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Journal of Nephropathology www.nephropathol.com doi: 10.15171/jnp.2019.02 J Nephropathol. 2019;8(1):e02 Journal of Nephropathology Protective effects of olive in renal failure; a review on current knowledge Esmaeel Babaeenezhad1,2 ID , Hassan Ahmadvand2,3, Reza Mohammadrezaei Kkorramabadi3*, Shahrokh Bagheri3, Peyman Khosravi3, Parisa Jamor4 1Department of Cardiology, Madani Heart Center, Lorestan University of Medical Sciences, Khorramabad, Iran 2Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran 3Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorramabad, Iran 4Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran ARTICLE INFO ABSTRACT Article type: Context: The pathogenesis of renal damage as a risk factor of renal failure can be due to oxidative Review stress resulting from an imbalance between the production of free radicals and antioxidants. Therefore, antioxidant therapy can be a good strategy to decrease the effects of such diseases. Hence, Article history: the aim of this review was to evaluate the protective effect of olive oil as an herb rich in antioxidant Received: 14 February 2018 Accepted: 10 June 2018 compounds on kidney damage in previous studies. Published online: 29 June 2018 Evidence Acquisitions: Present review is based on scrutinizing the contents of relevant papers searched in PubMed, Google Scholar, EBSCO, Embase, directory of open access journals (DOAJ), Web of Science and Scopus. Keywords: Results: Numerous studies have introduced herbal treatments, being rich sources of antioxidants, Olive as appropriate alternatives for several diseases, including renal damage, when considering the Oxidative stress pathogenesis of the diseases. The olive has also been recommended as a plant that has different Renal failure therapeutic effects, and its therapeutic effects on the kidneys are mentioned in several studies, Review including the reduction of renal damage parameters and an increase in the antioxidant power of enzymes in the body. Conclusions: Considering the numerous studies on animal models, particularly rats and renal cell lines, olive oil can be used as a reliable method for the treatment of various kidney damages. However, further studies are also recommended in humans. Implication for health policy/practice/research/medical education: Today, the need for plant derived compounds to treat diseases is felt more and more due to the lower side effects. On the other hand, studies have shown that medicinal plants, especially olives, have an effect on kidney disease. Please cite this paper as: Babaeenezhad E, Ahmadvand H, Mohammadrezaei Kkorramabadi R, Bagheri S, Khosravi P, Jamor P. Protective effects of olive in renal failure; a review on current knowledge. J Nephropathol. 2019;8(1):e02. doi: 10.15171/ jnp.2019.02. 1. Context inflammatory activities (2). The pathogenesis of renal damage as a risk factor of renal failure can be due to oxidative stress resulting from an 2. Evidence Acquisitions imbalance between the production of free radicals and For this review, we used a variety of sources by searching antioxidants (1). Therefore, antioxidant therapy can be through PubMed/Medline, Scopus, EMBASE, EBSCO, a good strategy to protect the renal damage from free Embase and Directory of Open Access Journals (DOAJ). radi cals (1). Many studies showed that olive oil, olive leaf The search was conducted, using combinations of the and olive fruit and their compounds such as oleuropein, following key words and or their equivalents; Olive, hydroxytyrosol, and oleic acid have antioxidant and anti- Oxidative stress and Renal failure *Corresponding author: Reza Mohammadrezaei Kkorramabadi; Email: [email protected] Babaeenezhad et al 3. Protective effects of olive and its various 3.1.2. Cisplatin compositions on renal failure Despite limitations in the use of cisplatin due to its 3.1. Protective effects of olive or its various compositions on side effects, in particular, nephrotoxicity, neurotoxicity, drug induced nephrotoxicity ototoxicity, nausea and vomiting, the drug is still 3.1.1. Doxorubicin considered as one of the most powerful drugs The antitumor effect of doxorubicin has been introduced administered in cancer chemotherapy for testicular, for the selection of this compound in order to deal with a ovarian, neck cervical, head and neck cancers (13). The range of cancers, such as leukemia, lymphoma, and solid role of oxidative stress and free radicals has been proven tumors in humans (3). However, the limiting factor in in the nephrotoxicity of cisplatin. In a study, it was shown the use of doxorubicin in the treatment of cancer is its that olive leaf extract reduced serum creatinine compared toxic effects on vital organs, such as the heart, kidneys, with