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Appendix 1 BNF Codes of Drugs Lists Used to Define Exposure Groups

Appendix 1 BNF Codes of Drugs Lists Used to Define Exposure Groups

Appendix 1

BNF Codes of drugs lists used to define exposure groups.

Anticholinergic d411. d412. Chlorpromazine d413. Chlorpromazine d414. Chlorpromazine d415. Chlorpromazine d41a. Chlorpromazine d41b. Chlorpromazine d41c. Chlorpromazine d41d. Chlorpromazine d4b1. d4e1. d4ex. PROMAZINE d4g.. d4g1. Thioridazine d4g2. Thioridazine d4g3. Thioridazine d4g5. Thioridazine d4g7. Thioridazine d4gp. Thioridazine d4gt. Thioridazine d4gu. Thioridazine d4gv. Thioridazine d4gw. Thioridazine d4gz. Thioridazine d4h.. d4h1. Trifluoperazine d4h2. Trifluoperazine d4h3. Trifluoperazine d4h4. Trifluoperazine d4hs. Trifluoperazine d4ht. Trifluoperazine d4hu. Trifluoperazine d4hx. Trifluoperazine d4l2. d4r1. d4r3. OLANZAPINE d4r7. OLANZAPINE d4s1. d4s2. QUETIAPINE d4s3. QUETIAPINE d4s5. QUETIAPINE d4ss. QUETIAPINE d4sx. QUETIAPINE d7... d71.. d711. Amitriptyline d712. Amitriptyline d713. Amitriptyline d719. Amitriptyline d71a. Amitriptyline d71b. Amitriptyline d71c. Amitriptyline d71d. Amitriptyline d71e. Amitriptyline d71f. Amitriptyline d71u. Amitriptyline d71v. Amitriptyline d71w. Amitriptyline d71y. Amitriptyline d71z. Amitriptyline d73.. d731. Clomipramine d732. Clomipramine d733. Clomipramine d736. Clomipramine d73s. Clomipramine d73t. Clomipramine d73u. Clomipramine d73v. Clomipramine d73w. Clomipramine d73z. Clomipramine d75.. d751. DOSULEPIN d752. DOSULEPIN d755. DOSULEPIN d756. DOSULEPIN d75y. DOSULEPIN d75z. DOSULEPIN d761. d762. Doxepin d765. Doxepin d76w. Doxepin d76x. Doxepin d76y. Doxepin d76z. Doxepin d77.. d771. Imipramine d772. Imipramine d775. Imipramine d776. Imipramine d79.. d791. Lofepramine d79z. Lofepramine d7a2. d7a3. Maprotiline d7b.. d7b1. MIANSERIN d7b3. MIANSERIN d7b4. MIANSERIN d7b7. MIANSERIN d7b9. MIANSERIN d7c1. d7c3. Nortriptyline d7c6. Nortriptyline d7c8. Nortriptyline d7cy. Nortriptyline d7d3. d7f1. d7f2. Trimipramine d7f3. Trimipramine d7fx. Trimipramine d7fy. Trimipramine d7fz. Trimipramine d911. Amitriptyline d913. Nortriptyline,flupenazine d914. Nortriptyline,flupenazine d916. Amitriptyline d917. Amitriptyline

