Efficacy of Small‑Dose Ganciclovir on Cytomegalovirus Infections in Children and Its Effects on Liver Function and Mir‑UL112‑3P Expression
EXPERIMENTAL AND THERAPEUTIC MEDICINE 22: 912, 2021 Efficacy of small‑dose ganciclovir on cytomegalovirus infections in children and its effects on liver function and miR‑UL112‑3p expression QINGXIU WANG1*, WENZENG ZHOU2*, BIN WANG3, GUOYUN QIN4, FENG'AI LIU5, DEXIANG LIU6 and TENGTENG HAN2 1Office of Hospital Infection Management, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031; 2Department of Child Rehabilitation, Zaozhuang Maternal and Child Health Hospital of Shandong Province, Zaozhuang, Shandong 277100; 3Department of Child Rehabilitation, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600; 4Department of Pharmacy, Yidu Central Hospital, Weifang, Shandong 262500; 5Department of Paediatrics, Haiyang People's Hospital of Shandong Province, Haiyang, Shandong 265100; 6Department of Pediatrics, Laoling People's Hospital, Laoling, Shandong 253600, P.R. China Received April 3, 2020; Accepted February 1, 2021 DOI: 10.3892/etm.2021.10344 Abstract. The aim of the study was to explore the efficacy treatment, there was also no significant difference between the of small‑dose ganciclovir on cytomegalovirus infections as two groups in miR‑UL112‑3p, TB, ALT, and AST, while after well as its effects on the liver function and miR‑UL112‑3p treatment, both groups showed lower levels of miR‑UL112‑3p, of children. A total of 141 children infected with cyto‑ TB, ALT, and AST, and the Obs group showed significantly megalovirus admitted to the Affiliated Hospital of Weifang lower levels thereof than the Con group (all P<0.05). In addi‑ Medical University from May 2015 to August 2017 were tion, the area under the curve (AUC), specificity, and sensitivity enrolled, of which 74 children were treated with small‑dose of miR‑UL112‑3p in the ROC curve of the Obs group were ganciclovir as an observation group (Obs group), and the rest 0.866, 73.77 and 84.62%, respectively, while the AUC, speci‑ were treated with conventional‑dose ganciclovir as a control ficity, and sensitivity of the ROC of the Con group were 0.837, group (Con group).
[Show full text]