Onsolidated R & D *Annual Project Report

RCC1.950804.003 REPORTS CONTROL SYMBOL CSCRO-16

ARMY MEDICAL SERVIC€

ONSOLIDATED R & D *ANNUAL PROJECT REPORT (EXCLUDING 0 M)

Tlg I-TTOII COWAIlYOD -IN IS UWCLASBIFm EUT YAY NOT W mI&tQ)WITmIJT Tm expR688 PwYISsIrn dc n QIIOI, R#Ascdm AI0 DIVISION. -ICE CF TIP SuaOn m,DEPART- mtrQlmARyy.

Whoa this document hr served its uur~oeeit my be di.Wlad of without reference to tha originating offiur. -. -.

I JANUARY - 31 DECEMBER 1957

RESEARCH AND DEVELOPMENT DIVISION OFF!CE OF THE SURGEON GENERAL US ARMY

pJm-yb-*?w?r. "-'-" .;~*:?q?.,~3.~ ' -1 . '* ,'.',. :)". .

I' AFXY MEDICAL SERVIm

CONSOLIDATSD R & D ANNUAL PROJECT REPORT

(Excluding GM)

(Reports Control Symbol CSCRD-16)

1 January - 31 December 1957

The information contained herein is unclassified but may not be published 5.iithout the express permission of the Chief, Research and Development Division, Office of Tho Surgeon General, Department of the Amy.

When this document has served its purpose it may be disposed of without reference to the originating office. Do not return this document.

Research and Development Division Office of The Surgeon General u. s. Army .. . _... - . .-..- - ... .--.. .- .. ,.. __ . - ,

TABU OF COIJTlEJTS Reports Control Symbol CSCRD-16 DIDEX OF PROJECTS 31 December 1957 CODE NO. PROJECT TITI;F: PROJECT NUIBEX PAGE 6.28 IIedical Wpment .I

Developnent of Uedical, Dental 8 Veterinary 3qyipment & Supplies 1 7.23 IiIedical Sciences 4 ArnTy eosthetics Research Program 4 Ocular Research 6

X-ray & Photographic Techniques 8

Biological &Medical Aspects of 10 Ionizing Radiatim

"Prophylaxis & Tnerapy of Radiation Injury *'Effects of Mernal Radiation and Internal hitters Resuscitation 13 qundanental Studies on Bespiratory Functions

Traunatic Surgery and Shock 16 *3acterial Factors in Traumatic Shock

%valuation of Art-ficidl ILibernation and mothennia 'Vhysio,pathology of Shock, Tv'aund Healing and Systernic Responses to Trauma 2

*Treatment of Radiation and Thermal Burns

*Inmunochemical and Immunological Studies of Skin Ihnografts

*Studies of Fluid, Zlectrolytes, Hormones and 'Jlssue T& in 3urns i I TABLE QF COIJTElJTS Reports Control Symbol CSCRD-16 INDEX OF PROJECTS (CONT'D) 31 December 1957 CODE m. PROJECT TITU PROJECT NLTI.IBER a 7.23 Medical. Sciences (Cont 'd) Artificial plasma Volume Expanders 6-59-U-929 2

*Disposition and Netabolism of Dextran *Chemical Studies of Oxypolygelatin, PVP, Polypeptides of Amino Acids as New Plasma Expanders Blood and Blood Derivatives 6-j9-l2-030 27 *Studies of Prolonging the Storage .' Ijfe of Red Blood Cells for Transfwicm *Study of Etiological Factors and Methods for Detection and Prevention of Blood Clotting and Bleeding Tendencies in the Severely Wounded

*Developent of lethods to -Render Hunum Plasma Bee of the Hepatitis Virus CUnical Investigations 6-60-01-002 Metabolism 6-60-Og-O12

*Metabolic Aspects of Trauma, Severe IUness and 1Ial.nutrition *Davelopnent of Effective Kethods of Correcting €4etabolic Disorders Neuropsychiatry 6-60-10-016 3E

*Development of Kethods for Prevention of Psychiatric Disorders

'Qevelopnent of Nethods for Diagnosis and Therapy of Psychiatric Disorders

'Qdentification of Neurophysiological Factors Related to Psychiatric Disorders

'- I *Dete&tion of the Soldier's Caloric, Vitamin and Nineral Requirments in all Environtnental Conditions

"Developnent of Suitable Fat Emulsions for Intravenuus Adrrdnistration to Severely Injured or Ill Patients New i>rugs & Antibiotics 6-60-I.3-016

Internal bbdicine 6-60-13417 .

*. *Investigations 'of Peptic Ulcer, Circulatory and Renal CcunpUcatians of Infectious Diseases *Basic Kechanisms Involved in Chronic Skin Diseases &countered 1 in the Tropics Reports Control Symbol CSCRD-16 INDEX OF PROJECTS (COIJT'D) 3lDecember 1957 CODE NO. FRWE CT TI- PROJECT NUMBER '. . p9

7-23 Medical Sciences (Cont'd) Ccamrmnicable Diseases 6 *Prevention and Improved Treatment of Parasitic Infections in 1% *prevention and moved Treatment of Viral &Rickettsial Infections inm *Prevention and Improved Treatment of Bacterial Infections in 14an Acute Respiratory Diseases 6-61-03-036

*prevention & Improved Treatment of Adenovirus Infections Aden&oxs Vaccine

*prevention & Improved Treatment of Influenza

*Prevention & Impraved Treatment of Streptococcal Disease ."',. . Studies in Immunization 6A43-037 7' *Development of Irdified Dengue Fever Vaccine *Study of the Basic Phenomena of Natural & Induced limmtnity

r)evelopnent of New & Improved Vaccines for Immunization of the Soldier

Ecology & Control of Disease Vectors & Reservoirs 4 qnsect Resistance to Insecticides

*Study of Ecology of Disease Vectors & Reservoirs Health Hazards of 14ilitary Chemicals 6=61-14-001 iv TAI3U OF COITTENTS Reports Ccntrol Symbol CSCRD-16 ma OF PROJECTS(CONT~I)) 31 December 1957 loIlE NO, PROJPCT TITLE PROJECT IRRm 7.23 Nedical Sciences (Cont'd) Oral Disease 6-63-01406 82 *Prevention & Treatment of Dental Caries & Periodontal Disease "Improvement of Dental Materials

Ad-sory Senrices 6&-01401 *Advbory Services of Specialists in Various Fields of lhdicine *Joint Support of Government Agencies in Collection and Dissemination of Scientific Idormation

Iwestigations in Hearing & Speech 6.64=-01410 88 magnosis, Therapy, and Rehabilitation of Hearing Disorders Enviroxnnental Physiology 6-6452-028 *Studies of the Physiological Effects of Cold on-

*Renal & Body Fluid Responses to Environmental Variables &ctic and subarctic Field Xedical 93 Problems Waste Diqosal and Bnteric Disease Under Arctic Conditions

*Health & %?bitability of Xilitary Shelters for Arctic Use Psychophysiological Studies 6-95-20-001 97 *-provernext of Control and Coordination In Complex Performance

*Determination of Xfects of Physical Znviroment on Performance Reports Control Syl CSCRD-16

I Coma ZROJZCT TITI3 PROnCT iJLW3EFL

7.23 Xedicd Sciences (Cont f d) Psychophysiological Studies ( Cont 'd) 6-95-20-001 *Investigation of Vision adPerception in Relation to Performurce Qvestigations of Sound and ilearj-ng in Relation to Performance Ytnvestigations of Fation urd Balance in Relation to Performance Investigations in Overseas Units 6-97-85-001 t,.iedicd Effects of Blast on Kian 6-97-87-0 01 Tsychological and Physiological Aspects of Blast Physical Standards Research 6-97-87402 Wound Ballistics 6-99-OZlOOl

VBdical Aspects of Protective hnor

vi INITIAL DISTRIBUTION No. of Conieq*** Recinient t omm AsSISTANT SECFEX'ARY OF DEFENSE (W) 18** Beports and Statistics Branch .+f . @.PIED FORCES OmmTzATIO~~s Zpidemiological Board . 1 - Presideni 1 Executive Secretary 8 Illembers (I each) ll Directors of Conmissions (1 each) * lhbers of Canmissions 2 Institute of Pathology Special Veapons Project 2 Headquarters 1 Field Command AR.EO SESCVICES OFtGAKtZATIONS 1 I4edical Ikteriel Standardization Committee 1 1 GZZXAL, STAFF 1 Deputy Chief of Staff, Logistics 1 Deputy Chief of Staff, Logistics Programs & metDivision 1 Deputy Chief of Staff, Operations Deputy Chief of Staff, Personnel 8 Chief, Research and Development 2' Assistmt Chief of Staff, Intelligence AFaS :GMcAL mnm Office of The Surgeon General 1 Execqtive Off ice 1 Program Coordination Section * Special Assistmt for Xuc1ea.r Energy 1 Historical unit 1 Inspector General. 1 Legal Office * lieci%cal Plans and Operations Division * Fidical Statistics Division 1 Preventive Kedicine Division * Professional Division

* Distribution limited to pertinent projects I ** 15 copies unbound -, . . . . .

1 Reference Library Research and Developnent Division 1' Chief 1 Assistant Chief 60 Budget and Reports Branch 1 Administrative Office * Basic Science Research aranch 1 Biophysics Research Branch * IIuman Resources Research Branch * 1-kdical. Research Branch * 'Preventive 14edicine Research Branch * Surgical Research Branch * Consultants and Investigators 1 Surrply -Division 1 Technical Liaison Office 2 Veterinasy Division 1 Army Nedical Service Board 80 Hospitals: Class I and XI and O/S (1 each) Labor atories Arqy Area and Branches (1 each) Axmy Environmental Heaith Army Xedical Research Arq Prosthetic Research i:l 1 Ibdical Nutrition .I 1 Ophthalmology Clinic, IW I 1 Research and Development Service, FBH 3 Surgical Research Unit 1 Tropical Research Xedical Laboratory 1 USAREUR 14edical 1 USARPAC IGedical u Walter Reed hjInstitute of Research 3 406th Kedical. General Schools 3 Arqy lfhdical Service I. &at and Dam Hygiene ! 14 Surgeons: CONARC, O/S and Axmy (1 each) !

1 Taacfi COP!S 1 Chief Cherdcal Officer 2 3esesrch and Developent Cammand 1 Cheiical FJarf are Laboratories CCFPS OF ENGERZRS 1 Research and Development Civision, OCE 1 Research aid Development Laboratories 1 Siio~r,Ice and Permafrost Establishment

C!UL?rn%Xrn CCFLS 1 Research and Development Division, OQlE Research and Development Center 2 Project Control Office 1 Technical Library 3 CI .r - 2c;. rs;d Container Institute sI.s?:.G cciws ?reject Kichigan .

WiSEORTATION CQRPS Research and Development Conmiand

1 I1 Co&d and General Staff College I1 'dashington Deputy, CONARC

L9..4ISG?I CFFTW 5 Eritish Ibdical 8 Canadian Yadical ;.TAm -Office of Naval Research 1 JWeau of Xedicine and Surgery 1 Preventive Ibdicine Division 1 Research Division (Code 71) 1 General IIedicine and Surgery Branch 1 Weau of Navd Personnel (~ers=15) 3 %eau of Ships (Code 320) 1 Meau of SupFlies and Accounts (Code 1 ClotMng Supply Office 1 Eaterid Laboratory (Code 9ZB) 1 Naval. Xedicd. Field Research Laboratory 1 Xaval Eedical Research Institute 2 U. S. Naval Radiological Defense Laboratory 3 U. S. Naval I.ledical Research Units Nrs. 1, 3, and 4 (1 each) AIR FORm Office of The Surgeon General Mrector of Professional Services 1 Office of Scientific Research, (SRU) . -1 , 1 Preventive Eedicine Division Air Research and Development 1 RDTDDO 3 L Surgeon 1 Aeromedical Laboratory 1 Aircxft Observer Research Laboratory 1 Arctic Xermedicd La'ooratory 1 OfCiccr Mu.cat.ion Research Laboratory 1 Operator Laboratory 1 Personnel and Training Research Center 2 School-of Aviation Ihdicine

Atomic Energy Commission BioScionces Infonnation &change Central Intelligence Agency Chemical-Biological. Coordination Center Civil Aeronautics Administration Jational Institutes of Health llational lkdical Library LXLL;:ZE~ Xesearch Council X-ixsfon 0.3 :;edic,?l Sciences 1 9r- Thomas Bradley Mztiona3. Science Foundation 1 Liirary 1 Prograta Director for XolecuCkr Biology 2 CQcrations.. -7.esearch OfZice 1 L (ztarais .'~c>dnFstr at ion

X TYPE OF REPORT R6-D PROJECT CARD Progress REP@f,&flJvL SYMBOL

. PROJECT TITLE 12. SECURITY OF PROJECT IS. PROJECT NO. Devdopment of Medical, Dental and U 6-59-04-049 Teter-inary Equipment and Supplies (U) 4. INDEX NUMBER 1. REPORT DATE 31 Dec.1957 . BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUWECT SUB GROUP 7A. TECH. OBJ. 3iilitary Medicine Equipment PO-16