Other a4... a41.. a451. Dicyclomine a453. Dicyclomine a454. Dicyclomine a455. Dicyclomine a45x. Dicyclomine a45y. Dicyclomine a471. HYOSCINE a473. HYOSCINE a47y. HYOSCINE a4b1. methyl a4by. Poldine methyl a4c1. Propantheline a4c2. Propantheline a821. Atropine a823. Atropine bf2f. c831. c833. Brompheniramine c84.. c841. Chlorphenamine c843. Chlorphenamine c84x. Chlorphenamine c84y. Chlorphenamine c851. c85y. Clemastine c88 c882. Diphenhydramine c885. Diphenhydramine c888. Diphenhydramine c8a.. c8i1. c8i2. Promethazine c8i9. Promethazine c8iu. Promethazine c8iv. Promethazine c8iw. Promethazine ch2h. Diphenhydramine ci1l. CHLORPHENAMINE ci1p. CHLORPHENAMINE ci1q. CHLORPHENAMINE d28.. Hydroxyzine d284. Hydroxyzine d281. Hydroxyzine d282. Hydroxyzine d28x. Hydroxyzine d28y. Hydroxyzine da6.. da61. Paroxetine da62. Paroxetine da63. Paroxetine da64. Paroxetine da65. Paroxetine da67. Paroxetine da68. Paroxetine dh51. diaS. Promethazine dr11. dr12. Trihexyphenidyl dr13. Trihexyphenidyl dr14. Trihexyphenidyl dr1w. Trihexyphenidyl dr1x. Trihexyphenidyl dr22. dr2y. Orphenadrine dr51. Anti-muscarinic dr6.. dr63. Procyclidine dr6w. Procyclidine dr6y. Procyclidine gd... gd21. gd41. gd42. Flavoxate gd4y. Flavoxate gd4z. Flavoxate gd92. gd9z. Terodiline gda.. gda1. Oxybutynin gdA1. TOLTERODINE gdA2. TOLTERODINE gda2. Oxybutynin gda3. Oxybutynin gda4. Oxybutynin gdA4. TOLTERODINE gdA5. TOLTERODINE gdA6. TOLTERODINE gda5. Oxybutynin gda6. Oxybutynin gda7. Oxybutynin gda9. Oxybutynin gdaA. Oxybutynin gdaG. Oxybutynin gdaI. Oxybutynin gdax. Oxybutynin gday. Oxybutynin gdaz. Oxybutynin gdB1. gdBy. TROSPIUM CHLORIDE gdBz. TROSPIUM CHLORIDE gdc1. HYDROCHLORIDE PROPIVERINE gdc2. HYDROCHLORIDE PROPIVERINE gdc4. HYDROCHLORIDE gdd1. SUCCINATE gdd2. SOLIFENACIN SUCCINATE gddy. SOLIFENACIN SUCCINATE gddz. SOLIFENACIN SUCCINATE gdfz. gdg2. FUMARATE gdgy. FESOTERODINE FUMARATE gdgz. FESOTERODINE FUMARATE j851. METHOCARBAMOL j85y. METHOCARBAMOL o311. Atropine o522. Chlorpromazine

