Mitochondrial Respiratory States and Rates
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The Moedal Experiment at the LHC. Searching Beyond the Standard
126 EPJ Web of Conferences , 02024 (2016) DOI: 10.1051/epjconf/201612602024 ICNFP 2015 The MoEDAL experiment at the LHC Searching beyond the standard model James L. Pinfold (for the MoEDAL Collaboration)1,a 1 University of Alberta, Physics Department, Edmonton, Alberta T6G 0V1, Canada Abstract. MoEDAL is a pioneering experiment designed to search for highly ionizing avatars of new physics such as magnetic monopoles or massive (pseudo-)stable charged particles. Its groundbreaking physics program defines a number of scenarios that yield potentially revolutionary insights into such foundational questions as: are there extra dimensions or new symmetries; what is the mechanism for the generation of mass; does magnetic charge exist; what is the nature of dark matter; and, how did the big-bang develop. MoEDAL’s purpose is to meet such far-reaching challenges at the frontier of the field. The innovative MoEDAL detector employs unconventional methodologies tuned to the prospect of discovery physics. The largely passive MoEDAL detector, deployed at Point 8 on the LHC ring, has a dual nature. First, it acts like a giant camera, comprised of nuclear track detectors - analyzed offline by ultra fast scanning microscopes - sensitive only to new physics. Second, it is uniquely able to trap the particle messengers of physics beyond the Standard Model for further study. MoEDAL’s radiation environment is monitored by a state-of-the-art real-time TimePix pixel detector array. A new MoEDAL sub-detector to extend MoEDAL’s reach to millicharged, minimally ionizing, particles (MMIPs) is under study Finally we shall describe the next step for MoEDAL called Cosmic MoEDAL, where we define a very large high altitude array to take the search for highly ionizing avatars of new physics to higher masses that are available from the cosmos. -
The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion Anna Karnkowska,*,1,2 Sebastian C
The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion Anna Karnkowska,*,1,2 Sebastian C. Treitli,1 Ondrej Brzon, 1 Lukas Novak,1 Vojtech Vacek,1 Petr Soukal,1 Lael D. Barlow,3 Emily K. Herman,3 Shweta V. Pipaliya,3 TomasPanek,4 David Zihala, 4 Romana Petrzelkova,4 Anzhelika Butenko,4 Laura Eme,5,6 Courtney W. Stairs,5,6 Andrew J. Roger,5 Marek Elias,4,7 Joel B. Dacks,3 and Vladimır Hampl*,1 1Department of Parasitology, BIOCEV, Faculty of Science, Charles University, Vestec, Czech Republic 2Department of Molecular Phylogenetics and Evolution, Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, Warsaw, Poland 3Division of Infectious Disease, Department of Medicine, University of Alberta, Edmonton, Canada 4Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic Downloaded from https://academic.oup.com/mbe/article-abstract/36/10/2292/5525708 by guest on 13 January 2020 5Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada 6Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden 7Institute of Environmental Technologies, Faculty of Science, University of Ostrava, Ostrava, Czech Republic *Corresponding authors: E-mails: [email protected]; [email protected]. Associate editor: Fabia Ursula Battistuzzi Abstract The discovery that the protist Monocercomonoides exilis completely lacks mitochondria demonstrates that these organ- elles are not absolutely essential to eukaryotic cells. However, the degree to which the metabolism and cellular systems of this organism have adapted to the loss of mitochondria is unknown. Here, we report an extensive analysis of the M. -
CHAPTER 12: the Atomic Nucleus
