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Methyl Vinyl Ketone Mvk
METHYL VINYL KETONE MVK CAUTIONARY RESPONSE INFORMATION 4. FIRE HAZARDS 7. SHIPPING INFORMATION 4.1 Flash Point: 30°F O.C. 20°F C.C. 7.1 Grades of Purity: 98.5+% Common Synonyms Liquid Colorless to light yellow Strong irritating 4.2 Flammable Limits in Air: 2.1% 15.6% 7.2 Storage Temperature: Cool ambient 3-Buten-2-one odor 4.3 Fire Extinguishing Agents: Dry 7.3 Inert Atmosphere: No requirement chemical, alcohol foam, carbon dioxide 7.4 Venting: Pressure-vacuum Mixes with water. Irritating vapor is produced. 4.4 Fire Extinguishing Agents Not to Be Used: Water may be ineffective. 7.5 IMO Pollution Category: Currently not available Evacuate. 4.5 Special Hazards of Combustion 7.6 Ship Type: Currently not available KEEP PEOPLE AWAY. AVOID CONTACT WITH LIQUID. Products: Not pertinent 7.7 Barge Hull Type: Currently not available Avoid inhalation. 4.6 Behavior in Fire: Vapor is heavier than Wear rubber overclothing (including gloves). air and may travel a considerable Shut off ignition sources. Call fire department. 8. HAZARD CLASSIFICATIONS distance to a source of ignition and flash Stay upwind. Use water spray to ``knock down'' vapor. back. At elevated temperatures (fire 8.1 49 CFR Category: Flammable liquid Notify local health and pollution control agencies. conditions) polymerization may take Protect water intakes. 8.2 49 CFR Class: 3 place in containers, causing violent 8.3 49 CFR Package Group: II rupture. Unburned vapors are very FLAMMABLE. irritating. 8.4 Marine Pollutant: No Fire Containers may explode in fire. 8.5 NFPA Hazard Classification: Flashback along vapor trail may occur. -
(CD-P-PH/PHO) Report Classification/Justifica
COMMITTEE OF EXPERTS ON THE CLASSIFICATION OF MEDICINES AS REGARDS THEIR SUPPLY (CD-P-PH/PHO) Report classification/justification of medicines belonging to the ATC group D07A (Corticosteroids, Plain) Table of Contents Page INTRODUCTION 4 DISCLAIMER 6 GLOSSARY OF TERMS USED IN THIS DOCUMENT 7 ACTIVE SUBSTANCES Methylprednisolone (ATC: D07AA01) 8 Hydrocortisone (ATC: D07AA02) 9 Prednisolone (ATC: D07AA03) 11 Clobetasone (ATC: D07AB01) 13 Hydrocortisone butyrate (ATC: D07AB02) 16 Flumetasone (ATC: D07AB03) 18 Fluocortin (ATC: D07AB04) 21 Fluperolone (ATC: D07AB05) 22 Fluorometholone (ATC: D07AB06) 23 Fluprednidene (ATC: D07AB07) 24 Desonide (ATC: D07AB08) 25 Triamcinolone (ATC: D07AB09) 27 Alclometasone (ATC: D07AB10) 29 Hydrocortisone buteprate (ATC: D07AB11) 31 Dexamethasone (ATC: D07AB19) 32 Clocortolone (ATC: D07AB21) 34 Combinations of Corticosteroids (ATC: D07AB30) 35 Betamethasone (ATC: D07AC01) 36 Fluclorolone (ATC: D07AC02) 39 Desoximetasone (ATC: D07AC03) 40 Fluocinolone Acetonide (ATC: D07AC04) 43 Fluocortolone (ATC: D07AC05) 46 2 Diflucortolone (ATC: D07AC06) 47 Fludroxycortide (ATC: D07AC07) 50 Fluocinonide (ATC: D07AC08) 51 Budesonide (ATC: D07AC09) 54 Diflorasone (ATC: D07AC10) 55 Amcinonide (ATC: D07AC11) 56 Halometasone (ATC: D07AC12) 57 Mometasone (ATC: D07AC13) 58 Methylprednisolone Aceponate (ATC: D07AC14) 62 Beclometasone (ATC: D07AC15) 65 Hydrocortisone Aceponate (ATC: D07AC16) 68 Fluticasone (ATC: D07AC17) 69 Prednicarbate (ATC: D07AC18) 73 Difluprednate (ATC: D07AC19) 76 Ulobetasol (ATC: D07AC21) 77 Clobetasol (ATC: D07AD01) 78 Halcinonide (ATC: D07AD02) 81 LIST OF AUTHORS 82 3 INTRODUCTION The availability of medicines with or without a medical prescription has implications on patient safety, accessibility of medicines to patients and responsible management of healthcare expenditure. The decision on prescription status and related supply conditions is a core competency of national health authorities. -
