DOCSLIB.ORG

THE FIGHTER Nadja Casadei Never Lets Anything Stand in the Way of Her Goals

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
THE FIGHTER Nadja Casadei Never Lets Anything Stand in the Way of Her Goals 2014 #4 medicormedicinska föreningen i stockholm 20 SEK 38 32 Insight with Nobel Prize winner Elizabeth Blackburn Edvard Moser THE FIGHTER Nadja Casadei never lets anything stand in the way of her goals 1 Prelude All You Want For Christmas... AS THE CHRISTMAS LIGHTS GLOW ALONG THE STREETS AND the snow lays gleaming at our feet, we gather together with family and friends that we so rarely our time spends. But there is some- thing more – we know that to open the Christmas gifts is what you’re really waiting for. And what better gift could there be than to find the latest issue of Medicor underneath the Christmas tree? What a Christmas read you would find, because we tell the tale of what make up the positioning system inside our mind. We had the pleasure of talking to Edvard Moser some more, read the entire story on page 34. He’s not the only Nobel Laureate we Medicor got, Elizabeth Blackburn is interviewed on the Insight spot. She discovered the secret behind aging, gradually unfolding a story about telomerase that’s indeed engaging. Furthermore, we met with Nadja Casadei to talk about what makes her keep fighting every day. It is a truly inspiring interview about never giving up and letting absolutely nothing stop you. For those of you who would prefer a lighter read, we have everything that you will need. If you ever wondered how Santa’s Photo by Jingcheng Zhao for little helper could get a nose so red, wonder no more and check Medicor Magasin out the “Julbord” spread. This magazine is filled with all that Grundad 2006. Åttonde årgången. you could wish, including articles from artificial meat to how to Utges av Medincinska Föreningen i Stockholm ISSN: 1653-9796 survive the winter bliss. Ansvarig utgivare: Robert de Meijere Tryck och reproduktion: Åtta45, Solna Adress: Medicinska Föreningen i Stockholm We hope you enjoy this last issue of the year and look forward to Nobels Väg 10, Box 250, 171 77, Stockholm seeing you again when the spring is getting near. Finally as always Utgivningsplan 2014: nr 1: mars, nr 2: maj, nr 3: oktober, nr 4: december. Kontakta Medicor: [email protected] there are a lot of people we wish to thank, because without them www.medicinskaforeningen.se these pages would be blank. So from all of us to all of you: Merry Frilansmaterial: Medicor förbehåller sig rätten att redigera inkommet material och Christmas and a Happy New Year to! ansvarar inte för icke beställda texter eller bilder, samt tryckfel. Upphovsman svarar för, genom Medicor publicerat, signerat frilansmaterial; denna(e)s åsikter represen- terar nödvändigtvis inte Medicors eller Medicinska Föreningens. Sincerely, Robert de Meijere Editor-in-Chief Cover photo by Martin Kjellberg for Medicor 2 Overture KAROLINSKA COVER STORY GLOBAL FOCUS DID YOU JOIN THE EBOLA - THE NEW 8 CHASE FOR YOUR 22 BLACK FUTURE? On how the media and our politicians should learn Careers in Health and from the massive attention Science Exposition. surrounding the Ebola outbreak. THE BLACK GOLD 11 Frida Segernäs is ponder- mHEALTH ing on the coffee drinking 23 Mobile health applications at KI. Is it too much? and the need for evidence before widespread imple- 24 mentation. NOV2K 2014 12 Medicor’s Jessica De THE FIGHTER HEALTH CARE AND Loma Olson reports from the event where Science “WHAT DOESN’T 40 REFUGEES Fiction becomes Science KILL YOU MAKES James Salisi on on refugees’ Faction. rights. YOU STRONGER.” An inspiring interview with Nadja Casadei. NOBEL THEME 30 An overview of the Nobel Prize. NOBEL SCIENCE THE CURIOUS CASE 15 OF THE MIND INSIGHT Karolina Werynska on ELIZABETH the psychiatric condition 38 known as DID. BLACKBURN A career that will get you the Nobel Prize. ORGANIC FOOD – 16 WHAT IS THE POINT? Haroon Bayani