DOCSLIB.ORG

Method Development for Analysis of Pharmaceuti-Cals in Environmental

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Method Development for Analysis of Pharmaceuti-Cals in Environmental Umweltforschungsplan des Bundesministeriums für Umwelt, Naturschutz, Bau und Reaktorsicherheit Forschungskennzahl 3715674130 UBA-FB-00 [trägt die UBA-Bibliothek ein] Method development for analysis of pharmaceuti- cals in environmental samples von Prof. Dr. Thomas Ternes Bundesanstalt für Gewässerkunde, Koblenz Dr. Georg Dierkes Bundesanstalt für Gewässerkunde, Koblenz Lise Boulard Bundesanstalt für Gewässerkunde, Koblenz Alexander Weizel Bundesanstalt für Gewässerkunde, Koblenz Bundesanstalt für Gewässerkunde Am Mainzer Tor 1 56068 Koblenz Im Auftrag des Umweltbundesamtes Abschlussdatum Februar 2018 UBA Texts Pharmaceuticals in environmental samples Abstract Since the last decades the increasing currency of pharmaceuticals in the aquatic environment and their risk potential for the aquatic life has become an urgent issue. The number of pharmaceuticals detecta- ble in the low µg/L range in the environment is rising each day. Against this background the aim of this project was the development, optimization, validation and comparison of analytical methods for quan- tification of selected pharmaceuticals in different environmental matrices (water, sediment, suspend- ed particular matter and biota). High sensitive LC-MS-MS methods for determination of extreme polar, polar and hormonal pharmaceuticals in water samples were developed and validated. Using these methods occurrence and distribution of the selected pharmaceuticals in water with different waste water content were determined. For analysis of pharmaceuticals in particular matter and biota sam- ples extraction and clean-up procedures were tested, but method development is still in process. Fur- thermore a monitoring campaign was set up and water samples, suspended particular matter and bio- ta (fish) samples from six different sampling sites were taken. Kurzbeschreibung Die Verbreitung von Arzneimittelrückständen in Gewässern und deren Gefährdungspotential für Was- serlebewesen hat in den letzten Jahren beunruhigende Ausmaße angenommen. Immer mehr Arznei- mittelwirkstoffe werden in Konzentrationen bis in den unteren µg/L-Bereich in der aquatischen Um- welt nachgewiesen. Vor diesem Hintergrund ist das Ziel dieses Projekts analytische Nachweisverfah- ren und Probenahmekonzepte für ausgewählte Arzneimittelwirkstoffe und verschiedene Matrizes (Wasser, Sediment, Schwebstoff, Biota) zu entwickeln, optimieren, validieren und vergleichen. Leis- tungsstarke LC-MS-MS Methoden wurden für den Nachweis von extrem polaren, polaren und hormo- nellen Wirkstoffen in Wasserproben entwickelt und validiert. Mit Hilfe dieser Methoden wurden an- schließend das Vorkommen und die Verteilung der ausgewählten Arzneimittelwirkstoffe in Wasser- proben aus Gewässern mit unterschiedlichen Abwasseranteilen ermittelt. Für die Analytik von Schwebstoff- und Biotaproben wurden Extraktions- und Aufreinigungsverfahren getestet, allerdings befinden sich diese Methoden noch in der Entwicklung. Des Weiteren wurde ein Monitoringskonzept entwickelt und Wasser-, Schwebstoff und Biotaproben aus sechs verschiedenen Gewässern entnom- men. 4 UBA Texts Pharmaceuticals in environmental samples Table of content Table of figures ................................................................................................................................................. 6 Table of tables .................................................................................................................................................. 7 Abbreviations.................................................................................................................................................... 8 1 Introduction .......................................................................................................................................... 13 2 Work package 1: Categorization and prioritization .............................................................................. 14 3 Work package 2: Method development and conception of a monitoring program ............................ 16 3.1 Method development ........................................................................................................... 16 3.1.1 Suspect-Screening ............................................................................................................ 16 3.1.1.1 Method 16 3.1.1.2 Results 17 3.1.2 Extreme polar pharmaceuticals (without hormones) ...................................................... 18 3.1.2.1 Material and Methods 19 3.1.2.2 Result and discussion 22 3.1.2.3 Conclusions 40 3.1.3 Middle polar pharmaceuticals ......................................................................................... 