Clinical Policy: Topical Agents: Corticosteroids
Clinical Policy: Topical Agents: Corticosteroids Reference Number: OH.PHAR.PPA.92 Effective Date: 01/01/2020 Revision Log Last Review Date: Line of Business: Medicaid See Important Reminder at the end of this policy for important regulatory and legal information. Description TOPICAL AGENTS: CORTICOSTEROIDS – LOW POTENCY NO PA REQUIRED “PREFERRED” PA REQUIRED “NON- PREFERRED” DESONIDE cream, ointment (generic of Desowen®) ALCLOMETASONE cream, ointment (generic of FLUOCINOLONE ACETONIDE 0.01% cream, solution Aclovate®) (generic of Synalar®) CAPEX® shampoo (fluocinolone acetonide) FLUOCINOLONE body oil, scalp oil (generic of Derma- DESONATE®gel (desonide) Smoothe/ FS®) DESONIDE lotion (generic of Desowen®) HYDROCORTISONE cream, lotion, ointment HYDROCORTISONE ACETATE WITH ALOE gel HYDROCORTISONE WITH UREA cream (generic of Carmol HC®) PANDEL® cream (hydrocortisone probutate) PEDIADERM HC® kit TOPICAL AGENTS: CORTICOSTEROIDS – MEDIUM POTENCY NO PA REQUIRED “PREFERRED” PA REQUIRED “NON--PREFERRED” BETAMETHASONE DIPROPIONATE-CALCIPOTRIENE BETAMETHASONE DIPROPIONATE lotion (generic of Ointment Diprolene®) BETAMETHASONE VALERATE cream, lotion (generic of CLOCORTOLONE PIVALATE (generic of Cloderm®) Valisone®) CORDRAN® tape (flurandrenolide) FLUTICASONE PROPIONATE cream, ointment (generic of DESOXIMETASONE cream, gel, ointment (generic of Cutivate®) Topicort®) MOMETASONE FUROATE cream, ointment, solution FLUOCINOLONE ACETONIDE 0.025% cream, ointment (generic of Elocon®) (generic of Synalar®) PREDNICARBATE cream (generic of Dermatop®) FLUTICASONE -
Steroids Topical
Steroids, Topical Therapeutic Class Review (TCR) September 18, 2020 No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, digital scanning, or via any information storage or retrieval system without the express written consent of Magellan Rx Management. All requests for permission should be mailed to: Magellan Rx Management Attention: Legal Department 6950 Columbia Gateway Drive Columbia, Maryland 21046 The materials contained herein represent the opinions of the collective authors and editors and should not be construed to be the official representation of any professional organization or group, any state Pharmacy and Therapeutics committee, any state Medicaid Agency, or any other clinical committee. This material is not intended to be relied upon as medical advice for specific medical cases and nothing contained herein should be relied upon by any patient, medical professional or layperson seeking information about a specific course of treatment for a specific medical condition. All readers of this material are responsible for independently obtaining medical advice and guidance from their own physician and/or other medical professional in regard to the best course of treatment for their specific medical condition. This publication, inclusive of all forms contained herein, is intended to be educational in nature and is intended to be used for informational purposes only. Send comments and suggestions to [email protected]. September -
Neuroactive Insecticides: Targets, Selectivity, Resistance, and Secondary Effects