goes though the arguments for consuming organic food. CULTURE THE HISTORY OF IN VITRO MEAT 44 18 CHOCOLATE? Medicor meets Mark Parvin Kumar tell us the Post, the creator of the story behind the most deli- world’s most expensive cious Christmas treat. hamburger. NAVIGATING THE COMPLEXITIES OF THE FEELING THE WINTER 34 BRAIN 46 BLUES? An interview with Edvard Moser, one of this year’s A guide to surviving the winners of the Nobel Prize in Medicine or Physiology, Swedish winter. and an in-depth look at the cells that constitute the po- sitioning system in our brain. medicor Robert de Meijere • Editor-in-Chief | Oskar Swartling • Associate Editor | Andrey Pyko • Creative Director Ibrahim Rayyes • Proofreader General | Vladimir Choi • Executive Editor | Sergio Scro • Editor of Global Focus | Yasmine Djoumi • Producer Janne Andersson • Senior Advisor | Amanda Kaba Liljeberg • Editor of Campus | Iskra Pollak Dorocic • Editor of Science | Poya Livälven • Editor of Culture Filippa Grönqvist, Vera Berg, Halima Hassan • Reporters | Martin Kjellberg, David Humphreys, Katarina Stojanovic, Maria Belikova • Photographers Gustaf Drevin, Yasmine Djoumi, James Salisi, Haroon Bayani, Karolina Werynska, Jens Magnusson, Parvin Kumar, Anna-Theresia Ekman, Frida Segernäs, Nicolas Guyon, Jessica De Loma Olson, Giulia Gaudenzi, Johanna Tauriainen • Writers | Fergal Horgan • Proofreaders | Mikael Plymoth, Jakub Lewicki • Illustrators 4 Aperture Mark Post holding the world’s most expensive hamburger made from cow stem cells. Medicor talked to him about the technology and ethics be- hind lab-grown meat. Read more on page 18. PHOTO BY: DAVID PARRY / PA WIRE 5 Julbord Christmas-themed Science EVERY CHRISTMAS THE BRITISH MEDICAL JOURNAL PUB- lishes a series of articles with a twist. Be sure to check out the BMJ issue around Christmas time to get information on It has been why Rudolph’s nose is red, how James Bond’s drinking habits hypothesized would affect his physical and mental status, the genetics of magic and much more. that Rudolph’s red nose is the result of a parasitic infection of his respiratory system. Ho Ho Ho In Canada the Canada Post uses “the characters H0H 0H0 as the postal code for letters to be sent to Santa Claus. Knäckand other Christmas hazards CHRISTMAS IS A VERY STRESSFUL TIME FOR MANY, LEAD- USA ing to an increase of injuries around the festive period. Dentists experience an increased income of patients with A STUDY FROM THE UNITED detached fillings, cracked teeth and toothache, caused by States suggests there is no peak in “knäck” and other sweets consumed around the holidays suicides during the holidays. The but also grinding of teeth due to stress. Other common study, conducted over a 35-year peri- injuries are burns caused by boiling “knäck” or preparing od, saw no increase of suicides before, the Christmas dinner. Not even the Christmas tree is not as during, or after holidays. On the contra- harmless as it seems. Every year people are injured falling ry, before Christmas the rates of psychi- from unstable chairs when decorating their Christmas trees, atric visits actually decrease or falling down from lofts when looking for decora- in the US, debunking tions. The decorations themselves are a danger to the popular belief toddlers that bite into glass baubles or choke on that suicides are more toy-like decorations. So, in order to fully enjoy common during the the holidays without cracked teeth or band- holidays, especially dur- aged body parts, make sure to avoid stress and ing Christmas. It is be- excessive amounts of alcohol since these are lieved that this is due the most common causes of injuries. to an increase in social support during the holidays. 