), 81 Abrasive blast cleaning, 79 transportation, 99–100 Cleaning, 76–86 Access control, 89 weld testing, 114 methods and aids, 77–81 Acid cleaning, 80 Autogenous ignition (autoignition) procedures, 81–84 Aluminum and aluminum alloys, 48 temperature of nonmetals safety, 77 American National Standards Institute data, 28–36t, 37 specific materials, 84 (ANSI), 117 test method, 28, 37, 38f Cleanliness American Petroleum Institute (API), 117 design for, 60–61, 60f B American Society for Testing and Materials inspection and verification, 82–84 Barricades, oxygen propellant test areas, (ASTM), 117 levels, 76, 77–78t 98–99 American Society of Mechanical Engineers maintaining in oxygen systems, 86 Blasts, 122–123 (ASME), 117 maintaining through assembly, 85–87 Breathing applications, 4 Ancillary equipment, in oxygen-enriched Clothing, in oxygen-enriched environment, 5 Building explosions, 121 environment, 5 Codes, regulations, and guidelines, 116–120 Bulk GOX and LOX storage Aqueous and semiaqueous cleaning, Cold flow, seals, 59 nonpropellant use, 90, 91t 80 Combustion tests, 16–46 propellant use, 90–91 ASME B31.3, 66–67, 70, 108, 110, 115 Compatibility assessment, 132 Burrs, 85 ASME Boiler Pressure Vessel Code, 95, 97, Component reassembly and functional 114 C testing, 84 Assembly, clean, 84–86 Cadmium, 48 Composites, 49–50 Association of American Railroads (AAR), Caustic cleaning, 80 Compressed Gas Association (CGA), emergency procedures, 7 Central nervous system -
Downloaded to the User’S Computer in a Variety of Formats
Int. J. Mol. Sci. 2012, 13, 6561-6581; doi:10.3390/ijms13066561 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 www.mdpi.com/journal/ijms Review State of the Art in Silico Tools for the Study of Signaling Pathways in Cancer Vanessa Medina Villaamil 1,*, Guadalupe Aparicio Gallego 1, Isabel Santamarina Cainzos 1, Manuel Valladares-Ayerbes 1,3 and Luis M. Antón Aparicio 2,3 1 Biomedical Research Institute (INIBIC), CHU A Coruña, Xubias de Abaixo s/n, PC 15006, A Coruña, Spain; E-Mails: [email protected] (G.A.G.); [email protected] (I.S.C.); [email protected] (M.V.-A.) 2 University of A Coruña (UDC), PC 15006, A Coruña, Spain; E-Mail: [email protected] 3 Medical Oncology Department, CHU A Coruña, PC 15006, A Coruña, Spain * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +34-981-178-272; Fax: +34-981-178-273. Received: 27 March 2012; in revised form: 3 May 2012 / Accepted: 10 May 2012 / Published: 29 May 2012 Abstract: In the last several years, researchers have exhibited an intense interest in the evolutionarily conserved signaling pathways that have crucial roles during embryonic development. Interestingly, the malfunctioning of these signaling pathways leads to several human diseases, including cancer. The chemical and biophysical events that occur during cellular signaling, as well as the number of interactions within a signaling pathway, make these systems complex to study. In silico resources are tools used to aid the understanding of cellular signaling pathways. -
Inert Lubricants Oils – Greases – Waxes Halocarbon Inert Lubricants
Inert Lubricants Oils – Greases – Waxes Halocarbon Inert Lubricants Halocarbon oils, greases and waxes are polychlorotrifluoroethylenes (PCTFE), which are chemically inert and nonflammable lubricants with high thermal stability, good lubricity, high dielectric strength and low compressibility. Halocarbon was the first to commercially produce PCTFE-based lubricants over 60 years ago. We offer a wide range of oils, greases and waxes to meet industries' needs. The inertness of our lubricant is required for the safe handling of highly reactive and/or aggressive chemicals like oxygen, chlorine, hydrogen peroxide, sulfur trioxide and nitric acid. This unique chemistry can also provide advantage