" Centaurium Erythraea (Gentianacaea)"

Total Page:16

File Type:pdf, Size:1020Kb

اﻟﺠﻤﮭﻮرﯾﺔ اﻟﺠﺰاﺋﺮﯾﺔ اﻟﺪﯾﻤﻘﺮاﻃﯿﺔ اﻟﺸﻌﺒﯿﺔ وزارة اﻟﺘﻌﻠﯿﻢ اﻟﻌﺎﻟﻲ و اﻟﺒﺤﺚ اﻟﻌﻠﻤﻲ ﺟﺎﻣﻌﺔ ﻣﻨﺘﻮري ﻗﺴﻨﻄﯿﻨﺔ ﻛـﻠﯿﺔ اﻟﻌﻠﻮم اﻟﺪﻗﯿﻘﺔ ﻗـﺴﻢ اﻟﻜـﯿﻤﯿـﺎء رﻗﻢ اﻟﺘﺮﺗﯿﺐ ......... رﻗﻢ اﻟﺘﺴﻠﺴﻞ ......... ﻣﺬﻛﺮة ﻣﻘﺪﻣﺔ ﻟﻨﯿﻞ ﺷﮭﺎدة اﻟﻤﺎﺟﺴﺘﯿﺮ ﻓﻲ اﻟﻌﻠﻮم ﺗﺨﺼﺺ ﺗﺤﺎﻟﯿﻞ ﻓﯿﺰﯾﻮﻛﯿﻤﯿﺎﺋﯿﺔ و ﻛﯿﻤﯿﺎء ﻋﻀﻮﯾﺔ ﺷﻌﺒﺔ ﻛﯿﻤﯿﺎء اﻟﻨﺒﺎت ﺗﺤﺖ ﻋﻨﻮان ﻓﺼﻞ و ﺗﺤﺪﯾﺪ ﻣﻨﺘﺠﺎت اﻷﯾﺾ اﻟﺜﺎﻧﻮي ﻟﻨﺒﺎت " Centaurium Erythraea (Gentianacaea)" !! ﺗﻘﺪﯾﻢ : ﺑﻮدرﻣﯿﻦ ﺳﮭﺎم ﺗﺤﺖ إﺷﺮاف اﻷﺳﺘﺎذ : د . اﻟﺸﺮﯾﻒ ﺑﮭﻠﻮل ﻟـﺠﻨﺔ اﻟﻤـﻨﺎﻗﺸﺔ: د. ﻓﻀﯿﻠﺔ ﺑﻦ ﻋﯿﺎش أﺳﺘﺎذة ﺑﺠﺎﻣﻌﺔ ﻣﻨﺘﻮري ﻗﺴﻨﻄﯿﻨﺔ رﺋﯿﺴﺔ !! ƒ!! !Œ !!! !!!¾ أﺳﺘﺎذ ﻣﺤﺎﺿﺮ ﺑﺠﺎﻣﻌﺔ ﻣﻨﺘﻮري ﻗﺴﻨﻄﯿﻨﺔ ﻣﺸﺮﻓﺎ د. ﺳﻤﯿﺮ ﺑﻦ ﻋﯿﺎش أﺳﺘﺎذ ﺑﺠﺎﻣﻌﺔ ﻣﻨﺘﻮري ﻗﺴﻨﻄﯿﻨﺔ ﻣﻤﺘﺤﻨﺎ د. ﻣﺤﻤﺪ ﺑﻮھﺮوم أﺳﺘﺎذ ﻣﺤﺎﺿﺮ ﺑﺠﺎﻣﻌﺔ ﻣﻨﺘﻮري ﻗﺴﻨﻄﯿﻨﺔ ﻣﻤﺘﺤﻨﺎ د. ﻋﻠﻲ ﺑﻨﺘﺎﻣﻦ أﺳﺘﺎذ ﻣﺤﺎﺿﺮ ﺑﺠﺎﻣﻌﺔ ﻣﻨﺘﻮري ﻗﺴﻨﻄﯿﻨﺔ ﻣﻤﺘﺤﻨﺎ دﯾﺴﻤﺒﺮ 2010 ♦أھﺪي ﺛﻤﺮة ﺟﮭﺪي إﻟﻰ أﻏﻠﻰ ﻣﺎ أﻣﻠﻚ واﻟﺪي اﻟﻜﺮﯾﻤﯿﻦ. ♦ إﻟﻰ إﺧﻮﺗﻲ اﻷﻋﺰاء. ♦ إﻟﻰ ﻛﻞ أﻓﺮاد اﻟﻌﺎﺋﻠﺔ. اﻟﺘﺸﻜﺮات أﺗﻮﺟﮫ ﺑﺎﻟﺸﻜﺮ اﻟﺨﺎص إﻟﻰ اﻷﺳﺘﺎذة اﻟﻐﺎﻟﯿﺔ ﻓﻀﯿﻠﺔ ﺑﻦ ﻋﯿﺎش ﻋﻠﻰ ﻛﻞ اﻟﻨﺼﺎﺋﺢ و اﻟﻤﻌﻠﻮﻣﺎت اﻟﻘﯿﻤﺔ ، و اﻟﺘﻲ ﻟﻢ ﺗﺒﺨﻞ ﺑﮭﺎ ﻋﻠﻲ و ﻟﻮ ﻋﻠﻰ ﺣﺴﺎب وﻗﺘﮭﺎ اﻟﺜﻤﯿﻦ ﻛﻤﺎ أﺷﻜﺮھﺎ ﻋﻠﻰ ﻗﺒﻮﻟﮭﺎ رﺋﺎﺳﺔ ﻟﺠﻨﺔ اﻟﻤﻨﺎﻗﺶ . أﺗﻘﺪم ﺑﺎﻟﺸﻜﺮ اﻟﺠﺰﯾﻞ وﻛﻞ اﻟﻌﺮﻓﺎن ﻟﻸﺳﺘﺎذ ﺳﻤﯿﺮ ﺑﻦ ﻋﯿﺎش ﻻﺳـﺘﻘﺒﺎﻟـﮫ ﻟﻨـﺎ ﻓﻲ ﻣﺨﺒﺮه " ﺗﺜﻤﯿﻦ اﻟﺜﺮوات اﻟﻄﺒﯿﻌﯿﺔ ذات اﻷﺻﻞ اﻟﻨﺒﺎﺗﻲ و اﺻﻄﻨﺎع اﻟﺠﺰﯾﺌﺎت اﻟﻔﻌﺎﻟﺔ ﺑﯿﻮﻟﻮﺟﯿﺎ VAREN و ﺗﻮﻓﯿﺮه ﻟـﻤﺨﺘﻠﻒ اﻟﻮﺳﺎﺋﻞ و اﻟﺘﺠﮭﯿﺰات ﻹﻧﺠﺎز ھﺬا اﻟﻌﻤﻞ و ﻛﺬا ﻋﻠﻰ اھﺘﻤﺎﻣﮫ ﺑﺈﻧﺠﺎز ھﺬا اﻟﺒﺤﺚ إﺿﺎﻓﺔ إﻟﻰ ﻗﺒﻮﻟﮫ اﻟﻤﺸﺎرﻛﺔ ﻓﻲ ﻟﺠﻨﺔ اﻟﻤﻨﺎﻗﺸﺔ أﺗﻘﺪم ﺑﺠﺰﯾﻞ اﻟﺸﻜﺮ واﻻﻣﺘﻨﺎن ﻟﻸﺳﺘﺎذ اﻟﻤﺸﺮف اﻟﺸﺮﯾﻒ ﺑﮭﻠﻮل ﻋﻠﻰ ﻧﺼﺎﺋﺤﮫ و ﺗﺪﻋﯿﻤﮫ ﻟﻲ ﺧﻼل ﻣﺮاﺣﻞ إﻧﺠﺎز ھﺬا اﻟﻌﻤﻞ . ﻛﻤﺎ أﺷﻜﺮ اﻷﺳﺘﺎذ ﺑﻮھﺮوم ﻣﺤﻤﺪ اﻟﺬي ﻛﺎن داﺋﻤﺎ اﻟﺪاﻓﻊ اﻟﻤﻌﻨﻮي ﻟﻲ و ﺑﻦ ﺛﺎﻣﻦ ﻋﻠﻲ ﻟﻘﺒﻮﻟﮭﻤﺎ اﻟﻤﺸﺎرﻛﺔ ﻓﻲ ﻟﺠﻨﺔ اﻟﻤﻨﺎﻗﺸﺔ . ﻛﻤﺎ أﺷﻜﺮ ﻛﻞ أﻓﺮاد ﻣﺨﺒﺮ VAREN ﻓﺎﻟﺒﺪاﯾﺔ اﻟﺸﻜﺮ اﻟﺨﺎﻟﺺ ﻟﻸﺳﺎﺗﺬة : ﺑﻠﻮم زھﯿﺔ، ﺑﻐﯿﺠﺔ ﻧﻮر اﻟﺪﯾﻦ ، و ﻛﻞ أﻓﺮاد دﻓﻌﺘﻲ ﻋﺒﺪ اﻟﺮﺣﻤﺎن،ﻋﻤﺮ، رﺿﻮان، ﺣﻨﺎن، ﻣﺤﻤﺪ، ﺳﻤﯿﺮة، ﻟﺒﯿﺐ، ﻣﺠﺪة، ﻓﺮﯾﺪ، ﻓﯿﺮوز، ﺳﯿﻒ، ﻟﻮﯾﺰة.اﺳﻤﺎء, ﻛﻤﺎ اﺷﻜﺮ ﻛﻞ ﻣﻦ اﻟﺴﯿﺪ ﯾﺤﯿﺎوي أﺣﻤﺪ ﻋﺒﺪ اﻟﺮﺣﯿﻢ وﻧﻮال و اﻟﺸﻜﺮ إﻟﻰ ﻛﻞ ﻣﻦ ﺳﺎﻋﺪﻧﻲ ﻣﻦ ﻗﺮﯾﺐ أو ﺑﻌﯿﺪ ﻓﻲ إﻧﺠﺎز ھﺬا اﻟﺒﺤﺚ . و أﺟﺪد ﺷﻜﺮي إﻟﻰ اﷲ رﺑﻲ و اﻟﺤﻤﺪ ﷲ رﺑﻲ اﻟﻌﺎﻟﻤﯿﻦ. اﻟﻔﮭﺮس اﻟﻤﻘﺪﻣﺔ................................................................................................................1 اﻟﻔﺼﻞ اﻷول : ﺑﻌﺾ ﻣﻨﺘﺠﺎت اﻷﯾﺾ اﻟﺜﺎﻧﻮي اﻟﻤﻮﺟﻮدة ﻓﻲ اﻟﻌﺎﺋﻠﺔ Gentianacea І-1-اﻹرﯾﺪوﯾﺪات les iridoïdes..................................................................................4 І-1- 1 ﺷﻜﻞ اﻹرﯾﺪوﯾﺪات....................................................................................4 І-1-2. ﺗﺼﻨﯿﻔﮭﺎ ...............................................................................................6 І-1-2-1 اﻹﯾﺮﯾﺪوﯾﺪات اﻟﺒﺴﯿﻄﺔ.............................................................................6 І-1-2-2اﻹﯾﺮﯾﺪوﯾﺪات اﻟﺴﻜﺮﯾﺔ.............................................................................8 8................................................................................ Séco-iridoïdes 2-3 -1-І 9....................................................................................Bis-iridoïde 2-4 -1-І І-1-3 ﻓﻌﺎﻟﯿﺘﮭﺎ اﻟﺒﯿﻮﻟﻮﺟﯿﺔ....................................................................................9 І-1- 4 اﻹﺻﻄﻨﺎع اﻟﺤﯿﻮي ﻟﻺرﯾﺪوﯾﺪات................................................................10 І-2-اﻟﻜﺴﻨﺘﻮﻧﺎت.......................................................................................................12 І-2-1 ﺗﻌﺮﯾﻔﮭﺎ...............................................................................................12 І- 2-2 اﻹﺻﻄﻨﺎع اﻟﺤﯿﻮي.................................................................................12 І- 3-2ﺑ ﻌﺾ أﺷﻜﺎل اﻟﻜﺴﻨﺘﻮﻧﺎت..........................................................................17 І- 4-2 اﻟﻔﻌﺎﻟﯿﺔ اﻟﺒﯿﻮﻟﻮﺟﯿﺔ..................................................................................18 І-3 اﻟﻔﻼﻓﻮﻧﻮﯾﺪات.....................................................................................................20 І-3-1 ﺗﻌﺮﯾﻔﮭﺎ...............................................................................................20 І- 2-3 اﻻﺻﻄﻨﺎع اﻟﺤﯿﻮي ﻟﻠﻔﻼﻓﻮﻧﯿﺪات.................................................................21 І- 3-3 أﻗﺴﺎم اﻟﻔﻼﻓﻮﻧﻮﯾﺪات...............................................................................24 І- 4-3 ﺗﻮزﯾﻌﮭﺎ ﻓﻲ اﻟﻤﻤﻠﻜﺔ اﻟﻨﺒﺎﺗﯿﺔ.......................................................................28 І- 5-3 اﻟﺨﻮاص واﻟﻔﻌﺎﻟﯿﺔ اﻟﺒﯿﻮﻟﻮﺟﯿﺔ ﻟﻠﻔﻼﻓﻮﻧﻮﯾﺪات..............................................30 І- 6-3 اﻟﺪراﺳﺔ اﻟﻜﯿﻤﯿﺎﺋﯿﺔ ﻟﻠﻔﻼﻓﻮﻧﻮﯾﺪات.....................................................................31 -6-1- اﻻﺳﺘﺨﻼص........................................................................................31 -6 -2- اﻟﻔﺼﻞ واﻟﺘﻨﻘﯿﺔ...................................................................................31 -6 -3- اﻟﺘﻌﯿﯿﻦ اﻟﺒﻨﯿﻮي ﻟﻠﻔﻼﻓﻮﻧﯿﺪات.....................................................................32 -6 -3-1 - ﺛﺎﺑﺖ اﻻﻧﺤﺒﺎس.........................................................................32 -6 2-3- -اﻟﻠﻮن اﻻﺳﺘﺸﻌﺎﻋﻲ.....................................................................32 -6 -3-2 -ﻣﻄﯿﺎﻓﯿﺔاﻻﺷﻌﺔ ﻓﻮق اﻟﺒﻨﻔﺴﺠﯿﺔ (UV)..............................................33 -6 2-3- -1- ﻃﯿﻒ اﻻﻣﺘﺼﺎص ﻓﻲ اﻟﻮﺳﻂ اﻟﻤﯿﺜﺎﻧﻮﻟﻲ……………...………… 33 -6 2-3- -2- ﻃﯿﻒ اﻻﻣﺘﺼﺎص ﻓﻲ وﺟﻮد اﻟﻜﻮاﺷﻒ..………..…….………… 34 -6 -3-2 -3- اﻹﻣﺎھﺔ اﻟﺤﻤﻀﯿﺔ…………………………..………………38 -6 2-3- -4- ﻣﻄﯿﺎﻓﯿﺔ اﻟﺮﻧﯿﻦ اﻟﻨﻮوي اﻟﻤﻐﻨﺎﻃﯿﺴﻲ.………...…………………38 اﻟﻔﺼﻞ اﻟﺜﺎﻧﻲ اﻟﺪراﺳﺔ اﻟﻔﯿﺘﻮﻛﯿﻤﯿﺎﺋﯿﺔ ﻟﻌﺎﺋﻠﺔ Gentianacea وﻧﺒﺘﺔ .Centaurium.erythreae ІI- ﻋﺎﺋﻠﺔ Gentianaceae………………..………………………….…………… 43 ІI-1- ﻣﻘﺪﻣﺔ……………………….………………………….…………… 43 IІ-2- اﻟﺘﺼﻨﯿﻒ اﻟﻜﻼﺳﯿﻜﻲ ﻟﻠﻌﺎﺋﻠﺔ........................................................................44 IІ-3- اﻟﻮﺻﻒ اﻟﻨﺒﺎﺗﻲ.......................................................................................44 ІI-4 -ﻋﺎﺋﻠﺔ Gentianaceae ﻣﻦ اﻟﻨﺎﺣﯿﺔ اﻟﻔﺮﻣﻮﻛﻮﻟﻮﺟﯿﺔ و اﻟﻔﯿﺘﻮ ﻛﯿﻤﯿﺎﺋﯿﺔ.............. .........45 IІ-4-1 اﻟﻨﺎﺣﯿﺔ اﻟﻔﺮﻣﻮﻛﻮﻟﺠﯿﺔ...................................................................45 І-4-2 I اﻟﻨﺎﺣﯿﺔ اﻟﻔﯿﺘﻮ ﻛﯿﻤﯿﺎﺋﯿﺔ........................................................ ...........46 2-1 - اﻻرﯾﺪوﯾﺪات................................................... .........................46 2-2-اﻟﻜﺴﻨﺘﻮﻧﺎت............................................................................ ..47 2-3 اﻟﻤﻨﺠﻮﻓﯿﺮﯾﻦ................................................ .............................48 2-4 اﻟﻔﻼﻓﻮﻧﻮﯾﺪات.…………………………………………… .......49 ІІ-5 ﻧﺒﺎت Centaurium erythreae................................................................ 49 ІІ-5-1 اﻟﺠﻨﺲ Centaurium................................................................ 49 ІІ-5-2 اﻟﺘﺴﻤﯿﺔ........................................................................ ...........49 ІІ-5-3 اﻟﺘﻮزﯾﻊ اﻟﺠﻐﺮاﻓﻲ...................................................................... 50 ІІ-5-4 اﻟﻮﺻﻒ اﻟﻤﻮرﻓﻮﻟﻮﺟﻲ ﻟﻠﻨﺒﺘﺔ.......................................... ................50 ІІ-5 -5اﺳﺘﻌﻤﺎﻻت ﻧﺒﺘﺔ Centaurium erythreae ......................................51 5 -1- ﻓﻲ اﻟﻄﺐ اﻟﺘﻘﻠﯿﺪي………………………..