6 Julbord Sweden MANY PEOPLE GAIN WEIGHT DURING 3% fat. Herring, salmon and nuts are also Christmas and since obesity and cardiovas- healthy alternatives. But the healthiest sug- cular diseases are an increasing problem gestion would be to enjoy everything in in the Western world, many Swedes have moderation. Swedish studies suggest that become more conscious of what they eat. nocturnal feasting per se does not make you Traditional Christmas food can be quite fat, so enjoying a midnight “lussebulle” is fatty, but there are healthy alternatives. given green light. Luckily enough, the most popular dish for Christmas, the Christmas ham is one of the healthier alternatives containing only Japan CHRISTMAS IS NOT WIDELY CELEBRATED in Japan, although some American cus- toms has been introduced. Christmas Eve is more similar to Valentine’s Day, a day for couples to spend time together and exchange gifts. Christmas eve, is also, the day for fried chicken. KFC and other restaurants serving fried chicken have their busiest day of the year on Christmas eve. Thanks to an extremely successful campaign in 1974, a bucket of Christmas Chicken is a must during the holidays. 7,000 Pieces of chicken fried in one KFC outlet in Tokyo on Christmas Eve. India ONLY 2.3 % OF THE INDIAN POPULATION ARE Christians, meaning that Christmas is a rela- 2.3% tively small festival in India compared to the of the Indian other ones celebrated. However, since the Indian population is about 1.2 billion, there population are more than 24 million Christmas celebra- are Christians tors in the country. 7 KAROLINSKA Did you join the for your future? Photo by David Humphreys & Katarina Stojanovic As a Healthcare or Life Sciences student, you may not always know which career path to choose once you graduate. Perhaps you are not even aware of all the non-traditional career options available to you. Is your future really set in stone after you have completed your education? Think differently! On the 12th of November, a group of students held the biggest career fair that Karolinska Institutet had ever seen: CHaSE (Careers in Health and Science Exposition). CHaSE is a career fair targeted at all students and graduates in the health and life sciences.
Load more

Recommended publications
  • 書 名 等 発行年 出版社 受賞年 備考 N1 Ueber Das Zustandekommen Der
    書 名 等 発行年 出版社 受賞年 備考 Ueber das Zustandekommen der Diphtherie-immunitat und der Tetanus-Immunitat bei thieren / Emil Adolf N1 1890 Georg thieme 1901 von Behring N2 Diphtherie und tetanus immunitaet / Emil Adolf von Behring und Kitasato 19-- [Akitomo Matsuki] 1901 Malarial fever its cause, prevention and treatment containing full details for the use of travellers, University press of N3 1902 1902 sportsmen, soldiers, and residents in malarious places / by Ronald Ross liverpool Ueber die Anwendung von concentrirten chemischen Lichtstrahlen in der Medicin / von Prof. Dr. Niels N4 1899 F.C.W.Vogel 1903 Ryberg Finsen Mit 4 Abbildungen und 2 Tafeln Twenty-five years of objective study of the higher nervous activity (behaviour) of animals / Ivan N5 Petrovitch Pavlov ; translated and edited by W. Horsley Gantt ; with the collaboration of G. Volborth ; and c1928 International Publishing 1904 an introduction by Walter B. Cannon Conditioned reflexes : an investigation of the physiological activity of the cerebral cortex / by Ivan Oxford University N6 1927 1904 Petrovitch Pavlov ; translated and edited by G.V. Anrep Press N7 Die Ätiologie und die Bekämpfung der Tuberkulose / Robert Koch ; eingeleitet von M. Kirchner 1912 J.A.Barth 1905 N8 Neue Darstellung vom histologischen Bau des Centralnervensystems / von Santiago Ramón y Cajal 1893 Veit 1906 Traité des fiévres palustres : avec la description des microbes du paludisme / par Charles Louis Alphonse N9 1884 Octave Doin 1907 Laveran N10 Embryologie des Scorpions / von Ilya Ilyich Mechnikov 1870 Wilhelm Engelmann 1908 Immunität bei Infektionskrankheiten / Ilya Ilyich Mechnikov ; einzig autorisierte übersetzung von Julius N11 1902 Gustav Fischer 1908 Meyer Die experimentelle Chemotherapie der Spirillosen : Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie / N12 1910 J.Springer 1908 von Paul Ehrlich und S.