in many other applications from lab-scale to the production plant. Have Questions? Contact Francisco Torres, Sr. Sales Manager: [email protected] Contents Chemical Composition 3 Thermal Stability 12 Chemical Inertness 3 Material Compatibility 12 Oxidizer Inertness Tests 5 Elastomers and Plastics 12 Oxygen Inertness Tests, Table 1 5 Metals 13 Shock Sensitivity, Table 2 5 Selecting a Halocarbon Oil Grade 14 Physical Properties 6 Industrial Lubricant Oils, Table 3 7 Viscosity Ratings, Table 6 14 Waxes, Table 4 7 Blending to a Custom Viscosity 15 Greases, Table 5 8 Oil Blending Chart, Figure 3 15 Vapor Pressures, Figure 1 9 Viscosity vs. Temperature, Figure 2 10 Quality Assurance 16 Solubilities 6, 11 Toxicity 16 Bulk Modulus 11 Lubricity 11 Export Shipments 17 Thermal Properties 11 Typical Applications 17 Surface Tension 12 Electrical Properties 12 2 Chemical Composition Halocarbon oils are saturated, hydrogen-free low molecular weight polymers of chlorotrifluoroethylene having the formula –(CF2CFCl)n–, where n ranges from 2 to approximately 10. -
Odorox, Odourized Oxygen Material Safety Data Sheet ______
Revision Date , Issuing Date 10-Feb-2011, Page 1 / 10 _____________________________________________________________________ Odorox, Odourized Oxygen Material Safety Data Sheet _____________________________________________________________________ 1. PRODUCT AND COMPANY IDENTIFICATION Product Name Odorox, Odourized Oxygen Product Code(s) 027-03-0006 UN-Number UN3156 Recommended Use Industrial use. Supplier Address* Linde Gas North America LLC - Linde Merchant Production Inc. - Linde LLC 575 Mountain Ave. Murray Hill, NJ 07974 Phone: 908-464-8100 www.lindeus.com Linde Gas Puerto Rico, Inc. Las Palmas Village Road No. 869, Street No. 7 Catano, Puerto Rico 00962 Phone: 787-641-7445 www.pr.lindegas.com Linde Canada Limited 5860 Chedworth Way Mississauga, Ontario L5R 0A2 Phone: 905-501-1700 www.lindecanada.com * May include subsidiaries or affiliate companies/divisions. For additional product information contact your local customer service. Chemical Emergency Phone Chemtrec: 1-800-424-9300 for US/ 703-527-3887 outside US Number 2. HAZARDS IDENTIFICATION WARNING! Emergency Overview Oxidizer Accelerates combustion and increases risk of fire. Irritating to eyes, respiratory system and skin Contents under pressure Keep at temperatures below 52°C / 125°F Appearance Colorless Physical State Compressed gas. Odor Extremely disagreeable OSHA Regulatory Status This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200). Potential Health Effects Odorox, Odourized Oxygen, Material Safety Data Sheet , Revision Date , Page 2 / 10 ___________________________________________________________________ Principle Routes of Exposure Inhalation. Eye contact. Skin contact. Acute Toxicity Inhalation Dimethyl sulfide is irritating to the respiratory system. Oxygen is not acutely toxic under normal pressure. Oxygen is more toxic when inhaled at elevated pressures. Depending upon pressure and duration of exposure, pure oxygen at elevated pressures may cause cramps, dizziness, difficulty breathing, convulsions, edema and death. -
Link to the Report
DISCLAIMER This report was prepared as an account of a workshop sponsored by the U.S. Department of Energy. Neither the United States Government nor any agency thereof, nor any of their employees or officers, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of document authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof. Copyrights to portions of this report (including graphics) are reserved by original copyright holders or their assignees, and are used by the Government’s license and by permission. Requests to use any images must be made to the provider identified in the image credits. On the cover: Argonne National Laboratory’s IBM Blue Gene/P supercomputer Inset visualization of ALG13 courtesy of David Baker, University of Washington AUTHORS AND CONTRIBUTORS Sponsors and representatives Susan Gregurick, DOE/Office of Biological and Environmental Science Daniel Drell, DOE/Office of Biological and Environmental Science Christine Chalk, DOE/Office of Advanced Scientific -