EN58CH06-Casida ARI 5 December 2012 8:11 Neuroactive Insecticides: Targets, Selectivity, Resistance, and Secondary Effects John E. Casida1,∗ and Kathleen A. Durkin2 1Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, 2Molecular Graphics and Computational Facility, College of Chemistry, University of California, Berkeley, California 94720; email: [email protected], [email protected] Annu. Rev. Entomol. 2013. 58:99–117 Keywords The Annual Review of Entomology is online at acetylcholinesterase, calcium channels, GABAA receptor, nicotinic ento.annualreviews.org receptor, secondary targets, sodium channel This article’s doi: 10.1146/annurev-ento-120811-153645 Abstract Copyright c 2013 by Annual Reviews. Neuroactive insecticides are the principal means of protecting crops, people, All rights reserved livestock, and pets from pest insect attack and disease transmission. Cur- ∗ Corresponding author rently, the four major nerve targets are acetylcholinesterase for organophos- phates and methylcarbamates, the nicotinic acetylcholine receptor for neonicotinoids, the γ-aminobutyric acid receptor/chloride channel for by Public Health Information Access Project on 04/29/14. For personal use only. Annu. Rev. Entomol. 2013.58:99-117. Downloaded from www.annualreviews.org polychlorocyclohexanes and fiproles, and the voltage-gated sodium channel for pyrethroids and dichlorodiphenyltrichloroethane. Species selectivity and acquired resistance are attributable in part to structural differences in binding subsites, receptor subunit interfaces, or transmembrane regions. Additional targets are sites in the sodium channel (indoxacarb and metaflumizone), the glutamate-gated chloride channel (avermectins), the octopamine receptor (amitraz metabolite), and the calcium-activated calcium channel (diamides). Secondary toxic effects in mammals from off-target serine hydrolase inhibi- tion include organophosphate-induced delayed neuropathy and disruption of the cannabinoid system. -
BOARD of PESTICIDES CONTROL January 15, 2020 Augusta Civic Center, 76 Community Drive, Kennebec/Penobscot Room, Augusta, Maine
STATE OF MAINE DEPARTMENT OF AGRICULTURE, CONSERVATION AND FORESTRY BOARD OF PESTICIDES CONTROL 28 STATE HOUSE STATION UGUSTA AINE JANET T. MILLS A , M 04333 AMANDA E. BEAL GOVERNOR COMMISSIONER BOARD OF PESTICIDES CONTROL January 15, 2020 Augusta Civic Center, 76 Community Drive, Kennebec/Penobscot Room, Augusta, Maine 1:00 - 1:30 PM Board Meeting 1:30 - 2:30 PM Public Forum On Notification 2:30 – 4:00 PM Board Meeting Continued AGENDA 1. Introductions of Board and Staff 2. Minutes of the November 8, 2019 Board Meeting Presentation By: Megan Patterson, Director Action Needed: Amend and/or Approve 3. Request for Financial Support from the Maine Mobile Health Program and the Eastern Maine Development Corporation Since 1995 the Board has supported a Migrant and Seasonal Farmworker Safety Education program. The Maine Mobile Health Program (MMHP) and Eastern Maine Development Corporation (EMDC provided training to 315 migrant agricultural workers during the 2019 season). Funding to support this effort in 2020 is being requested in the amount of $5,360, which is the same amount the Board provided in 2019. The funding has been accounted for in the Board’s FY20 budget. Presentation By: Chris Huh, Program Manager, Farmworkers Jobs Program, Eastern Maine Development Corporation Elizabeth Charles McGough, Director of Outreach, Maine Mobile Health Program MEGAN PATTERSON, DIRECTOR PHONE: (207) 287-2731 90 BLOSSOM LANE, DEERING BUILDING WWW.THINKFIRSTSPRAYLAST.ORG Action Needed: Discussion and Determination if the Board Wishes to Fund this Request 4. Request for Financial Support from the Maine State Apiarist for CLEAR Training Maine State Apiarist, Jennifer Lund, has requested funding to attend the National Certified Investigator & Inspector Basic Training held in Raleigh, North Carolina in March 2020. -