43 3.1.4 Hormone .......................................................................................................................... 43 3.1.4.1 Materials and Methods 45 3.1.4.2 Results and Discussion 48 3.1.4.3 Conclusions 57 3.1.5 Sediment and suspended particulate matter .................................................................. 58 3.2 Conception of a monitoring program ................................................................................... 62 4 Work package 3: Environmental monitoring ........................................................................................ 63 4.1 Rhine ..................................................................................................................................... 63 4.2 Occurrence of pharmaceuticals in surface waters ............................................................... 70 4.3 Comparison of suspect screening and target analysis .......................................................... 79 5 Summary and elaboration of recommendations (Work package 4): ................................................... 81 6 References ............................................................................................................................................ 83 7 Appendix ............................................................................................................................................... 90 5 UBA Texts Pharmaceuticals in environmental samples Table of figures Figure 1: Scheme of the data processing-steps for the used in-house Suspect-Screening .............................. 17 Figure 2: Identified suspect ............................................................................................................................ 18 Figure 3: Superposition of MRM transitions of a 500 ng/L multi-standard. .................................................... 23 Figure 4: Influence of the composition of the aqueous eluent and the column on the elution of metformin. ........................................................................................................ 24 Figure 5: Comparison of 2 injections of a 2000 ng/L standard with the HILIC Nucleodur. .............................. 25 Figure 6: Matrix effects .................................................................................................................................... 34 Figure 7: Post-column infusion of acyclovir-d4 ................................................................................................ 35 Figure 8: Post-column infusion of a multi-standard ........................................................................................ 36 Figure 9: Sodium adducts of emtricitabine ...................................................................................................... 37 Figure 10: Retention times and peak forms of a 1000 ng/L multi-standard dissolved in different diluents . ............................................................................................................. 38 Figure 11: Retention times and peak forms of a 1000 ng/L multi-standard measured with eluent B containing different ratio acetonitrile/Milli-Q .................................................... 39 Figure 12: Workflow of the developed method for the trace quantification of 60 steroid hormones by LC-MS/MS .................................................................................................... 46 Figure 13: Recoveries ....................................................................................................................................... 49 Figure 14: Chemical structures, extracted ion chromatogram of non-spiked WWTP effluent and high-resolution MS²-spectra. ....................................................................... 50 Figure 15: Boxplots of the recoveries of the extraction procedure with ultrasonic extraction and accelerated solvent extraction. ................................................................. 58 Figure 16: Boxplot of the recoveries obtained with different extraction solvents. MQ: Milli-Q, MeOH: methanol. ................................................................................................ 59 Figure 17: Boxplot of the recoveries obtained for different pH for the aqueous part of the extraction solvent methanol/water, 50/50, v/v. ......................................................... 60 Figure 18: Boxplot of the recoveries for different volumetric percentage of formic acid in the aqueous phase of the extraction solvent. .................................................................. 60 Figure 19: Boxplots of the recoveries obtained with different procedure ...................................................... 61 Figure 20: Map of the sampling locations along the Rhine .............................................................................