CHAPTER 12 The Atomic Nucleus ◼ 12.1 Discovery of the Neutron ◼ 12.2 Nuclear Properties ◼ 12.3 The Deuteron ◼ 12.4 Nuclear Forces ◼ 12.5 Nuclear Stability ◼ 12.6 Radioactive Decay ◼ 12.7 Alpha, Beta, and Gamma Decay ◼ 12.8 Radioactive Nuclides Structure of matter Dark matter and dark energy are the yin and yang of the cosmos. Dark matter produces an attractive force (gravity), while dark energy produces a repulsive force (antigravity). ... Astronomers know dark matter exists because visible matter doesn't have enough gravitational muster to hold galaxies together. Hierarchy of forces ◼ Sta Standard Model tries to unify the forces into one force Ernest Rutherford “Father of the Nucleus” Story so far: Unification Faraday Glashow,Weinberg,Salam Georgi,Glashow Green,Schwarz Witten 1831 1967 1974 1984 1995 Electricity } } } Electromagnetic force } } } Magnetism} } Electro-weak force } } } Weak nuclear force} } Grand unified force } } } 5 Different } Strong nuclear force} } D=10 String } M-theory ? } Theories } Gravitational force} +branes in D=11 Page 6 © Imperial College London Discovery of the Neutron 3) Nuclear magnetic moment: The magnetic moment of an electron is over 1000 times larger than that of a proton. The measured nuclear magnetic moments are on the same order of magnitude as the proton’s, so an electron is not a part of the nucleus. ◼ In 1930 the German physicists Bothe and Becker used a radioactive polonium source that emitted α particles. When these α particles bombarded beryllium, the radiation penetrated several centimeters of lead. The neutrons collide elastically with the protons of the paraffin thereby producing the5.7 MeV protons Discovery of the Neutron ◼ Photons are called gamma rays when they originate from the nucleus. -
Prokaryotic and Eukaryotic Organisms Pdf
Prokaryotic and eukaryotic organisms pdf Continue There are two types of cells: prokaryotic and eukaryotic. In this section, we will examine the similarities and differences between the two types. The objectives of the training to identify features common to all cells contrast the composition and size of prokaryotic and eukaryotic cells fall into one of two broad categories: prokaryotic and eukaryotic. Single-celled organisms of the domains Of Bacteria and Archaea are classified as prokaryotes (pro - before; carion - core). Animal cells, plant cells, fungi and proteanists are eukaryotes (eu - truth). Components of prokaryotic cells All cells have four common components: (1) plasma membrane, external coating separating the inner part of the cell from the environment; (2) cytoplasm, consisting of a jelly-like area inside the cell in which other cellular components are located; (3) DNA, the genetic material of the cell; and (4) ribosomes, particles that synthesize proteins. However, prokaryotes differ from eukaryotic cells in several ways. Figure 1. This image shows the generalized structure of the prokaryotic cell. A prokaryotic cell is a simple single-celled organism that lacks a nucleus or any other membrane organella. Soon we will see that this is significantly different in eukaryotes. Prokaryotic DNA is found in the central part of the cell: a darkened area called a nucleoid (Figure 1). Unlike archaea and eukaryote, bacteria have a cell wall of peptidoglycan consisting of sugars and amino acids, and many of them have a polysaccharide capsule (Figure 1). The cell wall acts as an additional layer of protection, helps the cell maintain its shape and prevents dehydration. -
Non-Collider Searches for Stable Massive Particles
Non-collider searches for stable massive particles S. Burdina, M. Fairbairnb, P. Mermodc,, D. Milsteadd, J. Pinfolde, T. Sloanf, W. Taylorg aDepartment of Physics, University of Liverpool, Liverpool L69 7ZE, UK bDepartment of Physics, King's College London, London WC2R 2LS, UK cParticle Physics department, University of Geneva, 1211 Geneva 4, Switzerland dDepartment of Physics, Stockholm University, 106 91 Stockholm, Sweden ePhysics Department, University of Alberta, Edmonton, Alberta, Canada T6G 0V1 fDepartment of Physics, Lancaster University, Lancaster LA1 4YB, UK gDepartment of Physics and Astronomy, York University, Toronto, ON, Canada M3J 1P3 Abstract The theoretical motivation for exotic stable massive particles (SMPs) and the results of SMP searches at non-collider facilities are reviewed. SMPs are defined such that they would be suffi- ciently long-lived so as to still exist in the cosmos either as Big Bang relics or secondary collision products, and sufficiently massive such that they are typically beyond the reach of any conceiv- able accelerator-based experiment. The discovery of SMPs would address a number of important questions in modern physics, such as the origin and composition of dark matter and the unifi- cation of the fundamental forces. This review outlines the scenarios predicting SMPs and the techniques used at non-collider experiments to look for SMPs in cosmic rays and bound in mat- ter. The limits so far obtained on the fluxes and matter densities of SMPs which possess various detection-relevant properties such as electric and magnetic charge are given. Contents 1 Introduction 4 2 Theory and cosmology of various kinds of SMPs 4 2.1 New particle states (elementary or composite) . -