Health of Physiology the Physiological Society and Are Registered in the UK and in the EU Respectively
The Physiological Society is a company limited by guarantee. Registered in England and Wales, No. 323575. Registered Office: Hodgkin Huxley House, 30 Farringdon Lane, London EC1R 3AW, UK. Registered Charity No. 211585. ‘The Physiological Society’ and the Physiological Society logo are trademarks belonging to Health of Physiology The Physiological Society and are registered in the UK and in the EU respectively. Health of Physiology Health of Physiology Contents 1. President’s Foreword 3 2. Executive summary Key findings 4 Recommendations 5 3. Introduction What is physiology? 6 The importance of physiology 7 The growth and fragmentation of physiology 7 4. UK life science policy Government actions 11 Current situation and future measures 12 5. The skills pipeline School 14 University 15 6. Academic output Published research 22 Research funding 24 Animal research 25 7. Diversity in physiology Diversity among physiologists 28 The Physiological Society 30 8. Conclusions and future direction The skills pipeline 32 Physiology research 34 Diversity in physiology 35 Visibility of physiology 36 9. Appendices Appendix I: Membership of steering group 38 Appendix II: Review methodology 39 Appendix III: Stakeholder meetings 40 Appendix IV: Universities responding to practical provision survey 42 President's Foreword This review addresses the question: How healthy is the discipline of physiology? Is physiology in 2016 now in a similar position to anatomy, which has largely run its course as a research discipline and has seen its departments closed, becoming -
19710010491.Pdf
... ••........° ............ .•.. .. .. o . .°°°. •.°..- % .. .. .. o° .. .. .•. ••.° 1 i! NATIONAL AE RON, -J C-, AND SPACE ADMINISTRATIO N ..... •....... ......................S P L O 1 N E TG T O F M .... •....... ... ..... .......... • •....... .... :..'•..........-. .......-. o.. •... ...... ........... ........ o... ...........:::::t g •° .'.. o%%...... .. °........ :..:..........FR .... °....°o°. AIN R~I ...... .... Sp ngel V 2 1 FINAL REPORT PANEL 7 REACTION PROCESSES IN HIGH-PRESSURE FLUID SYSTEMS MAY 28, 1970 W. R. Downs Chairman, Panel 7 CONTENTS Section Page INTRODUCTION . .. ...... I SECTION A - DESCRIPTION OF TANKS IN USE ON THE APOLLO SPACECRAFT ............... ......... 3 SECTION B - METALLURGY - APOLLO HIGH PRESSURE VESSELS . 19 SECTION C - CHEMISTRY SURVEY ................ 33 SECTION D - THERMODYNAMICS RESTRICTIONS ON ENERGY PROCESSES IN THE APOLLO 13 CRYOGENIC OXYGEN TANK NUMBER 2 .......... ........ .. 83 SECTION E - SUMMARY . .. ....... .......... .I..101 SECTION F - FINDINGS .......... .......... ... 105 SECTION G - ACKNOWLEDGMENTS ...... ............. ... 107 APPENDIX A - COMMAND AND SERVICE MODULE FLUIDS ON SPACECRAFT 109 .......... ............. 109 APPENDIX B - CONTAMINANTS DETECTED AND IDENTIFIED IN GROUND SUPPORT EQUIPMENT ........ ............ 113 APPENDIX C - HARDWARE ANALYSIS OF P/N 15241-637 . ...... 123 APPENDIX D - THE POSSIBILITY OF A CATASTROPHIC PRESSURE FLUCTUATION IN A NEAR-CRITICAL-POINT FLUID ......... .............. ... 129 APPENDIX E - CHEMISTRY AND THERMOCHEMISTRY OF FLUIDS IN THE CRITICAL AND -
Safety Standard for Oxygen and Oxygen Systems
