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Leprosy – Eliminated and Forgotten: a Case Report Shiva Raj K.C.1,5* , Geetika K.C.1, Purnima Gyawali2, Manisha Singh3 and Milesh Jung Sijapati4

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Leprosy – Eliminated and Forgotten: a Case Report Shiva Raj K.C.1,5* , Geetika K.C.1, Purnima Gyawali2, Manisha Singh3 and Milesh Jung Sijapati4 K.C. et al. Journal of Medical Case Reports (2019) 13:276 https://doi.org/10.1186/s13256-019-2198-1 CASE REPORT Open Access Leprosy – eliminated and forgotten: a case report Shiva Raj K.C.1,5* , Geetika K.C.1, Purnima Gyawali2, Manisha Singh3 and Milesh Jung Sijapati4 Abstract Background: Leprosy is a disease that was declared eliminated in 2010 from Nepal; however, new cases are diagnosed every year. The difficulty arises when the presentation of the patient is unusual. Case presentation: In this case report we present a case of a 22-year-old Tamang man, from the Terai region of Nepal, with a clinical presentation of fever, malaise, and arthralgia for the past 2 weeks with hepatosplenomegaly and bilateral cervical, axillary, and inguinal lymphadenopathy. Features of chronic inflammation with elevated erythrocyte sedimentation rate of 90 mm/hour and liver enzymes were noted. With no specific investigative findings, a diagnosis of Still’s disease was made and he was given prednisolone. On tapering the medication, after 2 weeks, the lymphadenopathy and fever reappeared. On biopsy of a lymph node, diagnosis of possible tuberculosis was made. On that basis anti-tuberculosis treatment category I was started. During his hospital stay, our patient developed nodular skin rashes on his shoulder, back, and face. The biopsy of a skin lesion showed erythema nodosum leprosum and he was diagnosed as having lepromatous leprosy with erythema nodosum leprosum; he was treated with anti-leprosy medication. Conclusion: An unusual presentations of leprosy may delay its prompt diagnosis and treatment; thus, increasing morbidity and mortality. Although leprosy has been declared eliminated, it should not be forgotten and physicians should have it in mind to make it a differential diagnosis whenever relevant. Keywords: Erythema, Mycobacterium, Nodosum, Still Introduction can be contagious, so its timely diagnosis and manage- Leprosy, also known as Hansen’s disease, is a chronic ment are extremely important [3]. granulomatous disease caused by the bacteria Mycobac- Here we present a case of a 22-year-old man with mis- terium leprae. It primarily affects the peripheral nerves leading primary presentation of fever, malaise, and arth- and skin. According to the World Health Organization ralgia, and he had generalized lymphadenopathy along (WHO), individuals having one of the following three with hepatosplenomegaly. With the above-mentioned features have leprosy: (i) definite loss of sensation in a findings and the presence of leukocytosis along with pale (hypopigmented) or reddish skin patch; (ii) a thick- neutrophilia, elevated C-reactive protein (CRP), and ab- ened or enlarged peripheral nerve with loss of sensation; normal liver function test, he was diagnosed as having and (iii) the presence of acid-fast bacilli in a slit-skin adult-onset Still’s disease (AOSD) and treated accord- smear [1]. Even with the declaration of the elimination ingly. However, during the course of management, he of leprosy in 2010, more than 3000 new cases have been developed nodules over his shoulder, back, and face. A diagnosed, which makes it necessary for us to consider it biopsy from the skin lesion finally revealed erythema a differential diagnosis [2]. Sometimes, the disease has nodosum leprosum (ENL). an unusual presentation, crippling complications, and Case presentation * Correspondence: [email protected] A 22-year-old Tamang man, from Terai region of Nepal, 1 Department of Pathology, KIST Medical College, Imadol, Lalitpur, Nepal presented to the medical out-patient department (OPD) 5Department of Pathology and Laboratory Medicine, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal of KIST Medical College Teaching Hospital, Lalitpur, on Full list of author information is available at the end of the article 8 February 2017 with complaints of fever, malaise, and © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. K.C. et al. Journal of Medical Case Reports (2019) 13:276 Page 2 of 6 arthralgia for the past 2 weeks and dry cough for the biopsy. The timeline of our patient from the initial past 5 days. The fever was associated with chills but no presentation is shown in Table 1. With present findings, rigor, the maximum temperature was not recorded, and that is, persistent fever, malaise, arthralgia, generalized a non-itchy erythematous skin lesion on his left foot was lymphadenopathy, persistent leukocytosis with neutro- seen 2 days prior to OPD visit. His past medical history philia, elevated SGOT and SGPT, positive CRP, and was uneventful. He did not give any significant family negative ANA and RA factor, Still’s disease was