Fagron Advanced Derma Compatibility Table
Fagron Advanced Derma Compatibility table Legend Skin types Compatible combination for Oily skin Balanced skin Dehydrated skin Very dehydrated skin Affected skin Specific skin area 14/15 days 30 days 60 days OCCLUVAN™ EMOLIVAN™ VERSATILE™ VERSATILE™ NOURIVAN™ FITALITE™ NOURILITE™ SERAQUA™ NOURISIL™ SOLYDRA™ ESPUMIL™ RICH ANTIOX 90 days Especially recommended combination Compatible combination up to x% Combination not studied Combination not compatible API/DCI concentration(s) Common Aloe Vera Extract 0.5 to 10% 8% 5% Alpha Bisabolol 0.5 to 5% 1% 1% Ammonium Lactate 1 to 12% 10% 10% 8% Anthralin/Dithranol 0.05 to 3% Arginine Hydrochloride 2.5% Ascorbic Acid (Vitamin C) 5 to 15% 5% 10% Azelaic Acid 10 to 20% Benzoyl Peroxide 2.5 to 10% 5% Benzyl Benzoate 25% Betamethasone Dipropionate 0.05% Betamethasone Valerate 0.025 to 0.1% 0.05% Caffeine 1 to 2% Chamomile Extract 0.5 to 5% Ciclopirox Olamine 1% Clindamycin Hydrochloride 1 to 3% Clobetasol Propionate 0.05% Clotrimazole 1 to 2% Coal Tar Crude (Pix Lithanthracis) 1 to 10% Coal Tar Solution (Liquor Carbonis 5 to 20% Detergens) 10% 10% 10% Cyanocobalamin (Vitamin B12) 0.07% Desonide 0.05 to 0.1% Desoximetasone 0.25% Dexpanthenol 0.5 to 5% Diclofenac Sodium 3% Erythromycin 0.5 to 4% Finasteride 0.1% Fluocinolone Acetonide 0.01 to 0.1% Glycerol 0.5 to 20% 8% 5% Glycolic Acid 5 to 15% Hyaluronic Acid Sodium 0.2 to 2.5% Hydrocortisone 0.25 to 2.5% Hydrocortisone Acetate 0.25 to 2.5% Hydroquinone 2 to 4% Ketoconazole 2% Kojic Acid 1 to 4% Lactic Acid 1 to 20% 10% Lidocaine 0.5 to 10% 5% Lidocaine -
Impact of Insecticides Used to Control Spodoptera Frugiperda (J.E
RESEARCH Impact of insecticides used to control Spodoptera frugiperda (J.E. Smith) in corn on survival, sex ratio, and reproduction of Trichogramma pretiosum Riley offspring Jander R. Souza1, Geraldo A. Carvalho1, Alexandre P. Moura2*, Marcelo H.G. Couto1, and Jader B. Maia1 Corn (Zea mays L.) is cultivated in large areas and considered one of the world’s major cereal crops. There are several arthropod pests that can reduce its production such as the fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lep.: Noctuidae), which is considered to be the main pest for corn. Fall armyworm is primarily controlled by insecticides. The use of biological control agents to manage this pest is growing with an emphasis on the egg parasitoid Trichogramma pretiosum Riley (Hym.: Trichogrammatidae). Thus, the aim of this research was to evaluate the impact of the following insecticides (g ai L-1) beta-cypermethrin (0.03), chlorfenapyr (0.60), chlorpyrifos (0.96), spinosad (0.16), etofenprox (0.10), triflumuron (0.08), alfa-cypermethrin/teflubenzuron (0.0425/0.0425), and lambda-cyhalothrin/thiamethoxam (0.11/0.083) on survival, sex ratio, reproduction, and T. pretiosum offspring. Distilled water was used as a control. Commercial insecticide formulations were diluted in distilled water. Bioassays used Anagasta kuehniella eggs treated with insecticides which were afterwards exposed to parasitism. Bioassays were conducted under controlled conditions at 25 ± 2 ºC, 70 ± 10% RH, and 12:12 h photoperiod. Alfa-cypermethrin/teflubenzuron, beta-cypermethrin, chlorpyrifos, chlorfenapyr, spinosad, etofenprox, and lambda-cyhalothrin/thiamethoxam reduced parasitism capacity of maternal generation females as well as the percentage of insect emergence from the F1 generation. -
A New Robust Technique for Testing of Glucocorticosteroids in Dogs and Horses Terry E
