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Download News 2/2020 Polymere und Fluoreszenz Gleichgewicht der 360°-Trinkwasseranalyse Kräfte Trilogie Fluoreszenzspektroskopie von Basispolymeren aus der Leistung und Robustheit in Automatische, simultane Industrie Einklang mit Empfindlichkeit und schnelle Analyse von und Geschwindigkeit Pestiziden INHALT APPLIKATION »Plug und Play«-Lösung für das Krankheits-Screening – MALDI-8020 zum Screening der Sichelzellen anämie 4 Maßgeschneiderte Software- Lösungen für jede Messung – Makro-Programmierung für Shimadzu UV-Vis und FTIR 8 Auf der sicheren Seite: Steroid - nachweis in Arzneimitteln und Nahrungsergänzungsmitteln mit einem LCMS-8045 11 MSn-Analyse nicht-derivatisier- ter und Mtpp-derivatisierter Peptide – Zwei aktuelle Unter- suchungen zur Anwendung von LC-MS-IT-TOF-Geräten 18 Polymere und Fluoreszenz – Teil 2: Wieviel Fluoreszenz zeigt ein Poly mer für eine Qualitäts - kontrolle? 26 PRODUKTE Gleichgewicht der Kräfte – LCMS-8060NX: Leistung und Robustheit mit Empfindlichkeit, und Geschwindigkeit 7 360°-Trinkwasseranalyse: Episode 2 – Automatische, simul- Enrico Davoli mit dem PESI-MS-System – einem Gerät zu reinen Forschungszwecken (research-use only = RUO) tane und schnelle Analyse von Pestiziden mit Online-SPE und UHPLC-MS/MS 14 Vielseitiges Tool für die Automobil - industrie – Neue HMV-G3 Serie 17 Eine globale Lösung Kopfschmerz ade – Anleitung zur Auswahl der idealen C18-Säule 22 Validierte Methode für monoklo- nale Antikörper-Medikamente – dank globaler Bewertung der nSMOL-Methodik in menschlichem Serum 24 AKTUELLES Zusammenarbeit Eine globale Lösung dank globaler Zusammenarbeit – Innovations - zentren von Shimadzu als Partner Krebsdiagnostik: Innovationszentren von Shimadzu der wissenschaftlichen Forschung 2 als Partner der wissenschaftlichen Forschung MÄRKTE s begann 1875 als Ein- Mann-Unternehmen im Chemical, Petrochemical, japanischen Kyoto und hat Biofuel and Energy E heute weltweit mehr als 10.000 Clinical Mitarbeiter: Shimadzu trägt mit seinen Lösungen dazu bei, „der Environment Gesellschaft zu nützen durch Wissenschaft und Technologie“, Food, Beverages, Agriculture so die Unternehmensphilosophie. Für seine zukünftigen Geräte - Pharmaceutical generationen, die den eigenen Anspruch „Excellence in Science“ Plastics and Rubber tragen, hat Shimadzu rund um den Globus Innovationszentren Automotive (SIC - Shimadzu Innovation Silvia Giordano und Enrico Davoli vor dem Mario-Negri-Institut, Mailand SHIMADZU NEWS 2/2020 AKTUELLES Cen ter) eingerichtet. 2017 wurde ogischen Untersuchung an einen talen Forschungs verbunds wesent - betrachten ihre Forschungsko - für Europa in Duisburg das Pathologen weiter, um zu ent - lich beteiligt war. opera tionen daher wie eine wis- European Innovation Center schei den, ob mehr Gewebeentfer - senschaftliche Zusammenarbeit, (EUIC) eröffnet. nung notwendig ist. Jede Probe SICs als wirtschaftlich- die niemals die akademische benötigt etwa 30 Minuten zur akademischer Partner Unabhängigkeit gefährdet, zu Basierend auf seinem seit mehr als Aufbereitung und Analyse, was Publikationen ermutigt und die 50 Jah ren entwickelten Netzwerk nicht nur hohe Kosten verursacht, In gewisser Weise lassen sich Hochschul-Ausbildung unter- in Europa, betreut Shimadzu seit sondern auch mit einer hohen Shimadzu Innovation Center als stützt. 