Load more

Recommended publications
  • O SIEMSGLUSS IBERICA, S.A
    SIEMSGLUSS IBERICA, S.A. Product list G Memantine HCI Propylparaben Sodium Pharma APls Gemfibrozil Mepiramina Maleato R Gentian Powder Methoxsalen Ramipril Gentian Violet Methyl Nicotinate Ranitidin HCI Glibenclamide Methylprednisolone Base Rapamycin (Slrollrnus) Glimepiride Metimazole Resorcin A e Gluthatione reduced Metronidazol Resveratrol (Veri-Te®) 11 Alpha Hydroxyprogesterone Caffein Anhydrous Cyproterone Acetate Guaiacol Glyceril Ether Mexiletine HcI Rifampicin 17 Alpha Estradiol Calcipotriol Mieonazole Nitrate o H Roxythromycin Acetyl Salicylic Acid Canrenone Miltefosine Desonide Micronized Hydroquinone AcetylSpiramycin Cantharidin Minocycline HcI Dexamethasone BaseMicro Hyaluronic Acid Sodium Salt s Adapalene Captopril Minoxidil Seenidazol Dexamethasone Isonicotinate Miero Hydrochlorthiazide Amidopyrine Carbamazepine Mometasone Furoato Silver Sulfadiazine Dexamethasone Sodium Phosphate Hydrocortisone Acetate Micro Amikacin Sulphate Carbidopa Montelukast Sodium Simvastatine Dexketoprofen Trometamol Hydrocortisone BaseMicro Amiloride Carisoprodol Sodium Cefonicide Dextrometorphan Bromhidrate Hydroxyzine HcI N Amitriptyline HCI Carvedilol $pironolactone Micro Dextrose (Glucosa) Anhydrous N Aeetyl Glueosamine Amoxlcillin Na + Clavulonate K Cefaclor Monohidrate Sulpiride Diacethyl Naproxen Powder Ibuprofen Amoxicillin Na + Clavulonate K(5:1) Cefadroxil Compaeted Dielofenae Sodium Neutral Pellets Idebenone T Amoxicillin Trihydrate Compacted Cefalexine Monohydrate Powder Difenhydramire Nisin Taerollmus Monohydrate Imiquimod Amoxlcillln
    [Show full text]
  • RIEMSER Group International Product List
    RIEMSER Group International Product List Product Active substance Presentation Indication Product Category Channel EMB Fatol Ethambutol • POI 1g/10ml Treatment of several forms and stages of Anti-infectives Rx dihydrochloride • TAB 100mg tuberculosis • FCT 400, 500 mg Eremfat Rifampicin • GRA 1.2g/60ml Anti-infectives Rx • POI 300, 600mg Tuberculosis therapy , combination treatment of • FCT 150, 300, 450, 600 leprosy, prophylaxis for meningococcal meningitis, treatment of infections caused by nontuberculous mycobacteria Isozid Isoniazid • TAB 50, 100, 200 mg During Chemotherapy, -prophylaxis and - Anti-infectives Rx • POI 500mg prevention for / of tuberculosis Isozidcomp Isoniazid / pyridoxine • TAB 100mg / 20mg Chemotherapy, -prophylaxis and -prevention for / Anti-infectives Rx • FCT 200mg /40 mg, 300mg/60mg of Tuberculosis PAS-Fatol Sodium aminosalicylate • POI 13.49g Chemotherapy for tuberculosis, caused by Anti-infectives Rx dihydrate mycobacterium tuberculosis and mycobacterium bovis. Peteha Protionamide • FCT 250mg Treatment of tuberculosis, leprosy and diseases Anti-infectives Rx caused by so-called ubiquitours (atypical) mycobacteria Pyrafat Pyrazinamide • FCT 500mg Combination therapy for all types of tuberculosis, Anti-infectives Rx • TAB 500mg caused by mycobacterium tuberculosis, mycobacterium africanum, or mycobacterium microtti. Terizidon Terizidone • CAP 250mg Treatment of tuberculosis caused by Anti-infectives Rx mycobacterium tuberculosis Vancomycin Enterocaps Vancomycin • CAP 250 mg Treatment of certain types of bowel
    [Show full text]
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
    [Show full text]
  • EAR, NOSE and OROPHARYNX Updated: October 2020
    Derbyshire Medicines Management, Prescribing and Guidelines DERBYSHIRE PRIMARY CARE FORMULARY CHAPTER 12: EAR, NOSE AND OROPHARYNX Updated: October 2020 The following prescribing guidelines are relevant to the ENT chapter and can be found here: • Allergic Rhinitis in adults and adolescents over 12 years of age • Management of chronic rhinosinusitis with or without nasal polyps 12.1 DRUGS ACTING ON THE EAR 12.1.1 Otitis externa Investigation is not routinely recommended for the initial diagnosis of otitis externa. Group Drug Astringent/acidic Acetic acid 2% ear spray preparations Self-care: patients are advised to purchase