. COGNIZANT AGENCY 12. CONTRACTOR AND/ OR LABORATORY CONTRACT/ W. 0. NO. The Sur eons General us krrrc-7, :Javj and fir Force ledical Squipment . DIRECTING AGENCY Development Laboratory 'SkXCC Fort Totten, New York 0. REOUESTING AGENCY h22ZC 1. PARTICIPATION AND/OR COORDINATION 13. RELATED PROJECTS 17. EST. COMPLETION DATES RES. Cont, DEV. Cont. 'TEST Cont. OP. KVAL. 18. FY. FISCAL ESTIMATES 14. DATE APPROVED -';R 8OIf 12 July 1954 59 10014 11. PRIORITY 16. MAJOR CATEGORY 2 6.28 9. REPLACED PROJECT CARD AND PROJECT STATUS

I I 0. REQUIREMENT AND/ OR JUSTIFICATION Advances made in the field of medicine and changes in concepts of mdern trarfare require continuing actions related to the improvement of existing medizal equipment and the development of new equipmente It is the purpose of this pro.ject. to provide for such actions. (Par 14.12~Om)

BRIEF OF PROJECT AND OWECTIVL a. 3ri3,C: It is the primary objective of this project to improve the battlsfield ?erformancs of field medLcal units by effecting improvements to existing n?edicaJ equipnt and by developirg new medical equipment which possess charscteristics peculiar to military usage. The development effort is directed to~::a-d, b~tnot limited to, ease of maintenance; simplicity of operation; %;zsdnecss ; conservation of space and weight; zninimm need for logistical support: 9fficisncy and reliability,

b. Amroach: Based on reqairements generated within the Army Nedical Sel-vice for byrovements to or development of items, reconmended subtasks are RID PROJECT CARD

. PROJECT TITLE L SECURITY OF PROJECT 3. PROJECT NO. Devezopment of Medical, 9sntd md Tctarixqr U 6-1;1. -3ii.d 4 Equipment md Supplies (U) 4. 5. REPORT DATE 31 Dec.1957

(2) Stackrdization 1tm.x - Not applicable (3) - Not applicable

Pr 0.i ec t. 7ro.iect Tit& I Navy im 91 00 00 Development and Zvaluation of Field Equipment Air Force 6325 Integration of Personal Equipment (6) Saec fic RevLew Points: - Not [email protected] e. Baclcmoimd 3Lsto-m md Prwress: (I) Backsround Histow Eply in 1945 the Secretaries of War aid ;?at-,.set up the jobt Amry-Nayy Ysdical Procure= rnent Office. Under supervision of t'nis office tho Laboratory was established in 19%. The Air Force joined the Amry-lJavy operation in 1949 and the Procurement Office was renamed tho Armed Services Xedical Procurement Agency (-A) The I-hdical Equipnent Developnent Lalooratory was designated a branch of that Agency. Under the Agency, a joint Aimed Services Xedical Materiel Standardization Coomnittee directed the Laboratory,

On 1 Ja.nmvj 1357, tbe Development TLaboratorjwas redesignated as a Class II activity ol" the hySurgeon General, At the saxe time the Stmdardieation Committee vas redesignated the Armed Services L4edical Nateriel Coordination PAGE 2 Of 3 PA01 DD ,'$"- 613-1 RWlACSS W FORM 6lS-1. 2 RLD PROJECT CARD lNTlNUATlON SHEET . PROJECT TITLE I 2. SECURITY OF PROJECT I 3. PROJECT NO. I. PROJECT TITLE 2. SECURITY OF PROJECT U Army Prosthetic Research Program 4. INDEX NUMBER S. RtPORT DATE 31 Dec. 1957 1. BASIC flELD OR SUBJECT 7. SUB FIELD OR SUWECT SUI GROUP 7A. TECH. OW. PIedical Sciences Devices, Prosthetics PO-1s

B. COGNIZANT AOENCY 12. CONTRACTOR AND/OR UBORATORY CONTRACT/W,O. no. Office of The Surceon 'General .DA D. DIRLCTINO AGINCY &my Prosthetic Research Lab. Res. & Dev. Div., OTSG :?alter !bed Army Wedical IO. REOUESTINO AOENCY Csnter

I I. PARTICIPATION AND/OR COORDINATION IS. RELATED PROJECTS 17. EST. COYPLKTION DATE8 veterans Administsation (pa) I Adv.Comm. on Artificial Limbs, NAS (C) Air Force (C) OR WAL. 18. FY. fl8CAL ESTIYATCI Navy (c) - ~ 14. DATE APPROVED 58 199M 12 July 1954 59 20011 13. PRIORITY 18. MAJOR CATSOORY T -4 2 7-23 IS. REPLACED PSOJECT CARD AND PROJLCT STATUE

L I. BRIEF Of PROJCCT AND OUICTIVI a. Brief: The objsctive of this ?reject is to conduct fundaiiental research into all phases of prosthetic replacement including time and motion studies and devdopment of individual components for the efficient fitting of anputations . b, -4rmroach: Fundamental ad appli$d rssearch in the fizld of prosthetics is cond-acted at the Prosthetics Eesearch Laboratory, I.klter Reed krny 1-Isdic2.1 Center.

C. Task: *Army Prosthetic Research

!Z. OASD (RblD) I SI(. CN. C. X. I '. C. FORM PAGE 1 OF 2 PAGES APRSI DD 613 t, ?LPLACCS DO FORM SlS, 1 I JAN 82. R&D PROJECT CARD SNTINUATION SHEET 1. PROJECT TlTLE I I SECURITY OF PROJECT 1 3. PROJECT NO.

Army Prosthetic Research Program

d. Other information: (1) This oroject consists entirely of scientific research. Number of research tasks - 1. Number of research contracts - 0.

(2) Standardization item - Not applicabla (3) Enzineering test - Not applicable (4) Operational availability date - Mot applicable (5) Same or related item - Not applicable (5) SDecific reviaw points - Not applicable

9. SackPround b'stom and Drouress:

(1) Background histom: The Army Prosthetics Research Laboratory was organized to conduct fundarrental studies on the amputee rehabilitation problen. It has the personnel and equipment to approach every conceivable angle of mptee rehabilitation and to assure standards of quality and performance in components of artificial limbs.

(2) PFoPress: Work is continuing on the developent of universal hand mechsnisms including the development of new and the improvement of existing components such as elbows, wrists, harness and transmission systems, terminal devices, an& prosthetic fabrication techniques. Progress is being made in the development of stain-resistant gloves, comatic leg covers, new techniques for fabricating soft sockets and artificial limbs from dry lay-ups and in the standardization of specifications for prosthstics.

f. Future plans: Controlled studies for the continuous and progressive improvement of prosthetics will continue.

g. References: Progress Reports of the Advisory Committee on Artificial Limbs, National Acadeqy of Sciences.

h. Modernization code: Not applicable

613-1 PAGE 2 OF 2 PAGES DO FORY 6IS-1. ' u. 5 weoc RLPORT RDD PROJECT CARD Progress REPORT CONTRPL SYMBOL . PROJECT TITLE 12, SLCURITY 01 PROJECT U 6-59-03-004 Ocular Research 4. INDEX NUMBER 3. REPORT DATE 31 Dec. 1957 1. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP TI. TKCR. OW. Medical Sciences Eye, Ear, Nose & Throat PO-16

I. COGNIZANT Aacncy 12. CONTRACTOR AND/OR LABORATORY CONTRACtlW. 0. NO. Office of The Surgeon General, DP. I. OtRECTlNG AOLNCY Res. & Dev. Mv., CrrSG See Item Zld(7) IO. RROUKITINQ AQLNCY

I. PARTIClPATION'A#lD/ OR COORDINATION 13. RELATED CROJLCTS 17. LIT. COMPLCTION DATU RII. Navy (C) ' Air Force (C) DIV. TLST OC. WAL. 18. FI. FISCAL IITIMATCS 14. DATE APCROVID 3 May 1952 59 . 29M 18. PRIORITY I@. MAJOR CATIQORY T 29E 2 7.23 19. RICLACLD fROJLCT CARD AND CROICCT STATU8 I

IO. RLQUIRKYLNT AND/OR JUSTIFICATION 1. Ocular injury and disease are a source of considerable morbidity in military personnel. 2. Treatment of eye injuries is unique in that special instruments and special training are required, 3. Visual skills are important in the classification of military personnel. (Par 1410c CDOG)

It. 8RICC OF CROJCCT AND OULCTIVK a. Brief; The object of ocular research is to study the cause and effect of ocular injury and disease in order to reduce morbidity and to provide better and more rapid treatment cnd rehabilitation.

b. Amroach: Studies are made of the effects of hemorrhage into the vitreous humor; the feasibility of maintaining a readily available suppu of corneas; and improvement of prosthetic eyes.

c. Task: "See Annual Research Task Summary" (Page 136) *Ocular Research 12. OASO (R 8 0) I SN. CN. C. I x. I '. C. FORM PAGE 1 or 2 rAac DD t ACRSS 613 / ~LPUCES DO CORM ma. 0 RLD PROJECT CARD lTlWUATlOW SHEET PROJECT tmE I 2. SECURITY OF PROJECT I 3. PROJECT NO.

d. Other Informztion: (1) This project consists entirely of scientific Pesezrch. Number of research tasks - 1. Number of research contracts - 3.

(3) 3nKLneerinT test = Not apFlicable

(4) 0ysrition.il arilzbility date - Not appliczble (5) Sane or relatad item - Not applicable (6) Specific ret.iex points - Not applicsble .. It- 12 - Coptractor and/or Laboratory:

3cular 4esomch Unit, V-zlter Reed .kny Institute of Reseerch ID-273 - Dr. Zachsrias Dische, Columbia University, New York, N. Y. .f.D-733 - T)r. John 3" Yair, Nedical Sollege of Georgia, Augusta, Gas -ID-394 - 3r. 23.si.iael J, Fogzn, Universitr of California, San Francisco, Calif.

e. ?-ckround history md DroqrBSS:

(1) ?ac!-zrmnd histom: Eye injuries during cgmbat accounted for some 4% of the total hospitalizations for injuries in the m. With the increased use of the frzgentation type Df weapon, eye injuries are becoming more common and sevwe, It is important that better admore conplete equipment be provided for use 'rj ophthalmologists in medical field installations, and thzt methods of prwention of eys injury be developed for use in combat.

(2) Promess: Methods for developing a prosthetic eye which can simulate and parallel the movements of the natural eye are being studied. Also being studied is the feasibility of maintaining a readily-available supply of corneas by 3 new nethod of preserving corneas by dehydrztion and storage in glycerine.

f. Future ~1ms: Beginning 1 January 1958 the 0cul.x Rese3rch Unit, 'dRAIR, will be discontinusd; ~OW~VSP,the work performed by this unit will be continued b>- the O$iI2!&1olo~ Sarvice, ?kilter Reed Army Hospital.

g. References: "See Annu~J.Research Task Su;mnar~"

h. ihdernization code : Not applic.able TYPE or REPORT R&D PROJECT CARD Progress I. PROJECT TLTLE 12. SECURITY OF PROJECT IS. PROJECT NO. U 5-5 9 -08 -012 X-ray and Photoerachic Techniques 4. INDEX NUMBER 5. REPORT DATE 131 Dec. 1957 6. BASIC FIELD OR SUBJECT 17. SUB FIELD OR SUWKCT SUB GROUP I 7A. TECH. OW. Xedicil Sciences Roentgenology and &diology I PO-16 I I 8. COGNIZANT AQENCY 12. CONTRACTOR AND/OR LABORATORY CQNTRACTIW. 0. No. Office of The Surgeon General, D 9. OIRCCTING AQENCY AmFedical Research Res. ?i'3ev. Div., OTSG Laboratory IO. REOUESTINO AGLNCY 'Fort Knox, Xy.

I I. PARTICIPATION AND/OR COORDINATION IS. RELATtD PROJECTS 17. ElT. COMPLETION DATES ?Jav.J (c) RES. DEV. Air Force (c) TEST OR WAL. 1B. FY. FISCAL ISTIMATES 14. DATE APrROVID 58 3WI 12 July 1954 59 34M 15. PRIORITY 18. YAJOR CATE00RV T 34N 1c 7.23 19. REPLACED PROJECT CARD AND PROJECT STATUS

10. REOUIREMENT AND/OR JUSTIFICATION Field use requires x-ray equipment to be maller, lighter, and nore rugged than commercial counterparts without sacrifice of essential quality. Techniques nust be ra?id, adaptable to requirements of inass casualties and improved with respsct to resolution. (Par 1410c DOG)

Pf. BRIEF OF PROJECT AN0 OWLCTIVK a. Brief: X-ray units share military specifications xith other equipment for fisld USB. ACX~V~T,considera5le radiology is prscticed in fixed medical installations so t!iat volume, weight, and ruggedness are less a requirement than impovenent of this neans of diagnosis md clinical stcdy. In b3th uses of x-ray equipment, simplification of tec:miques is advis3ble and aqmars oossi5le . b. Awx-oacfi: To achieve better rosntgenograFhic techniques t;?rough the ap?lication of pulse x-ray, utilization of color fiLn of stand-ard manufacture, mfi stu%?s of emdsions not sensitive to light but to x-ray.