    [Show full text]
  • Die Woche Spezial
    In cooperation with DIE WOCHE SPEZIAL >> Autographs>vs.>#NobelSelfie Special >> Big>Data>–>not>a>big>deal,> Edition just>another>tool >> Why>Don’t>Grasshoppers> Catch>Colds? SCIENCE SUMMIT The>64th>Lindau>Nobel>Laureate>Meeting> devoted>to>Physiology>and>Medicine More than 600 young scientists came to Lindau to meet 37 Nobel laureates CAREER WONGSANIT > Women>to>Women: SUPHAKIT > / > Science>and>Family FOTOLIA INFLAMMATION The>Stress>of>Ageing > FLASHPICS > / > MEETINGS > FOTOLIA LAUREATE > CANCER RESEARCH NOBEL > LINDAU > / > J.>Michael>Bishop>and GÄRTNER > FLEMMING > JUAN > / the>Discovery>of>the>first> > CHRISTIAN FOTOLIA Human>Oncogene EDITORIAL IMPRESSUM Chefredakteur: Prof. Dr. Carsten Könneker (v.i.S.d.P.) Dear readers, Redaktionsleiter: Dr. Daniel Lingenhöhl Redaktion: Antje Findeklee, Jan Dönges, Dr. Jan Osterkamp where>else>can>aspiring>young>scientists> Ständige Mitarbeiter: Lars Fischer Art Director Digital: Marc Grove meet>the>best>researchers>of>the>world> Layout: Oliver Gabriel Schlussredaktion: Christina Meyberg (Ltg.), casually,>and>discuss>their>research,>or>their> Sigrid Spies, Katharina Werle Bildredaktion: Alice Krüßmann (Ltg.), Anke Lingg, Gabriela Rabe work>–>or>pressing>global>problems?>Or> Verlag: Spektrum der Wissenschaft Verlagsgesellschaft mbH, Slevogtstraße 3–5, 69126 Heidelberg, Tel. 06221 9126-600, simply>discuss>soccer?>Probably>the>best> Fax 06221 9126-751; Amtsgericht Mannheim, HRB 338114, UStd-Id-Nr. DE147514638 occasion>is>the>annual>Lindau>Nobel>Laure- Geschäftsleitung: Markus Bossle, Thomas Bleck Marketing und Vertrieb: Annette Baumbusch (Ltg.) Leser- und Bestellservice: Helga Emmerich, Sabine Häusser, ate>Meeting>in>the>lovely>Bavarian>town>of> Ute Park, Tel. 06221 9126-743, E-Mail: [email protected] Lindau>on>Lake>Constance. Die Spektrum der Wissenschaft Verlagsgesellschaft mbH ist Kooperati- onspartner des Nationalen Instituts für Wissenschaftskommunikation Daniel>Lingenhöhl> GmbH (NaWik).
    [Show full text]
  • Nfap Policy Brief » O C T O B E R 2017
    NATIONAL FOUNDATION FOR AMERICAN POLICY NFAP POLICY BRIEF» O CTOBER 2017 IMMIGRANTS AND NOBEL PRIZES : 1901- 2017 EXECUTIVE SUMMARY Immigrants have been awarded 39 percent, or 33 of 85, of the Nobel Prizes won by Americans in Chemistry, Medicine and Physics since 2000. In 2017, the sole American winner of the Nobel Prize in Chemistry was an immigrant, Joachim Frank, a Columbia University professor born in Germany. Immigrant Reiner Weiss, who was born in Germany and came to the United States as a teenager, was awarded the 2017 Nobel Prize in Physics, sharing it with two other Americans, Kip S. Thorne and Barry C. Barish. In 2016, all 6 American winners of the Nobel Prize in economics and scientific fields were immigrants. These achievements by immigrants point to the gains to America of welcoming talent from across the globe. It does not mean America should welcome only Nobel Prize winners. Such a policy would be impossible to implement, since most immigrant Nobel Prize winners enter the United States many years before being awarded this honor. Most people immigrate to another country in their 20s, particularly employment-based immigrants, who either study in America or come here to work shortly after obtaining a degree abroad. The average of age of Nobel Prize winners at the time of the award is 59.5 years, according to economist Mark J. Perry.1 Table 1 Immigrant Nobel Prize Winners in Chemistry, Medicine and Physics Since 2000 Immigrant Nobel Winners Since 2000 33 of 85 American winners have been immigrants Percentage of Immigrant Winners Since 2000 39% Source: Royal Swedish Academy of Sciences, National Foundation for American Policy, George Mason University Institute for Immigration Research.
