Downloaded from genome.cshlp.org on October 4, 2021 - Published by Cold Spring Harbor Laboratory Press Maegawa et al. 1 Title: Age-related epigenetic drift in the pathogenesis of MDS and AML Authors: Shinji Maegawa,1,2 Sheryl Gough,3 Naoko Watanabe-Okochi,4,5 Yue Lu,2 Nianxiang Zhang,6 Ryan J. Castoro,2 Marcos R. H. Estecio,2,7 Jaroslav Jelinek,1,2 Shoudan Liang,6 Toshio Kitamura,4 Peter Aplan,3 Jean-Pierre J. Issa1,2 Affiliations: 1Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA, United States of America, 2Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States of America, 3Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, United States of America, 4Division of Cellular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 5Department of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 6Department of Biostatistics and Computational Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States of America, 7Department of Molecular Carcinogenesis, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States of America Corresponding author: Shinji Maegawa, Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA 19140. Phone: 215-707-3712; Fax: 215-707-4588; E-mail:
[email protected] Downloaded from genome.cshlp.org on October 4, 2021 - Published by Cold Spring Harbor Laboratory Press Maegawa et al. 2 Running title: DNA methylation in MDS model mice Keywords: DNA methylation, aging, MDS, AML Manuscript type: Research Abstract The Myelodysplastic syndrome (MDS) is a clonal hematologic disorder that frequently evolves to acute myeloid leukemia (AML).