this over the counter Gentamicin 0.3% ear/eye drops* Antibiotic preparations Ciprofloxacin 2mg/ml ear drops 0.25ml unit dose PF Betnesol-N ear/eye/ nose drops* Combined corticosteroid (Betamethasone 0.1% & neomycin 0.5%) and aminoglycoside Otomize ear spray* antibiotic preparations (Dexamethasone 0.1%, neomycin 0.5% & acetic acid 2%) Corticosteroid Prednisolone 0.5% ear/eye drops Lower potency preparations Betamethasone 0.1% ear/eye/ nose drops Higher potency Antifungal preparations Clotrimazole 1% solution 20ml (with dropper) * In view of reports of ototoxicity, manufacturers contra-indicate treatment with topical aminoglycosides in patients with a perforated tympanic membrane (eardrum) or patent grommet. 1. The following are GREY, not for first line empirical use, and should only be used when sensitivity is confirmed through swab results- • Hydrocortisone acetate 1%/gentamicin 0.3% ear drops • Flumetasone pivalate 0.02%/clioquinol 1% ear drops 2. How should I treat acute diffuse otitis externa? (CKS) • Remove or treat any precipitating or aggravating factors. • Prescribe or recommend a simple analgesic for symptomatic relief.
    [Show full text]
  • Ear, Nose and Oral Cavity
    NHS Borders Joint Prescribing Formulary Ear, nose, and oral cavity Black Text Drugs which may be prescribed by all prescribers Drugs which are either for specialist only prescription or for specialist Pink Text initiation, with prescribing transfer to GP Important Information: In addition to the disclaimer on NHS Borders website the following information is included confirming that the information contained in NHS Borders Joint Prescribing formulary is drawn from several sources, including BNF & BNF for children, product SPCs, local and national guidelines, local expert opinion, Lothian Joint Formulary and these are all gratefully acknowledged here. NHS Borders has done its utmost to ensure the information in the BJF is accurate and reliable, but NHS Borders cannot guarantee that the information is complete and accurate. Prescribers are referred to the SPCs, BNF and BNF for children to confirm prescribing information. June 2021 Contents Page Table of Contents 12.1 Drugs acting on the ear ................................................................................................ 3 Otitis externa ................................................................................................................ 3 Otitis media .................................................................................................................. 3 Removal of ear wax ..................................................................................................... 3 12.2 Drugs acting on the nose ............................................................................................
    [Show full text]
  • Potential of Guggulsterone, a Farnesoid X Receptor Antagonist, In
    Exploration of Targeted Anti-tumor Therapy Open Access Review Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer Sosmitha Girisa , Dey Parama , Choudhary Harsha , Kishore Banik , Ajaikumar B. Kunnumakkara* Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India *Correspondence: Ajaikumar B. Kunnumakkara, Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India. [email protected]; [email protected] Academic Editor: Gautam Sethi, National University of Singapore, Singapore Received: August 8, 2020 Accepted: September 14, 2020 Published: October 30, 2020 Cite this article: Girisa S, Parama D, Harsha C, Banik K, Kunnumakkara AB. Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer. Explor Target Antitumor Ther. 2020;1:313-42. https://doi.org/10.37349/ etat.2020.00019 Abstract Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. The importance of medicinal plants as primary healthcare has been well-known from time immemorial against various human diseases, including cancer. Commiphora wightii that belongs to Burseraceae family is one such plant which has been used to cure various ailments in traditional systems of medicine.