………………51 5 2- -ﻓﻲ اﻟﻄﺐ اﻟﺤﺪﯾﺚ…………………………………………51 ІІ- 6-5 اﻟﻔﻌﺎﻟﯿﺔ اﻟﺒﯿﻮﻟﻮﺟﯿﺔ ﻟﻨﺒﺘﺔ Centaurium erythreae...........................52 Centaurium erythreae 7-5-ІІ ﻣﻦ اﻟﻨﺎﺣﯿﺔ اﻟﻔﯿﺘﻮ ﻛﯿﻤﯿﺎﺋﯿﺔ.……...………52 -7-1- اﻻﻟﻜﻠﻮﯾﺪات.………………………………………………52 -2-7- اﻟﺘﺮﺑﯿﻨﺎت اﻟﺜﻼﺛﯿﺔ.……………………….…………………53 -3-7- اﻷﺣﻤﺎض اﻟﻔﯿﻨﻮﻟﯿﺔ…………………………………………54 -7-4- اﻻرﯾﺪوﯾﺪات………………………………………………55 -7-5 - اﻟﻜﺴﻨﺘﻮﻧﺎت ……………….…………………….……..…56 -7 -7- اﻟﻔﻼﻓﻮﻧﻮﯾﺪات.......................................................................58 ІІ-8- ﺑﻌﺾ اﻟﻔﻼﻓﻮﻧﻮﯾﺪات اﻟﻤﻔﺼﻮﻟﺔ ﻣﻦ ﻧﻔﺲ اﻟﺠﻨﺲ .…………………………..………58 اﻟﻔﺼﻞ اﻟﺜﺎﻟﺚ اﻟﺪراﺳﺔ اﻟﻜﯿﻤﺎﺋﯿﺔ ﻟﻨﺒﺘﺔ Centaurium erythrea وﻣﻨﺎﻗﺸﺔ اﻟﻨﺘﺎﺋﺞ ІII -1- اﻟﺪراﺳﺔ اﻟﻔﯿﺘﻮﻛﯿﻤﯿﺎﺋﯿﺔ ﻟﻨﺒﺘﺔ ''Centaurium Erythreae'........................................61 ІII -1-1 اﻻﺳﺘﺨﻼص..............………………………………… ...................61 І-1-2 II ﻃﺮﯾﻘﺔ اﻟﻔﺼﻞ واﻟﺘﻨﻘﯿﺔ…….…………………………………………64 II-1-2- І ﻓﺼﻞ و ﺗﻨﻘﯿﺔ اﻟﻜﺴﻮر……… .………………………………………67 ІІ-2- I اﻟﻨﺘﺎﺋﺞ و اﻟﻤﻨﺎﻗﺸﺔ…….............................. ………………………….............72 ІІ-2-1 I اﻟﺘﻌﯿﯿﻦ اﻟﺒﻨﯿﻮي ﻟﻠﻤﺮﻛﺐ MP04 .............................................................72 ІІI-2- 2 اﻟﺘﻌﯿﯿﻦ اﻟﺒﻨﯿﻮي ﻟﻠﻤﺮﻛﺐ MP06.............................................................79 ІІI-3- اﻟﺘﻌﯿﯿﻦ اﻟﺒﻨﯿﻮي ﻟﻠﻤﺮﻛﺐ MP13...............................................................86 اﻟﺨﺎﺗﻤﺔ………………………………………………………………………..…97 اﻟﻤﺮاﺟﻊ اﻟﻤﻘﺪﻣﺔ ﻧﺒﺬة ﻋﻦ ﺗﺎرﯾﺦ ﻋﻠﻢ اﻟﻨﺒﺎت ﻛﺎن اﻷﻗﺪﻣﻮن ﻓﻲ اﻷزﻣﻨﺔ اﻟﻐﺎﺑﺮة ﯾﺠﻤﻌﻮن اﻟﻨﺒﺎﺗﺎت اﻟﺒﺮﯾﺔ، وﯾﺼﻨﻔﻮﻧﮭﺎ، وﯾﺪرﺳﻮن ﺧﺼﺎﺋﺼﮭﺎ ﻟﻐﺮض اﻟﻤﻨﻔﻌﺔ ﻓﺤﺴﺐ، أﻣﺎ اﻟﺪراﺳﺔ اﻟﻌﻠﻤﯿﺔ اﻟﺒﺤﺘﺔ ﻓﻠﻢ ﺗﻜﻦ ﺗﺨﻄﺮ ﺑﺎﻟﺒﺎل ﻓﻲ ﺗﻠﻚ اﻟﺤﻘﺒﺔ، وﻛﺎﻧﺖ اﻟﻤﻨﻔﻌﺔ اﻟﻄﺒﯿﺔ أھﻢ اﻷﻏﺮاض اﻟﺘﻲ ﯾﺴﺘﻌﻤﻠﻮن ﻓﯿﮭﺎ اﻟﻨﺒﺎﺗﺎت. وﻓﻲ ﺑﻼد اﻹﻏﺮﯾﻖ اﻟﻘﺪﯾﻤﺔ ﺗﺄﻟﻔﺖ ﺟﻤﺎﻋﺔ ﺗﻀﻢ أﻃﺒﺎء وزراﻋﯿﯿﻦ، وﻛﺎن ﻏﺮﺿﮭﺎ ﺟﻤﻊ اﻷﺟﺰاء اﻟﻨﺒﺎﺗﯿﺔ اﻟﻤﺨﺘﻠﻔﺔ ﻣﻦ أوراق وﺟﺬور وﻏﯿﺮھﺎ ﺑﻘﺼﺪ اﺳﺘﻌﻤﺎﻟﮭﺎ ﻓﻲ ﻋﻼج ﺑﻌﺾ اﻷﻣﺮاض . وﻟﻢ ﯾﺒﺪأ اﻻھﺘﻤﺎم ﺑﺪراﺳﺔ اﻟﻨﺒﺎت ﻛﻌﻠﻢ إﻻ ﻓﻲ ﻋﮭﺪ أرﺳﻄﻮ (ﺣﻮاﻟﻲ ﺳﻨﺔ 380 ق. م.)، ﺛﻢ ﺟﺎء اﻹﺳﻜﻨﺪر اﻷﻛﺒﺮ (ﻋﺎم 356 ق. م.) ﻓﺸﺠﻊ اﻟﺪراﺳﺎت اﻟﻨﺒﺎﺗﯿﺔ، وﺧﺎﺻﺔ ﻣﺎ أﺗﺼﻞ ﻣﻨﮭﺎ ﺑﺎﻟﻨﺒﺎﺗﺎت اﻟﻄﺒﯿﺔ. أﻣﺎ أول ﺳﺠﻞ ﻣﺪون ﻣﻌﺮوف ﻓﻲ دراﺳﺔ اﻟﻨﺒﺎﺗﺎت وﺗﻘﺴﯿﻤﮭﺎ ﻓﮭﻮ ذﻟﻚ اﻟﺬي وﺿﻌﮫ ﺛﯿﻮﻓﺮاﺳﺘﻮس (اﻟﻌﺎﻟﻢ اﻹﻏﺮﯾﻘﻲ اﻟﺬي ﻋﺎش ﻓﻲ اﻟﻔﺘﺮة ﻣﻦ ﺳﻨﺔ 370 – 285 ق. م. وھﻮ أﺣﺪ ﺗﻼﻣﯿﺬ أرﺳﻄﻮ) ﺑﺎﺳﻢ "اﻟﺘﺎرﯾﺦ اﻟﻄﺒﯿﻌﻲ ﻟﻠﻨﺒﺎﺗﺎت". ﺟﺎء اﻟﻌﺎﻟﻢ اﻹﻧﺠﻠﯿﺰي دﯾﻮﺳﻜﻮرﯾﺪس (ﺳﻨﺔ 37 ﻣﯿﻼدﯾﺔ) ﻓﺄﻟﻒ ﻣﻮﺳﻮﻋﺘﮫ اﻟﻤﻌﺮوﻓﺔ "اﻟﻤﺎدة اﻟﻄﺒﯿﺔ" وﺿﻤﻨﮭﺎ وﺻﻔﺎً دﻗﯿﻘﺎً ﻟﺒﻀﻊ ﻣﺌﺎت ﻣﻦ اﻟﻨﺒﺎﺗﺎت اﻟﻄﺒﯿﺔ. وﻓﻲ اﻟﻘﺮن اﻟﺴﺎدس ﻋﺸﺮ دب اﻟﻨﺸﺎط ﻓﻲ دراﺳﺔ ﻋﻠﻢ اﻟﻨﺒﺎت ﻣﻦ ﺟﺪﯾﺪ، وأﺳﺘﻤﺮ ﺣﺘﻰ وﻗﺘﻨﺎ اﻟﺤﺎﺿﺮ. وﻓﻲ ﻣﺴﺘﮭﻞ اﻟﻘﺮن اﻟﺜﺎﻣﻦ ﻋﺸﺮ ﻇﮭﺮ اﻟﻌﺎﻟﻢ اﻟﺴﻮﯾﺪي (ﻟﯿﻨﯿﺲ –Linnaeus )اﻟﺬي ﻋﺎش ﻓﻲ اﻟﻔﺘﺮة ﻣﻦ 1707 – 1778 ﻣﯿﻼدﯾﺎً، واﻟﺬي ﯾﻌﺘﺒﺮ ﻣﻦ أﺑﺮز ﻋﻠﻤﺎء اﻟﻌﺼﺮ اﻟﺤﺪﯾﺚ، ﺣﯿﺚ أھﺘﻢ ﻟﯿﻨﯿﺲ ﻛﺜﯿﺮاً ﺑﻮﺻﻒ أﺟﺰاء اﻟﻨﺒﺎت (ﺳﺎﻗﮫ، وﺟﺬره، وأوراﻗﮫ، وأزھﺎره، وﺛﻤﺎره، وﺑﺬوره) وﻣﯿﺰ اﻻﺧﺘﻼﻓﺎت اﻟﻌﺪﯾﺪة ﻓﻲ ﺷﻜﻞ ھﺬه اﻷﻋﻀﺎء ﻓﻲ اﻟﻨﺒﺎﺗﺎت اﻟﻤﺨﺘﻠﻔﺔ، ﺛﻢ ﻗﺴﻢ اﻟﻨﺒﺎﺗﺎت ورﺗﺒﮭﺎ ﻋﻠﻲ ھﺬا اﻷﺳﺎس وأﻋﻄﻲ ﻟﻜﻞ ﻧﺒﺎت أﺳﻤﺎً ﻣﺨﺘﺼﺮاً ﺑﺴﯿﻄﺎً ]1[ . وﯾﺠﺐ اﻹﺷﺎرة ھﻨﺎ إﻟﻲ اﻹﺿﺎﻓﺎت اﻟﻘﯿﻤﺔ اﻟﺘﻲ أﺿﺎﻓﮭﺎ اﻟﻌﻠﻤﺎء اﻟﻌﺮب اﻟﻘﺪاﻣﻰ إﻟﻲ اﻟﺪراﺳﺎت اﻟﻨﺒﺎﺗﯿﺔ. وﻣﻦ أﺷﮭﺮ اﻟﻌﻠﻤﺎء اﻟﻌﺮب ﺟﺎﺑﺮ ﺑﻦ ﺣﯿﺎن
Recommended publications
  • Recovery Plan for Tyoj5llllt . I-Bland Plants
    Recovery Plan for tYOJ5llllt. i-bland Plants RECOVERY PLAN FOR MULTI-ISLAND PLANTS Published by U.S. Fish and Wildlife Service Portland, Oregon Approved: Date: / / As the Nation’s principal conservation agency, the Department of the Interior has responsibility for most ofour nationally owned public lands and natural resources. This includes fostering the wisest use ofour land and water resources, protecting our fish and wildlife, preserving the environmental and cultural values ofour national parks and historical places, and providing for the enjoyment of life through outdoor recreation. The Department assesses our energy and mineral resources and works to assure that their development is in the best interests ofall our people. The Department also has a major responsibility for American Indian reservation communities and for people who live in island Territories under U.S. administration. DISCLAIMER PAGE Recovery plans delineate reasonable actions that are believed to be required to recover and/or protect listed species. Plans are published by the U.S. Fish and Wildlife Service, sometimes prepared with the assistance ofrecovery teams, contractors, State agencies, and others. Objectives will be attained and any necessary funds made available subject to budgetary and other constraints affecting the parties involved, as well as the need to address other priorities. Costs indicated for task implementation and/or time for achievement ofrecovery are only estimates and are subject to change. Recovery plans do not necessarily represent the views nor the official positions or approval ofany individuals or agencies involved in the plan formulation, otherthan the U.S. Fish and Wildlife Service. They represent the official position ofthe U.S.