the group treated with cisplatin (13). and liver (4, 5). One of the main damaging mechanisms of this drug to various tissues including the heart, liver, 3.1.3. Cyclosporine and kidneys is related to the oxidative stress and reduction Renal complications induced by cyclosporine A of antioxidants, and also increased oxidants in particular consumption have been proven in the treatment of reactive oxygen species (6). Hence, there is a requirement transplant rejection and autoimmune diseases that to deal with oxidative stress and antioxidant compounds, suppress the immune system. Around 30% of patients in particular administration of herbal medicines. The treated with the drug are influenced by the resultant beneficial effects of the olive plant were evaluated in the kidney complications. Acute and chronic nephrotoxicity study conducted by Kumral and colleagues as an herbal can be defined as renal complications of this drug (14). remedy containing multiple antioxidant compounds (7). The production of free radicals and oxidative stress are Kumral et al proved that the use of olive leaf ethanol the mechanisms of creating renal damages by this drug extract, at the same time as doxorubicin on rats, reduces (14). Another mechanism caused as a result of this serum urea compared with a group which was treated drug is kidney damage. Other mechanisms involved in only with doxorubicin (8). The results showed that the renal complications arising from the consumption of ethanol extract of olive leaves reduced malondialdehyde this drug include; activation of the renin-angiotensin (MDA), protein carbonyl, and conjugated diene, while it system, increased activity of the sympathetic nervous also increased superoxide dismutase (SOD), glutathione system, increase in endothelium synthesis, induction (GSH), and GSH peroxidase in the kidneys (8). Today, of cytochrome P450 enzymes in renal microsomes, and antibiotics as antimicrobial agents are administered in the vasoconstriction (15). Mostafa-Hedeab et al showed treatment of infections. The side effects of antibiotics, that the treatment given to rats with olive leaf extract especially gentamicin sulfate, an antibiotic from the improved renal toxicity induced by cyclosporine (14). aminoglycosides group, have created restrictions on the The use of olive leaf extract increased the amount of use of this drug. The most well-known side effect of this GSH and activities of GSH, CAT, and SOD compared anti-gram-negative bacteria antibiotic is nephrotoxicity to the group treated with cyclosporine (14). (8-11). The mechanism of action of 2,4-dichlorophenoxyacetic The improvement of nephrotoxicity associated with the acid can be justified as an herbicide by disrupting cell drug has been the subject of numerous research studies. In division and protein synthesis and overall production of one study, it was shown that treatment of nephrotoxicity oxygen-free radicals (16). induced by gentamicin using ethanol extract of the olive In the research conducted by Nakbi et al, the treatment leaf had a remediation effect in rats (12). Additionally, it of male rats given 2,4-dichlorophenoxyacetic acid was was shown that ethanol extract of the olive leaf reduced studied using hydrophilic and lipophilic compounds creatinine, urea, and MDA, and also increased serum of olive oil (16). It was shown that renal marker levels, GSH, and activities of catalase (CAT) and SOD (12). including creatinine, urea, albumin, and uric acid, In addition, the glomerular volume in the group of rats were recovered due to their synergistic effects of these treated with gentamicin and treated olive leaf extract compounds. MDA levels were also improved in the group decreased, compared to the group treated only with treated with olive oil. Activities of antioxidant enzymes gentamicin (12). In addition, using a combination of such as CAT, superoxide (SOD) and GSH peroxidase in gentamicin and olive oil, this led to a reduction of urea the group treated with olive oil increased when compared and serum creatinine compared to the group treated only to the group given 2,4-dichlorophenoxyacetic acid, the with gentamicin (12). same as the control group (16,17). Histologically, the group treated with olive oil compared to the groups 2 Journal of Nephropathology, Vol 8, No 1, January 2019 www.nephropathol.com Protective effects of olive in renal failures treated with combinations of hydrophilic and lipophilic levels of urea and serum creatinine in the group treated compounds had a significant recovery rate in relation with olive leaf extract reduced, but not significantly. to glomerulus atrophy, the tubular expansion, vascular In terms of histological, the normality of the kidney and tissue congestion, degeneration
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