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Cytokine Nomenclature
RayBiotech, Inc. The protein array pioneer company Cytokine Nomenclature Cytokine Name Official Full Name Genbank Related Names Symbol 4-1BB TNFRSF Tumor necrosis factor NP_001552 CD137, ILA, 4-1BB ligand receptor 9 receptor superfamily .2. member 9 6Ckine CCL21 6-Cysteine Chemokine NM_002989 Small-inducible cytokine A21, Beta chemokine exodus-2, Secondary lymphoid-tissue chemokine, SLC, SCYA21 ACE ACE Angiotensin-converting NP_000780 CD143, DCP, DCP1 enzyme .1. NP_690043 .1. ACE-2 ACE2 Angiotensin-converting NP_068576 ACE-related carboxypeptidase, enzyme 2 .1 Angiotensin-converting enzyme homolog ACTH ACTH Adrenocorticotropic NP_000930 POMC, Pro-opiomelanocortin, hormone .1. Corticotropin-lipotropin, NPP, NP_001030 Melanotropin gamma, Gamma- 333.1 MSH, Potential peptide, Corticotropin, Melanotropin alpha, Alpha-MSH, Corticotropin-like intermediary peptide, CLIP, Lipotropin beta, Beta-LPH, Lipotropin gamma, Gamma-LPH, Melanotropin beta, Beta-MSH, Beta-endorphin, Met-enkephalin ACTHR ACTHR Adrenocorticotropic NP_000520 Melanocortin receptor 2, MC2-R hormone receptor .1 Activin A INHBA Activin A NM_002192 Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA Activin B INHBB Activin B NM_002193 Inhibin beta B chain, Activin beta-B chain Activin C INHBC Activin C NM005538 Inhibin, beta C Activin RIA ACVR1 Activin receptor type-1 NM_001105 Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1, Activin receptor-like kinase 2, ALK-2, TGF-B superfamily receptor type I, TSR-I, ACVRLK2 Activin RIB ACVR1B -
2016 Research in Action Awards
TREATMENT ACTION GROUP The Board of Trustees 2016 RESEARCH IN ACTION AWARDS and staff of amfAR, The Foundation Treatment Action Group’s (TAG’s) annual Research in Action Awards honor activists, scientists, philanthropists and creative artists who have made for AIDS Research extraordinary contributions in the fight against AIDS. Tonight’s awards ceremony is a fundraiser to support TAG’s programs and provides a forum for honoring heroes of the epidemic. salute the recipients of the HONOREES LEVI STRAUSS & CO. for advancing human rights and the fight 2016 TAG Research in Action Awards against HIV/AIDS ROSIE PEREZ actor/activist MARGARET RUSSELL award-winning design journalist/editor, Levi Strauss & Co. cultural leader and accomplished advocate for HIV prevention and care BARBARA HUGHES longtime AIDS activist and dedicated Rosie Perez President of TAG’s Board since 1996 HOSTS Margaret Russell JENNA WOLFE lifestyle and fitness expert BRUCE VILANCH comedy writer, songwriter, actor and Emmy ® Barbara Hughes Award winner THURSDAY, NOVEMBER 17, 2016 6PM Cocktails and Hors d’Oeuvres 7PM Awards Presentation SLATE www.amfar.org 54 West 21st Street New York City TAG ad 102716.indd 1 10/27/16 3:17 PM TAG 2016 LIMITED ART EDITION RIAA 2016 CO-CHAIRS SCOTT CAMPBELL Executive Director, Elton John AIDS Foundation DICK DADEY Executive Director, Citizens Union JOY TOMCHIN Founder of Public Square Films, Executive Producer of How to Survive a Plague and the upcoming documentary Sylvia and Marsha RIAA 2016 HONORARY CHAIRS 2014 RIAA honoree ALAN CUMMING and GRANT SHAFFER 2009 RIAA honoree DAVID HYDE PIERCE and BRIAN HARGROVE ROSALIND FOX SOLOMON Animal Landscape, 1979 Archival pigment print | 15 1/2 x 15 1/2 inches | 8-ply mat + granite welded metal frame + uv plexi 23 1/2 x 23 inches | Edition of 15 + 3 AP's | ©Rosalind Fox Solomon, www.rosalindsolomon.com RIAA 2016 COMMITTEE Courtesy of Bruce Silverstein Gallery Joy Episalla, Chair for Projects Plus, Inc. -
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AGING AND HIV THOUGHTS ON PrEP FROM the FIRST PERSON CURED of HIV ARE YOU AT RISK FOR ANAL CANCER? POSITIVELY AWARE THE HIV TREATMENT JOURNAL OF TEST POSITIVE AWARE NETWORK JANUARY+FEBRUARY 2015 LEONG-T RM suRVIVORS ARE Not JUST LIVING loNGER, they’RE KICKING TEZ ANDERSON AND MATT SHARP take on AIDS ASS SURVIVOR SYNDROME This page intentionally left blank. ➤ POSITIVELY AWARE [email protected] CORRE CTING A disease and remind us not to focus exclu- know that all the hard work that goes into CONTRADICTION sively on T-cells and antiretrovirals. compiling such a class A magazine is not IN TERMS —CARL STEIN, MHS, PAC, AAHIVS