    [Show full text]
  • THE IRISH RED DATA BOOK 1 Vascular Plants
    THE IRISH RED DATA BOOK 1 Vascular Plants T.G.F.Curtis & H.N. McGough Wildlife Service Ireland DUBLIN PUBLISHED BY THE STATIONERY OFFICE 1988 ISBN 0 7076 0032 4 This version of the Red Data Book was scanned from the original book. The original book is A5-format, with 168 pages. Some changes have been made as follows: NOMENCLATURE has been updated, with the name used in the 1988 edition in brackets. Irish Names and family names have also been added. STATUS: There have been three Flora Protection Orders (1980, 1987, 1999) to date. If a species is currently protected (i.e. 1999) this is stated as PROTECTED, if it was previously protected, the year(s) of the relevant orders are given. IUCN categories have been updated as follows: EN to CR, V to EN, R to V. The original (1988) rating is given in brackets thus: “CR (EN)”. This takes account of the fact that a rare plant is not necessarily threatened. The European IUCN rating was given in the original book, here it is changed to the UK IUCN category as given in the 2005 Red Data Book listing. MAPS and APPENDIX have not been reproduced here. ACKNOWLEDGEMENTS We are most grateful to the following for their help in the preparation of the Irish Red Data Book:- Christine Leon, CMC, Kew for writing the Preface to this Red Data Book and for helpful discussions on the European aspects of rare plant conservation; Edwin Wymer, who designed the cover and who, as part of his contract duties in the Wildlife Service, organised the computer applications to the data in an efficient and thorough manner.
    [Show full text]
  • Bioactivities of Centaurium Erythraea (Gentianaceae) Decoctions: Antioxidant Activity, Enzyme Inhibition and Docking Studies
    molecules Article Bioactivities of Centaurium erythraea (Gentianaceae) Decoctions: Antioxidant Activity, Enzyme Inhibition and Docking Studies Laura Guedes 1, Pedro B. P. S. Reis 2, Miguel Machuqueiro 2 , Asma Ressaissi 1, Rita Pacheco 1,3 and Maria Luísa Serralheiro 1,4,* 1 Faculty of Sciences, BioISI—Biosystems & Integrative Sciences Institute, University of Lisbon, 1649-004 Lisboa, Portugal; [email protected] (L.G.); [email protected] (A.R.); [email protected] (R.P.) 2 Faculty of Sciences, CQB—Centre of Chemistry and Biochemistry, University of Lisbon, 1649-004 Lisboa, Portugal; [email protected] (P.B.P.S.R.); [email protected] (M.M.) 3 Área Departamental de Engenharia Química, Instituto Superior de Engenharia de Lisboa, Av. Conselheiro Emídio Navarro, 1959-007 Lisboa, Portugal 4 Faculty of Sciences, Departamento de Química e Bioquímica, University of Lisbon, Campo Grande, 1749-016 Lisboa, Portugal * Correspondence: [email protected]; Tel.: +351-21-7500935 Received: 17 September 2019; Accepted: 21 October 2019; Published: 22 October 2019 Abstract: Centaurium erythraea is recommended for the treatment of gastrointestinal disorders and to reduce hypercholesterolemia in ethno-medicinal practice. To perform a top-down study that could give some insight into the molecular basis of these bioactivities, decoctions from C. erythraea leaves were prepared and the compounds were identified by liquid chromatography-high resolution tandem mass spectrometry (LC–MS/MS). Secoiridoids glycosides, like gentiopicroside and sweroside, and several xanthones, such as di-hydroxy-dimethoxyxanthone, were identified. Following some of the bioactivities previously ascribed to C. erythraea, we have studied its antioxidant capacity and the ability to inhibit acetylcholinesterase (AChE) and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR).
    [Show full text]
  • Studies on Variation and Evolution in Centaurium Erythraea Rafn and C
    Watsonia, 11, 7-31 (l976). 7 Studies on variation and evolution in Centaurium erythraea Rafn and C. littorale (D. Turner) Gilmour in the British Isles 1. Taxonomy and biometrical studies R. A. E. UBSDELL Department of Botany , University of Reading * ABSTRACT Analysis of populations of Centaurium erythraea Rafn subsp. erythraea and C. Iittorale (D. Turner) Gilmour subsp. Iittorale has shown that both show a wide range of morphological variation. Much of this variation is retained in cultivation and five varieties are recognized of subsp. erythraea and four of subsp. Iittorale. Despite this variation the two subspecies are quite distinct. Analysis of mixed populations of the two species from the coasts of Anglesey and Lancashire has shown tbat some plants are, to varying degrees, intermediate and probably of hybrid origin. In the majority of populations from the Lancashire coast, backcrossing to C. [ittorale appears to have taken place, although two suggest backcrossing to C. erythraea. This is in contrast to the situation in the population from Anglesey in which only F.-like hybrids were present. Analysis of two populations from northern Germany show all plants to be intermediate and F.-like. INTRODUCTION The genus Centaurium Hill (Erythraea Borkh. nom. iIlegit.) of the Gentianaceae is widespread in Europe, especially around the Mediterranean. Taxonomic investigations of the genus have pre­ sented great difficulties since the species are extremely variable. _Parallel variation in several characters is common in the groups of related species, and there have also been reports of natural hybrids. Species and infra-specific taxa are, therefore, often difficult to define and the literature is full of nomenclatural confusion.
    [Show full text]
  • Chemotaxonomy and Pharmacology of Gentianaceae
    Downloaded from orbit.dtu.dk on: Oct 01, 2021 Chemotaxonomy and pharmacology of Gentianaceae. Jensen, Søren Rosendal; Schripsema, Jan Published in: Gentianaceae - Systematics and Natural History Publication date: 2002 Document Version Publisher's PDF, also known as Version of record Link back to DTU Orbit Citation (APA): Jensen, S. R., & Schripsema, J. (2002). Chemotaxonomy and pharmacology of Gentianaceae. In L. Struwe, & V. Albert (Eds.), Gentianaceae - Systematics and Natural History (Vol. Chapter 6, pp. 573-631). Cambridge University Press. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Users may download and print one copy of any publication from the public portal for the purpose of private study or research. You may not further distribute the material or use it for any profit-making activity or commercial gain You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. 6 Chemotaxonomy and pharmacology of Gentianaceae S. R. JENSEN AND J. SCHRIPSEMA ABSTRACT The occurrence of taxonomically informative types of compounds in the family Gentianaceae, namely iridoids, xanthones, mangiferin, and C- glucoflavones, has been recorded. The properties, biosynthesis, and distribution of each group of compounds are described. The iridoids (mainly secoiridoid glucosides) appear to be present in all species investigated, with a predominance of swertiamarin and/or gentiopicroside; c.
