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Human AZU1 / Azurocidin 1 / CAP37 Protein (His Tag)

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Human AZU1 / Azurocidin 1 / CAP37 Protein (His Tag) Human AZU1 / Azurocidin 1 / CAP37 Protein (His Tag) Catalog Number: 10660-H08H General Information SDS-PAGE: Gene Name Synonym: AZAMP; AZU; AZU1; CAP37; HBP; hHBP; HUMAZUR; NAZC Protein Construction: A DNA sequence encoding the human AZU1 (NP_001691.1) (Met 1-Pro 250) with a C-terminal polyhistidine tag was expressed. Source: Human Expression Host: HEK293 Cells QC Testing Purity: > 95 % as determined by SDS-PAGE Endotoxin: Protein Description < 1.0 EU per μg of the protein as determined by the LAL method Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic Stability: antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil ℃ Samples are stable for up to twelve months from date of receipt at -70 granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member Ile 27 Predicted N terminal: of the serine protease family that includes Cathepsin G, neutrophil elastase Molecular Mass: (NE), and proteinase 3 (PR3), however, Azurocidin is not a serine proteinase since the active site serine and histidine residues are replaced. The secreted recombinant human AZU1 comprises 235 amino acids with a Neutrophils arriving first at sites of inflammation release Azurocidin, which predicted molecular mass of 25.6 kDa. As a result of glycosylation, rh acts in a paracrine fashion on endothelial cells causing the development of AZU1 migrates as an approximately 37 kDa band in SDS-PAGE under intercellular gaps and allowing leukocyte extravasation. It thus be regarded reducing conditions. as a reasonable therapeutic target for a variety of inflammatory disease conditions. Formulation: References Lyophilized from sterile PBS, pH 7.4 1.Lindmark A, et al. (1999) Characterization of the biosynthesis, processing, Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as and sorting of human HBP/CAP37/azurocidin. J Leukoc Biol. 66(4): 634-43. protectants before lyophilization. Specific concentrations are included in the 2.Heinzelmann M, et al. (2001) Heparin binding protein (CAP37) hardcopy of COA. Please contact us for any concerns or special differentially modulates endotoxin-induced cytokine production. Int J Surg requirements. Investig. 2(6): 457-66. 3.Soehnlein O, et al. (2005) Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances Usage Guide monocyte arrest under flow conditions. J Immunol. 174(10): 6399-405. Storage: Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: Detailed reconstitution instructions are sent along with the products. Manufactured By Sino Biological Inc., FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS. For US Customer： Fax: 267-657-0217 Tel：215-583-7898 Global Customer： Fax :+86-10-5862-8288 Tel:+86-400-890-9989 http://www.sinobiological.com .
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