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Condensed Table of Contents 1 Introduction G.O.H. NAUMANN, FRIEDRICH E. KRUSE 1 2 General Ophthalmic Pathology: Principal Indications and Complications, Comparing Intra- and Extraocular Surgery G.O.H. NAUMANN, F.E. KRUSE 7 3 Special Anatomy and Pathology in Surgery of the Eyelids, Lacrimal System, Orbit and Conjunctiva L.M. HOLBACH 29 3.1 Eyelids L.M. HEINDL, L.M. HOLBACH 30 3.2 Lacrimal Drainage System L.M. HEINDL, A. JÜNEMANN, L.M. HOLBACH 45 3.3 Orbit L.M. HOLBACH, L.M. HEINDL, R.F. GUTHOFF 49 3.4 Conjunctiva and Limbus Corneae C. CURSIEFEN, F.E. KRUSE, G.O.H. NAUMANN 67 4 General Pathology for Intraocular Microsurgery: Direct Wounds and Indirect Distant Effects G.O.H. NAUMANN, F.E. KRUSE 76 5 Special Anatomy and Pathology in Intraocular Microsurgery 5.1 Cornea and Limbus C. CURSIEFEN, F.E. KRUSE, G.O.H. NAUMANN 97 5.2 Glaucoma Surgery A. JÜNEMANN, G.O.H. NAUMANN 131 5.3 Iris G.O.H. NAUMANN 152 5.4 CiüaryBody G.O.H. NAUMANN 176 5.5 Lens and Zonular Fibers U. SCHLÖTZER-SCHREHARDT, G.O.H. NAUMANN 217 Bibliografische Informationen digitalisiert durch http://d-nb.info/973635800 gescannt durch XII Condensed Table of Contents 5.6 Retina and Vitreous A.M. JOUSSEN and G.O.H. NAUMMAN with Contributions by S.E. COUPLAND, E.R. TAMM, B. KIRCHHOF, N. BORNFELD 255 5.7 Optic Nerve and Elschnig's Scleral Ring C.Y. MARDIN, G.O.H. NAUMANN 335 6 Influence of Common Generalized Diseases on Intraocular Microsurgery G.O.H. NAUMANN, U. SCHLÖTZER-SCHREHARDT 350 6.1 Diabetes Mellitus G.O.H. NAUMANN 351 6.2 Arterial Hypertension and "Vis A Tergo" G.O.H. NAUMANN 353 6.3 Pseudoexfoliation Syndrome: Pathological Manifestations of Relevance to Intraocular Surgery U. SCHLÖTZER-SCHREHARDT, G.O.H. NAUMANN 354 6.4 Other Generalized Diseases G.O.H. NAUMANN 378 6.4.1 Infectious Disorders (AIDS, Sepsis) 378 6.4.2 Hematologic Disorders 378 6.5.3 Neurologic and Muscular Diseases 378 General References 379 List of Figures 381 List of Tables 387 Subject Index 391 Contents 1 Introduction G.O.H. NAUMANN, F.E. KRUSE 1 1.1 Ophthalmic Pathology in Clinical Practice, Teaching and Research 1 1.1.1 Confirmation and Quality Control of Clinical Diagnoses 1 1.1.2 Modern Ophthalmomicrosurgery is Applied Ophthalmopathology 1 1.1.3 Ophthalmic Pathology is the Science of the Phenotype 1 1.1.4 Ophthalmic Pathology also Connects Experimental and Clinical Ophthalmology 2 1.2 Historical Sketch of Ophthalmic Surgery from Antiquity to Modern Times 2 1.3 Overview of Advances in Ophthalmic Pathology in the Nineteenth and Twentieth Centuries 4 References 6 2 General Ophthalmic Pathology: Principal Indications and Complications, Comparing Intra- and Extraocular Surgery G.O.H. NAUMANN, F.E. KRUSE 7 2.1 Principal Indications: Clinico-pathologic Correlation 7 2.1.1 Defects 7 2.1.2 Excess of Tissue 8 2.1.3 Altered Tissue In Situ 8 2.1.4 Displaced Tissue 8 2.1.5 Neovascularization and Sears 9 2.2 Intraocular Compared with Extraocular Surgery: Distinguishing Features and Potential Complications 11 2.2.1 Anterior Movement of the Iris-Lens Diaphragm ("Vis a