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 2007 A new robust technique for testing of glucocorticosteroids in dogs and horses Terry E. Webster Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Veterinary Toxicology and Pharmacology Commons Recommended Citation Webster, Terry E., "A new robust technique for testing of glucocorticosteroids in dogs and horses" (2007). Retrospective Theses and Dissertations. 15029. https://lib.dr.iastate.edu/rtd/15029 This Thesis is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. A new robust technique for testing of glucocorticosteroids in dogs and horses by Terry E. Webster A thesis submitted to the graduate faculty in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Major: Toxicology Program o f Study Committee: Walter G. Hyde, Major Professor Steve Ensley Thomas Isenhart Iowa State University Ames, Iowa 2007 Copyright © Terry Edward Webster, 2007. All rights reserved UMI Number: 1446027 Copyright 2007 by Webster, Terry E. All rights reserved. UMI Microform 1446027 Copyright 2007 by ProQuest Information and Learning Company. All rights reserved. This microform edition is protected against unauthorized copying under Title 17, United States Code. ProQuest Information and Learning Company 300 North Zeeb Road P.O. Box 1346 Ann Arbor, MI 48106-1346 ii DEDICATION I want to dedicate this project to my wife, Jackie, and my children, Shauna, Luke and Jake for their patience and understanding without which this project would not have been possible. -
1532 Corticosteroids
1532 Corticosteroids olone; Ultraderm; Malaysia: Synalar†; Mex.: Cortifung-S; Cortilona; Gr.: Lidex; Ital.: Flu-21†; Topsyn; Mex.: Topsyn; Norw.: Metosyn; Pharmacopoeias. In Br. Cremisona; Farmacorti; Flumicin; Fluomex; Fusalar; Lonason; Synalar; Philipp.: Lidemol; Lidex; Singapore: Lidex†; Spain: Klariderm†; Novoter; BP 2008 (Fluocortolone Hexanoate). A white or creamy-white, Norw.: Synalar; NZ: Synalar; Philipp.: Aplosyn; Cynozet; Synalar; Syntop- Switz.: To p s y m ; To p s y m i n ; UK: Metosyn; USA: Lidex; Vanos. ic; Pol.: Flucinar; Port.: Oto-Synalar N; Synalar; Rus.: Flucinar (Флуцинар); odourless or almost odourless, crystalline powder. It exhibits pol- Multi-ingredient: Austria: Topsym polyvalent; Ger.: Jelliproct; Topsym ymorphism. Practically insoluble in water and in ether; very Sinaflan (Синафлан); S.Afr.: Cortoderm; Fluoderm; Synalar; Singapore: polyvalent; Hung.: Vipsogal†; Israel: Comagis; Mex.: Topsyn-Y; Philipp.: Flunolone-V; Spain: Co Fluocin Fuerte; Cortiespec; Fluocid Forte; Fluoder- Lidex NGN; Spain: Novoter Gentamicina; Switz.: Mycolog N; Topsym slightly soluble in alcohol and in methyl alcohol; slightly soluble mo Fuerte; Flusolgen; Gelidina; Intradermo Corticosteroi†; Synalar; Synalar polyvalent; UK: Vipsogal. in acetone and in dioxan; sparingly soluble in chloroform. Pro- Rectal Simple; Swed.: Synalar; Switz.: Synalar; Thai.: Cervicum; Flu- ciderm†; Flunolone-V; Fulone; Supralan; Synalar; UK: Synalar; USA: Capex; tect from light. Derma-Smoothe/FS; DermOtic; Fluonid; Flurosyn†; Retisert; Synalar; Syn- emol; Venez.: Bratofil; Fluquinol Simple†; Neo-Synalar; Neoflu†. Fluocortin Butyl (BAN, USAN, rINNM) ⊗ Fluocortolone Pivalate (BANM, rINNM) ⊗ Multi-ingredient: Arg.: Adop-Tar†; Tri-Luma; Austria: Myco-Synalar; Procto-Synalar; Synalar N; Belg.: Procto-Synalar; Synalar Bi-Otic; Braz.: Butil éster de la fluocortina; Butylis Fluocortinas; Fluocortine Fluocortolone, pivalate de; Fluocortolone Trimethylacetate; Dermobel†; Dermoxin; Elotin; Fluo-Vaso; Neocinolon; Otauril†; Otocort†; Butyle; SH-K-203. -
