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Us 2012/0074.014 A1 2 .. 1 US 2012O074O14A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0074.014 A1 Tran et al. (43) Pub. Date: Mar. 29, 2012 (54) PRODUCT TYPICALLY BASED ON SALT OF Publication Classification PEROXYMONOSULFURIC ACID AND (51) Int. Cl SUITABLE FOR MEDICINAL USAGE, AND iBio/02 (2006.01) ASSOCATED PRODUCT FABRICATION B23P 19/00 (2006.01) A633/42 (2006.01) (75) Inventors: David Van Tran, San Jose, CA A6IR 9/14 (2006.01) (US); David Nguyen Tran, San CD7C 409/244 (2006.01) Jose, CA (US) A6II 3/327 (2006.01) s (52) U.S. Cl. ............. 206/438: 562/1; 514/578; 424/605; 424/400; 29/428 (73) Assignee: LuTran Industries, Inc. (57) ABSTRACT 21) Appl. No.: 13AO47,742 Products based on salt of peroxyperoxVmonosulfuric acid are suit (21) Appl. No 9 able for treating or/and preventing diseases and other debili tating medical conditions caused by bacterial, eukaryotic, (22) Filed: Mar. 14, 2011 prion, and viral pathogens and by non-pathogenic inflamma tion. The products may alternatively be based on inorganic Related U.S. Application Data halide and an oxidizing agent reactable in water with the inorganic halide to generate hypohalite ions. In addition, the (60) Provisional application No. 61/386,928, filed on Sep. products can be employed in other applications such as com 27, 2010. mercial and industrial applications. 5T. 2 .. 2. 1.4. J., Patent Application Publication Mar. 29, 2012 Sheet 1 of 2 US 2012/0074014 A1 cro Q-D 22 Fig. 2a Fig.2b Patent Application Publication Mar. 29, 2012 Sheet 2 of 2 US 2012/0074014 A1 90 92 US 2012/0074014 A1 Mar. 29, 2012 PRODUCT TYPCALLY BASED ON SALT OF the antibiotic. The adverse side effects of antibiotics are var PEROXYMONOSULFURIC ACID AND ied, and range from fever and nausea to major allergic reac SUITABLE FOR MEDICINAL USAGE, AND tions. ASSOCATED PRODUCT FABRICATION 0007 Fungi are eukaryotic pathogens similar to bacteria. Spores are metabolic byproducts of the life cycle of some CROSS-REFERENCE TO RELATED bacteria and fungi. Bacteria produce endospores located APPLICATION within the cytoplasm of the parental cells. Fungi produce a 0001. This claims priority to U.S. provisional patent appli variety of exospores. Spores are highly resistant to physical cation 61/386,928, filed 27 Sep. 2010, the contents of which and chemical agents. are incorporated by reference to the extent not repeated 0008. In medical parasitology, the term “parasite' means a herein. This is also related to U.S. patent application Ser. No. eukaryotic pathogenic organism. Hence, protozoan and meta 12/726,326, filed 17 Mar. 2009, the contents of which are Zoan infectious agents are classified as parasites whereas likewise incorporated by reference to the extent not repeated bacteria and viruses are not. Many parasites, such as proto herein. Zoa, fleas, and worms (helminths), carry disease or cause Sores or lesions which can become infected. FIELD OF USE 0009 Parasites live on or in the host from which it gets Some or all of its nourishment. Parasites are generally harmful 0002 This relates to products suitable for treating and to their hosts. The damage ranges widely from minor incon preventing debilitating conditions, including debilitating Venience to debilitating or fatal disease. An ectoparasite, Such medical conditions of humans. This also relates to manufac as a louse, tick, or leech, lives or feeds on the outer Surface of turing Such products. the host's body. Ectoparasites do not usually cause disease themselves. However, they are frequently a vector of disease. BACKGROUND OF THE INVENTION For example, tick parasites transmit organisms that can cause 0003 Inflammation is caused by tissue injury consisting disease. An endoparasite lives inside the body of its host. of complex reactions involving vascular and connective tis Endoparasites include organisms such as tapeworms, hook Sues. Tissue damage may result from microbial invasion, worms, and trypanosomes that live within the host's organs or auto-immune processes, tissue infection, allograft rejection, tissues as well as organisms such as sporozoans that invade and such hurtful and/or destructive external influences as the host's cells. heat, cold, radiant energy, electrical or chemical stimuli, and 0010 Aprion is an infectious agent generally made solely mechanical trauma. Tissue damage may involve any part of of protein and lacking nucleic acid. Prions are believed to the human body such as the joints (arthritis), bowels (inflam infect and propagate by refolding abnormally into a structure matory bowel disease), and lungs (pulmonary inflammation). which converts normal molecules of the protein into an abnor Whatever the cause or bodily site, inflammatory responses to mally structured form. Prions are generally quite resistant to tissue