(12) Patent Application Publication (10) Pub. No.: US 2015/0307441 A1 Ogrodzinski Et Al
US 20150307441A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2015/0307441 A1 Ogrodzinski et al. (43) Pub. Date: Oct. 29, 2015 (54) NEW COMPOUNDS AND USES THEREOF A 6LX3L/277 (2006.01) A63L/36 (2006.01) (71) Applicant: Biostatus Limited. Shepshed, A6II 45/06 (2006.01) Leicestershire (GB) (52) U.S. Cl. CPC ............. C07C 225/36 (2013.01); A61 K3I/136 (72) Inventors: Stefan Ogrodzinski, Shepshed, (2013.01); A61K 45/06 (2013.01); A61 K Leicestershire (GB); Paul Smith, 3I/277 (2013.01); G0IN 31/225 (2013.01) Shepshed, Leicestershire (GB); Stephanie McKeown, Shepshed, Leicestershire (GB); Laurence (57) ABSTRACT Patterson, Shepshed, Leicestershire (GB); Rachel Jane Errington, An anthraquinone compound of formula I (Such as the com Shepshed, Leicestershire (GB) pounds of formulae II to X) and processes for making the (73) Assignee: Biostatus Limited. Shepshed, same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an Leicestershire (GB) agent capable of reducing the level of oxygenation of a (21) Appl. No.: 14/420,184 tumour, are also provided. Additionally, an option for com bination with chemotherapeutic and radiotherapeutic modali (22) PCT Filed: Aug. 7, 2013 ties to enhance overall tumour cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, (86). PCT No.: PCT/GB2O13/O52106 are additionally provided. S371 (c)(1), (2) Date: Feb. 6, 2015 Formula I O (30) Foreign Application Priority Data X4 X e sas Aug. 8, 2012 (GB) ................................... 12141693 e as Publication Classification S. 1. X3 X2 (51) Int.
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