Tergo") 13 2.2.2 Paracentesis Effect 14 2.2.3 Expulsive Choroidal Hemorrhage and Uveal Effusion 17 2.2.4 Pupillary and Ciliary Block 17 2.2.5 Purulent Endophthalmitis 18 2.2.6 Sympathetic Uveitis 19 2.2.7 Diffuse and Cystic Epithelial Ingrowth 19 2.2.8 Hemorrhage from Vasoproliferative Processes 21 2.2.9 "Toxic Anterior Segment Syndrome" (TASS) 22 2.2.10 "Intraoperative Floppy Iris Syndrome" (IFIS) 22 2.3 Choice of Anesthesia and Knowledge of Ophthalmic Pathology 24 2.4 Instrumentation and Physical Principles 26 References 27 XIV Contents 3 Special Anatomy and Pathology in Surgery of the Eyelids, Lacrimal System, Orbit and Conjunctiva L.M. HOLBACH 29 3.1 Eyelids L.M. HEINDL, L.M. HOLBACH 30 3.1.1 Surgical Anatomy 30 3.1.1.1 Arterial Supply 32 3.1.1.2 Venous Drainage 32 3.1.1.3 Lymphatic Drainage 32 3.1.1.4 Motor Nerve Supply 32 3.1.1.5 Sensory Nerve Supply 32 3.1.2 Surgical Pathology 33 3.1.2.1 Disorders of Eyelid: Position and Movement 33 3.1.2.1.1 Surgical Pathology and Anatomie Principles of Ectropion Repair 34 3.1.2.1.2 Surgical Pathology and Anatomie Principles of Entropion and Distichiasis Repair 37 3.1.2.1.3 Surgical Pathology and Anatomie Principles of Blepharoptosis Repair 39 3.1.2.2 Eyelid Tumors 40 References 44 3.2 Lacrimal Drainage System L.M. HEINDL, A. JÜNEMANN, L.M. HOLBACH 45 3.2.1 Surgical Anatomy 45 3.2.2 Surgical Pathology 46 3.2.3 Principles of Lacrimal Surgery 47 3.2.3.1 External Dacryocystorhinostomy (with or without Silicone Tube Intubation) 47 3.2.3.2 External Canaliculo-Dacryocystorhinostomy 47 3.2.3.3 External Dacryocystorhinostomy with Bypass Tube Insertion 48 References 48 3.3 Orbit L.M. HOLBACH, L.M. HEINDL, R.F. GUTHOFF 49 3.3.1 Surgical Anatomy 49 3.3.2 Surgical Pathology 50 3.3.2.1 Orbital Tumors 50 3.3.2.2 Thyroid-Associated Orbitopathy - Endocrine Orbitopathy/ Ophthalmopathy - Graves' Ophthalmopathy 62 3.3.3 Principles of Orbital Surgery 64 3.3.3.1 Surgical Approaches to the Orbit in Orbital Tumor Surgery 64 3.3.3.1.1 Anterior Orbitotomy 64 3.3.3.1.2 Lateral Orbitotomy 65 3.3.3.2 Surgical Management in Thyroid Eye Disease 65 3.3.3.2.1 Orbital Decompression 65 3.3.3.2.2 Extraocular Muscle Surgery 65 3.3.3.2.3 Eyelid Surgery to Prevent Lagophthalmus 65 3.3.3.3 Surgical Approaches in Anophthalmic Socket Surgery 65 3.3.3.3.1 Enucleation with Orbital Implants 65 3.3.3.3.2 Evisceration 66 3.3.3.33 Exenteration 66 References 66 Contents XV 3.4 Conjunctiva and Limbus Corneae C. CURSIEFEN, F.E. KRUSE, G.O.H. NAUMANN 67 3.4.1 Introduction 67 3.4.2 Surgical Anatomy, Landmarks, Nerve Supply, and Vascular Supply with Blood Vessels and Lymphatics, Induding Regional Lymph Nodes and Aqueous Episcleral Veins 67 3.4.2.1 Limbal Stern Cells, Vogt's Palisades, Cornea Verticillata, Tear Film 69 3.4.2.2 Langerhans Cells in the Limbal and Corneal Epithelium 69 3.4.2.3 Bowman's Layer as Mechanical Barrier 69 3.4.2.4 Keratocyte Distribution, Reaction to Trauma 69 3.4.2.5 Nerve Supply of Superficial Cornea 69 3.4.2.6 Anatomie Landmarks for Surgical Limbus: Edge of Bowman's Layer, Schlemm's Canal, Scleral Spur 69 3.4.3 Surgical