    [Show full text]
  • Nandrolone Decanoate Enhances Hypothalamic Biogenic Amines in Rats
    Nandrolone Decanoate Enhances Hypothalamic Biogenic Amines in Rats 1 1 2 2 TETSURO TAMAKI , TAKEMASA SHIRAISHI , HIROSHI TAKEDA , TERUHIKO MATSUMIYA , 3 3,4 ROLAND R. ROY , and V. REGGIE EDGERTON 1Department of Physiology, Division of Human Structure and Function, and 2Department of Pharmacology, Tokyo Medical College, Tokyo, JAPAN; and 3Brain Research Institute and 4Department of Physiological Science, University of California, Los Angeles, CA ABSTRACT TAMAKI, T., T. SHIRAISHI, H. TAKEDA, T. MATSUMIYA, R. R. ROY, and V. R. EDGERTON. Nandrolone Decanoate Enhances Hypothalamic Biogenic Amines in Rats. Med. Sci. Sports Exerc., Vol. 35, No. 1, pp. 32–38, 2003. Purpose: To identify possible mechanisms for an anabolic-androgenic steroid induced increase in aggressive behavior and work capacity, the levels of some biogenic amines considered to be closely related to a systemic hyper-adrenergic state were measured in selected regions of the brain. Methods: Wistar male rats were divided randomly into five groups: nontreated (control), oil-vehicle-treated (vehicle) or one of three (therapeutic dose and 10- or 100-fold higher dose) anabolic-androgenic steroid-treated (steroid-1, -2, -3) groups. Rats in the steroid and vehicle groups were given a single dose of nandrolone decanoate or oil vehicle, respectively, one week before tissue sampling. The levels of norepinephrine (NE) and its metabolite, 4-hydroxy-3-methoxyphenylglycol (MHPG), serotonin (5-HT) and its metabolite, 5-hydroxy- indole-3-acetic acid (5-HIAA) were measured in the cerebral cortex, hypothalamus and cerebellum by high-performance liquid chromatography. Immunostaining for c-fos was performed as a confirmation of increased neural activity. Results: The levels of NE and MHPG were increased by ~2- and ~7-fold in the hypothalamus of the steroid-2 compared with the control and vehicle groups.
    [Show full text]
  • Parallel Import (PI) Licences Granted in May 2017
    Parallel import (PI) licences granted in May 2017 PL Number Grant Date Licence Holder Licensed Name(s) Active Ingredient Quantity Units Legal Status* PLPI 15184/1699 03/05/2017 LEXON (UK) LIMITED TIMOPTOL UNIT DOSE 0.25% W/V EYE DROPS SOLUTION TIMOLOL 2.5 MILLIGRAMMES PER MILLILITRE POM PLPI 15184/1700 03/05/2017 LEXON (UK) LIMITED TIMOPTOL UNIT DOSE 0.5% W/V EYE DROPS SOLUTION TIMOLOL 0.5 MILLIGRAMMES PER MILLILITRE POM PLPI 16369/1716 03/05/2017 G-PHARMA LIMITED CELIPROLOL HYDROCHLORIDE 200MG TABLETS CELIPROLOL HYDROCHLORIDE 200.000 MILLIGRAMMES POM PLPI 21828/0717 03/05/2017 LANDMARK PHARMA LIMITED LEVOCARNITINE PAEDIATRIC 30% ORAL SOLUTION LEVOCARNITINE 30.00 PERCENT WEIGHT IN VOLUME POM PLPI 33532/0768 03/05/2017 MPT PHARMA LIMITED COLESTYRAMINE SUGAR FREE 4G-SACHET COLESTYRAMINE 4.000 GRAMMES POM PLPI 33532/0768 03/05/2017 MPT PHARMA LIMITED QUESTRAN LIGHT 4G-SACHET POWDER FOR ORAL SUSPENSION COLESTYRAMINE 4.000 GRAMMES POM PLPI 33532/0778 03/05/2017 MPT PHARMA LIMITED SERETIDE 500 ACCUHALER FLUTICASONE PROPIONATE 500.00 MICROGRAMMES POM PLPI 33532/0778 03/05/2017 MPT PHARMA LIMITED SERETIDE 500 ACCUHALER SALMETEROL XINAFOATE 0.0725 MILLIGRAMMES POM PLPI 33532/0779 03/05/2017 MPT PHARMA LIMITED TRIMIPRAMINE 25MG FILM-COATED TABLETS TRIMIPRAMINE MALEATE 34.9 MILLIGRAMMES POM PLPI 39352/0376 03/05/2017 KOSEI PHARMA UK LIMITED DESMOPRESSIN ACETATE 0.1MG TABLETS DESMOPRESSIN ACETATE 0.1 MILLIGRAMMES POM PLPI 39352/0377 03/05/2017 KOSEI PHARMA UK LIMITED FLUMETASONE PIVALATE/CLIOQUINOL 0.02% W/V / 1% W/V EAR DROPS SOLUTION CLIOQUINOL