22. OASD (RBD) I SN. CN. C. X. I. C. FORM PAGE 1 OF 2 PAQLS DD I APRSS 013 RCPLACES DD CORM 619. 8 I JAN 82. I R&D PROJECT CARD JNTlWUATlON SHEET' I. rmm TITLE 12. SECURITY Of PROJECT I 3. PROJECT NO. U -59-08-012 X-ray and Photographic.Techniques 5. REPORT DATE

C. Task: "See Annual Research Task Summary" (Page 144)

*X-ray and Photographic Techniques

d. Other kformation: Not applicable

e. . Backeround Nst om an d momess:

(1) Backnround histom: Pursuant to Change 2, AR 40-440, dated 7 June 1955, The Surgeon &nerd is charged with the responsibility for research directed toward improvement of x-ray and photographic techniques used the 1- Medical Service.

(2) bO6WeSS; One-shot color radiography, using commercial color film, has been proven successful, This procedure will give greater detail in radio- graphs than has been heretofore obtained in ordinary black and white negatives. f. @*we Studies will be continued in order to achieve better roentgenographic techniques . go References: "See Annual Research Task Summary" h. Modernization code i Not applicable

PAGE 2 OF 2 PAGES I. PROJECT TITLE 2. SECURITY OF PROJECT S. PROJECT NO. U 6-59-08-014 Biological & Medical Aspects of Ionizing Radiation 4. INDEX NUMBER 1. REPORT DATE 31 Dec.1957 1. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OW. Biological Sciences Roentgenology and Radiology AW-6 1. COGNIZANT AOLNCY 12. CONTRACTOR AND/OR LABORATORY CONTRACT/W. 0. NO. Office of The Surgeon General,DA 1. DlRECTlNG AGENCY See Item Zld(7)

I I. PARTICIPATION ANDIOR COORDINATION IS. RELATED PROJECTS 17. K8T. COYCLCTION ,DATCS AFswp (PI Navy Dep-ent (C) I Aj,r Force (a) TEST OR WAL. 16. FY. ClWAL E#TlYATKS 14. DATE MPROVLD 58 350M 12 Juls 199 59 35014 18. PRlOfflTY 16. YAJOR CATEGORY T 35014 1c 7.23 19. RLPLACED PROJECT CARD AND PROJECT STATUS

!O. REQUIRCYENT AND/OR JUSTlClCATlON Itmizing radiation is used by the bqy Medical Service for diagnosis and therapy. It may be used against us as a weapon or be a by-product of modern weapoz18. Use of radioisotopes is increasing. No rational therapy yet dsts for radiation sickness, nor we all effects knm. (Par UlOf CIXIG)

!I. BRICf Of PROJECT AID OBJLCTIVE

'4. a. Brief: Potential use of nuclear weapons necessitates an understanding of basic mechanisms imrolved in damage to biologic material by ionizing radiation in order that prophylactic and therapeutic measures ma;y be developed. Conversely, controLled suurces of this type of energy have been used for more than half a century for diagnosis and therapy of disease and trauma, including those of military significance. The availability of radioisotopes during the last decade has spurred advances in biochemis~,physiology, and other biologic sclences and offers intriguiag possibilities for more accurate diagnosis and less insult to patients during therapy.

1. OASD (RBD) I SN. CN. C. X. I. C. FORM PAOE 1 OT 3 PAOES DD i APRSS 613 IEPMCLS DD FORM 613, 10 JAN Si?. RID PROJECT CARD )NTINUATION SHEET I. PROJECT TITLE 2. SECURITY OF PROJECT 3. PROJECT NO. Biological & Medical Aspscts of Ionizing Radi at' ion U 6159 -08-Ol4 4. S. REPORT DATE 31 Bca1957

be &3Drd: To develop workable techniques in application of radioisotopes, t:, detemins radiobiological effects in humans, to determine effects of radiation upon physical trauma, and to design a system of instmnta- tion that will give fundamental information regarding the effests of accuntlated gama emitting isotopes upon marc

CO Tasks: "See Anrid Resexck Task Sunxapj,''(T~es g-51 Incla& 57)

*Pro~jhxLsand Therapy of Radiation Injury

?-o."iact Title R10 PROJECT CARD

1. PROJECT TlTLE 2. SECURITY OF PROJET 3. PROJECT NO. U 6-59-08-014 Biological & Medical Aspects of Ionizing Radiation 4. 5. RLCORT DATE 31 Decal957

Task - Bffects af External Radiation and Intarnal Brxitters

g2 mer- : "See Annual Besesrch Task Sumaqy,"

12 [ TYPE OF REPORT R&D PROJECT URD POL SYMBOL Progre s s I WIYiL5-L0 I. PROJECT TITLE 12. SECURITY OF PROJECT 3. PROJECT NO. U I 5-59-09-010 1 2esuscitation 4. INDEX NUMBER 15. REPORT DATE 31 Dec. 1957 6. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OBJ.

;.isciical Scimces Anesthesiology e Resuscitation PQ-U I I I 8. COGNIZANT AGENCY 112. CONTRACTOR AND/OR LABORATORY I CONTRACT/ W. 0. NO. I Office of The Surreon General.DA( 19. DIRECTING AGENCY ~~ 1 Res. & Dev. Div., OTSG See Item 21d:7) 10. REQUESTING AGENCY

11. PARTICIPATION AND/OR COORDINATION 13. RELATED PROJECTS 17. EST. COMPLETION DATES Chenical Corps (F) RES. Navy Department (P) DEV. &r Force (P) TEST OP. EVAL. 16. FY. FISCAL ESTIMATES 14. DATE APPROVED 58 86X 12 July 1954 59 01 7.tI. IS. PRIORITY 16. MAJOR CATEQORY T 10114 1c 7.23 19. REPLACED PROJECT CARD AND PROJECT STATUS

I I I I I 20. REQUIREMENT AND/OR JUSTIFICATION X3.lita-y personnel during training and especially during combat are exposed frequently to high-tension .,res, are often in danger of submersion in water, and may be exposed to chemical agents such as phosgene and nerve gases. These exposures my cause casualties who will require prompt and effectivs artificial respiration measures if their lives me to be saved. It is therefore essential that continued efforts be directed toward improvfng the methods of artificial respiration, both manual and mechanical, (Par 141% CX3)

21. BRIEF OF PROJECT AND OWECTIVE a. Brief: To develop simple, effective netnods of artificial res?iration which can be used on military casdkies requiring this procedure.

b. Amroach: To conduct physiologic evaluations of mechanical rsspirators, to svaluate new resuscitators, and to improve first aid treak-ent of nsme gas casualties.

c. Tasks: "See Annual Research Task Smnary" n?) *Resuscitation - Fundamental Studies on RespiratorJ Functions R&D PROJECT CARD

I. PROJECT Tins 2. SECURITY OF PROJECT 3. PROJECT NO. U $59-09-010 Resuscitation 5. REPORT DATE

d. Other Information: (1) This project consists entirely of scientific researcho Number of research tasks - 1. Number of research contracts - 6.

(2) Standardization item - Not applicable (3) Engineering test - Not applicable

(4) ope rational availability date a Not applicable (5) Same or related items - Agencx Project Number -Title Air Force 7759 Air Evacuation

Chevmical Corps 4-80-02-030 Mask-to-Kask Resuscitator

Navy Department NS 181-009 Improvement of Navy Type wgen Breathing Apparatui

(6) Snecific review Doints - Mot applicable (7) Item 3.2 - Contractor and/or Laboratorv: MD-189 - Dro Fred A, Hitchcock, Ohio State University, Columbus, Ohio MD-209 - Dr. David 0. Greene, University of Buffalo, Buffalo, N. Yo MD-507 - 9.. James 0. Elm, Roswell Park Memorial Institute, Buffalo, N. Ye MD-598 - Dr, Benjamin 8. Ross, University of Oregon, Portland, Ore, MD-858 - Dr, Peter Sdar, Baltimore City Hospitals, Baltimore, Md. MD-183 - Dr. Robert D. Dripps, University of Pennsylvania, Philadelphia, Pa. (Terminated 30 June 1957)

e. Backmound histom and monress;

(1) Backaround histom; This proJect was initiated in 1950 to evaluate the various methods of manual artificial respiration, At that time there vas growing evidence that the then popular Schafer method of manual artificial respiration did not produce an adequate air exchange in the lungs, and that other methods might be more effective,

(2) mess: Studies are continuing in order to ascertain the preferred method of resuscitation, At present, results indicate the mouth-to-mouth and mouth-to-airway methods should be generally adopted,

1 3D I’gL 613-1 PAGE 2 OF 3 PAGP W DO rwW 6IS-I. 14 FLI 5s. L RID PROJECT CARD CONTINUATION SHEET 1. PROJECT TITLE 2. SECURITY OF PROJECT 3. PROJECT NO. U 6-59-09-010 Re suscitation 4. 5. REPORT DATE 71 Dec. 1957

f. Future: Work of investigators will be continusd.

g. References: "See Annual Research Task Summary" h. Modernization code: Not applicable

PAGE 3 OF 3 PAGES 613-1 W FORM 6lS-1. >mu. . TYPE OF REPORT R&D PROJECT CARD Progress I. PROJECT TITLE 12. SECURITY OF PROJECT IS. PROJECT NO, U 6-59 -12 -022 Trrruaatic Surgery and Shock 1. INDEX NUMBER 15. REPORT DATE 31 Dec, 19-57 6. BASIC FIELD OR SUOJLCT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OW. Xsdic al Sciences Therapeutics PO-16

E. COGNIZANT AGKNCY 12. CONTRACTOR AND/OR LABORATORY conTircTlw. 0. no. OFfFce of The Surgeon General,DA 9. DIRECTING AGENCY Res. & Dev, Div., OTSG See Item 21d(7) IO. REQUESTING AGENCY

11. PARTICIPATION AND/OR COORDINATION 13. RELATED PROJECTS 17. ear. COMPLETION DATES

~iz.7,~ ( 2) RES. Air Force(C) DLV TEST

14. DATE APPROVED 12 July 1954 15. PRIORITY 16. MAJOR CATEGORY 1c 7.23 19. REPLACED PROJECT CARD AND PROJECT STATUS

20. REQUIREMENT AMD/OR JUSTIFICATION Traumatic wounds and shock are the classical injuries suffered by the vast majority of battle casualties. Reduction of mortality, hospitalization and permanent disability, and early restoration of the wounded to duty, are directly dependent upon the advances which can be made in this field. (Far 1LclOc CXG)

c I. aRiEF OF PROJECT AND owEctive a. Brief: To study the mechanisms, effects and control of hemorrhagic and traumatic shock, and the acute physiologic effects of wounding: to determine the factors essential for optimum wound healing, and to develop practical methods to promote wound hehing; to develop improved surgical methods for the handling and repair of combat wounds and traumatic injuries; to determine the causes, prevention, and treatment of the complications of traumatic wounds and injuries.

bo Amroach: Studies of the surgery of wounds cnd of the mechanism md treshent of shock will be cmtinued. These include chemical studies and investigations of the aetabolic and nutrition& state of the wounded in relation

?EPLACICS DO CORM 61S, 1 R&D PROJECT CARD ITIWUATION SHEET PRQ)ECT TmE I SECURITY Of PROJfCT 3. PROJECT NO. U 6-59-12-022 rraumatic Surgery and Shock 4. 5. REPORT DATE 31 Dec. 1957

to their recovery, development of better treatment of severe abdominal wounds md head wounds, research on wound healing and infections, post-traumatic renal insufficiency, resuscitation, and vascular surgery.