Pathology 69 3.4.3.1 Hereditary Anomalies of the Conjunctiva: Conjunctival Lymphangioma 70 3.4.3.2 Conjunctival Inflammations 70 3.4.3.3 Sarcoidosis and Conjunctival Involvement in Systemic Disease 71 3.4.3.4 Pterygium 72 3.4.3.5 Conjunctival Cysts 72 3.4.3.6 Conjunctival Tumors 72 3.4.3.6.1 Melanocytic Lesions 72 3.4.3.6.2 Acquired Epithelial Melanosis 72 3.4.3.7 Amniotic Membrane Transplantation 73 3.4.3.8 Limbal Stern Cell Transplantation 73 3.4.3.9 Dry Eye 73 3.4.3.10 Superior Limbal Keratitis (Theodore) 74 3.4.3.11 Ligneous Conjunctivitis (Conjunctivitis Lignosa) 74 3.4.4 Indications for Smear Cytology, Incisional or Excisional Biopsies, Autologous or Homologous Transplantation, Radiation, and Local and Systemic Chemotherapy 74 3.4.4.1 Conjunctival Oncology: Melanocytic Processes 75 3.4.4.2 Limbus Stern Cell Insufficiency 75 3.4.4.3 Amnion Transplantation 75 3.4.5 Wound Healing: Influence of Basic Disease and Adjunct Therapy (Radiation, Chemotherapy) 75 References 75 4 General Pathology for Intraocular Microsurgery: Direct Wounds and Indirect Distant Effects G.O.H. NAUMANN, F.E. KRUSE 76 4.1. Access into the Eye: Principal Options and Anterior Segment Trauma 76 .1 Direct Incisions and Wounds 76 .1.1 Transcorneal Access 76 . 1.2 Access via Corneal "Limbus," Fornix and Limbus Based Conjunctival Flaps 86 .1.3 Pars Plana Transscleral Approaches 90 .2 Indirect Distant Effects 90 4.2 Obvious and Potential Compartments of the Intraocular Space 90 4.3 Variants of Intraocular Microsurgery 90 4.3.1 Wide Open Sky Approach 90 4.3.2 Minimally Invasive Intraocular Microsurgery 91 4.3.3 Intraocular Surgery Without Opening of the Eye Wall 91 XVI Contents 4.4 Microsurgical Manipulations in the Anterior Chamber: Critical Structures and Vulnerable Cell Populations 92 4.4.1 Free Access to Trabecular Meshwork in Open Angle and Free Flow in the Pupillary Zone and Between the Pars Plicata and Lens Equator.. 92 4.4.2 Corneal Endothelium 92 4.4.3 Iris Microanatomy 93 4.4.4 Lens Capsule and Anterior Zonular Insertion 93 4.5 Surgical Manipulation in the Vitreous Cavity: Critical Structures and Vulnerable Cell Populations 93 4.5.1 Vitreous Attachments 93 4.5.2 Sensory Retina, Retinal Pigment Epithelium and Optic Nerve Head 93 4.5.3 Posterior Lens Capsule and Posterior Zonula Insertion 94 4.5.4 Choroidal Hemorrhage 94 4.6 RoleoftheSizeoftheEye 94 4.7 Wound Healing After Intraocular Microsurgery and Trauma 94 4.7.1 "Surgically Induced Necrotizing Scleritis" (SINS) 96 4.7.2 Concept of a "Minimal Eye" 96 References 96 5 Special Anatomy and Pathology in Intraocular Microsurgery 5.1 Cornea and Limbus C. CURSIEFEN, F.E. KRUSE, G.O.H. NAUMANN 97 5.1.1 Surgical Anatomy of the Cornea and Limbus 97 5.1.1.1 Corneal Epithelium 97 5.1.1.2 Bowman's Layer 98 5.1.1.3 Corneal Stroma 100 5.1.1.4 Descemet's Membrane 100 5.1.1.5 Endothelial Cells 101 5.1.1.6 Limbal Vascular Arcade 101 5.1.1.7 Tear Film 102 5.1.1.8 Anterior Chamber Associated Immune Deviation (ACAID), Corneal Immune Privilege, Corneal Antiangiogenic Privilege 105 5.1.1.9 Limbal Epithelial and Corneal Stromal Stern Cells U.