Other antidepressants d8... MONOAMINE-OXIDASE INHIBITORS d8... MONOAMINE-OXIDASE INHIBITORS d81.. d811. NARDIL 15mg tablets d81z. PHENELZINE 15mg tablets d82.. * d821. *MARSILID 25mg tablets d822. *MARSILID 50mg tablets d82y. *IPRONIAZID 25mg tablets d82z. *IPRONIAZID 50mg tablets d83.. d831. *MARPLAN 10mg tablets d83z. ISOCARBOXAZID 10mg tablets d84.. d841. *PARNATE 10mg tablets d84z. TRANYLCYPROMINE 10mg tablets d85.. d851. MANERIX 150mg tablets d852. MOCLOBEMIDE 150mg tablets d853. MANERIX 300mg tablets d854. MOCLOBEMIDE 300mg tablets COMPOUND d9... DRUGS d91.. COMPOUND ANTIDEPRESSANTS A-Z d911. *LIMBITROL 5 capsules d912. *LIMBITROL 10 capsules d913. *MOTIPRESS tablets x28CP d914. *MOTIVAL tablets d915. *PARSTELIN tablets d916. TRIPTAFEN tablets d917. TRIPTAFEN-M tablets da2.. da21. OPTIMAX 500mg tablets da22. *OPTIMAX 1g/6g powder da23. *OPTIMAX WV 500mg tablets da24. *PACITRON 500mg tablets da2y. TRYPTOPHAN 500mg tablets da2z. *TRYPTOPHAN 1g/6g powder da3.. MALEATE da31. FAVERIN 50mg tablets da32. FLUVOXAMINE MALEATE 50mg tabs da33. FAVERIN 100mg tablets FLUVOXAMINE MALEATE 100mg da34. tabs da4.. HYDROCHLORIDE da41. FLUOXETINE 20mg capsules da42. *PROZAC 20mg capsules x30 da43. FLUOXETINE 20mg/5mL oral liq da44. PROZAC 20mg/5mL oral liquid da45. PROZAC 20mg capsules da46. FLUOXETINE 60mg capsules da47. *PROZAC 60mg capsules da48. *FELICIUM 20mg capsules da49. OXACTIN 20mg capsules da4A. RANFLUTIN 20mg capsules da4B. PROZIT 20mg/5mL oral solution da4C. PROZEP 20mg/5mL oral solution da5.. HYDROCHLORIDE da51. SERTRALINE 50mg tablets da52. SERTRALINE 100mg tablets da53. LUSTRAL 50mg tablets da54. LUSTRAL 100mg tablets da6.. PAROXETINE HYDROCHLORIDE da61. PAROXETINE 20mg tablets da62. SEROXAT 20mg tablets x30 da63. PAROXETINE 30mg tablets da64. SEROXAT 30mg tablets x30 da65. PAROXETINE 10mg/5mL s/f liq da66. SEROXAT 10mg/5mL s/f liq da67. PAROXETINE 10mg tablets da68. SEROXAT 10mg tablets da7.. da71. VENLAFAXINE 37.5mg tablets da72. VENLAFAXINE 75mg tablets da73. EFEXOR 37.5mg tablets da74. EFEXOR 75mg tablets da75. *VENLAFAXINE 50mg tablets da76. *EFEXOR 50mg tablets da77. VENLAFAXINE 75mg m/r capsules da78. EFEXOR XL 75mg m/r capsules da79. VENLAFAXINE 150mg m/r capsules da7A. EFEXOR XL 150mg m/r capsules da8.. da81. *NEFAZODONE HCL 100mg tabs da82. *NEFAZODONE HCL 200mg tabs da83. *DUTONIN 100mg tablets da84. *DUTONIN 200mg tablets da85. *NEFAZODONE initiation tabs pk da86. *DUTONIN initiation tabs pack da9.. da91. CITALOPRAM 20mg tablets da92. CIPRAMIL 20mg tablets da93. CITALOPRAM 10mg tablets da94. CIPRAMIL 10mg tablets da95. CITALOPRAM 40mg tablets da96. CIPRAMIL 40mg tablets da97. CIPRAMIL 40mg/mL drops 15mL da98. PAXORAN 10mg tablets da99. PAXORAN 20mg tablets da9A. PAXORAN 40mg tablets da9z. CITALOPRAM 40mg/mL oral drops daA.. daA1. REBOXETINE 4mg tablets daA2. EDRONAX 4mg tablets daB.. daB1. MIRTAZAPINE 30mg tablets daB2. *ZISPIN 30mg tablets daB3. MIRTAZAPINE 30mg disp tabs daB4. ZISPIN SOLTAB 30mg disp tabs daB5. MIRTAZAPINE 15mg disp tabs daB6. ZISPIN SOLTAB 15mg disp tabs daB7. MIRTAZAPINE 45mg disp tabs daB8. ZISPIN SOLTAB 45mg disp tabs daBy. MIRTAZAPINE 45mg tablets daBz. MIRTAZAPINE 15mg tablets daC.. daC1. ESCITALOPRAM 10mg tablets daC2. CIPRALEX 10mg tablets daC3. ESCITALOPRAM 20mg tablets daC4. CIPRALEX 20mg tablets daC5. ESCITALOPRAM 5mg tablets daC6. CIPRALEX 5mg tablets daC7. ESCITALOPRAM 10mg/mL oral dps daC8. CIPRALEX 10mg/mL oral drops