overlooked. May you be blessed. PHYSiciAN ASSISTANT —C HERYL VITELLO R egarding “Can Hepatitis C Be Sexually OWEN MEDICAL GROUP GATESVILLE, TX Transmitted?” in the November+December SAN FRANCISCO, CA StiGMA 2014 issue: On page 28 Andrew Reynolds responds: I am currently incarcerated at Collins the author writes, Correctional Facility in Collins, New York. “We know that Dear Carl and other readers, I want to tell how I was a target of HIV stigma HCV is present in Thank you for the careful (“Have you ever been the target of HIV stigma blood, but there reading and feedback on the or discrimination?” poll, September+October is no evidence article “Can Hepatitis C Be 2014). It started right in my own neighbor- that it is found Sexually Transmitted?” You are hood after I disclosed to someone who I in semen....” On absolutely correct in my contra- thought was a friend. He eventually told some page 29 the author diction on pages 28 and 29. -
Hemispherx Biopharma, Inc
Hemispherx Biopharma, Inc. HEB‐NYSE EXECUTIVE INFORMATIONAL OVERVIEW® November 27, 2016 Company Description Hemispherx Biopharma, Inc. (or “the Company”) is a specialty pharmaceutical company addressing critical unmet medical needs. The Company has invested over two decades of R&D into safe, effective ways to modulate and amplify the immune system, and is now poised to enter a confirmatory Phase III U.S. trial with an RNA† Hemispherx Biopharma, Inc. macromolecule that could become the only FDA‐approved therapy 1617 JFK Blvd., Suite 500 for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Philadelphia, PA 19103 This candidate, Ampligen®, was approved for CFS/ME in Argentina in Phone: (215) 988‐0080 August 2016 and is available to patients in Europe through an early access program (EAP). CFS/ME is a debilitating disease with no Fax: (215) 988‐1739 www.hemispherx.net/ known treatment to date but very active patient advocacy groups. Hemispherx also holds rights to an FDA‐approved product for genital warts, Alferon N Injection®, which is believed to be the world’s only Ticker (Exchange) HEB (NYSE) approved natural interferon (IFN). Hemispherx has refined Alferon’s Recent Price (11/25/2016)* $0.85 manufacturing to drastically increase efficiencies and reduce costs, and now seeks FDA approval for the new production method before 52‐week Range $0.72 ‐ $2.64 relaunching Alferon. Hemispherx is headquartered in Philadelphia Shares Outstanding** ~24.1 million with GMP manufacturing and research facilities in New Jersey. Market Capitalization ~$20.5 million Average 3‐month Volume 110,574 Key Points Insider Ownership ~3.6 million The Ampligen® technology has also shown utility as a broad‐ Institutional Ownership ~5% spectrum antiviral that could help seasonal flu vaccines work EPS (Qtr. -
Pulmonary Delivery of Biological Drugs
pharmaceutics Review Pulmonary Delivery of Biological Drugs Wanling Liang 1,*, Harry W. Pan 1 , Driton Vllasaliu 2 and Jenny K. W. Lam 1 1 Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China; [email protected] (H.W.P.); [email protected] (J.K.W.L.) 2 School of Cancer and Pharmaceutical Sciences, King’s College London, 150 Stamford Street, London SE1 9NH, UK; [email protected] * Correspondence: [email protected]; Tel.: +852-3917-9024 Received: 15 September 2020; Accepted: 20 October 2020; Published: 26 October 2020 Abstract: In the last decade, biological drugs have rapidly proliferated and have now become an important therapeutic modality. This is because of their high potency, high specificity and desirable safety profile. The majority of biological drugs are peptide- and protein-based therapeutics with poor oral bioavailability. They are normally administered by parenteral injection (with a very few exceptions). Pulmonary delivery is an attractive non-invasive alternative route of administration for local and systemic delivery of biologics with immense potential to treat various diseases, including diabetes, cystic fibrosis, respiratory viral infection and asthma, etc. The massive surface area and extensive vascularisation in the lungs enable rapid absorption and fast onset of action. Despite the benefits of pulmonary delivery, development of inhalable biological drug is a challenging task. There are various anatomical, physiological and immunological barriers that affect the therapeutic efficacy of inhaled formulations. This review assesses the characteristics of biological drugs and the barriers to pulmonary drug delivery. -