NSS 1740.15 JANUARY 1996 National Aeronautics and Space A_tration SAFETY STANDARD FOR OXYGEN AND OXYGEN SYSTEMS Guidelines for Oxygen System Design, Materials Selection, Operations, Storage, and Transportation Office of Safety and Mission Assurance Washington, DC 20546 Safety Standard for Oxygen and Oxygen Systems Guidelines for Oxygen System Design, Materials Selection, Operations, Storage, and Transportation PREFACE This safety standard establishes a uniform Agency process for oxygen system design, materials selection, operation, storage, and transportation. This standard contains minimum guidelines applicable to NASA Headquarters and all NASA Field Installations. Installations are encouraged to assess their individual programs and develop additional requirements as needed. "Shalls" and "wills" denote requirements that are mandated in other existing documents referenced at the end of each chapter and in widespread use in the aerospace industry. This standard is issued in loose-leaf form and will be revised by change pages. Comments and questions concerning the contents of this publication should be referred to the National Aeronautics and Administration Headquarters, Director, Safety and Risk Management Division, Office of the Associate for Safety and Mission Assurance, ashington, DC 20546. EFFECTIVE DATE: JAN 3 0 1996 Safety and Mission Assurance ACKNOWLEDGEMENTS The NASA Oxygen Safety Handbook was originally prepared under NASA contract NAS3- 23558 by Paul M. Ordin, Consulting Engineer. The support of the NASA Hydrogen-Oxygen Safety Standards Review Committee in providing technical monitoring of the standard is gratefully acknowledged. The committee included the following members: William J. Brown (Chairman) NASA Lewis Research Center Cleveland, Ohio Frank J. Benz NASA Johnson Space Center White Sands Test Facility Las Cruces, New Mexico Mike Pedley NASA Johnson Space Center Houston, Texas Dennis Griffin NASA Marshall Space Flight Center Alabama Coleman J. -
Genome Sequencing: Then & Now
“Aint you got an ‘ome to go to?” Genomics Transcriptomics Proteomics Metabolomics Physiomics toxicogenomics pharmacogenomics ecotoxicopharmacogenomics phosphatome, glycome, secretome metronome, mobilome, gardenome, etc… http://omics.org/index.php/Alphabetically_ordered_list_of_omes_and_omics --A-- Alignmentome: conceived before 2003. The whole set of Bacteriome: an organelle of bacteria. (Bacteriome.org). Also Carbome: BiO center. 2003. The whole set of carbone multiple sequence and structure alignments in the totality of baterial genes and proteins. based living organisms in the universe. (Carbome.org) bioinformatics. Alignments are the most important Bacterome: The totality of (Bacterome.org) Carbomics: BiO center. 2003. (Carbomics.org) representation in bioinformatics especially for homology and Behaviorome: The totality of (Behaviorome.org) Cardiogenomics: The omics approach research of evolution study. (Alignmentome.org) Behavioromics: The omics approach research of Cardiogenome (Cardiogenomics.org) in biology Alignmentomics: conceived before 2003. The study of Behavioromics (Behavioromics.org) in biology Cellome: concept is derived from the understanding that aligning strings and sequences especially in bioinformatics. Behaviourome: The totality of (Behaviourome.org) cells as a whole can be used for therapeutic purposes. As an (Alignmentomics.org) Behaviouromics: The omics approach research of important bioresource, cells are kept for biotechnology. As Alignome: 2003 . The whole set of string alignment Behaviouromics (Behaviouromics.org) in biology a distinct group concept, cellome refers to such cells and algorithms such as FASTA, BLAST and HMMER. Bibliome: 1999. EBI (European Bioinformatics Institute). their genetic materials. (Cellome.org) (Alignome.org) The whole of biological science and technology literature. Cellomics: The study of Cellome. Cellomics is also a Alignomics: The omics approach research of Alignomics Within bibliome, each word and context is interconnected company name Cellomics, Inc. -