    [Show full text]
  • Plant Check List
    1 Vascular Plants of MacKerricher State Park A Latin Binomial Common Name Glass Bch. only FERNS Athyriaceae Athyrium filix-femina var. cyclosorum lady fern Azollaceae Azolla filiculoides mosquito fern Blechnaceae Struthiopteris spicant deer fern Woodwardia fimbriata giant chain fern Cystopteridaceae Cystopteris fragilis fragile fern Dennstaedtiaceae Pteridium aquilinum var. pubescens bracken Dryopteridaceae Drypoteris arguta wood fern Polystichum munitum western sword fern Equisetaceae Equisetum arvense field horsetail Equisetum hyemale ssp. affine common scouring-rush Equisetum laevigatum smooth scouring-rush Equisetum telmateia ssp. braunii giant horsetail Ophioglossaceae Sceptridium multifidum moonwort; grape fern Polypodiaceae Polypodium californicum California polypody Polypdium calirhiza polypody fern Polypodium scouleri Pteridaceae Pentagramma triangularis goldback fern GYMNOSPERMS Cupressaceae Hesperocyparis macrocarpa* Monterey cypress Sequoia sempervirens coast redwood Pinaceae Abies grandis grand fir Pinus contorta ssp. contorta shore pine; beach pine Pinus muricata Bishop pine Pinus radiata* Monterey pine Pseudotsuga menziesii Douglas-fir NYMPHAEALES Nymphaeaceae Nuphar polysepala yellow pond-lily EUDICOTS Adoxaceae Sambucus racemosa var. racemosa red elderberry Aizoaceae Carpobrotus chilensis* sea fig; iceplant Carpobrotus edulis* Hottentot-fig; iceplant Lampranthus spectabilis* redflush iceplant Tetragonia tetragonioides* New Zealand spinach Anacardiaceae Toxicodendrom diversilobum poison-oak Apiaceae Angelica hendersonii
    [Show full text]
  • Gentiana Lutea Linn. (Yellow Gentian): a Comprehensive Review
    Journal of Ayurvedic and Herbal Medicine 2017; 3(3): 175-181 Review Article Gentiana lutea Linn. (Yellow Gentian): A comprehensive ISSN: 2454-5023 review J. Ayu. Herb. Med. 2017; 3(3): 175-181 Om Prakash1, Ruchi Singh1, Saroj Kumar1, Shweta Srivastava1, Akash Ved1 © 2017, All rights reserved 1 Goel Institute of Pharmacy and Sciences, Faizabad Road, Lucknow, Uttar Pradesh - 226016, India www.ayurvedjournal.com Received: 18-07-2017 Accepted: 04-09-2017 ABSTRACT Gentiana lutea Lin. commonly known as yellow gentian, bitter root and bitterwort belonging to family Gentianaceae is a common traditional medicine freely available in hilly areas in Japan, Europe and adjoining continents, its medicinal properties are also mentioned in Ayurveda. The plant is reported to posse’s antioxidant, antifungal, anti-inflammatory, stomachic, appetizer and immunomodulatory properties etc.Gentiana lutea is an important source of bitter phytoconstituents such as amarogentin, gentiopicrinor gentiopicroside, gentiolutelin and its dimethyl acetal, gentioluteol, gentanine, amaroswerin, gentioside including a new iridoid named gentiolutelin. Traditionally the plant is used as stomachic tonic, bitter tonic, dyspepsia, gastric inefficiency in infants, digestive tonic, catarrhal diarrhoea, anaemia, malarial disease etc. The present review is an effort to generate an interest among the mosses regarding its immense potential in preventing and treating several diseases. Keywords:Gentiana lutea Lin., Yellow Gentian, Bitter Root, Gentianaceae, Phytochemistry, Pharmacological activities. INTRODUCTION Gentiana lutea belonging to Gentianaceae family which comprises more than 400 species spread in the mountain areas of central and Southern Europe, Americas, Australia and New Zealand, Alps, Jura, Massif [1, 2] Central, Pyrenees as well asadjoining continent up to the altitude of 2500 m .
    [Show full text]
  • Determination of Amino Acids of Some Plants from Gentianaceae Family
    Pharmacia 68(2): 441–448 DOI 10.3897/pharmacia.68.e67052 Research Article Determination of amino acids of some plants from Gentianaceae family Liliia Budniak1, Liudmyla Slobodianiuk1, Svitlana Marchyshyn1, Olha Demydiak1, Iryna Dakhym1 1 I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine Corresponding author: Liliia Budniak ([email protected]) Received 7 April 2021 ♦ Accepted 21 April 2021 ♦ Published 20 May 2021 Citation: Budniak L, Slobodianiuk L, Marchyshyn S, Demydiak O, Dakhym I (2021) Determination of amino acids of some plants from Gentianaceae family. Pharmacia 68(2): 441–448. https://doi.org/10.3897/pharmacia.68.e67052 Abstract Medicines from plants are widely used in the complex treatment of different diseases every day. Therefore, theoretical and practical interest is the in-depth study of the herb of perspective plants like Centaurium erythraea Rafn. and Gentiana cruciata L. These plants have a long history of usage and interest of people. The aim of the study was to determine the content of amino acids in these plants. The amino acids composition and content in the herb of study species of the familyGentianaceae determined by the HPLC method. The results of the research revealed that the raw material of Centaurium erythraea Rafn. and Gentiana cruciata L. contains free and bound amino acids. Sixteen free and seventeen bound amino acids were identified in the herb of Centaurium erythraea Rafn. The herb of Gentiana cruciata L. contained thirteen free and fifteen bound amino acids. L-glutamic acid, L-arginine, L-aspartic acid, and L-cystine were predominant of Centaurium erythraea Rafn. herb. Amino acids L-lysine, L-serine, L-aspartic acid, and L-phenylal- anine were present in the herb of Gentiana cruciata L.