du6.. du6.. AMFEBUTAMONE du61. ZYBAN 150mg m/r tablets du6z. BUPROPION HCL 150mg m/r tabs AMFEBUTAMON HCL 150mg m/r du6z. tabs

gde.. gde1. YENTREVE 20mg g/r capsules gde2. YENTREVE 40mg g/r capsules gde3. CYMBALTA 30mg g/r capsules gde4. *CYMBALTA 60mg g/r capsules gdew. *DULOXETINE 60mg g/r capsules gdex. DULOXETINE 30mg g/r capsules gdey. DULOXETINE 20mg g/r capsules gdez. DULOXETINE 40mg g/r capsules

dq6.. dq61. ELDEPRYL 5mg tablets dq62. ELDEPRYL 10mg tablets dq63. ELDEPRYL 10mg/5mL syrup dq64. *VIVAPRYL 5mg tablets dq65. *VIVAPRYL 10mg tablets dq66. *STILLINE 5mg tablets dq67. *STILLINE 10mg tablets dq68. *CENTRAPRYL 5 tablets dq69. *CENTRAPRYL 10 tablets dq6A. ZELAPAR 1.25mg tablets dq6w. SELEGILINE HCL 1.25mg tablets dq6x. SELEGILINE HCL 10mg/5mL syrup dq6y. SELEGILINE HCL 10mg tablets dq6z. SELEGILINE HCL 5mg tablets

Benzodiazepines

d14.. FLUNITRAZE d141. ROHYPNOL d14z. FLUNITRAZE d15.. FLURAZEPAM d151. DALMANE d152. DALMANE d153. PAXANE d154. PAXANE d15y. FLURAZEPAM d15z. FLURAZEPAM d16.. LOPRAZOLAM d161. LOPRAZOLAM d162. DORMONOCT d17.. LORMETAZEP d171. LORMETAZEP d172. LORMETAZEP d173. d174. d18.. NITRAZEPAM d181. NITRAZEPAM d182. NITRAZEPAM d183. NITRAZEPAM d184. NITRAZEPAM d185. MOGADON d186. MOGADON d187. NITRADOS d188. d189. REMNOS d18a. REMNOS d18b. d18c. SOMNITE d18d. d18e. UNISOMNIA d18f. NITRAZEPAM d1a.. TEMAZEPAM d1a1. TEMAZEPAM d1a2. TEMAZEPAM d1a3. TEMAZEPAM d1a4. TEMAZEPAM d1a5. TEMAZEPAM d1a6. NORMISON d1a7. NORMISON d1a8. TEMAZEPAM d1a9. TEMAZEPAM d1aa. TEMAZEPAM d1ab. TEMAZEPAM d1ac. TEMAZEPAM d1ad. TEMAZEPAM d1ae. TEMAZEPAM d1af. TEMAZEPAM d1ag. TEMAZEPAM d1ah. TEMAZEPAM d1ai. TEMAZEPAM d1aj. TEMAZEPAM