C. Tasks: "See Annual Research Task Swnnary" (Pages ll8-I29 InclJi 14.5)

*Bacterial Factors in Traumatic Shock

*Evaluation of Artificial Hibernation and Hypothermia

*Physiopathology of Shock, Wound Healing and Systemic Responses to Trauma

d, Other Inf'arrn ation: (1) This project consists entirely of scientific research. Number of research tasks - 3. Number of research contracts - 45. (2) StandaKlization item - Bot applicable (3) Enaineerina test - Not applicable (4) Operational availability date - Not applicable (5) Same or related items - Not applicable (6) S.Decific review points - Not applicable (7) Item 12 - Contractor and/or Laboratom: Task - Bacterial Factors in Traumatic Shock Surgical Research Unit, Brooke Army Medical Center Walter Reed Army Institute of Research, Walter Reed Array Medical Center National Bureau of Standards, Washington, D. C. (Terminated 1 July 1957) MD-884 - Dr. Jay P. Sanford, University of Texas Southwestern Medical School, Dallas, Texas MD-724 - Dr. Daniel L, Weiss, George Washington University, Washington, D. C. MD-245 - Dr, Jacob Fine, Harvard University, Cambridge, Mass. m-551 - Dr. W. A, Altemeier, University of Cincinnati, Cincinnati, Ohio m-868 - Dr, James D. McMurrey, Baylor University, Houston, Texas m-732 - Dr. John M, Howard, Gmory University, Ga. (Terminated 31 July 1957) m-892 - Dr, Sidney &hen, Harvard University, Cambridge, Mass. R&D PROJECT CARD ONTINUATION SHEET I. PROJ~tmE I 2. SECURITY OF PROJECT 1 3. PROJECT NO. U 5-59-12 -022 Traumatic Surgery and Shock 4. 5. REPORT DATE . 31 Dec. 1957

Task - Evaluation of Artificial Hibernation and Hypothermia Surgical Research Unit, Brooke Army Medical Center Walter Reed AlTllly Institute of Research, Walter Reed Army Medical Center KD-599 - Dr. Robert D. Dripps, University of Pennwlvania, Philadelphia, Pa. MD-629 - Dr. Lester C. Mark, Columbia University, New York, Ha Y. MD-155 - Dr. E. F, Adolph, University of Rochester, Rochester, N. Y. Im-715 - Dr. Bernard Fisher, University of Pittsburgh, Pittsburgh, Pa, MD-564 - Dr. Michael E. DeBakey, Baylor University, Houston, Texas I-!!-865 - 9.. Everett 0. Grantham, University of Louisville, Louisville, Ky, MD-150 - Dr. Steven M. Horvath, State University of Iowa, Iowa City, Iowa ED-5ll - Dr. Harry M. Vars, University of Pennsylvania, Philadelphia, Pa. i Task - Physiopathology of Shock, Nound Healing and Systemic Responses to Trauma

Surgical Research Unit, Brooke Army bdical Center Walter Reed Army Institute of Research, Walter Reed Army Medical Center Triplex- Array Hospital, T. H. (Terminated 30 April 1957) MI)-038 = Dr. 8, S. Mayerson, Tulane University,, New Orleans, La. ED-750 - Dr. Richard H, Adler, University of Buffalo, Buffalo, N. Y. MD-886 - Dr, Ira A, Ferguson, Ehory University, Ga, MD-666 - Dr. Robert E. Scully, Massachusetts General Hospital, Boston, Mass. MD-545 - Dr. Jaakss B. Caxpbell, Columbia University, New York, N. Y- ID-576 - Dr. Michael E, DeBakey, Baylor University, Houston,, Texas (Terminated 31 Auga5t 1957) MD-597 - Dr. Sidney 0. Brown, Texas QgM Res, Foundation, College Station, Tab MD-747 - Dro John A. Schilling, Oklahoma Medical Reso Foundation, Oklahama City, Okla . MD-?3? & MD-674 - Dr. R. Adams Cowley, University of Maryland, Baltimore, Md. (MD-737 Terminated 30 June 1957) MD-739 - Dr. Sherman Kupfsr , l4t Sinal Hospital, Hew York # No Yo MD-707 - Dr. Lewis W. Bluemle, Jr., Universit.37 of Pennsylvania, Philadelphia, Pa. MD-761 - Dr. David Seligson, University of Pennsylvania, Philadelphia, Pa. MIL523 - Dr. H. T, Ballantine, Jr., Massachusetts General Hospital, Boston, Yasso MD-657 - Mr. Seymour Jablon, National Acadeqy of Sciences, Washington, Do C. (Terminated 30 June 1957) MD-489 - Dr. Wo To Fitts, University of Pennsylvania, Philadelphia, Pa. (Terminated 31 July 1957) 3fD-388 - Dr. David Po Barr, Cornel1 University, bwYork, No Y. (Terminated 31 December 1957) MD-519 d MD-872 - Dr, Abra1ie.n T. Draude, UniversitS of Pittsburgh, Pittsburgh, Pa4 (MD-519 Terminat sd ?:. I)ece!nber 1957) MD-668 - Dr. Charles W, Crumptm, University of Wisconsin, Madisonp Wisc. I 3D 613-1 PAGE 3 Of 4. PT PUCE8 DO FORM 6lS-1. 18 I cu 3s. R60 PROJECT CARD ONTINUATION SHEET 1. PROJECT TITLE I 2. SECURITY OF PROJECT I 3. PROJECT NO. U 6-59-12-022 Traumatic Surgery and Shock 5. REPORT DATE

MD-116 - Dr, Franklin 9. Epstein, Yale University, hTew Haven, Conn. MD-591 - Dr. James J. Smith, Marquette University, Milwaukee, WiSCe ?EL888 - Dr. Joseph S, Barr, Kassachusetts General. Hospital, Boston, Mass. XD-889 - Dr. Petar V. Karpovich, Springfield College, Springfield, Mass. MD-645 - Dr. Gustave J, Dammin, Harvard University, Cambridge, Mass. MD-429 - Dr, John P, Merrill, Harvard University, Cambridge, Mass. MD-697 - Dr, He William Scott, Jr., Vanderbilt University, Nashville, Tenn. MD-769 - Dr. Morton M, Ziskind, Tulane University, New Orleans, La. MD-630 - Dr, Oscar Creech, Jr., Baylor University, Houston, Texas (Terminated 30 April 1957) ND-799 - Dr. Morton D. Pareira, The Jewish Hospital of St. Louis, St. Louis, Mo, e. Background historv and Drozress:

(1) Backerround historv: In order to reduce mortality, hospitalization and permanent disability; and to effect early restoration of the wounded to duty, continuous research in traumatic surgery and shock is necessary. (2) Proareas: Progress is being made in developing methods to repair tissue and arterial defects by use of synthetic fabrics, Of the various fabrics tested, coarse-woven Teflon has been found to be the best.

In addition to its primary purpose of treating acute renal failure, the artificial kidney has proved superior to natural kidneys in removing certain radioactive elements from the body, It has also been proved valuable in removing poisons like barbiturates and bromides from the blood,

One of the major advances in the treatment of long bone fractures is the insertkon of long metal nails into the shaft of the broken bone in a manner that the break is bridged by the nail,

f. Future ~lans: Studies will continue on the mechanimsp effects and control of hemorrhagic and traumatic shock; to develop improved surgical methods for the handling and repair of combat wounds and traumatic injuries; and to determine the causes, prevention and treatment of the complications of traumatic wounds and injuries.

g. References: “See Annual Research Task Summary” h, Modernization code: Not applicable

PAGE 4 OF 4 PAGES 19 TYPE OF REPORT R6D PROJECT CARD Progress REmOIITP SYMBOL

I. PROJECT TITLE 2. SECURITY OF PROJECT 3. PROJECT NO. TI 5-53-12-028 3adiation and Thermal Burns 4. INDEX NUMBER 5. REPORT DATE 31 3ec. 1952 8. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7.4. TECH. OW. 1,Zedica1 Science s Therapeutics AW-6

B. COGNIZANT AGENCY 12. CONTRACTOR AND/OR LABORATORY CONTRACT/ W. 0. NO. Office of the Surgeon General.DX, a. OlRECTlNG AGINCY

i Res. 8i Jhv. Div., OTSG See Item 21d(7) IO. REQUESTING AGENCY

~~~~~~- 11. PARTICIPATION ANb/OR COORDINATION 13. RELATED PROJECTS 17. EST. COMPLPTION DATES RES. nrv TEST

18. FY. FISCAL ESTIMATES 14. DATE APPROVED 58 500X I 12 July 1954 59 550M IS. PRIORITY 116. MAJOR CATEGORY T 550M 1c 7 023

!O. REQUIREMENT AND/OR JUSTIFICATION The large number of casualties expected from atomic explosions presents staggering medical problems. The majority of these casualties will suffer thermal burns, many extensive and severe. A number of the burns will be camplicated by traumatic and/or radiation type injuries Detailed knowledge of the types and combination of injuries, and practical nethods of rescue resuscitation and treatment, which are applicable to a large number of casualties are urgently required. (Pzr UlOf CDGG)

!I. BRIEF OF PROJECT AND OBJECTIVE a. Brief: The objectives of this project are to develop new and improve existing methods for treatment of extensively burned patients; to study potential drugs suitable for treatment of thermal burns of the respiratory tract: to find methods of controlling infection in burned patients; to devise methods of replacing the burned patients skin; and to study nethods of prompt removal of Surn eschars and early closure of burn wounds.

b. Amroach: To study all phases or' burn therapy. These include studies of blood for transfusion, plasma and plasma expanders, renal functions in 5-.arns, metabolism in burns and antibiotics; methods of making homograftd of skin permanently acceptable to the recipient; relationships of hormones, vi%amins, :2. OASD (R6'D) [ SN. CN. C. X. I. C. PAGE PAGES FORM OF 4 DD I APRSI 613 1 IEPLACES DO FORM 613. 20 JAN 52. R&D PROJECT CARD DNTINUATION SHEET 1. PROJECT WILE 2. SECURITY OF PROJECT 3. PROJECT NO. U 6-59-12-028 Radiation and Thermal Burns 4. 5. REPORT DATE 31 Dec. 1957

enzymes and nutrition to recovery processes in the burned patient; and the practicability and feasibility of debriding large full-thickness burns by enzymes and by surgery.

C. Tasks: "See Annual Research Task S~arg"(Pages 130-133; & 142-143) *Treatment of Radiztion and Thermal Burns *hunochemical and Imtnunological Studies of Skin Homografts *Studies of Fluid, Electrolytes, Hormones and Tissue Toxin in kt-ns

d. Other Information: (1) This project consists entirely of scientific research. Number of research tasks - 3. Number of research contracts - 26. (2) Sltandardization item - Not applicable (3) Enff ineering test - loot applicable (4) Operational availability date - Not applicable (5) Same or related items - 4BEx Project Number

Navy Department NM 62 00 00 Medical Problems Related to Ionizing Radiation

Air Force 7756 Air Force Clinical Medicine Atomic Energy Caarmission HW-47500 Eiologg Research Annual Report

Atomic Energy Carrmission UR-491 Pathways and Rate of Hemo- W-7401-Eng-49 globin Catabolism bing Experimental Hemoglobinemia in Swim

(6) Specific review points - Not applicable (7) Item 12 - Contractor and/or Laboratory: Task - Treatment of Radiation and Thermal Burns SWgical Research Unit, Brooke Army Medical Center , PAGE 4 PAGES OD 613-1 2 OF Do maw Sls-1, ;m sa. 21 R&D PROJECT CAR0 INTINUATION SHEET I. PROJECT TmE I 2 SECURITY OF PROJECT I I. PROJECT NO. U 6-5 9-12-028 Radiation and Thermal Burns 4. 5. REPORT DATE 31 1957

Walter Reed Army Institute of Research, Walter Reed Army Medical Center I~zD-447 - Jho Truman Go Blocker, University of Texas, Galveston, Texas MD-726 - Dr. Oliver Cope, Harvard University, Cambridge, Mass. %I)-881 - Dr. James De Telfer, University of Louisville, Louisville, Ky. :4D-689 - Dr. Frank Glenn, Cornel1 University, New York, N. Yo MD-200 - Dr. Carl F. Schmidt, University of Pennsylvania, Philadelphia, Pa. KO-099, MD-759 & MD-904 - Dr. Boyd W. Haynes, Jr., Medical College of Virginia, Richmond, Virginia (MD-435 Terminated 30 June 1957 ; ID-758 Terminated 30 November.1957) Td-725 - Dr, 0. J. Malm, Medical College of Virginia, Richmond, Va. Task - Immunochemical and Imunological Studies of Skin Homografts Surgical Research Unit, Brooke Army Medical Center Walter Reed Army Institute of Research, Walter Reed Army Medical Center >ID-016 - Dr. W. A. Altemeier, University of Cincinnati, Cincinnati, Ohio NIL014 - Dr. Edward L, Howes, Columbia University, New York, N. Yo MD-466 - Dr. Seth W. Smith, University of California, Los Angeles, Calif, (Terminated 31 December 1957) MD-072 - DF. Louis M. Rousselot, St. Vincent's Hospital, Mew York, No Y. MD-646 - Dr. Franklin L. Ashley, University of California, Los Angeles, Calif. ElD-032 - Dr. C. M. Pomerat, University of Texas, Galveston, Texas ND-764. - Dr, William D. Holden, University Hospitals of Cleveland, Cleveland, Ohic Task - Studies of Fluid, Electrolytes, Homones and Tissue Toxin in Burns Surgical. Research Unit, Brooke Amy Medical Center Valter Reed Amy Institute of Research, Walter Reed Army Medical Center MD-607 - Dr. McChesney Goodall, Duke University, Durham, N. C. MD-627 - Dr. James D. Hardy, University of Mississippi, Jackson, Miss. MD-760 - Dr. Boyd W, Haynes, Jr ., Medical College of Virginia, Richmond, Va. MD-571 - Dr. Miles D. McCarthy, Pomona College, Clsremont, Calif. (Terminated 31 August 1957) MD-287 - Dr. William C. Boyd, Boston University, Boston, Mass. (Terminated 31 October 1957) HD-716 - h.. Alfred Deutsch, California Foundation for Biochemical Research, Los Angeles, Calif (Terminated 31 March 1957) %D-628 - Charles L. Fox, Jr., New York Medical College, New York, N, Yo MD-419 - Dr. Jo Thomas Payne, University of Washington, Seattle, Wash. (Terminated 28 February 1957)

*(AFswp Funds) D PROJECT CARD NTlWUATlON SHEET PROJECT TITLE 2 SECURITY OF PROJECT 3. PROJECT NO. U 5-5 9-12 -028 Radiation and Thermal Burns 4. 5. REPORT DATE 31 Dec. 1957 e. Backaround history and Progress:

(1) Backeround histom: As approximately 85% of atomic casualties suffer blast and thermal burns, this is one of the most important medical problems in atomic warfare. Present nethods of treatment are inadequate and improved methods, applicable to large numbers of casualties, are urgently required.

(2) Promess: Present studies indicate that antibiotics are a great help in controlling infection in burns. A new drug known as l'45-50" is being studied as a possible aid in the treatment of thermal burns of the respiratory tract.

f. Future plans : Studies of all phases of burn therapy will continue. Increased emphasis will be placed on the development of methods to prolong the survival of homograft skin on extensively burned patients. Investigations will continue separately and in combination, on radiation; traumatic and thermal types of injuries, which are expected to result from atomic explosions, and to develop optimun and practical methods of treatment with special emphasis on the handling of mass casualties.

g. References: Blocker , Jr ,, To G., Annual 3eport U. So Army Contract No. D.449-007-MD=44'7. See also Annual Research Task Summary

h. Modernization code: Not applicable TYPE OF REPORT 0 VOL SYMBOL R6.D PRQJECT CARD Pro,rrr3ss I m@%6-Y9 I. PROJECT TITLE 12. SECURITY OF PROJECT 9. PROJECT NO. U 5-59-12-029 Artificial Plasma volume Eqanders 4. INDEX NUMBER 5. REPORT DATE

I 31 Dec. 1957--. 1. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB OROUP 7A. TECH. ON. Medical Sciences Therapeutics Alll-6

I. COGNIZANT AGgNCY 12. CONTRACTOR AND/OR LABORATORY CONTRACT1 W. 0. NO. Office of The Surgeon Genera1,DA b. DIRECTING AGENCY Res . & Dev. Div., OTSG See Item 21d(7) IO. REQUESTING AGINCY

11. PARTICIPATION AND/OR COORDINATION 13. RELATED PROJECTS 17. EST. COMPLETION DATES .-.In\yp Deprtnent ( C) RES. 'Liz- ?orce (C) I TEST OP. WAL.

1 1 1 August 1955 g 1c 7.21I --d I IS. REPLACED PROJECT CARD AND PROJECT STATUS I. I

I I !O. REOUIRBYENT AND/OR JUSTlPlCATlON The use of atomic weapons in warfare will produce enormous numbers of militxry and civilian casualties. On an emergency basis there will not be enough blood or blood derivatives to restore effectively the circulating blood volume of these casualties. Stockpiles of a suitable artificial tlshock solution" or artificial plasma volume expander are urgently neededo (Par lllOf C3OG)

!l. BRIEF OF PROJECT AND OBJECTIVE a. Brief: The objective of this project is to develop a cheap, stzble, sa73 and effective artificial plasma volume expander which can be stockpiled in 1,mge quantities.

b. Amroach: To study and evaluate artificial plasma volume expanders, which r~sadministered to animals and humans, to determine the degree of plasma volume expansion, th3 duration of the effect, how %he artificidl substance is eliminated from the body and the undesirable effects of these substances, Substances such as gelatin, oxypolygelatin, sp~theticpolypeptides, polyvinylpyrrolidin (FW), dextran, and keratin are being studied, 4 I OASD SN. CN. C. X. c. j !Z. (R61D) I I I* FORM PAat 1 OF 3 ?A* DD i APRSS 613 PEPLACES OD FORM 81% 211. JAN 82. R&D PROJECT CARD ITlNUATlON SHEET PROJECT TITLE 2. SECURITY OF PROJECT 3. PROJECT NO. U 6-59 -12 -029 Artificial Plasma Volume Expanders 4. 5. REPORT DATE 31 Dec. 1957

C. Tasks: “See Annual %search Task Summary” (Pages 134 li 135 Incl,) *Disposition and Metabolism of Dextran

*Chemical Studies of Oxgpolygelatin, PVP, Polypeptides of Mno Acids as New Plasma Expanders

d, Other information: (1) This project consists entirely of scientific research. Number of research tasks - 2. Number of research contracts - 13. (2) Standardization item - Not applicable (3) Engineering test - Not applicable (4) Operational availability date - Not applicable (5) Same or related items - Not applicable (6) Specific review points - Not applicable (7) Item 12 - Contractor and/or Laboratory: Task - Msposition and Metabolism of Dextran Surgical Research Unit, Brooke hdical Center MD-205 - Dr, StanleyqE. Bradley, Columbia University, New York, N. Ye MD-298 - Dr, Dan H. Campbell, California Inst. of Technologg, Pasadena, Calif. MD-248 - Dr. Paul H. Maurer, University of Pittsburgh, Pittsburgh, Pa. 14D-272 - Dr. James E, Neill, Cornel1 University, New York, N. Ye MD-369 - Dr. Loais G. Welt, University of North Carolina, Chapel Hill, N. C, Task - Chemical Studies of Oxypolygelatin, PVP, Polypeptides of Amino Acids as New Plasma manders

Surgical Research Unit, Brooke Medical Center IES-577 - Dr. W, A, Altemeier, University of Cincinnati, Cincinnati, Ohio MI-710 - Dr. Walter L, Bloom, Emory University, Ga, (Terminated 31 March 1957) MD-880 - Dr. T. G. Blocker, University of Texas, Galveston, Texas MD-219 - Dr. Elkan R. Blout, Children’s Medical Center, Boston, Mass. MD-127 - Dr, Andre Cournand, Columbia University, New York, €4. Y, (Terminated 31 December 1957) m-1I.l - Dr. F. Re Eirich, Polytechnic Institute of Brooklyn, Brooklyn, E- Yo Dept. of Agriculture, Peoria, Ill, - Dr. C. E. Rist, Northern Regional Research - Branch PAGE PAGES 2 OF 3 R&D PROJECT CARD )NTINUATION SHEET . PROJECT TITU 2. SfCURITY OF PROJECT 3. PROJECT NO. U 5-59-12-029 Artificial Plasma Volume Expanders 4. 5. REPORT DATE 31 Dec. 1957 National Bureau of Standards - Dr, S. G. Veissberg (Terminated 1 July 1957)

e. Background historv and rrogress: (1) packmound historv: In the event of atomic warfare a mass of casualties suffering from shock incident to burns, traumatic wounds and hemorrhage dl1 present an immediate problem of profound magnitude, The use of blood and blood derivatives to expand the circulating blood volume in the treatment of shock is a well established surgical. principle. Available supplijs of blood and blood derivatives to meet this emergency would be insufficient. It is imperative that a suitable product or products be developed, which can '09 stockpiled for use as plasma volume expanders in the event of an emergency,

(2) Prowess: Recent reports indicate that dextran is probably the most suitable plasma volume expander now available, Studies on other substances will continue.

f. Future Dlans: Work of investigators will be continued.

g. References: "See Annual Research Task Summa~T"

h. Modernization code: Not applicable

