<<

Figure 1 - source data 2

0.0010 12T- 100 13T-India

359T-

364T-Paraguay A 360T-Paraguay Clade 1 361T-Paraguay

583T-

100 84 582T-Chile 371T-Chile

419T-Chile 71 372T-Chile 71 420T-Chile 90 379T-

423T-Ecuador

94 623T-Ecuador

71 622T-Ecuador 73 624T-Ecuador 90 625T-Ecuador

621T-Ecuador

429T-Ecuador

422T-Ecuador

463T-

430T-Ecuador

424T-Ecuador

377T-Ecuador

531T-

532T-Colombia

414T-Panama

428T-Ecuador

421T-Ecuador

326T-Ecuador

425T-Ecuador

426T1-Ecuador

427T-Ecuador

560T-

525T- 96 527T-Guatemala

432T-USA (Guatemala) 99 523T-Guatemala

650T-

649T-Honduras

644T-Honduras

645T-Honduras

647T-Honduras

530T1-Guatemala 96 535T-Nicaragua

453T-

459T-Belize

457T-Belize

815T-Belize 79 452T-Belize

69 824T-Belize

820T-Belize

454T-Belize

451T-Belize

87 455T1-Belize 77 456T-Belize

823T-Belize

822T-Belize

821T-Belize

819T-Belize

817T-Belize

816T-Belize

511T-Belize

814T-Belize

179T1-Nicaragua

84 92T-Nicaragua

571T-Nicaragua

558T-Nicaragua

534T-Nicaragua 73 93T-Nicaragua

575T-Nicaragua

556T-Nicaragua

559T-Nicaragua

99T-Nicaragua

98T-Nicaragua

96T-Nicaragua

100T-Nicaragua

95T-Nicaragua

61T-

97 62T-Mexico

88 49T-Mexico

68 53T-Mexico 82 56T-Mexico

50T1-Mexico

180T-Mexico

57T-Mexico 88 86 60T-Mexico

54T-Mexico 98 55T-Mexico

59T-Mexico

370T-Mexico

4T-Mexico

2T-Israel

65 801T-Romania 77 321T2-Tanzania

324T2-Tanzania

834T1-

808T-Ukraine

807T1-Ukraine

616T-Ukraine 67 66 629T-Ukraine

98 447T-Ukraine 68 661T-Ukraine

88 494T-Ukraine 493T1-Ukraine

460T-Ukraine

492T1-Ukraine

799T-Romania 88 800T-Romania 100 84 833T1- (Romania)

611T-Malawi

78 614T-Malawi 100 613T-Malawi 65 615T-Malawi 96 656T-Malawi

135T-Australia

137T1-Australia

515T-Australia

71 513T-Australia

286T1-Australia

269T-Australia

265T-Australia

143T-Australia

136T-Australia

140T-Australia

45T1-Australia

41T-Australia

29T1-Australia

267T-Australia

266T-Australia

24T-Australia

139T-Australia

142T-Australia

37T-Australia

90T-Australia

47T-Australia 67 48T1-Australia

40T-Australia

39T-Australia

38T-Australia

22T-Australia

25T-Australia

44T-Australia 62 89T-Australia

88T-Australia

512T-Australia

514T-Australia

23T-Australia 87 43T-Australia

52T1-Samoa

516T-Australia

27T-Australia

95 28T-Australia 26T-Australia

285T-Australia

490T-Ukraine

449T-Ukraine

100 448T-Ukraine

446T-Ukraine 61 630T-Ukraine

450T-Ukraine

491T1-Ukraine

1381T-China

602T-Russia 71 835T-Russia

99 1380T-China

660T-Ukraine

472T-Russia

809T-Ukraine

CTVT1

B 635T- 433T-The Gambia 1.0E-4 346T-The Gambia 100 610T-The Gambia Clade 2 813T-The Gambia 468T-The Gambia 812T-The Gambia 618T-The Gambia 640T-The Gambia 810T1-The Gambia 667T-The Gambia 666T-The Gambia 639T1-The Gambia 636T-The Gambia 609T-The Gambia 608T-The Gambia 607T-The Gambia 606T-The Gambia 434T-The Gambia 469T-The Gambia 638T- 773T1- 756T-Brazil 91 68 769T1-Brazil 84T-Brazil 80T-Brazil 68 771T1-Brazil 767T-Brazil 762T-Brazil 761T1-Brazil 759T-Brazil 757T-Brazil 758T-Brazil

772T1-Brazil 86T-Brazil

93 82T-Brazil 81T-Brazil 775T2-Brazil 79T-Brazil 362T-Paraguay 83T-Brazil 94 85T-Brazil 763T-Brazil 69 764T-Brazil 774T1-Brazil 760T-Brazil 91 766T1-Brazil 69 770T1-Brazil 336T- 196T-Grenada 861T-Grenada 862T-Grenada 859T-Grenada 75 860T-Grenada 502T1- 857T-Grenada 849T-Grenada 854T-Grenada 509T-Suriname 387T-Suriname 93 507T-Suriname 498T-Suriname 495T-Suriname 391T-Suriname 504T-Suriname 381T-Suriname 383T-Suriname 67 499T-Suriname 393T-Suriname 501T-Suriname 388T-Suriname 497T-Suriname 124T-Grenada 126T-Grenada 390T-Suriname