d1ak. TEMAZEPAM d1al. EUHYPNOS d1am. EUHYPNOS d1an. EUHYPNOS d1ao. TEMAZEPAM d1b.. TRIAZOLAM d1b1. TRIAZOLAM d1b2. TRIAZOLAM d1b3. HALCION d1b4. HALCION d21.. d211. DIAZEPAM d212. DIAZEPAM d213. DIAZEPAM d214. DIAZEPAM d215. DIAZEPAM d216. DIAZEPAM d217. d218. d219. d21A. DIAZEPAM d21B. RIMAPAM d21C. RIMAPAM d21D. RIMAPAM d21E. DIALAR d21F. DIALAR d21G. VALCLAIR d21J. DIAZEPAM d21a. ATENSINE d21b. ATENSINE d21c. ATENSINE d21d. DIAZEMULS d21e. d21f. d21g. d21h. d21i. d21j. d21k. STESOLID d21l. STESOLID d21m. TENSIUM d21n. TENSIUM d21o. TENSIUM d21p. d21q. d21r. VALIUM d21s. VALIUM d21t. VALIUM d21u. VALIUM d21v. VALIUM d21w. d21x. d21y. VALIUM d21z. DIAZEPAM d22.. ALPRAZOLAM d221. XANAX d222. XANAX d22y. ALPRAZOLAM d22z. ALPRAZOLAM d23.. BROMAZEPAM d231. LEXOTAN d232. LEXOTAN d23y. BROMAZEPAM d23z. BROMAZEPAM d24.. CHLORDIAZE d241. CHLORDIAZE d241. CHLORDIAZE d242. CHLORDIAZE d242. CHLORDIAZE d243. CHLORDIAZE d244. CHLORDIAZE d245. CHLORDIAZE d246. CHLORDIAZE d247. CHLORDIAZE d248. CHLORDIAZE d249. LIBRIUM d24a. LIBRIUM d24b. LIBRIUM d24c. LIBRIUM d24d. LIBRIUM d24e. d24f. TROPIUM d24g. TROPIUM d24h. TROPIUM d24i. TROPIUM d24j. TROPIUM d26.. CLOBAZAM d261. CLOBAZAM d262. FRISIUM d263. CLOBAZAM d264. FRISIUM d27.. CLORAZEPAT d271. TRANXENE d272. TRANXENE d27y. CLORAZEPAT d27z. CLORAZEPAT d29.. KETAZOLAM d291. d292. d29y. d29z. d2a.. d2a1. LORAZEPAM d2a2. LORAZEPAM d2a3. d2a4. d2a5. ATIVAN d2a6. ATIVAN d2a7. ATIVAN d2ax. d2az. LORAZEPAM d2b.. MEDAZEPAM d2b1. NOBRIUM d2b2. NOBRIUM d2by. MEDAZEPAM d2bz. MEDAZEPAM d2d.. OXAZEPAM d2d1. OXAZEPAM d2d2. OXAZEPAM d2d3. OXAZEPAM d2d4. OXAZEPAM d2d5. d2d6. d2d7. d2e.. PRAZEPAM d2e1. d2ez.