Lesson 6.3 You Experience Is Related to Your Location on the Globe
Key Objectives 6.3.1 DESCRIBE trends among elements for 6.3 Periodic Trends atomic size. 6.3.2 EXPLAIN how ions form. 6.3.3 DESCRIBE trends for first ionization energy, ionic size, and electronegativity. CHEMISTRY & YOUY Additional Resources Q: How are trends in the weather similar to trends in the properties of elements? Although the weather changes from day to day. The weather Reading and Study Workbook, Lesson 6.3 you experience is related to your location on the globe. For example, LESSON 6.3 Available Online or on Digital Media: Florida has an average temperature that is higher than Minnesota’s. Similarly, a rain forest receives more rain than a desert. These differ- • Teaching Resources, Lesson 6.3 Review ences are attributable to trends in the weather. In this lesson, you will • Small-Scale Chemistry Laboratory Manual, Lab 9 learn how a property such as atomic size is related to the location of an element in the periodic table. Key Questions Trends in Atomic Size What are the trends among the What are the trends among the elements for atomic size? ? elements for atomic size One way to think about atomic size is to look at the units that form How do ions form? when atoms of the same element are joined to one another. These What are the trends among the units are called molecules. Figure 6.14 shows models of molecules Engage elements for first ionization energy, (molecular models) for seven nonmetals. Because the atoms in each ionic size, and electronegativity? molecule are identical, the distance between the nuclei of these atoms CHEMISTRY YOUYOY U Have students read the can be used to estimate the size of the atoms. -
Novel Lineages of Oxymonad Flagellates from the Termite Porotermes Adamsoni (Stolotermitidae): the Genera Oxynympha and Termitim
Protist, Vol. 170, 125683, December 2019 http://www.elsevier.de/protis Published online date 21 October 2019 ORIGINAL PAPER Novel Lineages of Oxymonad Flagellates from the Termite Porotermes adamsoni (Stolotermitidae): the Genera Oxynympha and Termitimonas a,1 b a c b,1 Renate Radek , Katja Meuser , Samet Altinay , Nathan Lo , and Andreas Brune a Evolutionary Biology, Institute for Biology/Zoology, Freie Universität Berlin, 14195 Berlin, Germany b Research Group Insect Gut Microbiology and Symbiosis, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany c School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia Submitted January 21, 2019; Accepted October 9, 2019 Monitoring Editor: Alastair Simpson The symbiotic gut flagellates of lower termites form host-specific consortia composed of Parabasalia and Oxymonadida. The analysis of their coevolution with termites is hampered by a lack of informa- tion, particularly on the flagellates colonizing the basal host lineages. To date, there are no reports on the presence of oxymonads in termites of the family Stolotermitidae. We discovered three novel, deep-branching lineages of oxymonads in a member of this family, the damp-wood termite Porotermes adamsoni. One tiny species (6–10 m), Termitimonas travisi, morphologically resembles members of the genus Monocercomonoides, but its SSU rRNA genes are highly dissimilar to recently published sequences of Polymastigidae from cockroaches and vertebrates. A second small species (9–13 m), Oxynympha loricata, has a slight phylogenetic affinity to members of the Saccinobaculidae, which are found exclusively in wood-feeding cockroaches of the genus Cryptocercus, the closest relatives of termites, but shows a combination of morphological features that is unprecedented in any oxymonad family. -
Search for Supersymmetry Events with Two Same-Sign Leptons