    [Show full text]
  • Biography of Carol W. Greider BIOGRAPHY
    Biography of Carol W. Greider BIOGRAPHY hen biochemist and mol- in Berkeley, things clicked again. ‘‘I re- ecular biologist Carol ally liked my conversations with Liz, and Greider was a first-year there were a number of other people in graduate student at the the department that would be poten- WUniversity of California, Berkeley, in tially fun to work with, so I went there,’’ 1984, she began to study a topic slightly says Greider. off the beaten path. With her adviser, Elizabeth Blackburn, Greider investi- First Glimpse of Telomerase gated how a certain single-celled pond Throughout the late 1970s and early organism maintained the tens of thou- 1980s, Blackburn and other researchers sands of caps on the ends of its mini- had found that telomeres show unusual chromosomes—specialized structures behavior and structure. The chromosome known as telomeres that protect against caps consist of multiple repeats of a sim- DNA damage. On Christmas Day, 9 ple motif, which in the pond ciliate Tetra- months later, Greider spotted signs of a hymena was six nucleotides long. The new enzyme, telomerase, that appeared mechanism by which these sequence re- to be responsible for this chromosomal peats were added to the ends of telomeres maintenance. The finding helped kick in ciliates and yeast had not yet been off a field of research that would attract identified. Most researchers believed re- the attention of longevity researchers, combination was responsible, but Black- cancer biologists, and the biotechnology burn favored the explanation of specific industry. repeat addition by an as-yet-unknown Today, so many papers are published enzyme.
    [Show full text]
  • Lettre Parrain 2010
    Paris, February 2012 We are pleased to launch the Call for Nominations for the 2013 L’ORÉAL-UNESCO Awards For Women in Science dedicated to the Physical Sciences. Dear Professor, You are invited to submit candidates for the 2013 L’ORÉAL-UNESCO Awards in Physical Sciences. You can propose outstanding women scientists from any continent. The five US$100,000 Awards will be presented in March 2013 at UNESCO Headquarters in Paris, France to five women scientists who have made an outstanding contribution to scientific advancement. You will find enclosed The Call for Nominations describing the procedures, the official nomination form (one per geographic region), and a brochure of the Award Laureates from 1998 through 2011. THE DEADLINE FOR SUBMITTING NOMINATIONS IS MAY 30th 2012 The L’ORÉAL-UNESCO Awards Jury in Physical Sciences is presided by Professor Ahmed Zewail, Nobel Prize in Chemistry 1999, in the presence of Professor Christian de Duve, Nobel Prize in Medicine 1974 and Founding President of the Awards. In 2011, the Jury designated the following Laureates in Physical Sciences: Professor Faiza Al-Kharafi (Kuwait) for AFRICA & the ARAB STATES Professor Vivian Wing-Wah Yam (Hong Kong) for ASIA-PACIFIC Professor Anne L’Huillier (Sweden) for EUROPE Professor Silvia Torres-Peimbert (Mexico) for LATIN AMERICA Professor Jillian Banfield (USA) for NORTH AMERICA Fondation d’entreprise régie par la loi n°87-571 du 23 juillet 1987 modifiée 41 rue Martre – 92117 Clichy Cedex – Tél. + 33 (0) 1 47 56 72 74 – Fax : + 33 (0) 1 47 56 42 59 - E-Mail : [email protected] Siège Social : 14 rue Royale – 75008 Paris Since its inception in 1998, the For Women in Science partnership expands each year.