DD tFgL613-1 PAGE 3 OF 3 W TORY 613-1. 26 imsa TYPE OF REPORT RC.D PROJECT CARD REPORT CONTRO/L SYMBOL Progress CSCRD-lo . PROJECT TITLE 12. SECURITY OF PROJECT 13. PROJECT NO. U 6-59-12-030 Slood and Blood Derivatives 4. INDEX NUMBER 5. REPORT DATE 31 Dec, 1957 . BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OBJ. Medical Sciences Therapeutics CONTRACT/W. 0. NO. 12. CONTRACTOR AND/OR LABORATORY E . COGNIZANT AGENCY Office of The Surgeon General,C DIRECTING AGENCY Res. & Dev. Mv., OTSG See Item 21d(7) 3. REOUESTING AGENCY

I. PARTICIPATION AND/OR COORDINATION 13. RELATED PROJECTS 17. EST. COMPLFTION DATES Navy Department (C) RES. Air Force (C) DEV. TEST

14. DATE APPROVED 1 August 1955 65m IS. PRIORITY I 16. MAJOR CATEGORY T 650M 1c 7.23 D. REPLACED PROJECT CARD AND PROJKCT STATUS I

In the event of future warfare with atdc weapons, an enormous number of rnilitary and civilian casualties with burns, traumatic wounds, and wound shock are anticipated. Large quantities of who13 blood and blood derivatives will be needed immediately. There are still many problems inherent in the large scale use of whole blood and blood derivatives. (Par lllOf CDOG)

1. BRIEF OF PROJECT AND OBJECTIVE a. Brief: The objectives of this project are to develop a practical method to prolong the usable life of whole blood or red cell suspensions, an effective, safe method for sterilization of whole blood and plasma to rid them Of hepatitis virus, improved methods for prevention and treatment of bleeding and intravascular clotting, and ways and means of reducing transfusion reactions.

b. Amroach: kent effort is to study the effects of storage, heat- and other methods of treatment upon plasma and plasma substitutes; red and white blood cells and platelets in connection with blood storage, preservation and coagulation; hemorrhagic disturbances and abnormalities of blood clotting; methods &f Dreservinp blood; and effects of transfusions of banked blood. CAsD(R 8 D) [ SN. CN. C. X. 1. C. PAGE OF PAGES 3o I :OP% 6 13 I 4

‘@’L*CcaJhId I- DO CORM 813, 27 I. MOJ~TmE f SECURITY OF PROJECT 3. PROJECT NO. U 6-59-12-030 Blood and Blood Derivatives 4. S. REPORT DATE 31. Dec. 19

I C. Taskg: "See Annual Research Task Summary" (Pages 136 .I 141 Incl.) *Studies of Prolonging the Storage Life of Red Blood Cells for Transfusion. i *Study of Etiological Factors and Methods for Detection and Preventia I of Blood Clotting and Bleeding Tendencies in the Severely Wounded. *Development of Methods to Render Human Plasma Free of the Hepatitis virus do ion: (1) This project consists entirely of scientific research. Number of research tasks - 3. Number of research contracts - 37. (2) Standardization item - Not applicable (3) Enn ineerina test - Not applicable (4) Cbsrational availability date - Not applicable (5) Same or related itemg - 4km9x ProlectBumber Navy Department NR 182-112 Preservation of Blood Cells and Isolation of Plasma Derivatives I I Air Force. 77% Air Force Clinical Medicine

(6) Specific revlew Dointg - Not applicable (7) Item~l2- Contractor and/or Laboratoa: rI i I Task - Studies of Prolonging the Storage Life of Red Blood Cells for Transfusion

Walter Reed Army Institute of ReS€iarCh, Walter Reed Arrny &dical Center MD-553 - Dr. John P. Bunker, Massachusetts General HOSpitd-, Boston, Mass, MD-464 - Dr. Russell A. Huggins, Baylor University, Houston, Texas MD-542 - Dr, Fabian Uonetti, Boston University, Boston, Mass. Mq-693 & MD-894 - Dr, Henry T. Randall, Sloan-Kettering Institute far Cancer Research, New Pork, N. Y. (m-693 Terminated 31 October 1957)

PAGE N DD 1'~~613-1 20F4 -US W FQ(IY 61S-I. 1 mu. 28 R&D PROJECT CARD 3NTINUATlON SHEET 1. PRQIECT TITLE 2. SECURITY OF PROJECT 3. PROJECT NO. u 649-12430 Blood and Blood Derivatives 4. 5. REPORT DATE 31 Dec. 1957 MD-713 - Dr. Robert F, Schilling, University of Wisconsin, Madison, Wisc. MD-611 - Dr. David Re Schwarz, Schwarz Laboratories, Ht, Vernon, Me P. MD-720 - Dr. Alex Id. UUn, Hahnemann Medical College, Philadelphia, Pa. Z.ID-632 - Dr. Lawrence E. Young, University of Rochester, Rochester, NO Y. la-605 - Dr, Beverly W. Gabrio,. Washington University, Seattle, Wash. (Terminated 31 March 1957) MI-699 - Dr. Grant R, Bartlett, San Diego Blood Bank, San Diego, Calif. (Terminated 31 December 1957) MD-160 & MD-762 - Dr. mred Chanutin, University of Virginia, Charlottedlle, Va. (MD-160 Terminated 31 May 1957) m-50% - Dr. Clement A. Finch, Univsrsity of Washington, Seattle, Wash. MD-610 - Dr. John 0, Gibson 11, Harvard University, Canbridge, Mass, MD-534 & Navy Contract - Dr. Robert B. Pennell, Protein Foundation, Jamaica Plain, Mass. MD-SI5 - Dr a Herbert So Kupperman, N .Yo University-Bellevue Medical Center 8 New YOrk, No Ya MD-458 - Dr. Eric H. Ponder, Nassau Hospital, Minneola, N. Y. MD-042 - Dr. Max Ma Strumia, Bryn Maw Hospital, Bryn Mawr, Pa. W-MD-485 - Dr. Elmer Le DeGowin, State University of Iowa, Iowa city, Iowa (Terminated 31 January 1957) -HD-?29 - Dr. John La he, Sloan-Kettering Institute for Cancer Research New Pork, N. Ye (Terxuinated 30 June 1957) Task - Study of Etiological Factors and Methods for Detection and Prevention of Blood Clotting and Bleeding Tendencies in the Severely Wounded

Walter Reed Army Institute of Research, Walter Reed Anny Medical Center ND-l7l - Dr. Benjamin Alexander, Harvard University, Cambridge, Mass. MD-652 - Dr. Charles E, &.amble University of Notre Dame, lotre Dame, Snd. XD-701 - Dr. Frank B. Gardner, Harvard University, Cambridge, Mass. M)-087 - Dr. J. Haskell Milstone, Yale University, New Haven, Corn. MD-195 - Dr, E. T. Mertz, -due University,, Lafayette, Ind.. ED-275 - Dr. John H, Olwin, Presbyterian Hospital, Chicago, Ill. PD-612 - Dr, George D. Penick, University of North Carolina, cnapel Hill, Ne c. (Terminated 31 March 1957) MD-717 - Dr, Walter Redisch, N. Y. University -Belleme Medical Center, New York, Ne P. MD-736 - Dr, S. 'dilliam Ross, University of Arkansas, Fayetteville, Ark. m-64.7 - Dr. Helen Van Vunakis, N. P. State Department of Health, Albany, No Y. MD-198 - Dr. David F. Xaugh, Massachusetts Institute of Technology, Boston, Mass, RID PROJECT CARD )NTIWUATION SHEET I.PROJECT TmE I 2, SECURITY OF PROJECT I 3. PROJECT NO. U 6-59-12-030 Blood-ad Blood Derivatives 4. 5. REPORT DATE 31 hc. 1957 Task - Development of Methods to Bender Human Plasma Free of the Hepatitis Virus

Walter Reed Army Institute of Research, Walter Reed Artps Medical Center MD-551 - Dr. George P. Fulton, Boston University, Boston, Mass. MTL908 - 9.. E. R, Jennings, Wayne State University, Detroit, Mich. MD-614 - Dr. Dwight J. Mulford, University of Kansas, Lawrence, Kans, XD-911 - TIP. Robert Bo Pennell, Protein Foundation, Jamaica Plain, Mass.

8. Backmound historv and mogress:

(1) The increasing need for large quantities of whole blood and blood derivatives required for treatment of burns, traumatic wounds and for use in new bold techniques of surgery has presented many problems. Blso in the event of warfare with atomic weapons, an even greater need for blood wfll exist.

(2) Promess; Army Medical Service investigators have shown that a hepatitis-fbe plasma can be prepared by partial fractionation and heat treatment for ten hours at 600 C. The addition of substances known as inosine and adenosine to whole blood has prolonged survival of red blood cells. Studies with platelet transfusions and other recently discovered blood-clotting substances are being continued. It is nuw reasonably certain that pooled plasm can be rendered free of infective hepatitis virus by storage in the liquid state at 32' C, for six months and possibly for shorter periods.

f. Euture ~lans: Work of investigators will be continued.

g. References: "See Annual Research Task Summary"

E h. Modernization code: Not applicable

DD ,Fm613-1 PAGE 4 OF 4 PAGB ~m~~lum FORM SISI. TYPE OF REPORT RGD PROJECT CARD Progress R.f@J&jC-yp SYMBOL

1. PROJECT TITLE I 2. SECURITY OF PROJECT 19. PROJECT NO. TJ 6-60 -0110 02 CJin~calInvestigations 4. INDEX NUMBER 1. REPORT DATE 31 Dece19.57 5. BASIC FIELD OR SUBJECT 17. SUB FIELD OR SUWECT SUB GROUP 7A. TECH. OW. Investigations, Authorized I PO-16 I B. COGNIZANT AGENCY 12. CONTRACTOR AND/OR LABORATORY CONTRACT1W. 0. NO. Office of The Surgeon General,DA 1. DIRECTING AGENCY See Item 21d(7) hse & Dtj~eMv. OTSG IO. REOUESTINQ AGENCY

I 1. PARTICIPATION AND/OR COORlblNATlON 13. RELATED PROJLCTS 17. EST. COYPLKTION DATES RES. DIV. TEST or. EVAL. 18, FY. FISCAL ISTIMATES 14. DATE APPROVED 58 2.5M 5 January 1953 59 234 15. PRIORITY 16. MAJOR CATEOORY T 29-1 1c 7 023 19. REPLACED PROJECT CARD AND PROJECT STATUS

tjs win’xch oclh LO. REQUIREMENT AND/OR JUSTIFICATIO~ 01 tne cuseasFS an- yrsmel require difficult procedures for diagnosis, htrieate and exac- methods of tTeahent, and often long period8 of rehabilitation, After treatmnt and rehabilitation have been completed, each individual patient mclst be carefully evaluated to deterrafne his fitrress for nrilitarg duty, For some, only a Mted type duty will be possible; for others, discharge or retirement for medic39 reasons wili be in order. It is essential that diagnostfc methods, thmapeutic procedures 4 r&aMiiization programs in all A~IIWhospitals be constan5y impro?red and re- Vf3ed Li mder to assure the be& possible medical care for milftaq patients in xmmmmmne snortest periua ox sum e 17; 2.9 s-ab -1 Lo *LtU.ze the best available criteria, and to constant.l.y *rove and expand these criteria for determining physical and inentdl fft;nes to prforn mi1i.t.q duty, R.ssearch 21these areas is designed to decrease patZsnf 5ospiital s%a;r and t.9 return nore patients to militaryj duty, Lhus effecti-ng a sav5ng af m&.Li%ary man- WJW. (Par I~~CICcDcG)

T1-q 3RI3F OF EWJECT AM) 03.J3CTIm: R&D PROJECT CARD )NTINUATION SHEET PROJECT TmE t SECURITY OF PROJECT 3. PROJECT NO. U 6-60-01-002 Crinj.qaJ. Investigations 4. 5. REPORT DATE 31 Dec.1957 est&Esh better criteria for detemLn5q physical ar,d inental fitness for military duty,

'0, Amroach: Clinical investigs5ions are SeZng conducted on patients at various Arniy hospitals i? illl effort to hiprove pwt.isnt carer by developf-% and improving di-nostic methods, therapeutic techniques and rehabilitation procedures*

cJ Ta.aIc: "See Annual Research Task Sw;lmary," (Page 75) *Clinical Investigations de Qther Information:- (1) This project comes under the category of significant scientrfic researchg EJder of research tasks - 1, Nwnber of research contracts .. 0,

(3) &gineerim Test: - Xot a.pplicabla (4) -rational AvWIhaDat.9: - Not applicable

(7) ~terzu Contractor and/or Laboratory: Valter Reed iLmy Medical Center, Washington, D. C, Vallez- Forge byiiospital I P:ioenkwille, Pa, bt;tmnan Arxy Hospital, San rR~mcfsco, California 3~okaAxmy Xospital, Brooks Amy Iledicat Center, Fort Sam gouston, Texas

60 &$&.po?md Histom dmwQj(1) moundEistorv: Yi patients in Arw hospitals have diseases and injuries, t:hich are peculiar to or are much mors prevabnt in military personnel than Ln the civilian population. mj hospitals now contain a malt21 of clinical mtorid which3 if adequately st;ixKed, should provide valuable new infomation which would great3y aid in the solntLon of myof those military medical problsms. In addition, the inakwa- tion Gf a fonnal and integrated, clinical investigation program at various Arrrry kospitds, provides a great stimulus to medical. offi,cel-ss especially young interns and residents, and affords them opportunity to 2articipate in important militw inedLcd rosearch. Tile ultimate aim of this project is to reduce the hospital stay of patisnts in hospitals, to return wure patients to active military duty, and to clarify and refine the medical. criteria for discharge and retirement for rr'l rwI. DD ,gk 613-1 PAGE 2 OF 3 Pm

00 FollM 6lS-1. 32 t mm.

i 10 PROJECT CARD ~MTlNUATIOijSHEET . PROJECT TlTLE 1 2. SECURITY OF PROJECT I 3. PROJECT NO. U 6-~0-01-002 Zlinical Investigations 4. 5. REPORT DATE 31 Dec, 1957

(2) Progress: This project is designed to develop greater creative productivity, technieal interest, and competence nithin the Army Medlcal Service. New methods and materials are evaluated, The abundance of clinisal material available affords an tmusual opportunity for clinical investig2tions of diseases and injuries peculinir to the military.

f, Future Plans: To improve diagnostic methods, therapeutic procedures and rehabilitation programs in Army hospitals by adopting, after carefd. and controlled evaluztion, the latsst scientific information pertaining to diseases of militarj importance.