COVID-19 Treatment and Vaccine Tracker This Document Contains an Aggregation of Publicly Available Information from Validated Sources
COVID-19 Treatment and Vaccine Tracker This document contains an aggregation of publicly available information from validated sources. It is not an endorsement of one approach or treatment over another but simply a list of all treatments and vaccines currently in development. TREATMENTS Current Type of FDA-Approved Clinical Trials for Funding Clinical Trials for Anticipated Next Number Developer/Researcher Stage of Published Results Sources Product - Treatment Indications Other Diseases Sources COVID-19 Steps Timing Development ANTIBODIES PhRMA Begin Phase 1 trials in late Polyclonal hyperimmune Alliance among Takeda, CSL Behring, Wall Street Journal spring. To patients between 1 globulin (H-IG), formerly N/A Biotest AG, Bio Products Laboratory, Pre-clinical Pink Sheet December 2020 and December known at TAK-888 LFB, and Octapharma Press release from the 2021 alliance Biomedical Stat News Advanced MarketWatch Antibodies from mice, Research and Reuters 2 REGN3048-3051, against the N/A Regeneron Pre-clinical Start Phase 1 June 2020 Development Bloomberg News spike protein Authority FierceBiotech (BARDA) FiercePharma Korea Herald Antibodies from recovered 3 N/A Celltrion Pre-clinical Start Phase 1 in July 2020 UPI COVID-19 patients Celltrion press release Super-antibody or antibody 4 cocktail to target potential N/A Celltrion Pre-clinical Celltrion press release mutations of SARS-CoV-2 Antibodies from recovered BioSpace 5 N/A Kamada Pre-clinical COVID-19 patients AbbVie Stat News Antibodies from recovered 6 N/A Vir Biotech/WuXi Biologics/Biogen Pre-clinical Start Phase 1 ~ July 2020 Vir Biotech COVID-19 patients Vir Biotech * Indicates updated or new field This document contains an aggregation of publicly available information from validated sources. -
Novel Therapies for Eosinophilic Disorders
Novel Therapies for Eosinophilic Disorders Bruce S. Bochner, MD KEYWORDS Eosinophil Therapies Antibodies Targets Pharmacology Biomarkers KEY POINTS A sizable unmet need exists for new, safe, selective, and effective treatments for eosinophil-associated diseases, such as hypereosinophilic syndrome, eosinophilic gastrointestinal disorders, nasal polyposis, and severe asthma. An improved panel of biomarkers to help guide diagnosis, treatment, and assessment of disease activity is also needed. An impressive array of novel therapeutic agents, including small molecules and biologics, that directly or indirectly target eosinophils and eosinophilic inflammation are undergoing controlled clinical trials, with many already showing promising results. A large list of additional eosinophil-related potential therapeutic targets remains to be pursued, including cell surface structures, soluble proteins that influence eosinophil biology, and eosinophil-derived mediators that have the potential to contribute adversely to disease pathophysiology. INTRODUCTION Eosinophilic disorders, also referred to as eosinophil-associated diseases, consist of a range of infrequent conditions affecting virtually any body compartment and organ.1 The most commonly affected areas include the bone marrow, blood, mucosal sur- faces, and skin, often with immense disease- and treatment-related morbidity, Disclosure Statement: Dr Bochner’s research efforts are supported by grants AI072265, AI097073 and HL107151 from the National Institutes of Health. He has current or recent consul- ting or scientific advisory board arrangements with, or has received honoraria from, Sanofi-A- ventis, Pfizer, Svelte Medical Systems, Biogen Idec, TEVA, and Allakos, Inc. and owns stock in Allakos, Inc. and Glycomimetics, Inc. He receives publication-related royalty payments from Elsevier and UpToDate and is a coinventor on existing and pending Siglec-8-related patents and, thus, may be entitled to a share of future royalties received by Johns Hopkins University on the potential sales of such products. -
The Cytokine Network in Asthma and Chronic Obstructive Pulmonary Disease
