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Clade 1 361T-Paraguay Figure 1 - source data 2 0.0010 12T-India 100 13T-India 359T-Paraguay 364T-Paraguay A 360T-Paraguay Clade 1 361T-Paraguay 583T-Chile 100 84 582T-Chile 371T-Chile 419T-Chile 71 372T-Chile 71 420T-Chile 90 379T-Ecuador 423T-Ecuador 94 623T-Ecuador 71 622T-Ecuador 73 624T-Ecuador 90 625T-Ecuador 621T-Ecuador 429T-Ecuador 422T-Ecuador 463T-Panama 430T-Ecuador 424T-Ecuador 377T-Ecuador 531T-Colombia 532T-Colombia 414T-Panama 428T-Ecuador 421T-Ecuador 326T-Ecuador 425T-Ecuador 426T1-Ecuador 427T-Ecuador 560T-Nicaragua 525T-Guatemala 96 527T-Guatemala 432T-USA (Guatemala) 99 523T-Guatemala 650T-Honduras 649T-Honduras 644T-Honduras 645T-Honduras 647T-Honduras 530T1-Guatemala 96 535T-Nicaragua 453T-Belize 459T-Belize 457T-Belize 815T-Belize 79 452T-Belize 69 824T-Belize 820T-Belize 454T-Belize 451T-Belize 87 455T1-Belize 77 456T-Belize 823T-Belize 822T-Belize 821T-Belize 819T-Belize 817T-Belize 816T-Belize 511T-Belize 814T-Belize 179T1-Nicaragua 84 92T-Nicaragua 571T-Nicaragua 558T-Nicaragua 534T-Nicaragua 73 93T-Nicaragua 575T-Nicaragua 556T-Nicaragua 559T-Nicaragua 99T-Nicaragua 98T-Nicaragua 96T-Nicaragua 100T-Nicaragua 95T-Nicaragua 61T-Mexico 97 62T-Mexico 88 49T-Mexico 68 53T-Mexico 82 56T-Mexico 50T1-Mexico 180T-Mexico 57T-Mexico 88 86 60T-Mexico 54T-Mexico 98 55T-Mexico 59T-Mexico 370T-Mexico 4T-Mexico 2T-Israel 65 801T-Romania 77 321T2-Tanzania 324T2-Tanzania 834T1-Russia 808T-Ukraine 807T1-Ukraine 616T-Ukraine 67 66 629T-Ukraine 98 447T-Ukraine 68 661T-Ukraine 88 494T-Ukraine 493T1-Ukraine 460T-Ukraine 492T1-Ukraine 799T-Romania 88 800T-Romania 100 84 833T1-Netherlands (Romania) 611T-Malawi 78 614T-Malawi 100 613T-Malawi 65 615T-Malawi 96 656T-Malawi 135T-Australia 137T1-Australia 515T-Australia 71 513T-Australia 286T1-Australia 269T-Australia 265T-Australia 143T-Australia 136T-Australia 140T-Australia 45T1-Australia 41T-Australia 29T1-Australia 267T-Australia 266T-Australia 24T-Australia 139T-Australia 142T-Australia 37T-Australia 90T-Australia 47T-Australia 67 48T1-Australia 40T-Australia 39T-Australia 38T-Australia 22T-Australia 25T-Australia 44T-Australia 62 89T-Australia 88T-Australia 512T-Australia 514T-Australia 23T-Australia 87 43T-Australia 52T1-Samoa 516T-Australia 27T-Australia 95 28T-Australia 26T-Australia 285T-Australia 490T-Ukraine 449T-Ukraine 100 448T-Ukraine 446T-Ukraine 61 630T-Ukraine 450T-Ukraine 491T1-Ukraine 1381T-China 602T-Russia 71 835T-Russia 99 1380T-China 660T-Ukraine 472T-Russia 809T-Ukraine CTVT1 B 635T-The Gambia 433T-The Gambia 1.0E-4 346T-The Gambia 100 610T-The Gambia Clade 2 813T-The Gambia 468T-The Gambia 812T-The Gambia 618T-The Gambia 640T-The Gambia 810T1-The Gambia 667T-The Gambia 666T-The Gambia 639T1-The Gambia 636T-The Gambia 609T-The Gambia 608T-The Gambia 607T-The Gambia 606T-The Gambia 434T-The Gambia 469T-The Gambia 638T-Uruguay 773T1-Brazil 756T-Brazil 91 68 769T1-Brazil 84T-Brazil 80T-Brazil 68 771T1-Brazil 767T-Brazil 762T-Brazil 761T1-Brazil 759T-Brazil 757T-Brazil 758T-Brazil 772T1-Brazil 86T-Brazil 93 82T-Brazil 81T-Brazil 775T2-Brazil 79T-Brazil 362T-Paraguay 83T-Brazil 94 85T-Brazil 763T-Brazil 69 764T-Brazil 774T1-Brazil 760T-Brazil 91 766T1-Brazil 69 770T1-Brazil 336T-Grenada 196T-Grenada 861T-Grenada 862T-Grenada 859T-Grenada 75 860T-Grenada 502T1-Suriname 857T-Grenada 849T-Grenada 854T-Grenada 509T-Suriname 387T-Suriname 93 507T-Suriname 498T-Suriname 495T-Suriname 391T-Suriname 504T-Suriname 381T-Suriname 383T-Suriname 67 499T-Suriname 393T-Suriname 501T-Suriname 388T-Suriname 497T-Suriname 124T-Grenada 126T-Grenada 390T-Suriname 389T1-Suriname 389T2-Suriname 508T-Suriname 506T1-Suriname 500T-Suriname 394T-Suriname 97 385T-Suriname 75 386T-Suriname 382T-Suriname 505T-Suriname 32T-Portugal 33T-Cape Verde 96 34T-Cape Verde 830T-India 