g. References: “See Annual Research Task Summay“ h. Modernization Code: Not applicable TYPE Of REPORT R& D PROJECT CARD Progress "wcfiBN'fPgLSYMBOL

1. PROJECT TITLE 12. SECURITY OF PROJECT IS. PROJECT NO. U I 6-60=09-012 4. INDEX NUMBER I 5. REPORT DATE 31 00~~1957 6. BASIC FIELD OR SUBlECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OW. Illtend. &&cine ?le tabolic PO-1B 8. COGNIZANT AGENCY 12. CONTRACTOR AND/OR LABORATORY I CONTRACTIW. 0. NO. Qi'fice of The Surgeon Gener 9. DIRECTING AGENCY See Item 21d(7)

10. REQUESTING AGENCY

II. PARTICIPATION AND/OR COORDlNATlON IS. RELATED PROJECTS 17. IST. COYPLITION DATW 2'2J.S;. (c) RES. !,lr 3xze (c) DEV. TEST OP. $VAL. 11. FY. flSCAL ISTIMATIIS 14. DATE ArPROVED 58 8OOX u. July 1955 59 850H f6. YMOR CATKBORY 15. PRIORITY T 85ON le 7.23 19. REPLACED PROJECT CARD AND PROJECT STATUS

I I 20. REOUIREMENT AND/OR JUSTICICATION Abrio-vi metabolic alterations occurr;ing with adverse climatic and erw5.romentzl factors at the tiii of the soldier's illness or 5njury impose I iidditional inrpediments to his recovery and convalescencec (Par l4lOc CDOG)

El. 8RIEF OF PROJECT AND OBJECTIVE a, Sfief: To study the requirements of macronutrients (fat, carbohydrate atxi prcf;ein) and the micro-nutrients (vitdn and mineral) in soldiers severely bjumd or ill, 3. AxnDach: Studies are designed to delineate essential and significant mkibo3.c dezmgements and their relaticqnshipsto wound healing and recuperation fcl?.m.iLng disease and injury. e C. Tasks: "See Annual Xesearch Task sum mar^.^' (Pages 76-79 aCl.1

I I i !2. OASD (RslD) I SN. CN. C. X. 1. c. i FORM PAGE 1 OF 4 PAQZS DD 1~~~55613 -1. ?LPLACES DD fORM 613. 24 ID PROJECT CARD INTINUATION SHEET . PROJECT TmE I 2 SECURY OF PROJECT 3. PROJECT NO. 6=60-09 412 S. REPORT DATE 31 Dec,1957

*Metabolic Aspects of Trauma, Severe Illness and 1"klnutrition *DeveloPmnt of Effective Nethods of Correctirg Xetabolic Disorders

do Other Infomation: (I) This project includes importmt scientific research taskso Number of research tasks - 2. hnber of research contracts - 38.

(3) E€J€&mr5.m Test: - mot applicable (4) Ooerataaal Availabilitv DateL - Not applicable (5) 5- or Re1.ated Items:

k?&Wx Pro-iect 110, Proiect Title , Air Force 7756 Air Force clinical Kedicine 1na9-277 Tracs Elements in Biological NONR-186604 S;lrstems (6) S=cj3b Review Points: - Not applicable (7) ztem 12 Contractor and/ or Laboratoa

Metabolic Aspects of Trauma, Savere Illness and Xblnutritfon U. S, Army [email protected] Medical Research Laboratoq, San Juan, ?,Re Walter Reed Army Institute of Research, Walter Reed knqy Xedical Center, UD-772 - Dr. Neal S, Briclcer, lkshington University, St. Louis, Missouri Ia-bE31 - Dr. Win, A. Erodsky, University of Louisville, Keatuclqy UD-662 - Dr. Wm. W. Burr, Jr., Southwestern Ihdical School of University of Texas ~~&Z- Dr. Wm. B. Castle, Harvard University, Cambridge, Nass. iiD-781 - Dr. Tho- C. chalmers, Hanrard University, Cambridge, Xass, I-D-698 - Dr. tbn. E.. Cornatzer, University of North Dakota, Grand Forks, N.D. w37= Dr. John Do Cradord, Harvard University, Cambridge, Mass. 1*&702 - Dr. WendeLI E, GMfith, University of California, Los Angeles, Calif. ('Terminated 30 June 1957) m-592 - Dr. Frederick W. Hoffbauer, University of Fiesota l9=513 - Dr. Stdey It. Levenson, Bkdicd College of Virgida, Ridmond, Va. I'a-636 = Dr. Carl A. &pr, Wasfiington University, St, Louis, NiSSOuri. (Termina.ted 31 May 1957) RBO PROJECT CARD R&D PROJECT CARD NTINUATION SHEET PROJECT TITLE I I SECURITY OF PROJECT I 3. PROJECT NO.

Requbed trater intake is of the greatest importance to ;urvivd. Tmder adverse cliatic conditions. Atteztppts are being made to establish the water reqairemnts of the soldier under catastrophic environment-d. .conditions as well as in spec-Sic diseases or injuries.

f, FuWe Plans : To obtah a rnore fundamental *mderstmdii?E: of the metaboUc derulgmeiits in severe injury and diseass ad to develop effective inethods for correcting these ixetallolic abnomalitles

e* Refarences; '#See Research Tas!c Sv," h. Ikdernizaticm Code: - Xot applicable TTPC Of REPORT RbD PROJECl CARD Progress I. PROJECT TITLE 12. SECURITY OF PROJECT IS. PROJECT NO. 3 6-60 -10-c1G .I 4. INDEX NUMBER S. REPORT DATE 31 Dec.1957 1. BASIC FIELD OR SUBJECT 7. SUB flELD OR SUBJLCT SUB GROUP 7A. TECH. OW. IJeuropsychiatry L I!ewology PO-15

12. CONTRACTOR AND/OR LABORATORY CONTRACTIW. 0. NO.

B. DIRECTING AGENCY

11. PARTICIPATION AND/OR COORDINATION 1% RELATED PROJECTS 17. UT. COMPLETION DATES RES. DEV. TEST OP. LVAL. 18. Cy. I FISCAL KSTIMATLS

IS. PRIORITY 16. YUOR CATEGORY 1c 7.23 19. REPLACED PROJECT CARD AND PROJECT STATUS

LO. REOUIREMENT AND/OR JUSllflCATlON Since neuropsychiatric disorders in niX.tary peu'soimd. represent one of ths iwst i.xportant and pess-bs ned5.cal problem in the Arqy today, ai urgent require- rnmt for tPis research ehsts. It is considered essent-id. that techniques be dsvdoped to effectively reduce the large manpotrer losses resultline; from neuro- p,sychiaWic casualties Adequate methods for the identification 05 potmtial neuropsgahLatris casualties as wen as ef Zectit-e therapeutic measures that will r~stor~:Athe largest possible number of personnel to du5y in the shortest perid of the m~t.be developed. (Pzr 1420h SDCG) Ll. BRIEF Of PROJECT AND OBJECTIVE

z0 BPlisf: This is a scientific project md vas initiated to identify the fimdamntd. physiologic and psychodynamic factors and Int3rrelzkionship of the f;ic tc.rs which Froduce neuropsychiatric clisorders e Subseq-wit Lz ident Ffica.tim or' the pert:irien-i, factors invo?-vsd, qqmpriate methdrs znd techniques will. be deV?hpc?dl.rhi$h idll pen;licY altera5'Yion of these faztors

REPLACES DD FORM 61% I JAN 82. i RLD PROJECT CARD NTlWUATlON SHEET ~ I PROJLtT TlTLE 2, SECURITY OF PROJECT 3. PROJECT NO. U 6-60 =lo9016 I I fJeuropsychiatry 4. 5. REPORT DATE 31 Dee. 1957

bo @moa&: An analysis has been made of a variety of diagnostic techniques and therapeutic procedures and of the underlying principles involved in their use. This approach has involved both laboratory experhenta- tion with animals and clinical study of hospital patients. The causes of psychiatric disorders in the military have been studied by use of sociome*W.c techniques, psychiatric interviews, and by measurement of the behavioral changes accrulng from the experimental manipulation of the interpersonal relationships involved,

C. Tasks: "See Annual Research Task Siimmary." (Pages 58 - 60; & 220) *Development of Methods for Prevention of Psychiatric Disorders

r)evelopment of Methods for Diagnosis and Therapy of Psychiatric Disorders

' rdentification of Neurophysiological Factors Related to Psychiatric Disorders

d. OtherInfmnation: (1) This project includes important scientific research, Number of research tasks - 3. Number of research contracts - 33. (2) 'zation Item - Not applicable (3) ~in@3rixwTest - Not applicable (4) s&ssti-Ay*- 't~Date - Not applicable (5) same* Related Itew - Mot applicable (6) cific Revl'm Paints - Not applicable (7) Pa 12 - contractor andf or Laboratom - Task - Development of Xethods for Prevention of PsychiaMc Disorders \falter Reed Arqy Institute of Research, Walter Reed Army Medical Center United States Military Acadmy, West Point, N, Yo H3-569 - Dr, F'red E. Fiedler, University of Illinois, Urbana, Ill. la-754 - Dr. Edgar H, Schein, Massachusetts Institute of Technology, Cambridge, Mass i m-685 - Dr. William A, Caudill, Harvard University, Cambridge, Mass. (Terminated 30 September 1957) RBD PROJECT CARD INTINUATION SHEET I. PROJECT TlTLE 2. SECURITY OF PROJECT 3. PROJECT NO. U 6-60-10-016 Neuropsjchie.try 4. 5. REPORT DATE 31 Dec, 1957 KD-6;11 - Dr. Jack 1.. Vernon, Princeton University, Princeton, X. J. MD-634 - Dr. James R. Miller, Universitj of Kichigan, Ann Arbor, Mich. (Terminated 31 August 1957) Task - Development of Hethods for Diagnosis adThergpy of Psychiatric Disorders

Walter Reed Antry Institute of Research, Walter Reed A.mu. bdical Center XD-74.6 - Dr. 5Jilliam G. Reese, University of Arkansas, Little Rock, Ark6 ?.TD-734 - Dr. C, Wesley ihtson, New England Center Hospital, Boston, Mass. MD-672 - Dr, Morton Reiser, Albert 3instei.n College of 14sdicine, Yeshiva Unit-ersity, New York, J, (Terminated 31 Decm5er 1957) m-620 - Dr, Raymond N. Czttell, University of Illinois, Urbana, Ill. (Terninated 31 July 1957) Task - Identification of Neurophysiological Factors Related to Psychiatric Disorders

Walter Reed Army Institute of Research, Walter Reed Arqy Medical Center XD-763 - Dr. Kzrl Pribram, Jr., Institute of Living, Hartford, COM. 1-D-740 - Dr. David Nachmmsohn, Columbia University, Mew York, Ne Y. ND-902 - Ttr. Donald L, Burnham, Xashington School of Psychiatry, Washington, D4C. Eng-459 Dr. Roy R. Grinker, Michael Reese Hospital, hisago, Ill. (Terminated 31 July 1957)

eo Backmound history aRd Promess:

(1) Bachround historv: These studies were initiated to conduct investig-tions and study data to determine the interrelationship of many psycho- dynanic factors which produce neuropsychiatric disorders 2nd the possible 1 measures wb-ich might act as preventztives. By tracing out the electro- physiological aspects the nervous system and measuring simultaneously the ! of correlative behavioral aspects, it will be possiSle to understand and eventudLly control s~meof the underlying factors in psychiatric disorders.

(2) Progress: Studies so far have included investigation of various dFug effscts, especially epinephrine and nor-epinephrine, 3.nd an intensive follow-UP of schizophrenic pdAsnts who have been provided with "milieun therapy. Investig2tions 3avs recently been completed concerning the Kappa component of human brain waves which showed a direct relation to mectal activity in that ! proportion of thz population in which the phenomenon is neasurable. studies have Seen iaitisted on animals to deternine the nerve pathways employed and the brain cells which are activated when pain impulses arrive in the central nervous

I PAGE 3 OF 4 PMip 3D 1's"w 613-1 Dwo W mY618-1. 5s. 4.0 m 1

J R1D PROIECT CARD DNTINUATION SHEET 1. PROJECT TITLE 2. SECURITY OF PROJECT 3. PROJECT NO. I 6-bo-10-016 Meuropsychiatric 1-4. I s*31 Dec.DATE 1957 system from the body surface., Studies of former prisoners-of-war have been conducted and follow-up studiss x-2 in progress to determine the present adaptive behavior of thase men. Data from these studies ad from studies correlating personal and social factors existing prior to militarJ service with performance after entering service -are in the process of being analyzed 2nd interpreted.

f, Future ulans: To develop informltion relrting to tne factors under- l-fing neuropsjchiztric $disordersad specificZLl7 those that are the result of the many stresses imposed on the soldier as a consequence of his rigorous training and combat experience. Further, therapeutic measures approprizte to the nilitary situation must be developed, Studies will continue to identify the czusative mechanisms of ti18 grezt manpower loss resulting from n8uro- psphiztric casudties and to develop prophylactic, therapeutic and rehabilitative measures for them,

g, References: "See Annual Research Task Sumary" h. Modernization code: Not applicable

DD lxL613-1 PAGE 4 OF 4 PAGES 41 TYPE OF REPORT RGQ PROJECT CARD vs.,.,,..... r, REP!J$T,_C;ON'?$OL SYMBOL . I_._ ..i*-' ',...*LilJO,') I. PROJECT TITLE It. SECURITY OF PROJECT 13. PROJECT NO.

3' 7 .f LT .,A - ec v1.3.;. 7. SUB FIELD OR SUWECT SUB GROUP 7A. TECH. OBJ. I POd.5

CONTRACT/W. 0. NO.

I I. PARTICIPATION AND/OR COORDINATION 13. RELATED PROJECTS 17. EST. COMPLETION DATES -, RES. .- . I '. DEV. .- ? . I ,-\ -.-. . ',+.J TEST

14. DATE APPROVED

15. PRIORITY 16. MAJOR CATEGORY

-I (7 .l.J 9,2"?4 19. REPLACED PROJECT CARD AND PROJECT STATUS ~ R&D PROJECT CARD NTlNUATlON SHEET , CROJm TITLE 2 SECURITY OF PROJECT 3. PROJECT NO.

~ U 6-60-lo-017 stress 4. 5. REPORT DATE

for measuring the effects of stress. Investigations are also relating the principal physiological and erwiromnental dete-ts of psychological stress to their behavioral conconbtants,