Oxygen Compatibility and Challenge Testing of the Portable Life Support System Variable Oxygen Regulator for the Advanced Extravehicular Mobility Unit
47th International Conference on Environmental Systems ICES-2017-369 16-20 July 2017, Charleston, South Carolina Oxygen Compatibility and Challenge Testing of the Portable Life Support System Variable Oxygen Regulator for the Advanced Extravehicular Mobility Unit Colin Campbell,1 Marlon Cox,2 Carly Meginnis3 NASA Lyndon B. Johnson Space Center, Houston, TX, 77058 and Eric Falconi4, Bruce Barnes5, Bruce Conger6 Jacobs Engineering, JSC Engineering Technology and Science (JETS), Houston, TX, 77058 The Variable Oxygen Regulator (VOR), a stepper-actuated two-stage mechanical regulator, is being developed for the purpose of serving as the Primary Oxygen Regulator (POR) and Secondary Oxygen Regulator (SOR) within the Advanced Extravehicular Mobility Unit (EMU) Portable Life Support System (PLSS), now referred to as the xEMU and xPLSS. Three prototype designs have been fabricated and tested as part of this development. Building upon the lessons learned from the 35 years of Space Shuttle/International Space Station EMU Program operation, including the fleet-wide EMU Secondary Oxygen Pack (SOP) contamination failure that occurred in 2000, NASA is analyzing, designing, and testing the VOR for oxygen compatibility with controlled Non-Volatile Residue (NVR) and a representative worst-case hydro-carbon system contamination event (>100 mg/ft2 dodecane). This paper discusses the steps taken in testing of VOR 2.0 for oxygen compatibility, and discusses follow-on design changes implemented in the VOR 3.0 (3rd prototype) as a result. Nomenclature ABO Aviator’s -
Paper Number 07ICES-295 Development of a Test Facility for Air Revitalization Technology Evaluation
Paper Number 07ICES-295 Development of a Test Facility for Air Revitalization Technology Evaluation Sao-Dung Lu MEI Technologies, Inc. / ESCG Amy Lin Jacobs Sverdrup / ESCG Melissa Campbell Hamilton Sundstrand / ESCG Frederick Smith, Su Curley NASA Johnson Space Center Copyright © 2007 SAE International ABSTRACT surface habitat cabin. This includes the capability to remove contaminants and condition cabin atmosphere, Development of new air revitalization system (ARS) supply and store atmospheric gases, and closed loop technology can initially be performed in a subscale processes which recycle resources. Processes include laboratory environment, but in order to advance the separation by physical adsorption, absorption, and maturity level, the technology must be tested in an end- mechanical filtration. Other processes may include to-end integrated environment. The Air Revitalization chemical adsorption, reduction, and oxidation. Technology Evaluation Facility (ARTEF) at the NASA Johnson Space Center serves as a ground test bed for Lithium hydroxide and charcoal have been the dominant evaluating emerging ARS technologies in an technology used to scrub the cabin atmosphere for environment representative of spacecraft atmospheres. decades. This open loop technology is so simple and At the center of the ARTEF is a hypobaric chamber reliable that no significant changes have been which serves as a sealed atmospheric chamber for necessary. Until the International Space Station (ISS), closed loop testing. A Human Metabolic Simulator the mission durations have been short. In order to (HMS) was custom-built to simulate the consumption of develop new regenerative technology, a test facility must oxygen, and production of carbon dioxide, moisture and be able to sufficiently simulate a spacecraft atmosphere heat of up to eight persons.