389T1-Suriname 389T2-Suriname 508T-Suriname 506T1-Suriname 500T-Suriname 394T-Suriname 97 385T-Suriname 75 386T-Suriname 382T-Suriname 505T-Suriname 32T-Portugal 33T-Cape Verde 96 34T-Cape Verde 830T-India 79 271T-India 97 281T-India 437T-India 64 405T-India 831T-India 441T-India 66 438T-India 79 832T-India 66 442T-India 827T-India 829T-India 828T-India 65 439T-India 440T-India 443T-India 435T-India 436T-India 703T- 412T-India 400T-India 63 410T-India 409T-India 408T-India 404T-India 396T-India 317T-India 315T-India 310T-India 308T-India

309T-India 407T-India 402T-India 406T-India 710T-Pakistan 714T-Pakistan 704T1-Pakistan 94 711T1-Pakistan 708T-Pakistan 706T1-Pakistan 705T1-Pakistan 375T-Pakistan 279T-India 276T-India 275T-India 153T-India 274T-India 273T-India 235T-India 234T-India 233T-India

63 232T-India 231T-India 230T-India 226T-India 154T-India 152T-India 151T-India 149T-India 148T-India 146T-India 11T-India 110T-India 108T-India 109T-India 107T-India 105T-India 106T-India 104T-India 103T-India 101T-India 102T-India 805T-Romania

802T-Romania 803T-Romania 804T-Romania 64 122T-Kenya 64 431T1-Kenya 86 415T-Greece 416T-Greece 72 604T-Greece 73 605T-Greece 123T-Kenya 209T-Kenya 631T- 120T1-Kenya 65 634T-Kenya 682T- 683T-South Africa 653T-Malawi 612T-Malawi 93 652T-Malawi 796T-South Africa

61 680T-South Africa 691T-South Africa 684T-South Africa 791T-South Africa 873T-South Africa 868T-South Africa 681T-South Africa 867T-South Africa 869T-South Africa 693T-South Africa 466T-South Africa 465T-South Africa 686T-South Africa 790T-South Africa 875T-South Africa 795T-South Africa 794T-South Africa 792T-South Africa 61 793T-South Africa 687T-South Africa 874T-South Africa 866T-South Africa 798T-South Africa

685T-South Africa 68 694T-South Africa 462T-Reunion 467T-South Africa 3T-South Africa 642T1-Lesotho 62 7T-Italy 6T1-Italy 5T1-Italy 1T-Italy 15T1-Italy 17T1-Italy 18T1-Italy 853T-Grenada 850T-Grenada 87 134T-Grenada 125T-Grenada 82 339T-Grenada 344T-Grenada 847T-Grenada 84 855T-Grenada

587T- 100 592T-Venezuela 133T-Grenada 856T-Grenada 858T-Grenada 79 343T-Grenada 851T-Grenada 64 338T-Grenada 848T-Grenada 345T-Grenada 335T-Grenada 64 341T-Grenada 585T-Venezuela 100 586T-Venezuela

99 598T-Venezuela 588T-Venezuela 590T-Venezuela 601T-Venezuela 596T-Venezuela 584T-Venezuela 87 595T1-Venezuela 72 599T-Venezuela 63 594T-Venezuela 591T-Venezuela 96 600T-Venezuela 589T-Venezuela 597T-Venezuela CTVT2

C CladeClade 3 3

313T-India 1.0E-5 411T-India 1.0E-5 94T-Nicaragua 313T-India 367T-Paraguay 411T-India 86 366T-Paraguay 94T-Nicaragua 66 363T-Paraguay 367T-Paraguay 86 365T-Paraguay 366T-Paraguay 572T-Nicaragua 66 363T-Paraguay

67 74 555T-Nicaragua 365T-Paraguay

564T-Nicaragua 572T-Nicaragua

67 74 551T-Nicaragua 555T-Nicaragua 64 564T-Nicaragua 540T-Nicaragua

66 551T-Nicaragua 550T-Nicaragua 740T-Belize 540T-Nicaragua 66 550T-Nicaragua342T-Grenada 740T-Belize369T-Mexico 342T-Grenada 68 782T-Belize 369T-Mexico 738T-Belize 68 782T-Belize 739T-Belize 95 738T-Belize 464T-Belize 739T-Belize 95 74 839T1-Belize 464T-Belize 74 839T2-Belize839T1-Belize

CTVT3 (donor haplotype) 839T2-Belize

CTVT3

D 1.0E-4 Clade 4

1.0E-4 401T-Belize 401T-India 100 100 270T-Belize270T-India 399T-India399T-Belize CTVT4 CTVT4

E Clade 5

CTVT5

627T1-

628T1-Nigeria

Figure 1 - source data 2. Maximum likelihood phylogenetic trees for CTVT clades 1 to 5. Maximum likeli- hood phylogenetic trees for CTVT mtDNA in (A) clade 1 (n = 170) (B) clade 2 (n = 252) (C) clade 3 (n = 22) (D) clade 4 (n = 3) and (E) clade 5 (n = 2), rooted with haplotypes CTVT1 to CTVT5 respectively, which contain

4). Bootstrap values were calculated from 100 bootstrap replicates and are shown where bootstrap values ≥ 60. Scale bars indicate base substitutions per site. Clade 5 contains only two tumours, which are identical both to each other and to the CTVT5 haplotype; thus the tree for this clade was created separately and does not have a scale bar.