sus- history. There was no history of contact with patients pected as it met almost all the criteria (Table 2). with tuberculosis. There was no history of loss of appe- Our patient was prescribed 40 mg of orally adminis- tite or weight loss; he was not on any medication. There tered prednisolone. With the administration of steroids, was no history of the use of long-term medications. his fever subsided and his enlarged lymph node started On examination, he was febrile with a temperature of to shrink. Because of a satisfactory response to a high 37.8 °C (100 °F). A general physical examination revealed dose of steroids, he was discharged. After 2 weeks of 40 bilateral cervical, axillary, and inguinal lymphadenopathy mg of prednisolone, a tapering dose was initiated. Once and hepatosplenomegaly. Other systemic examination he reached 20 mg dose of prednisolone, his fever and was unremarkable. No skin lesion was visible at the time lymphadenopathy recurred. He revisited our OPD and of examination. Routine investigations, which included with the possibility of collagen vascular disease was re- complete blood count (CBC) with erythrocyte sedimen- ferred to a hematologist in another hospital. tation rate (ESR), liver function test, CRP, and antinu- The hematologist recommended performing a lymph clear antibody (ANA) tests, were performed. He had node biopsy. His inguinal lymph node was excised and leukocytosis (21,700/mm3) with neutrophilia (19,300/ sent to histopathology. On microscopic examination, the mm3) and raised ESR of 90 mm/hour. Serum glutamic lymph node had an intact capsule with partial efface- oxaloacetic transaminase (SGOT) was elevated at 154 ment of the nodal architecture. Occasional histiocytic (normal, 12–78 IU/L) and serum glutamic pyruvic trans- granulomas were seen in the lymph nodes. Caseous ne- aminase (SGPT) was elevated at 210 (normal, 46–116 crosis or Langhans type of multinucleated giant cells was IU/L). Total bilirubin and total protein were within nor- not seen. Other areas showed lymphoid follicles with mal limits. CRP was positive whereas the results of ANA prominent germinal center. With the presence of granu- and rheumatoid arthritis (RA) factor tests were negative. lomas and tuberculosis being quite common, the possi- Other tests done were urine routine examination; the re- bility of tuberculosis was considered and on that basis sult of which was unremarkable. Urine culture, blood anti-tuberculosis treatment category I was initiated. The culture, and sputum culture were negative for patho- anti-tubercular treatment category I include 2 months of genic microorganisms. Since brucellosis and scrub ty- isoniazid, rifampicin, pyrazinamide, and ethambutol, phus are endemic, serological tests were performed for followed by 4 months of isoniazid and ethambutol. Brucella antigen and scrub typhus along with hepatitis B During that period, our patient developed nodular rash virus and human immunodeficiency virus (HIV). All at the shoulder, back, and face. A skin biopsy was per- serological tests performed in our patient were negative. formed on 10 April 2017, which showed superficial as A serum adenosine deaminase (ADA) test was also per- well as deeper dermis with patchy infiltration by epithe- formed to rule out tuberculosis and was within normal lioid cells and lymphoid populations, along with foam limits. A chest X-ray and computed tomography scan of cells and neutrophils. The infiltration was mainly limited his chest and abdomen were done and were unremark- to perineural and around the sweat glands and arrector able. During the first week of his hospital stay, he was pili muscles. Subcutaneous tissue also showed infiltra- treated with acetaminophen for fever. Since the fever did tion by similar population of cells (Figs. 1 and 2). Wade- not subside and a definite diagnosis was not formulated Fite stain in the tissue section showed several acid-fast with the above-mentioned tests, further investigations bacilli (Fig. 3). He was diagnosed as having ENL. Anti- were ordered with a provisional diagnosis of pyrexia of tubercular treatment was stopped and he was referred to unknown origin (PUO). Bone marrow aspiration and a bi- Anandaban Leprosy Hospital, Lalitpur, Nepal. opsy were performed which showed myeloid hyperplasia In Anandaban Leprosy Hospital, a detailed history was suggesting inflammatory pathology. He was treated with taken retrospectively. There was no contact history and broad-spectrum antibiotics and corticosteroids. previous history of treatment for leprosy. He gave a his- During his hospital stay, he developed skin rash at ex- tory of transposition of ulnar nerve when he was 12 tensor surface of his foot. An incisional biopsy of the years of age, although he did not know the cause and no skin was performed and sent to histopathology. The skin medical file was available. On examination, many ery- biopsy was superficial and was not adequate for report- thematous lesions along with ENL nodules were present ing.
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