Search for supersymmetry events with two same-sign leptons Dissertation der Fakult¨atf¨urPhysik der Ludwig-Maximilians-Universit¨atM¨unchen vorgelegt von Christian Kummer geboren in M¨unchen M¨unchen, im Januar 2010 1. Gutachter: Prof. Dr. Dorothee Schaile 2. Gutachter: Prof. Dr. Wolfgang D¨unnweber Tag der m¨undlichen Pr¨ufung: 09.03.2010 meiner Familie Abstract Supersymmetry is a hypothetic symmetry between bosons and fermions, which is broken by an unknown mechanism. So far, there is no experimental evidence for the existence of supersymmetric particles. Some Supersymmetry scenarios are predicted to be within reach of the ATLAS detector at the Large Hadron Col- lider. Final states with two isolated leptons (muons and electrons), that have same signs of charge, are suitable for the discovery of supersymmetric cascade decays. There are numerous supersymmetric processes that can yield final states with two same-sign or more leptons. Typically, these processes tend to have long cas- cade decay chains, producing high-energetic jets. Charged leptons are produced from decaying charginos and neutralinos in the cascades. If the R-parity is con- served and the lightest supersymmetric particle is a neutralino, supersymmetric processes lead to a large amount of missing energy in the detector. The most important Standard Model background for the same-sign dilepton channel is the semileptonic decay of top-antitop-pairs. One lepton originates from the leptonic decay of the W boson, the other lepton originates from one of the b quarks. Here, the neutrinos are responsible for the missing energy. The Standard Model background can be strongly reduced by applying cuts on the transverse momenta of jets, on the missing energy and on the lepton isolation. -
Patterns of Conservation of Spliceosomal Intron Structures and Spliceosome Divergence in Representatives of the Diplomonad and Parabasalid Lineages Andrew J
Hudson et al. BMC Evolutionary Biology (2019) 19:162 https://doi.org/10.1186/s12862-019-1488-y RESEARCH ARTICLE Open Access Patterns of conservation of spliceosomal intron structures and spliceosome divergence in representatives of the diplomonad and parabasalid lineages Andrew J. Hudson1,2†, David C. McWatters1,2†, Bradley A. Bowser3, Ashley N. Moore1,2, Graham E. Larue3, Scott W. Roy3,4 and Anthony G. Russell1,2* Abstract Background: Two spliceosomal intron types co-exist in eukaryotic precursor mRNAs and are excised by distinct U2- dependent and U12-dependent spliceosomes. In the diplomonad Giardia lamblia, small nuclear (sn) RNAs show hybrid characteristics of U2- and U12-dependent spliceosomal snRNAs and 5 of 11 identified remaining spliceosomal introns are trans-spliced. It is unknown whether unusual intron and spliceosome features are conserved in other diplomonads. Results: We have identified spliceosomal introns, snRNAs and proteins from two additional diplomonads for which genome information is currently available, Spironucleus vortens and Spironucleus salmonicida, as well as relatives, including 6 verified cis-spliceosomal introns in S. vortens. Intron splicing signals are mostly conserved between the Spironucleus species and G. lamblia. Similar to ‘long’ G. lamblia introns, RNA secondary structural potential is evident for ‘long’ (> 50 nt) Spironucleus introns as well as introns identified in the parabasalid Trichomonas vaginalis. Base pairing within these introns is predicted to constrain spatial distances between splice junctions to similar distances seen in the shorter and uniformly-sized introns in these organisms. We find that several remaining Spironucleus spliceosomal introns are ancient. We identified a candidate U2 snRNA from S. vortens, and U2 and U5 snRNAs in S. -
Chapter 8. the Atomic Nucleus
Chapter 8. The Atomic Nucleus Notes: • Most of the material in this chapter is taken from Thornton and Rex, Chapters 12 and 13. 8.1 Nuclear Properties Atomic nuclei are composed of protons and neutrons, which are referred to as nucleons. Although both types of particles are not fundamental or elementary, they can still be considered as basic constituents for the purpose of understanding the atomic nucleus. Protons and neutrons have many characteristics in common. For example, their masses are very similar with 1.0072765 u (938.272 MeV) for the proton and 1.0086649 u (939.566 MeV) for the neutron. The symbol ‘u’ stands for the atomic mass unit defined has one twelfth of the mass of the main isotope of carbon (i.e., 12 C ), which is known to contain six protons and six neutrons in its nucleus. We thus have that 1 u = 1.66054 ×10−27 kg (8.1) = 931.49 MeV/c2 . Protons and neutrons also both have the same intrinsic spin, but different magnetic moments (see below). Their main difference, however, pertains to their electrical charges: the proton, as we know, has a charge of +e , while the neutron has none, as its name implies. Atomic nuclei are designated using the symbol A Z XN , (8.2) with Z, N and A the number of protons (atomic element number), the number of neutrons, and the atomic mass number ( A = Z + N ), respectively, while X is the chemical element symbol. It is often the case that Z and N are omitted, when there is no chance of confusion. -