Proton Pump Inhibitors

a61.. a611. TAGAMET 200mg tablets a612. TAGAMET 400mg tablets a613. TAGAMET 800mg tablets a614. TAGAMET 200mg/5mL syrup a615. *TAGAMET 200mg/2mL injection a616. *TAGAMET 4mg/mL i-v inf 100mL a617. *DYSPAMET CHEWTAB 200mg tabs a618. *DYSPAMET 200mg/5mL suspension a619. *CIMETIDNE 200mg/5mL sus 600mL a61A. *GALENAMET 200mg tablets a61B. *GALENAMET 400mg tablets a61C. *GALENAMET 800mg tablets a61D. *CIMETIDINE 400mg eff tabs a61E. *CIMETIDINE 200mg chew tabs a61F. *PHIMETIN 200mg tablets a61G. *PHIMETIN 400mg tablets a61H. *PHIMETIN 800mg tablets a61I. CIMETIDINE 200mg/5mL s/f soln a61J. *CIMETIDINE 400mg/100mL inf a61K. *ZITA 200mg tablets a61L. *ZITA 400mg tablets a61M. *ZITA 800mg tablets a61N. *ULTEC 200mg tablets a61O. *ULTEC 400mg tablets a61P. *ULTEC 800mg tablets a61Q. *ACITAK-200 tablets a61R. *ACITAK-400 tablets a61S. *ACITAK-800 tablets a61T. *TAGAMET DUAL ACTION liq 200mL a61U. *TAGAMET DUAL ACTION liq 600mL a61a. *ALGITEC 200mg/500mg chew tabs a61b. *ALGITEC 100mg/250mg/5mL susp a61c. *CIMETIDINE COMPOUND susp a61d. *TAGAMET EFFERVESC 400mg tabs a61e. *PEPTIMAX 200mg tablets a61f. *PEPTIMAX 400mg tablets a61g. *PEPTIMAX 800mg tablets a61s. *CIMETIDINE+ALGINIC chew tabs a61s. *CIMETIDINE+ALGINIC chew tabs a61t. *CIMETIDINE+ALGINATE susp a61t. *CIMETIDINE+ALGINATE susp a61u. CIMETIDINE 200mg tablets a61v. CIMETIDINE 400mg tablets a61w. CIMETIDINE 800mg tablets a61x. CIMETIDINE 200mg/5mL syrup a61y. *CIMETIDIN 200mg/2mL injection a61z. *CIMETIDINE 4mg/mL i-v inf a62.. a621. ZANTAC 150mg tablets a622. *ZANTAC 150mg disp tabs a623. ZANTAC 300mg tablets a624. ZANTAC 50mg/2mL injection a625. ZANTAC 150mg/10mL sf syr 300mL a626. ZANTAC EFFERVESCENT 150mg tabs a627. ZANTAC EFFERVESCENT 300mg tabs a628. RANITIDINE 150mg eff tabs a629. RANITIDINE 300mg eff tabs a62A. *RACIRAN 150mg tablets a62B. *RACIRAN 300mg tablets a62C. *ZAEDOC 150 tablets a62D. *ZAEDOC 300 tablets a62E. *RANTEC 150mg tablets a62F. *RANTEC 300mg tablets a62G. RANITIC 150mg tablets a62H. RANITIC 300mg tablets a62I. HISTAC 150mg tablets a62J. HISTAC 300mg tablets a62K. RANITIL 150mg tablets a62L. RANITIL 300mg tablets a62M. ZANTAC 75 DISSOLVE eff tabs a62N. RANITIDINE 75mg tablets a62O. GAVILAST-P 75mg tablets a62P. RANZAC 75mg tablets a62Q. ZANTAC 75 tablets a62u. RANITIDINE 75mg eff tablets a62v. RANITIDINE 150mg/10mL s/f syr a62v. RANITIDINE 150mg/10mL s/f soln a62w. RANITIDINE 150mg tablets a62x. *RANITIDINE 150mg disp tabs a62y. RANITIDINE 300mg tablets a62z. RANITIDINE 50mg/2mL injection a63.. a631. *GASTROZEPIN 50mg tablets a63z. *PIRENZEPINE 50mg tablets a64.. BISMUTH CHELATE a641. *DE-NOL 120mg/5mL liquid 100mL a642. *DE-NOL 120mg/5mL liquid 560mL a643. DE-NOLTAB 120mg tablets a64y. *BISMUTH CHELATE 120mg/5mL liq a64z. BISMUTH CHELATE 120mg tablets a65.. a651. ANTEPSIN 1g tablets a652. ANTEPSIN 1g/5mL suspension a65y. SUCRALFATE 1g/5mL suspension a65z. SUCRALFATE 1g tablets a66.. SODIUM [GI] a661. *BIOGASTRONE 50mg tablets