The cytokine network in asthma and chronic obstructive pulmonary disease Peter J. Barnes J Clin Invest. 2008;118(11):3546-3556. https://doi.org/10.1172/JCI36130. Review Series Asthma and chronic obstructive pulmonary disease (COPD) are very common inflammatory diseases of the airways. They both cause airway narrowing and are increasing in incidence throughout the world, imposing enormous burdens on health care. Cytokines play a key role in orchestrating the chronic inflammation and structural changes of the respiratory tract in both asthma and COPD and have become important targets for the development of new therapeutic strategies in these diseases. Find the latest version: https://jci.me/36130/pdf Review series The cytokine network in asthma and chronic obstructive pulmonary disease Peter J. Barnes National Heart & Lung Institute, Imperial College London, London, United Kingdom. Asthma and chronic obstructive pulmonary disease (COPD) are very common inflammatory diseases of the air- ways. They both cause airway narrowing and are increasing in incidence throughout the world, imposing enormous burdens on health care. Cytokines play a key role in orchestrating the chronic inflammation and structural changes of the respiratory tract in both asthma and COPD and have become important targets for the development of new therapeutic strategies in these diseases. Introduction Inflammation in asthma and COPD The most common inflammatory diseases of the airways are Despite the similarity of some clinical features of asthma and asthma and chronic obstructive pulmonary disease (COPD), COPD, there are marked differences in the pattern of inflamma- and the incidence of both is increasing throughout the world. tion in the respiratory tract, with different inflammatory cells, The prevalence of asthma in developed countries is approxi- mediators, consequences, and responses to therapy (1). -
Importance of Cytokines in Murine Allergic Airway Disease and Human Asthma Fred D
Importance of Cytokines in Murine Allergic Airway Disease and Human Asthma Fred D. Finkelman, Simon P. Hogan, Gurjit K. Khurana Hershey, Marc E. Rothenberg and Marsha Wills-Karp This information is current as of September 29, 2021. J Immunol 2010; 184:1663-1674; ; doi: 10.4049/jimmunol.0902185 http://www.jimmunol.org/content/184/4/1663 Downloaded from References This article cites 257 articles, 63 of which you can access for free at: http://www.jimmunol.org/content/184/4/1663.full#ref-list-1 Why The JI? Submit online. http://www.jimmunol.org/ • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication *average by guest on September 29, 2021 Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2010 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Importance of Cytokines in Murine Allergic Airway Disease and Human Asthma ,†,‡ x { Fred D. Finkelman,*x Simon P. Hogan, Gurjit K. Khurana Hershey, Marc E. Rothenberg, and Marsha Wills-Karp‡ Asthma is a common, disabling inflammatory respira- lymphocytosis and mastocytosis; alternative macrophage ac- tory disease that has increased in frequency and severity tivation; epithelial cell proliferation with goblet cell hyper- in developed nations. -
Public Summary of Opinion on Orphan Designation Rintatolimod for the Treatment of Ebola Virus Disease
19 May 2015 EMA/COMP/204227/2015 Committee for Orphan Medicinal Products Public summary of opinion on orphan designation Rintatolimod for the treatment of Ebola virus disease On 24 April 2015, orphan designation (EU/3/15/1480) was granted by the European Commission to NV Hemispherx BioPharma Europe, Belgium, for rintatolimod for the treatment of Ebola virus disease. What is Ebola virus disease? Ebola virus disease is a severe disease caused by infection with viruses known as ebolaviruses. There are 5 known species of ebolavirus, 4 of which are known to cause the disease in humans. Zaire ebolavirus, sometimes referred to simply as ‘ebola virus’ or EBOV, is the cause of the largest outbreaks of the disease to date and has led to the most deaths. Infection is caused by contact with the body fluids of an infected person. After infection there is an incubation period of between 2 to 21 days, following which the newly infected person starts