A Free-Living Protist That Lacks Canonical Eukaryotic DNA Replication and Segregation Systems
bioRxiv preprint doi: https://doi.org/10.1101/2021.03.14.435266; this version posted March 15, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 A free-living protist that lacks canonical eukaryotic DNA replication and segregation systems 2 Dayana E. Salas-Leiva1, Eelco C. Tromer2,3, Bruce A. Curtis1, Jon Jerlström-Hultqvist1, Martin 3 Kolisko4, Zhenzhen Yi5, Joan S. Salas-Leiva6, Lucie Gallot-Lavallée1, Geert J. P. L. Kops3, John M. 4 Archibald1, Alastair G. B. Simpson7 and Andrew J. Roger1* 5 1Centre for Comparative Genomics and Evolutionary Bioinformatics (CGEB), Department of 6 Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada, B3H 4R2 2 7 Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom 8 3Oncode Institute, Hubrecht Institute – KNAW (Royal Netherlands Academy of Arts and Sciences) 9 and University Medical Centre Utrecht, Utrecht, The Netherlands 10 4Institute of Parasitology Biology Centre, Czech Acad. Sci, České Budějovice, Czech Republic 11 5Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Science, 12 South China Normal University, Guangzhou 510631, China 13 6CONACyT-Centro de Investigación en Materiales Avanzados, Departamento de medio ambiente y 14 energía, Miguel de Cervantes 120, Complejo Industrial Chihuahua, 31136 Chihuahua, Chih., México 15 7Centre for Comparative Genomics and Evolutionary Bioinformatics (CGEB), Department of 16 Biology, Dalhousie University, Halifax, NS, Canada, B3H 4R2 17 *corresponding author: [email protected] 18 D.E.S-L ORCID iD: 0000-0003-2356-3351 19 E.C.T. -
Phylogenomic Analyses Support the Monophyly of Excavata and Resolve Relationships Among Eukaryotic ‘‘Supergroups’’
Phylogenomic analyses support the monophyly of Excavata and resolve relationships among eukaryotic ‘‘supergroups’’ Vladimir Hampla,b,c, Laura Huga, Jessica W. Leigha, Joel B. Dacksd,e, B. Franz Langf, Alastair G. B. Simpsonb, and Andrew J. Rogera,1 aDepartment of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada B3H 1X5; bDepartment of Biology, Dalhousie University, Halifax, NS, Canada B3H 4J1; cDepartment of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic; dDepartment of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom; eDepartment of Cell Biology, University of Alberta, Edmonton, AB, Canada T6G 2H7; and fDepartement de Biochimie, Universite´de Montre´al, Montre´al, QC, Canada H3T 1J4 Edited by Jeffrey D. Palmer, Indiana University, Bloomington, IN, and approved January 22, 2009 (received for review August 12, 2008) Nearly all of eukaryotic diversity has been classified into 6 strong support for an incorrect phylogeny (16, 19, 24). Some recent suprakingdom-level groups (supergroups) based on molecular and analyses employ objective data filtering approaches that isolate and morphological/cell-biological evidence; these are Opisthokonta, remove the sites or taxa that contribute most to these systematic Amoebozoa, Archaeplastida, Rhizaria, Chromalveolata, and Exca- errors (19, 24). vata. However, molecular phylogeny has not provided clear evi- The prevailing model of eukaryotic phylogeny posits 6 major dence that either Chromalveolata or Excavata is monophyletic, nor supergroups (25–28): Opisthokonta, Amoebozoa, Archaeplastida, has it resolved the relationships among the supergroups. To Rhizaria, Chromalveolata, and Excavata. With some caveats, solid establish the affinities of Excavata, which contains parasites of molecular phylogenetic evidence supports the monophyly of each of global importance and organisms regarded previously as primitive Rhizaria, Archaeplastida, Opisthokonta, and Amoebozoa (16, 18, eukaryotes, we conducted a phylogenomic analysis of a dataset of 29–34).