79 271T-India 97 281T-India 437T-India 64 405T-India 831T-India 441T-India 66 438T-India 79 832T-India 66 442T-India 827T-India 829T-India 828T-India 65 439T-India 440T-India 443T-India 435T-India 436T-India 703T-Pakistan 412T-India 400T-India 63 410T-India 409T-India 408T-India 404T-India 396T-India 317T-India 315T-India 310T-India 308T-India 309T-India 407T-India 402T-India 406T-India 710T-Pakistan 714T-Pakistan 704T1-Pakistan 94 711T1-Pakistan 708T-Pakistan 706T1-Pakistan 705T1-Pakistan 375T-Pakistan 279T-India 276T-India 275T-India 153T-India 274T-India 273T-India 235T-India 234T-India 233T-India 63 232T-India 231T-India 230T-India 226T-India 154T-India 152T-India 151T-India 149T-India 148T-India 146T-India 11T-India 110T-India 108T-India 109T-India 107T-India 105T-India 106T-India 104T-India 103T-India 101T-India 102T-India 805T-Romania 802T-Romania 803T-Romania 804T-Romania 64 122T-Kenya 64 431T1-Kenya 86 415T-Greece 416T-Greece 72 604T-Greece 73 605T-Greece 123T-Kenya 209T-Kenya 631T-Uganda 120T1-Kenya 65 634T-Kenya 682T-South Africa 683T-South Africa 653T-Malawi 612T-Malawi 93 652T-Malawi 796T-South Africa 61 680T-South Africa 691T-South Africa 684T-South Africa 791T-South Africa 873T-South Africa 868T-South Africa 681T-South Africa 867T-South Africa 869T-South Africa 693T-South Africa 466T-South Africa 465T-South Africa 686T-South Africa 790T-South Africa 875T-South Africa 795T-South Africa 794T-South Africa 792T-South Africa 61 793T-South Africa 687T-South Africa 874T-South Africa 866T-South Africa 798T-South Africa 685T-South Africa 68 694T-South Africa 462T-Reunion 467T-South Africa 3T-South Africa 642T1-Lesotho 62 7T-Italy 6T1-Italy 5T1-Italy 1T-Italy 15T1-Italy 17T1-Italy 18T1-Italy 853T-Grenada 850T-Grenada 87 134T-Grenada 125T-Grenada 82 339T-Grenada 344T-Grenada 847T-Grenada 84 855T-Grenada 587T-Venezuela 100 592T-Venezuela 133T-Grenada 856T-Grenada 858T-Grenada 79 343T-Grenada 851T-Grenada 64 338T-Grenada 848T-Grenada 345T-Grenada 335T-Grenada 64 341T-Grenada 585T-Venezuela 100 586T-Venezuela 99 598T-Venezuela 588T-Venezuela 590T-Venezuela 601T-Venezuela 596T-Venezuela 584T-Venezuela 87 595T1-Venezuela 72 599T-Venezuela 63 594T-Venezuela 591T-Venezuela 96 600T-Venezuela 589T-Venezuela 597T-Venezuela CTVT2 C CladeClade 3 3 313T-India 1.0E-5 411T-India 1.0E-5 94T-Nicaragua 313T-India 367T-Paraguay 411T-India 86 366T-Paraguay 94T-Nicaragua 66 363T-Paraguay 367T-Paraguay 86 365T-Paraguay 366T-Paraguay 572T-Nicaragua 66 363T-Paraguay 67 74 555T-Nicaragua 365T-Paraguay 564T-Nicaragua 572T-Nicaragua 67 74 551T-Nicaragua 555T-Nicaragua 64 564T-Nicaragua 540T-Nicaragua 66 551T-Nicaragua 550T-Nicaragua 740T-Belize 540T-Nicaragua 66 550T-Nicaragua342T-Grenada 740T-Belize369T-Mexico 342T-Grenada 68 782T-Belize 369T-Mexico 738T-Belize 68 782T-Belize 739T-Belize 95 738T-Belize 464T-Belize 739T-Belize 95 74 839T1-Belize 464T-Belize 74 839T2-Belize839T1-Belize CTVT3 (donor haplotype) 839T2-Belize CTVT3 D 1.0E-4 Clade 4 1.0E-4 401T-Belize 401T-India 100 100 270T-Belize270T-India 399T-India399T-Belize CTVT4 CTVT4 E Clade 5 CTVT5 627T1-Nigeria 628T1-Nigeria Figure 1 - source data 2. Maximum likelihood phylogenetic trees for CTVT clades 1 to 5. Maximum likeli- hood phylogenetic trees for CTVT mtDNA in (A) clade 1 (n = 170) (B) clade 2 (n = 252) (C) clade 3 (n = 22) (D) clade 4 (n = 3) and (E) clade 5 (n = 2), rooted with haplotypes CTVT1 to CTVT5 respectively, which contain 4). Bootstrap values were calculated from 100 bootstrap replicates and are shown where bootstrap values ≥ 60. Scale bars indicate base substitutions per site. Clade 5 contains only two tumours, which are identical both to each other and to the CTVT5 haplotype; thus the tree for this clade was created separately and does not have a scale bar..
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