    [Show full text]
  • Laudatio Jack W. Szostak
    Laudatio Jack W. Szostak Your Royal Highness, Your Excellencies, Members of the Board of the Heineken Foundation and the Alfred Heineken Fondsen Foundation, in particular their Chair, Mrs. De Carvalho, Ladies and gentlemen, Dear professor Szostak, The oldest of the Heineken Prizes, the one for Biochemistry and Biophysics, has often been awarded for a single outstanding discovery. This year, however, the prize will be awarded to Professor Jack Szostak for a range of highly original contributions to our understanding of the processes of life. Born in 1952, Jack Szostak’s career has been quite remarkable. He was only 19 years old when he started his PhD programme. He obtained his degree at Cornell University in 1977. He has been a professor at Harvard Medical School for most of his professional life, and now combines this position with an appointment as the Alex Rich Distinguished Investigator at Massachusetts General Hospital. Many of his discoveries were initially controversial, but they often opened up new fields of research. Let me describe a few of his major findings. In the early 1980s, Szostak and Rothstein discovered that the end of a linear double-stranded DNA triggers recombination in yeast in a manner similar to recombination events during meiosis (meiosis is the process of cell division that generates the germ cells in sexual reproduction). Szostak then made the unorthodox proposal that double strand breaks in fact could be the initiating event in normal meiotic recombination. This discovery had major practical implications for yeast genetics and biochemistry, as it became easy to transform yeast cells with DNA fragments of choice.
    [Show full text]
  • All Living Organisms Are Organised Into Large Groups Called Kingdoms. Fungi Were Orig
    What are fungi and how important are they? All living organisms are organised into large groups called Kingdoms. Fungi were originally placed in the Plant Kingdom then, scientists learned that fungi were more closely related to animals than to plants. Then scientists decided that fungi were not sufficiently similar to animals to be placed in the animal kingdom and so today fungi have their own Kingdom – the Fungal Kingdom. There are thought to be around up to 3.8 million species of fungi, of which only 120,000 have been named. The fungal kingdom is largely hidden from our view and we usually only see the “fruit” of a fungus. The living body of a fungus is called a mycelium and is made up of a branching network of filaments known as hyphae. Fungal mycelia are usually hidden in a food source like wood and we only know they are there when they develop mushrooms or other fruiting bodies. Some fungi only produce microscopic fruiting bodies and we never notice them. Fungi feed by absorbing nutrients from the organic material that they live in. They digest their food before they absorb it by secreting acids and enzymes. Different fungi have evolved to live on various types of organic matter, some live on plants (Magneportha grisea – the rice blast fungus), some on animals (Trichophyton rubrum - the athlete’s foot fungus) and some even live on insects (Cordyceps australis). Helpful fungi Most of us use fungi every day without even knowing it. We eat mushrooms and Quorn, but we also prepare many other foods using fungi.
    [Show full text]
  • Nobel Media and Astrazeneca and Bring Nobel Laureate Elizabeth Blackburn to Korea
    Press Release 2 9 October 2012 Nobel Media and AstraZeneca and bring Nobel Laureate Elizabeth Blackburn to Korea First AstraZeneca Nobel Medicine Initiative event in Korea aims to inspire local students and scientists Nobel Media AB, the company responsible for managing and developing media rights in connection with the Nobel Prize and AstraZeneca, a global innovation-driven biopharmaceutical company, will bring Professor Elizabeth Helen Blackburn, the 2009 Nobel Laureate in Physiology or Medicine, to Catholic University and Seoul National University in Seoul, Korea on 1-2 November. The aim of the visit is to increase interest in the Nobel Prize awarded achievements within the fields of Physiology or Medicine and inspire the students and researchers in Korea. The initiative in Korea consists of various educational events including lectures at universities on Professor Blackburn’s research on telomeres and telomerase. Professor Blackburn was jointly awarded the 2009 Nobel Prize in Physiology or Medicine along with Carol W. Greider and Jack W. Szostak "for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase". They have solved a major problem in biology: how chromosomes are completely copied during cell division and how they are protected against degradation. The Nobel Laureates have shown that the solution is to be found at the ends of the chromosomes – the telomeres – and the enzyme that forms them – telomerase. During her visit, Professor Elizabeth Blackburn will deliver lectures at both the Catholic University and the Seoul National University. At the Catholic University, Professor Blackburn will give a lecture entitled “Cancer and Responses to Perturbing Telomere Maintenance.” And at the Seoul National University, she will speak about “Telomeres and Telomerase: their implications for human health and disease.” Following the lectures, students and faculty will have the unique opportunity to interact directly with the Nobel Laureate, through round table discussions and student interviews.