2017 über ein Dutzend aktuelle Infektionswahrscheinlichkeit ein- Hybrid aus Industrie und Wissen - Projekte mit dem EUIC. Sie um - hergeht. schaftswelt betrachten. Alle SICs Der Erfolg von SICs baut auf fassen Lebensmittel-, Umwelt - haben das Ziel, neue Märkte zu neuen Gedanken und Zugangs - schutz und klinische Anwendun - Neue Lösung dank globaler erschließen, aber Märkte wachsen weisen auf. Deshalb stimmen sich gen mit Fokus auf neue Metho - Partner nicht nur aus wirtschaftlichem die Teams von Shimadzu fort- den, Werkzeuge, Techniken, Antrieb, sondern auch durch laufend mit den Universitäts for - Diagnostik und Lösungen. Eine Japan ist ein führendes Land bei wachsende Kompetenz und Ex - schern ab, um von wissenschaft - ganz aktuelle Zusammen arbeit den Behandlungsergebnissen für pertise, erläutert Dr. Ann-Christin lichen Fragestellungen zu erfah - wird die Krebsbehandlung voran- Leberkrebs, größtenteils aufgrund Niehoff, EUIC-Produktmanager ren, bei deren Lösung Innovatio - bringen. der neuartigen diagnostischen für analytische Bildgebungstech - nen von Shimadzu helfen können. Techniken in Japan (Kudo, 2018). nologien (Imaging). Deshalb bilden SICs auch For - Forschung zur Verbesserung Im Projekt von Davoli und schungsnetzwerke, wodurch auch der Krebserkennung Shimadzu wird KI darauf trai niert, Davoli und Takeda einander vor - eine Probe von PESI-MS-Daten gestellt wurden. Takeda wurde An einem neuen Ansatz, Krebs - ohne irgendeine Histo logie oder eingeladen, während des Shimadzu zellen zu diagnostizieren, forscht Laboraufbe reitung zu ana lysieren. Global Innovation Summit 2017 Shimadzu zusammen mit Dr. KI trifft eine binäre Entschei dung im japanischen Kyoto zu spre - Enrico Davoli. Er arbeitet am mit statistischer Wahr - chen. Dort lernte er auch andere Mario-Negri-Institut für Pharma - scheinlichkeit – normal oder wissenschaftliche Partner von kologische Forschung im italienis- Krebs. Vom Zeitpunkt der Pro - Shimadzu kennen und konnte sich chen Mailand, und war der erste ben gewin nung durch den Chirur - mit Ihnen über ihre letzten Ergeb - Präsident der italienischen Gesell - gen bis zur KI-Ent scheidung nisse in der analytischen For - schaft für Massenspektrometrie. dauert der gesamte Vorgang nicht schung austau schen. Shimadzu regte die Zusammen - länger als zwei Minuten. arbeit für Europa an, nachdem das „Der Gesellschaft zu nützen Unternehmen erfolgreich eine Nachdem Takeda und Shimadzu durch Wissenschaft und Tech - Kooperation mit Professor Sen die Effektivität dieses Ansatzes in nologie“ – diese Philosophie wen- Takeda von der Yamanashi Uni - Japan gezeigt hatten, ergab sich die den Shimadzu und seine SICs an, versität in Japan begonnen hatte. Frage, ob eine Hochrechnung auch um akademisch-wissenschaftliches Dabei geht es um ein neues Sys - auf andere Länder mög lich sei, da Fachwissen von Universitäten in tem, das künstliche Intelligenz die KI ursprünglich mit Daten von technologische Lösungen zu über- (KI) mit einer Elektrospray- japanischen Proben trainiert wor- tragen und einige der weltweit Ionisations-Massenspektrometrie- den war. So trat Shimadzu