Evaluation of Reduced Risk Pesticides for Control of Onion Thrips on Onions
Evaluation of Reduced Risk Pesticides for Control of Onion Thrips on Onions Jennifer Allen1,3, Jeff Tolman2 and Cynthia Scott-Dupree3 1 – Ontario Ministry of Agriculture, Food and Rural Affairs, Guelph ON N1G 4Y2, E-mail: [email protected] 2 – Southern Crop Protection and Food Research Centre – AAFC, London ON N5V 4T3 3 – Dept. Environmental Biology, University of Guelph, Guelph ON N1G 2W1 INTRODUCTION RESULTS Onion thrips (OT) are a cosmopolitan species that are found in onion growing 2001 – Foliar Treatments 140 120 regions around the world. They have been recorded as economic pests on onion, 120 100 100 garlic, leeks, tomatoes, cucumbers and beans. 80 80 * 60 60 * Adults and nymphs feed by piercing and sucking leaf tissues, removing cell Mean # OT/Plant 40 40 * 20 OT/Plant # Mean 20 contents (Fig. 1). Light feeding results in silvery streaks while heavy feeding may 0 55 0 Days After Treatment 23 result in plant die-back. Research has shown that onion losses can exceed 40% Days After Treatment Novaluron Spinosad (L) + B. bassiani Spinosad (H)+ B. bassiani B. bassiani Novaluron Spinosad (L) Spinosad (H) when high OT populations cannot be controlled. Spinosad (H) Lambda-cyhalothrin Control Lambda-cyhalothrin Kaolin Clay Control 2002 – Foliar Treatments 25 100 20 80 15 60 40 10 * * * * Mean # OT/Plant * * 20 Mean # OT/Plant * 5 * * * 0 * 0 275 28 Days After Treatment Days After Treatment Kaolin Lambda-cyhalothrin Novaluron (L) Lambda-cyhalothrin Spinosad (L) Spinosad (H) Control Novaluron (H) Pyriproxifen Pymetrozine Control a) b) NYSAES PHOTO c) 2003 – Foliar Treatments Fig.1. -
Fluocinoloneacetonide 0.01% and Dexamethasone 0.1% Mouthwash in the Treatment of Symptomatic Oral Lichen Planus
Research Article Adv Dent & Oral Health Volume 3 Issue 3 - January 2017 DOI: 10.19080/ADOH.2017.03.555611 Copyright © All rights are reserved by Patnarin Kanjanabuch Fluocinolone acetonide 0.01% and Dexamethasone 0.1% Mouthwash in the Treatment of Symptomatic Oral Lichen Planus Achara Vathanasanti1 and Patnarin Kanjanabuch2* 1Department of Pharmacology, Chulalongkorn University, Thailand 2Department of Oral Medicine, Chulalongkorn University, Thailand Submission: September 30, 2016; Published: January 04, 2017 *Corresponding author: Patnarin Kanjanabuch, Department of Oral Medicine, Chulalongkorn University, Bangkok 10330, Thailand, Tel: ; Email: Abstract Purpose: The objective of this study was to compare the effectiveness of fluocinolone acetonide 0.01% and dexamethasone 0.1% mouthwashPatients in and treating Methods: symptomatic oral lichen planus (OLP). Thirty-four patients (27 females and 7 males; mean age 47.26±11.78 years) with symptomatic OLP were treated for 6 weeks with either fluocinolone acetonide 0.01% mouthwash or dexamethasone 0.1% mouthwash in a randomized, double-blind, clinical trial.Results: Pain severity and lesion size and severity were assessed using the VAS pain score and clinical score, respectively. At the end of the treatment period, pain symptoms (VAS pain score) and lesion size and severity (clinical score) were significantly lower in the fluocinolone acetonide 0.01% and dexamethasone 0.1% mouthwash groups compared with baseline. However, the difference in theseConclusion: scores between the groups was not significant. fluocinolone acetonide 0.01% and dexamethasone 0.1% mouthwash were effective in treating symptomatic OLP. However, additionalKeywords: studies using a larger population and a longer treatment period and follow-up are needed to confirm these findings.