    [Show full text]
  • Hope Funds for Cancer Research Press Release
    Hope Funds for Cancer Research Press Release 2019 Hope Funds Honoree William G. Kaelin to Receive Nobel Prize For Immediate Release Media Contact: John A. Wells 212-769-2170 [email protected] Newport, RI - October 7, 2019 - The Hope Funds for Cancer Research, dedicated to advancing innovative research for the most difficult-to-treat cancers, congratulates its 2019 Award of Excellence recipient William G. Kaelin, M.D., for being awarded the 2019 Nobel Prize in Physiology or Medicine for his work in the discovery of how cells sense and adapt to oxygen availability. The Nobel Committee stated that Dr. Kaelin, along with Sir Peter Radcliffe and Gregg Semenza, established the basis for our understanding of how oxygen levels affect cellular metabolism and physiological function. Their discoveries have also paved the way for promising new strategies to fight anemia, cancer and many other diseases. "A noted target resulting from these discoveries is HIF (hypoxia-inducible factor)," stated Leah Rush Cann, Hope Funds Trustees, "Applications for increased HIF-expression are to treat anemia. Cancers result from tumors having increased HIF-expression, so drugs that inhibit HIF-expression could have wide ranging impact in cancer treatment." "We at the Hope Funds for Cancer Research congratulate Dr. William G. Kaelin, Jr. for being named a recipient of the 2019 Nobel Prize in Physiology or Medicine," stated Lewis C. Cantley, Ph.D., Chairman of the Hope Funds Board of Trustees. The awards were announced earlier today in Stockholm. To view the Nobel release, Click Here About William G. Kaelin, M.D. Dr. Kaelin is the Sidney Farber Professor of Medicine, in the Department of Medicine at the Dana-Farber Cancer Institute and the Brigham and Women's Hospital, Harvard Medical School.
    [Show full text]
  • Nobel Prize Inspiration Initiative in PARTNERSHIP with Spain 2018
    Nobel Prize Inspiration Initiative IN PARTNERSHIP WITH Spain 2018 Dossier Nobel Prize Inspiration Initiative (NPII) es un programa global, diseñado para que los Premios Nobel puedan compartir su experiencia personal y su visión sobre la ciencia, inspirando a estudiantes y jóvenes investigadores CUENTA CON UN IMPORTANTE PANEL DE PREMIOS NOBEL Cada evento tiene una duración de 2 o 3 días ▪ Dr. Peter Agre ▪ Dr. Barry Marshall ▪ Dr. Bruce Beutler ▪ Dr. Craig Mello ▪ Dra. Elizabeth Blackburn ▪ Dr. Paul Nurse ▪ Dr. Michael Brown ▪ Dr. Oliver Smithies ▪ Dr. Martin Chalfie ▪ Dr. Françoise Barré-Sinoussi ▪ Dr. Peter Doherty ▪ Dr. Randy Schekman ▪ Dr. Joseph Goldstein ▪ Dr. Harold Varmus ▪ Dr. Tim Hunt ▪ Dr. Brian Kobilka ▪ Dr. Roger Kornberg LAS ACTIVIDADES SE ORGANIZAN EN TORNO A TOPICS QUE PERMITEN COMPARTIR SU VISIÓN SOBRE EL DESARROLLO DE CARRERAS INVESTIGADORAS Los eventos incluyen la celebración de ponencias, ✓ Advice for Young Scientists ✓ Inspiration and Aspiration mesas redondas, entrevistas, sesiones de preguntas ✓ Career Insights ✓ Life after the Nobel Prize y respuestas, paneles de debate, promoviendo ✓ Characteristics of a Scientist ✓ Mentorship especialmente interacciones informales con los ✓ Clinician Scientists ✓ Surprises and Setbacks científicos más jóvenes. ✓ Collaboration ✓ The Nature of Discovery ✓ Communicating Research ✓ Work-Life Balance Los Premios Nobel se reúnen con jóvenes de ✓ Early Life ✓ Your Views diferentes instituciones, universidades, centros de ✓ Getting Started investigación, etc. 2 Los diferentes formatos de