    [Show full text]
  • The Format of This Leaflet Was Determined by the Ministry of Health and Its Content Was Checked and Approved by It on July 2012
    The format of this leaflet was determined by the Ministry of Health and its content was checked and approved by it on July 2012 1. NAME OF THE MEDICINAL PRODUCT PROGYLUTON Tablets 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Calendar-pack containing 11 white tablets of 2 mg estradiol valerate each, plus 10 light brown tablets of 2 mg estradiol valerate and 0.5 mg norgestrel each. 3. PHARMACEUTICAL FORM Coated tablets. 4. CLINICAL PARTICULARS 4.1 Therapeutic indication Two phase preparation for climacteric and cycle disturbances. 4.2 Posology and method of administration Proguluton is a cyclic HRT product. One tablet is to be taken orally once a day for 21 days, followed by a 7 day tablet free interval. Therefore each new pack is started after a 28 day cycle. The white tablets should be taken from days 1 to 11 followed by the brown tablets from days 12 to 21. It is recommended that the tablets are taken at the same time every day For initiation and continuation of treatment of peri- and post-menopausal symptoms the lowest effective dose for the shortest duration (see also Section 4.4) should be used. For women still having periods, the first tablet should be taken on the 5th day of their menstrual period. If menstruation has stopped, or is infrequent or sporadic, then the first tablet can be taken any time If the patient is being transferred from a continuous HRT product, the patient may start Progyluton on any convenient day. For those transferring from a cyclic or sequential product, Progylton should be started following completion of the previous regimen If a tablet is missed, it should be taken as soon as possible, unless it is more than 12 hours late.
    [Show full text]
  • EUROPEAN PHARMACOPOEIA 10.0 Index 1. General Notices
    EUROPEAN PHARMACOPOEIA 10.0 Index 1. General notices......................................................................... 3 2.2.66. Detection and measurement of radioactivity........... 119 2.1. Apparatus ............................................................................. 15 2.2.7. Optical rotation................................................................ 26 2.1.1. Droppers ........................................................................... 15 2.2.8. Viscosity ............................................................................ 27 2.1.2. Comparative table of porosity of sintered-glass filters.. 15 2.2.9. Capillary viscometer method ......................................... 27 2.1.3. Ultraviolet ray lamps for analytical purposes............... 15 2.3. Identification...................................................................... 129 2.1.4. Sieves ................................................................................. 16 2.3.1. Identification reactions of ions and functional 2.1.5. Tubes for comparative tests ............................................ 17 groups ...................................................................................... 129 2.1.6. Gas detector tubes............................................................ 17 2.3.2. Identification of fatty oils by thin-layer 2.2. Physical and physico-chemical methods.......................... 21 chromatography...................................................................... 132 2.2.1. Clarity and degree of opalescence of
    [Show full text]
  • Download News 2/2020