damage are quite similar, consisting of complicated denaturation by protease, heat, radiation, and formalin treat functional and cellular adjustments involving microcircula ments, although potency or infectivity may be reduced. tion, fluid shifts, and inflammatory cells (leukocytes). When 0011 A virus consists of a single nucleic acid, either deox tissue damage occurs, soluble chemical Substances are elabo yribonucleic acid (“DNA) or ribonucleic acid (“RNA”), and rated which initiate the inflammatory response. Inflammation a protein shell or coat Surrounding the nucleic acid. A com can be mild and self-limited or prolonged and seriously plete viral particle is called a virion. A virus uses the machin debilitating and chronic. ery of a host cell to reproduce and resides within the host cell. 0004 Numerous drugs have been developed to fight Consequently, viruses are difficult to eliminate without kill inflammation inhumans. The most prominent in current treat ing the host cells. It is believed that viral infections trigger ment are anti-inflammatory steroidal drugs, corticosteroids inflammatory responses which do not respond to anti-viral and non-steroidal anti-inflammatory drugs such as salicy drugs. Patients often ask for, and physicians often prescribe, lates. While these drugs are generally effective, they often antibiotics. While antibiotics destroy or prevent the growth of have adverse side effects. bacteria, antibiotics are useless in treating viral (and fungal) 0005. A pathogen is an infectious biological agent, some infections. Their misuse in treating viral diseases is one of the times referred to as a germ, which causes disease or illness to causes of antibiotic resistance to bacteria. its host. Many medical advances, such as vaccination, antibi (0012 Sporkenbach et al. (“Sporkenbach'), U.S. Pat. No. otics, and fungicides, have been used to safeguard against 4.404,191, discloses a viricide technique for inactivating infection by pathogens. Nevertheless, pathogens continue to viruses on animate and inanimate surfaces by contacting the threaten human life. Primary pathogens are bacteria, eukary surfaces with a salt of peroxymonosulfuric acid (H2SOs) otes, prions, and viruses. commonly known as Caro's acid. The peroxymonosulfuric 0006 Bacteria constitute one of the smallest organisms acid salt, applied from an aqueous solution, can be a salt of an containing all the material required for growth and self-rep alkali metal Such as potassium, Sodium, or lithium, a salt of an lication. Bacterial infections can be treated with antibiotics, alkaline earth metal Such as calcium or magnesium, or an classified as bacteriocidal if they kill bacteria and as bacte ammonium salt. Sporkenbach preferably employs KHSOs as riostatic if they prevent the bacteria from multiplying so the the peroxymonosulfuric acid salt. KHSOs is provided from human immune system can overcome them. There are many the mixed triple salt having the chemical formula 2KHSOs. types of antibiotics. Each type of antibiotic inhibits a process KHSOKSO, where KHSO is potassium hydrogen sulfate whose pathogen is different from that found in the host. The and KSO is potassium sulfate sometimes referred to as effectiveness of individual antibiotics varies with the location dipotassium sulfate. of the infection, the ability of the antibiotic to reach the site of (0013 KHSOs and 2KHSO.KHSOKSO, each have infection, and the ability of the bacteria to resist or inactivate multiple chemical names. Both KHSOs and 2KHSOs. US 2012/0074014 A1 Mar. 29, 2012 KHSOKSO are commonly referred to as “potassium phosphate, disodium phosphate, trisodium phosphate, tetra monopersulfate'. To avoid confusion, KHSOs is referred to Sodium pyrophosphate, monopotassium phosphate, dipotas herein as "potassium hydrogen peroxymonosulfate' or sim sium phosphate, tripotassium phosphate, and tetrapotassium ply “potassium peroxymonosulfate. 2KHSOs. KHSO. pyrophosphate. According to Auchincloss, one embodiment KSO. is referred to herein as “potassium monopersulfate of the biocide apparently consisted of 1.5 parts of sodium triple salt” or sometimes simply as "potassium monoperSul chloride, 50 parts of potassium monopersulfate triple salt, 10 fate’. parts of Sulfamic acid, 5 parts of malic or Succinic acid, 18.5 0014 Sporkenbach identifies poliovirus, coxsackie virus, parts of sodium hexametaphosphate and (possibly) other simian vacuolating virus 40 and adenovirus as being inacti alkali metal phosphate, and 15 parts of sodium dodecylben vated by potassium hydrogen peroxymonosulfate. Poliovirus Zene Sulfonate as the Surfactant. causes poliomyelitis. There are two forms of coxsackie Virus, 0019 Auchincloss reported generally good results in vari type A and type B. Coxsackie A virus causes hand,
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