    [Show full text]
  • Biozentrum Lectures
    Biozentrum Lectures The Ribosome – How stop codons are recognized during translation Venki Ramakrishnan Nobel Prize Laureate Professor, MRC Laboratory of Molecular Biology Cambridge, UK Tuesday, 13 October 2015, 6.15 pm Venki Ramakrishnan: The Ribosome – How stop codons are recognized during translation Ribosomes are the large molecular machines that translate genetic information into functional proteins. Since the elucidation of the atomic structures of the ribosomal subunits over 15 years ago, a goal of the community has been to visualize the ribosome trapped in various stag- es of translation. An important aspect of this is termination, in which one of three stop codons enters the A site of the ribosome and is recognized by release factors. We began our studies on termination almost 10 years ago with bacterial ribosomes. However, eukaryotic termination is different, with a single evolutionarily unrelated release factor able to recognize all three stop codons. We have used recent advances in electron microscopy to determine the structure of a eukaryotic release factor in the act of recognizing all three Venki Ramakrishnan is a group leader and Deputy stop codons to elucidate the differences between eukaryotic and bac- Director at the MRC Laboratory of Molecular Biology terial translational termination. in Cambridge, UK. He obtained a PhD in physics from Ohio State University in 1976 before moving into biology. As a Postdoc at Yale University he began to work on ribosomes, his lifelong interest. In 1995, he became Professor in Bio- chemistry at Utah University. Four years later, he moved to his current position at the MRC. Venki Ramakrishnan studies ribosomes by combining biochemical analysis with structure determination.
    [Show full text]
  • Annual Report 2018
    ANNUAL REPORT 2017-2018 Table of Contents 2 Director’s Letter 3 History and Mission 4 Faculty 8 Faculty News 12 Faculty Research Programs 22 Scientific Advancements 34 Collaborations 46 Academic and Community Activities 51 Faculty Publications FY 2018 59 Teaching 62 Postdoctoral Trainees 64 Visiting Scientists 65 Graduate Students 69 Grants and Contracts 77 Events 77 Zilkha Seminar Series 80 8th Annual Zach Hall Lecture 82 Los Angeles Brain Bee 84 Soprano and Musical Ambassador Renée Fleming visits Zilkha 85 Music to Remember – LA Opera/Alzheimer’s Greater Los Angeles 86 Searching for Solutions: 5th Annual AD Symposia Held at Zilkha Institute 87 Administration and Operating Budget 88 Development 1 Director’s Letter Dear Friends, The year 2018 began with a strong start when the department of Physiology & Neuroscience was ranked number 3 in the nation according to the Blue Ridge Institute. I am proud of the work we have done to achieve this great honor and in awe of our faculty who have made this accomplishment possible, by receiving a large number of federal awards for their research. Of course, as much as we love to have well-funded research programs, it is the science that really matters, and as you will see across the following pages, we have made great strides in so many different areas, from neural circuits and genomics, to imaging and Alzheimer’s. I am proud of the work we are doing and happy to be recognized for it. In addition to awards received, we welcomed a number of visitors and speakers who came to the Zilkha Neurogenetic Institute, some to share their cutting-edge research, others to learn of the advances we have made.
    [Show full text]