mit größten Herausforderungen zu Sonde (PESI-MS - Probe Electro - Davoli in Verbindung und fragte lösen. spray Ionization Mass Spectro - an, ob er Zugang zu Gewebe - Prof. Sen Takeda von der Universität metry) kombiniert, um den for - proben aus italienischen Klini ken Yamanashi beim Shimadzu Global Die Informationen inklusive der schungsbasierten Nachweis von habe. Davoli war begeistert Innovation Summit 2017 Partner und der Titel der in die - Krebszellen der Leber zu fördern mitzuwirken. sem Artikel genannten Personen (Yoshimura et al., 2012). „Mehr als 90 % der promovierten entsprechen dem Stand zum Zeit - „Ein Forscher wünscht sich sein Chemiker bleiben nicht im Wis - punkt der Interviews (Dezem ber Leberzellkarzinome sind eine häu- ganzes Leben lang, einen Prototyp senschaftsbetrieb. Wir helfen beim 2018). fige Ursache bei Krebstod. Zur zu besitzen und der erste zu sein, Aufbau ihrer Karriere“, sagt sie. üblichen Behandlungsweise gehört der etwas versucht. Das Instru - Deshalb fördert Shimadzu Promo - Referenzen die Abtragung der Krebszellen. ment ist brandneu. Der Ansatz ist tionsstudierende und kann sogar Kudo, M. (2018). Management of Hepato - Die Fachwelt diskutiert, wie viel brandneu. Es war eine sehr gute Mitantragsteller für Zuschüsse cellular Carcinoma in Japan as a World- gesundes, in die Teilentfernung Gelegenheit”, sagt er. sein. Zu den Beispielen gehören Leading Model. Liver Cancer 7, 134-147. einbezogenes Gewebe der Leber gemeinsame Projekte an der für das Überleben des Patienten Die ersten Ergebnisse sind viel - Klinik im französischen Limoges, Yoshimura, K., Chen, L.C., Mandal, am besten ist: Einige Forscher hal- versprechend, und mit Förderung und dem University College M.K., Nakazawa, T., Yu, Z., Uchiyama, ten eine kleine Pufferzone für ak - von Shimadzu erweitert Davoli London, England, bei denen das T., Hori, H., Tanabe, K., Kubota, T., Fujii, zeptabel, in der gesundes Gewebe seine Probensammlungen auf EUIC mit Promotionsstipendien H., et al. (2012). Analysis of renal cell carci- entfernt wird, während andere der andere solide Tumore. „Unser für drei Jahre unterstützt. noma as a first step for developing mass Ansicht sind, dass nichts anderes Plan besteht darin, mit anderen spectrometry-based diagnostics. J Am Soc als das Tumorgewebe entfernt europäischen Nationen zusammen Unabhängig von der hohen Qua - Mass Spectrom 23, 1741-1749. werden sollte. zu arbeiten, um PESI-MS an lität seiner technologischen Lö - anderen Populationen zu testen“, sungen sieht Shimadzu das pri - Im Verlauf einer Operation leitet sagt er und fügt hinzu, dass das märe Ziel seiner SICs darin, der der Chirurg eine Probe zur histol- EUIC am Aufbau eines kontinen- Gesellschaft zu nützen. SICs SHIMADZU NEWS 2/2020 3 APPLIKATION »Plug und Play«-Lösung für das Krankheits-Screening Das MALDI-8020 zum Screening der Sichelzellenanämie 3D-Illustration von Sichelzellen ie Weltgesundheits ver - schrieben. Derzeit finden sich ca. Die Anforderungen der und Datenverarbeitungssoftwares sammlung verabschiedete 80 % aller Fälle von Sichelzellen - Gesundheitsschutzmaßnahmen basieren. Wirtschaftlichkeit ist D 2006 eine Resolution, die anämie in tropischen
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