    Polymere und Fluoreszenz Gleichgewicht der 360°-Trinkwasseranalyse Kräfte Trilogie Fluoreszenzspektroskopie von Basispolymeren aus der Leistung und Robustheit in Automatische, simultane Industrie Einklang mit Empfindlichkeit und schnelle Analyse von und Geschwindigkeit Pestiziden INHALT APPLIKATION »Plug und Play«-Lösung für das Krankheits-Screening – MALDI-8020 zum Screening der Sichelzellen anämie 4 Maßgeschneiderte Software- Lösungen für jede Messung – Makro-Programmierung für Shimadzu UV-Vis und FTIR 8 Auf der sicheren Seite: Steroid - nachweis in Arzneimitteln und Nahrungsergänzungsmitteln mit einem LCMS-8045 11 MSn-Analyse nicht-derivatisier- ter und Mtpp-derivatisierter Peptide – Zwei aktuelle Unter- suchungen zur Anwendung von LC-MS-IT-TOF-Geräten 18 Polymere und Fluoreszenz – Teil 2: Wieviel Fluoreszenz zeigt ein Poly mer für eine Qualitäts - kontrolle? 26 PRODUKTE Gleichgewicht der Kräfte – LCMS-8060NX: Leistung und Robustheit mit Empfindlichkeit, und Geschwindigkeit 7 360°-Trinkwasseranalyse: Episode 2 – Automatische, simul- Enrico Davoli mit dem PESI-MS-System – einem Gerät zu reinen Forschungszwecken (research-use only = RUO) tane und schnelle Analyse von Pestiziden mit Online-SPE und UHPLC-MS/MS 14 Vielseitiges Tool für die Automobil - industrie – Neue HMV-G3 Serie 17 Eine globale Lösung Kopfschmerz ade – Anleitung zur Auswahl der idealen C18-Säule 22 Validierte Methode für monoklo- nale Antikörper-Medikamente – dank globaler Bewertung der nSMOL-Methodik in menschlichem Serum 24 AKTUELLES Zusammenarbeit Eine globale Lösung
    [Show full text]
  • Queensland Health List of Approved Medicines
    Queensland Health List of Approved Medicines Drug Form Strength Restriction abacavir * For use in accord with PBS Section 100 indications * oral liquid See above 20 mg/mL See above tablet See above 300 mg See above abacavir + lamivudine * For use in accord with PBS Section 100 indications * tablet See above 600 mg + 300 mg See above abacavir + lamivudine + * For use in accord with PBS Section 100 indications * zidovudine tablet See above 300 mg + 150 mg + 300 mg See above abatacept injection 250 mg * For use in accord with PBS Section 100 indications * abciximab (a) Interventional Cardiologists for complex angioplasty (b) Interventional and Neuro-interventional Radiologists for rescue treatment of thromboembolic events that occur during neuroendovascular procedures. * Where a medicine is not TGA approved, patients should be made fully aware of the status of the medicine and appropriate consent obtained * injection See above 10 mg/5 mL See above abiraterone For use by medical oncologists as per the PBS indications for outpatient and discharge use only tablet See above 250 mg See above 500 mg See above acamprosate Drug and alcohol treatment physicians for use with a comprehensive treatment program for alcohol dependence with the goal of maintaining abstinence. enteric tablet See above 333 mg See above acarbose For non-insulin dependent diabetics with inadequate control despite diet; exercise and maximal tolerated doses of other anti-diabetic agents tablet See above 50 mg See above 100 mg See above acetazolamide injection 500 mg tablet 250 mg acetic acid ear drops 3% 15mL solution 2% 100mL green 3% 1 litre 6% 1 Litre 6% 200mL Generated on: 30-Aug-2021 Page 1 of 142 Drug Form Strength Restriction acetylcysteine injection For management of paracetamol overdose 2 g/10 mL See above 6 g/30 mL See above aciclovir cream Infectious disease physicians, haematologists and oncologists 5% See above eye ointment For use on the advice of Ophthalmologists only.
    [Show full text]