a662. *DUOGASTRONE 50mg tablets a663. *PYROGASTRONE chewable tablets a664. *PYROGASTRONE liquid a66z. *CARBENOXOLONE SOD 50mg tabs a67.. LIQUORICE DEGLYCYRRHIZINISED a671. *CAVED-S tablets a672. *RABRO tablets a68.. a681. FAMOTIDINE 20mg tablets a682. FAMOTIDINE 40mg tablets a683. PEPCID 20mg tablets a684. PEPCID 40mg tablets a69.. a691. NIZATIDINE 150mg capsules a692. NIZATIDINE 300mg capsules a693. AXID 150mg capsules a694. AXID 300mg capsules a695. *AXID 100mg/4mL injection a696. *NIZATIDINE 100mg/4mL inj a697. *ZINGA 150mg capsules a698. *ZINGA 300mg capsules a6a.. a6a1. MISOPROSTOL 200mcg tablets a6a2. CYTOTEC 200micrograms tablets a6a3. *CYTOTEC 200microgram tablets a6b.. a6b1. OMEPRAZOLE 20mg e/c capsules a6b2. *LOSEC 20mg capsules x28 a6b3. LOSEC 20mg capsules a6b4. LOSEC 40mg capsules a6b5. OMEPRAZOLE 40mg e/c capsules a6b6. LOSEC 10mg capsules a6b7. OMEPRAZOLE 10mg e/c capsules a6b8. OMEPRAZOLE 40mg inj pdr+solv a6b9. LOSEC 40mg inj powder+solvent a6bA. OMEPRAZOLE 40mg i-v inf powder a6bB. LOSEC 40mg i-v infusion powder a6bC. LOSEC MUPS 10mg tablets a6bD. LOSEC MUPS 20mg tablets a6bE. LOSEC MUPS 40mg tablets a6bF. *OMERAN 10mg e/c tablets a6bG. *OMERAN 20mg e/c tablets a6bH. *OMERAN 40mg e/c tablets a6bI. ZANPROL 10mg e/c tablets a6bJ. *GALPHARM 10mg tabs a6bJ. *GALPHARM HEARTBURN 10mg tabs a6bK. UNICHEM HRTBRN RELIEF 10mg tab a6bK. UNICHEM HRTBRN RELIEF 10mg tab a6bL. VANTAGE HRTBURN RELF 10mg tabs a6bM. CARE HEARTBURN RELIF 10mg tabs NUMARK HEARTBURN RLF 10mg a6bN. tabs a6bO. MEPRADEC 10mg e/c capsules a6bP. MEPRADEC 20mg e/c capsules a6bu. OMEPRAZOLE 10mg e/c tablets a6bv. *OMEPRAZOLE 20mg e/c tablets a6bw. *OMEPRAZOLE 40mg e/c tablets a6bx. OMEPRAZOLE 10mg tablets a6by. OMEPRAZOLE 20mg tablets a6bz. OMEPRAZOLE 40mg tablets a6c.. a6c1. *ZOTON 30mg capsules a6c2. LANSOPRAZOLE 30mg capsules a6c3. LANSOPRAZOLE 15mg capsules a6c4. *ZOTON 15mg capsules a6c5. *LANSOPRAZOLE 30mg suspension a6c6. *ZOTON 30mg oral suspension a6c7. LANSOPRAZOLE 15mg disp tabs a6c8. LANSOPRAZOLE 30mg disp tabs a6c9. ZOTON FASTAB 15mg disp tabs a6cA. ZOTON FASTAB 30mg disp tabs a6d.. RANITIDINE BISMUTH CITRATE a6d.. RANITIDINE BISMUTH CITRATE a6d1. *RANITIDINE BISMUTH 400mg tabs a6d1. *RANITIDINE BISMUTH 400mg tabs a6d2. *PYLORID 400mg tablets a6e.. a6e1. PANTOPRAZOLE 40mg e/c tablets a6e2. PROTIUM 40mg e/c tablets a6e3. PANTOPRAZOLE 40mg inj powder a6e4. PROTIUM I.V 40mg inj powder a6e5. PANTOPRAZOLE 20mg e/c tablets a6e6. PROTIUM 20mg e/c tablets a6f.. SODIUM a6f1. RABEPRAZOLE NA 10mg e/c tabs a6f2. RABEPRAZOLE NA 20mg e/c tabs a6f3. PARIET 10mg e/c tablets a6f4. PARIET 20mg e/c tablets COMBINATION ULCER HEALING a6g.. DRUG *CLARITHROMY+LANSOPRZ+AMOX a6g1. pck a6g2. *HELICLEAR triple pack *CLARITH+LANSOPRZ+METRONID a6g3. pck a6g4. *HELIMET triple pack a6h.. a6h1. NEXIUM 20mg tablets a6h2. NEXIUM 40mg tablets a6h3. NEXIUM 40mg i-v inj powder a6hx. ESOMEPRAZOLE 40mg i-v inj pdr a6hy. ESOMEPRAZOLE 40mg tablets a6hz. ESOMEPRAZOLE 20mg tablets