to experience symptoms. The first symptoms typically are fever, headache, fatigue, muscle pain and sore throat. These are followed by other symptoms such as diarrhoea, vomiting, rash, kidney and liver problems and, in some cases, internal bleeding and bleeding from the gums, eyes, nose and ears. Patients are infectious once they start experiencing symptoms. Ebola virus disease is a life-threatening condition that is frequently fatal due to fluid loss and severe bleeding. What is the estimated number of patients affected by the condition? At the time of designation, Ebola virus disease affected less than 0.01 in 10,000 people in the European Union (EU). -
Treatment Strategies for Allergy and Asthma
REVIEWS Treatment strategies for allergy and asthma Stephen T. Holgate* and Riccardo Polosa‡ Abstract | Allergic diseases have reached epidemic proportions worldwide. An understanding of the cellular and soluble mediators that are involved in allergic inflammatory responses not only helps in understanding the mechanisms of current treatments, but is also important for the identification of new targets that are amenable to both small-molecule and biological interventions. There is now considerable optimism with regards to tackling the allergy epidemic in light of improvements in systemic and mucosal allergen-specific immunotherapy, the identification of key cytokines and their receptors that drive T-helper-2-cell polarization, a clearer understanding of the pathways of leukocyte recruitment and the signalling pathways that are involved in cell activation and mediator secretion, and new approaches to vaccine development. T helper 2 cells Allergic diseases are those that are mediated by the mediators involved and the innate and adaptive immune (T 2 cells). A T-helper-cell T helper 2 cell H expansion of the (TH2-cell) subset of responses that regulate its expression. Progress has also subset that has an important T cells, together with isotype switching of B cells to gen- occurred in understanding the structural and intrinsic role in humoral immunity and erate IgE antibodies specific for common environmental biology of environmental agents that determine their in allergic responses. T 2 cells H 1 produce cytokines that allergens . Although almost half of the urban population allergenicity, and the role of other environmental factors, regulate IgE synthesis (IL‑4), worldwide is atopic (genetically predisposed to produce such as pollutants and microorganisms, in augmenting eosinophil proliferation (IL‑5), IgE antibodies in serum) and most allergy sufferers are or inhibiting allergen sensitization5. -
Overview of Planned Or Ongoing Studies of Drugs for the Treatment of COVID-19
Version of 16.06.2020 Overview of planned or ongoing studies of drugs for the treatment of COVID-19 Table of contents Antiviral drugs ............................................................................................................................................................. 4 Remdesivir ......................................................................................................................................................... 4 Lopinavir + Ritonavir (Kaletra) ........................................................................................................................... 7 Favipiravir (Avigan) .......................................................................................................................................... 14 Darunavir + cobicistat or ritonavir ................................................................................................................... 18 Umifenovir (Arbidol) ........................................................................................................................................ 19 Other antiviral drugs ........................................................................................................................................ 20 Antineoplastic and immunomodulating agents ....................................................................................................... 24 Convalescent Plasma ...........................................................................................................................................