    [Show full text]
  • Flora and Vegetation
    FLORA AND VEGETATION OF BARRAMBIE SURVEY AREA, BORE FIELDS AND WATER PIPELINE CORRIDOR Prepared for: Aquaterra and Reed Resources Ltd Prepared by: Mattiske Consulting Pty Ltd October 2009 MATTISKE CONSULTING PTY LTD RRL0902/093/09 MATTISKE CONSULTING PTY LTD TABLE OF CONTENTS Page 1. SUMMARY ................................................................................................................................................ 1 2. INTRODUCTION ...................................................................................................................................... 2 2.1 Location ................................................................................................................................................. 2 2.2 Flora and Vegetation ............................................................................................................................. 2 2.3 Groundwater Dependant Ecosystems .................................................................................................... 2 2.4 Climate .................................................................................................................................................. 4 2.5 Clearing of Native Vegetation ............................................................................................................... 4 2.6 Rare and Priority Flora ......................................................................................................................... 4 2.7 Threatened Ecological Communities ....................................................................................................
    [Show full text]
  • Swertia Chirayita: a Review to Revitalize Its Importance in Pharmaceutical Arena Vikas Sharma1*, Nidhi Srivastava1, Barkha Kamal1, A.K
    Vikas Sharma et al. / Journal of Pharmacy Research 2011,4(6),1784-1787 Review Article Available online through ISSN: 0974-6943 http://jprsolutions.info Swertia chirayita: A review to revitalize its importance in Pharmaceutical Arena Vikas Sharma1*, Nidhi Srivastava1, Barkha Kamal1, A.K. Dobriyal2 & Vikash S. Jadon1 1Plant Molecular Biology Lab., Department of Biotechnology, Sardar Bhagwan Singh (P.G.) Institute of Biomedical Sciences & Research Balawala, Dehradun-248161, Uttarakhand, India 2Department of Zoology & Biotechnology, H.N.B.Garhwal Central University, Campus Pauri, Pauri Garhwal-246001, Uttarakhand, India Received on: 11-02-2011; Revised on: 16-03-2011; Accepted on:21-04-2011 ABSTRACT The present review is the pragmatic approach to ensue important aspect of very important medicinal herb Swertia chirayita, as this genitan species is renowned for its medicinal benefits in different traditional systems of medicines like Ayurvedic, Unani and Sidha. A lot of important attribute have been assigned to this species. This review has been done on various aspects from its botany, conservation, phytochemical contents and pharmaceutical applications. Key words: Swertia, conservation, chemical constituents, medicinal activity, amarogentin INTRODUCTION India - a country of immense biotic wealth - has more than 7000 plant species comprises ca 150 species and is annual, biennial or perennial herb ranging reportedly used for medicinal purposes most of which are being exploited from 2-4 cm. to over 1.5 m in height with 4-5 merous flowers, 1 or 2 nectaries recklessly for the extraction of drugs. The age old traditional values attached at the base of characteristically rotate corolla lobes. The genus mostly occurs with the various forest types and the varieties of forest products (i.e., medicinal in alpine or temperate habitats in Asia, Africa and N.
    [Show full text]
  • Medicinal, Biological and Phytochemical Properties of Gentiana Species
    31/08/2021 Medicinal, biological and phytochemical properties of Gentiana species J Tradit Complement Med. 2017 Oct; 7(4): 400–408. PMCID: PMC5634738 Published online 2017 Jan 28. PMID: 29034186 doi: 10.1016/j.jtcme.2016.12.013: 10.1016/j.jtcme.2016.12.013 Medicinal, biological and phytochemical properties of Gentiana species Fatemeh Mirzaee,a Amirsaeed Hosseini,b Hossein Bakhshi Jouybari,a Ali Davoodi,a and Mohammad Azadbakhta,∗ aDepartment of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran bTraditional and Complementary Medicine Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Mohammad Azadbakht: [email protected] ∗Corresponding author. [email protected] Received 2016 Oct 19; Revised 2016 Dec 18; Accepted 2016 Dec 30. Copyright © 2017 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Abstract Gentiana, a cosmopolitan and important genus of the Gentianaceae family, comprises 400 species distributed among the world. Based on the studies of Iranian traditional medicine texts, there are some promising bioactivities for this genus that is unknown in modern medicine and some of them are still the basis of new remedies. In traditional medicine texts, Gentiana's different exclusive forms of preparations are effective for treatment of some disorders such as menstrual over-bleeding, conjunctivitis, vitiligo, animals venom poisoning, injuries, infected wounds, pain and swelling of liver, spleen, stomach and sprains of muscles. There are some activities that are the same in traditional and modern medicine such as anti-inflammatory, hepatoprotective and diuretic effects.
    [Show full text]
  • Species Status Assessment Report for Bradshaw's Lomatium (Lomatium
    Species Status Assessment Report for Bradshaw’s lomatium (Lomatium bradshawii (Rose ex. Math.) Mathias & Constance) Version 1.0 (Photo by Jeff Dillon, U.S. Fish and Wildlife Service) January 2018 Pacific Region (Region 1) U.S. Fish and Wildlife Service Portland, Oregon Species Status Assessment Report for Bradshaw’s lomatium ● Version 1.0 This document was prepared by Tom Brumbelow. Kim Garner and Paul LaFemina contributed to earlier versions of this report. Additionally we would like to thank Ed Alverson (Lane County Parks), Wes Messinger (Army Corps of Engineers), and Kathy Pendergrass (Natural Resources Conservation Service) for providing peer review of a prior draft of this report. Throughout this document, words that appear in bold type are defined in the Glossary. Suggested reference: U.S. Fish and Wildlife Service. 2018. Species status assessment report for Bradshaw’s lomatium (Lomatium bradshawii). Version 1.0. Oregon Fish and Wildlife Office, Portland, Oregon. 64 pp. i Species Status Assessment Report for Bradshaw’s lomatium ● Version 1.0 EXECUTIVE SUMMARY This Species Status Assessment Report is a comprehensive review of the biology and status of Bradshaw’s lomatium (Lomatium bradshawii), a perennial herb that was listed as endangered under the Endangered Species Act of 1973, as amended (Act), in 1988 (53 Federal Register 38448-38451). The purpose of this report is to evaluate the viability of Bradshaw’s lomatium as indicated by measures of population resiliency, redundancy, and representation. This report was prepared for the purposes of conducting a 5-year review of the status of the species, as required by section 4(c)(2)(A) of the Act.
    [Show full text]