Appendix 2:

List of activities used to define the ‘low activity’ component of the frailty measure.

Vigorous activities

Running or jogging

Swimming

Cycling

Aerobics or gym workout

Tennis

Heavy gardening (digging with a spade)

Mowing the lawn (manual)

Moderate activities

Moderate gardening (raking, hoeing)

Mowing lawn (electric)

Cleaning the car

Walking at a moderate pace

Dancing

Floor or stretching exercises

Heavy housework (cleaning windows, scrubbing floors)

Mildly energetic activities

Light gardening (weeding, pruning)

Bowls

Light housework (vacuuming, mopping floors, ironing, making beds)

Home repairs (DIY)

Appendix 3

Sensitivity analysis, repeating table 2 (third column) in the main text, and adding an identical analysis but with each comorbidity included in the proportional hazards regression model individually. Variables Multivariate Multivariate (Number of (Individual comorbidities) comorbidities)

Hazard ratio Hazard ratio (95% CI) (95% CI)

PIM Antipsychotics 3.28* 3.58* (1.85 - 5.80) (1.99 - 6.45) Tricyclic Antidepressants 1.06 1.16 (0.72 - 1.55) (0.78 - 1.71) Anticholinergics 1.17 1.16 (0.83 - 1.66) (0.82 - 1.64) Other Antidepressants 0.90 0.89 (0.66 - 1.22) (0.65 - 1.22) 0.72 0.74 (0.45 - 1.16) (0.46 - 1.20) Proton Pump Inhibitor 1.05 1.08 (0.86 - 1.30) (0.87 - 1.34) Polypharmacy 0-4 5-9 1.17 1.16 (0.95 - 1.45) (0.93 - 1.45) 10+ 1.60* 1.59* (1.16 - 2.22) (1.13 - 2.22) Covariates Age at interview (per year) 1.10* 1.11* (1.08 - 1.12) (1.09 - 1.12) Gender (female) 0.57* 0.62* (0.46 - 0.69) (0.50 - 0.77) MMSE score (per point) 0.91* 0.92* (0.89 - 0.94) (0.89 - 0.95) Care Home Residence 1.20 1.11 (0.81 - 1.80) (0.74 - 1.68) Frailty frailty = 1, pre-frail 1.56* 1.56* (1.11 - 2.20) (1.10 - 2.21) frailty = 2, frail 1.90* 1.82* (1.32 - 2.72) (1.26 - 2.62) Comorbidities Number of comorbid health conditions (per 1.05 condition) (0.98 - 1.13)

Comorbidities Heart attack 1.30 (0.97 - 1.74) Fits or 1.24 (0.70 - 2.21) Chronic bronchitis 1.18 (0.89 - 1.57) Asthma 1.09 (0.81 - 1.46) Parkinson’s disease 1.98* (1.01 - 3.87) Peptic ulcers 1.36 (0.98 - 1.87) deficiency 1.47 (0.95 - 2.27) Arthritis 0.99 (0.80 - 1.21) Stroke 1.30* (1.01 - 1.67) Angina 0.85 (0.64 - 1.12) High blood pressure 0.80* (0.65 - 0.97) Cancer 1.17 (0.90 - 1.52) Diabetes 1.43* (1.10 - 1.85) Cardiovascular disease 0.68 (0.30 - 1.57) 0.76 (0.55 - 1.03) MMSE: Mini-Mental State Examination score (0-30 with higher scores indicating better cognition). *p<0.05 HR(95% CI)

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