C, Tasks= "See Annual Research Task Summary." (pages 80, 172, & 221) *The Biocheanistcry of Stress *Basic Phpiological Mechanisms of Stress *The Mornnental Deterndnants of Stress d, Other Information:. (1) All. the tasks of this project come under the category of significant scientific researc% Number of research tasks - 3. Number of research contracts - 14. (2) s- ion Item:. - Not applicable (3) Exrainesri,pg, Test: - Not applicable

(4) &&%%.A-a 'tv DatG 0 Not applicable (5) ias-or elated Items:- Not applicable (6) SRe cific Re* Points : - Sot applicable (7) ZCt= 32.- Contractor an d/or IaboratoE Task - The Biochedstrg of Stress

MDdW I Dr. Ralph I. Dorffnan, Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts MD-I30 - Dr, Thomas F. Dougherty, University of Utah, Salt Lake City, Utah -38 - Dr, Fred Elnadjian, Worce&er Foundation for Experimental. Biology MD-13J.k - Dr, Fred L, Engel, Duke University, Durham, North Carolina MDdl3 - Dr, Henry M. Fox, mardUniversity, Cambridge, Massachusetts MD-341 .. Dr. Thomas F. Gallagher, Sloan-Kettering Institute for Cancer Research I?ew Pork, New Pork YD-204 - Dr. l4aJ.com W, Gordon, The Institute of Liw, Hartford, Conn. 14lIJt96 n Dr, James II, Hardy, University of Pennsylvania, Philadelphia, Pa. -24 - Dr, Ehgene t/4 Landis, Haward University, Boston, Mass. MD486 - Dr, Hans Selye, University of Montreal, Montreal, Canada -5 - Dr, George W. Thorn, Harvard University, Cadridge, Mass.

DD 613-1 PAGE 2 OF 3 PAGES mucp w mu.la-1, 43 R&D PROJECT CARD DNTlNUATlON SHEET 1. PROJECT TITLE 2. SECURITY OF PROJECT 3. PROJECT NO. U 6-60-19-017 Stxass 1. REPORT DATE

e, 3ackTr4mnd s.t,;ry mci Trwress: (I) Eac?g~*~~mdIYsLb= These stwkies were Lnitiatcd to obt& infomz.?.i.oz for ccjlilpWatfve experihental analysis 3.r behavior under stress, Effsrts have beer. made to detomhe and ;?rovi.de a cofi- stmctfve means to mdiQ efhcts d' stresss Considerable effort has &so been mads to ;xnders*xmd the body's reaction to stressful sitcations and to at;txnpt to ?remnt, if possible, or treat, if necessary, the stressed soldier ar2d prepare him t:, F!b%w20 (2) fronress; Somd teckzfiques for ?.he extmneljr accwatc xr.eaSswernent sf certain substances occurring ia tts blood and wine, such as adrendir,s, nor- adi?ena%k=, and other Frod3CtS elaborated by the adrend. have been deveiosd, 1nkt;i.d f-bcEnp inLdicate titat, duodenal ulcers my be demonstrated in anixds sub- jected to laboratorj induced stress Soiio, relationsifips bekeen beitavio?al stress %nrpnseti IC;- sustained avoidance behatrior and g~stro-Lntestina1patholaw have been establishedr Certain effects of aLrrts sleep bep5.vation upon physiologisal and pq~hr;log5-ca.lprocesses have been tenta5ively ident'Lfied

f, Ehxe p1.9,~:To obtain Wonnatiosl pertabiing to atresJful situations ocrmring in soldiers 3u.r- rigorous +yra.inLng ~ts'.c! ~cmbat; to acquire more funria- ,wctal krmwledge rehtj-ve to tne basic mechanims bvol.red i? adapting to the s;tmssfd.situations encoixiitered in military Lfe; arid to develop therapettic tscLniqv.es for t'ne coatrol of coi5bat stressed soldiers, in order thzt +hey may be retuned to early effective duty.

Ge Rcfsrences: "See Arnual Xsseazch Tazk Sa%r8qrb'I TYPE OF REPORT C NJ'ROL SYMBOL R&D PROJECT CARD Progress I 7?!P%l-Po I. PROJECT TITLE 12. SECURITY OF PROJECT IS. PROJECT NO. TJ k-60-11-020 Ihutrition 4. INDEX NUYBPR IS. REPORT DATE 31 Dea. 1957 1. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUWULCT SUB GROUP 7A. TECH. OW. &dicaJ. Sciences Nutrition PO-1%

I. COQNIZANT AGENCY 12. CONTRACTOR AND/OR LABORATORY I CONTRACT/ W. 0. NO. <. )ffice of The Surgeon Genera1,DA I. DlRECtlNQ AOLNCY

Res. t Dsv. 3iv., OTSG , .See Item 21d(7) '0. RCOUESTINO AQENCY I 1. PARTICIPATION AND/OR COORDINATION 1% RILATED PROJECT8 IT. EST. COY?LITION DATES RES.

3-c (P&C) OW. us.:y (c) Tin USN (s) OF. IVAL.

14. DATE APCROVED 11 July 1955 IS. PRIORITY 1 16. MAJOR CATIOORY - I 7.23 I 9. RLPUCLD CROJECT CARD AND PROJLCT STATUI

!O. REOUlREYENT AND/OR JUSTIFICATION Adequate nutrition is a prime necessity in maintaiaing the health, efficiancy and morale of the soldier, especially in combat or under adverse environmental conditions as well as in severe illnesses and injuries. (Par 1410~CDW)

L1. BRIEF OF PROJLCT AND OWLCTIVI a. ljrief: The purpose of this project is to assure the adequacy cf th3 5012Ler1sdiet under dl conditions thzt he may be expezted to effieisntly yeerfom; 30 determine the nutritional factors involved in hepatic. injury $ad zthar diseases 'celievgd to be of malnutritimal origin; and to pr9vLde suitable flt -omds5ons for intravenous supplemsntal alimentation to seriously ill or 11?.$1-~edyztiants umb13 to maintain proper caloric ictske b3; mouth.

3, .%n.oroach: To study tne soldier's caloric .vihnlr. and xhnral Teqdr9- 73::ts in health and disease undFr all conditions that he may SC expected to o>lsrite 5-3 to d&.a,-mine safe dosage for intr?.vsno-iLsl:T adrninistsring fat %uisims :.rhsn such tl?eraDy is indicated. 2.OASD (R@D) [ SN. CN. C. X. I C. - PAGES

I. 4 7

R&D PROJECT CARD MTINUATION SHBET 1. PVJPCT TITLE L SECURITY OF PROJECT U -60-11-020 Nutrition I 4. 5. REPORT DATE

c, Tasks: '%e8 bnual Research Task Summy" (Pages 31 - 82) *Deterxination of the Soldier's Caloric, Vitamin adKinera1 Requirements in all Envirmmentzl Conditions

*Development of Suitable Fat Ehillsions for Intravenous Adainistration to Saverely Injured or I11 Patients

d, Othar Informatian: (1) This project consists entirely of scientific research tasic5, some of which include furthr refinament of an item, Number of research tasks - 2, Number of research contracts - 10, (2) Standardization item: Not applicable (3) Enaineerine: test - Not applicable (4) (herational availability date : Not q$icable

(5) Sane or related items: bencx Project Nun& Title

OgIG 7-84-01-002 Radixtion Preservation of Food

WG 7-83-01-004 Operational Effectiveness of the $$!-Equipped Soldier

(5) aecific review Doints - Not applicable (7) Item 12 .. Contractor mdor Lzboratorv - Task - Determination of the Soldier's Caloric, Vitmin and Mineral Rsquirements in all Environmental Conditions

Hedical Nutrition Laboratory I Denver Colorado FD-978 - Dr Paul Gyorgy , University-of Pennsylvaniz, Phila1 elphia, Pa. KO-524 - 3r, Harc11.i G. Wolff, Cornell liniversitj, New Pork, h', Ye C#4 Contract - Dr, Ancel Keys, University of Winnssota, Minneapolis, Minn,

3D 613-1 PAGE 2 OF 3 ru Wucm OD FOaY 61s-1, 46 m ua. RID PROJECT CARD INTINUATION SHEET . PamTITLE I SECURITY OF PROJET 3. PROJECT NO. U 6-60-11-020 Nutrition 4. 5. REPORT DATE 31 Dec. 1957 Task - Development of Suitable Fat Emulsions for Intravenous Administration to Sevgrely Injured or Ill Patients

Medical Nutrition hboratory , Denver, Colorado Department of Agriculture, Agricultural Research Service, New Orleans, La. MD-659 - Dr. Gerald H. Becker, Michael Reese Hospital, Chicago, Ill, MD-879 - Dr. Isidore Cohn, Jr., Louisiana State University, New &leans, La. MD-048 - Dr. Frederick J. Stare, Harvard University, Cambridge, Mass. MD-548 = Dr. No~mapF. Xitt, University of Colorado, Boulder, Colo. MD-ZjZ - Dr. John 8. Youmans, Vanderbilt University, Nashville, Tern-. MD-905 - Dr. Hugo 7. Koeller, University of California, SmFrancisco, blif. MD-800 - Dr. John Fe Mueller, University of Cincinnati, Cincinnati, Ohio e. Backmaund histom and ~ro~ress:

(1) Back=- d historv: This project was initiated to:&sstlre the adequacy of the soldier's diet under all environmentd. conditions under which he may be expected to operate and to provide suitable fat emulsions for intravenous administration to seriously ill or injured patients unable to maintain proper caloric intake b~mouth. Studies are referred to the Advisory Committee on Nutrition for advice, comment and recommendations. This committee is composed of eminent civilian scientists in the field of nutrition.

(2) Promess; A mitable fat emulsion has been developed for intravenous administration which does not provoke serious untoward reactions in the patient. Nutritional investigations will continue. The ever

changingf* pattern-=P=- o dietary intakes, the problems of food additives and preservation of fob3 other than conventional process requre constant surveillance in order to assure that members of the Amed Forces receive a properly balanced end adequately nutritious ration.

Although a I?+emulsion has been developed for intravenous administration under room temperature conditions, efforts will be made to develop a fat emulsion that can be used in arctic climates.

g, Referencles: Y3ee Annual Research Task Smary"

h. Modernizgtion code: Not applicable TYPE OF REPORT RGD PROJECT CARD 7- rrogrsss . PROJECT TITLE I 2. SECURITY OF PROJECT IS. PROJECT NO. TJ 5-60 -13 -016 4. INDEX NUMBER 1. REPORT DATE 31 Dec. 1957 I. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OW. ::s iicsl Scisnces Tierqeutic s PO-14

1. COGNIZANT AGENCT 12. CONTRACTOR ANDf OR LABORATORY CONTRACTlW. 0. NO. Off: ..m af The Surgeon Geners1,D: I. DIRECTING AGENCY 35s. c9 De~eXV., CrrSS 0. REQUESTINO AGENCY

1. PARTICIPATION AND/OR COORDINATION 1% RELATED PROJECTS 17. EST. COMPLItlON DATlS RES. DLV. TKST OP. EYAL. 18. FY. FISCAL ESTIMATES 14. DATE APPROVED . 58 5 3.: 21 1951 59 5% 16. MAJOR CATIOORY ,T 5 31”: 7-23 IO. REPLACED PROJtCT CARD AND PROJECT STATUS

I I !O. REQUIREMENT AND/OR JUSTIFICATION Ts avaluate new drugs md .znti’Diotics in the treatment of ciiseases and Lnfsztions, (Par l4lOc CDOG)

!l. BRIEF OF PROJECT AND OBJECTIVE 3risf: This is a scientific Froject and tha studies are conducted to *,-,.,-.z~ic:!Xy ” md eqerinentslllj test and evaluate new &up and antibiotics in ... . ,- IB .:li-cis’n;rlxxis X-L! trestnent of various diseases ?..nd inzsctions

!2. OASD (RbD) I SN. CN. C. X. I. C. FORM PAGE 1 OF 3 PAGES DD IAPRS~613 I. n y.0 ?hPUCLe OD FORM 01s. R&D PROlECT CARD MTlNUATlON SHEET PROJECT TITLE I 2. SECURITY OF PROJECT I 3. PROJECT NO. U 6-60-13-016 Rew Drugs and Antibictics 1. 5. REPORT DATE 31 Dec.1957 mechanisn of atibiotic induced lysis of bacteria, grata inhibitialls and coordinated bachrial. biosynathcsis of nucleic acids and proteins in the treatmnt of parasitic diseasOsn (3) Rasearch ad evduation continues on the dermatologic usefulness of naphthoquinmes and related compouncls,

*New Drugs and Antibiotics

d. Other Infm, ti.03: * (1) TUS project includes important scientific research. Nmber of research tasks -1, Number of contracts - 0. (2) wrdi.sation Ita: - Not applicabla (3) maJ?se~ine: Tesk:. - not applicable (4) omp@.&&&A- i13 +,y Date : - Not applicable (5) -SI : - Not applicable (6) s=c3f ic Rervir3w Paints: - Xot applicable

(7) Item 12 .I bntractor and/or Laboratory: Task - New Drugs and Antibiotics Surgieal iieszarch Unit, Brooke Arxqy Nedical Center, Furt Sam Eouston, Texas Walter Reed Institute of Research, Walter Reed Army Medical Center, Washington, De C,

eo * 3istoffy and Pro- z (1) &- Hi stom: A large number of new drags and antibiatics are constantXy be- developed and offered to the medical- ~ofession numy aseases ami Often in the treatment of w~5.e~. these drugs and ?dmra.pe!uticagents are enthusiwtieally endorsed and acckimed as "cure-alls", hcrwesrerr, eamful clinical testing, in instances, discloses unfavorable rsaet&ons and wideme that fails to substantiate the previous enthu- siastic endorsemmt. This project was initiated to evaluate experiment* and Chically new chgs and antibiotics in the prophylax=is ad treatment of various diseases and infections .,

(2) (1) Furtther studies on the mtifungal. aqtibiotic are being evaluated in advanced histophsmsis,. ccccidiaidcmycosis and cryptococcGsis humans'. (2) Studies are continuing on canrpomdz which have been screened for actipity against mature infect,ions of Schistosoma- in mice* (3) Evduatim

- PAGE OF PAG,CS 2 3 49 RID PROJECT CARD DNTINUATION SHET 1. PROJECT TITLE 2. SECURITY OF PROJECT 3. PROJECT NO. U 6-60-13-016 New Drugs and Antibiotics 4. 5. REPORT DATE 31 Dece1957

of dermatologic usefulness of naphthoquinones and related coxpounda has led to a better understanding of chemical principles behind topical therapy of skin disoders associated with faulty keratinization.

fr) Future Planst To conwe the evaluation of new drugs and antibiotics in the treatment of diseases and infectians.

gi Referen cas:. "See Atkiual Resozrcb Task Summary." ha Modernization Code: - Not applicable

PAGE 3 OF 3 Pm DD ,fgk. -_ 613-1 wuctl Do ?ann 61a-1. 50 I msa. TYPE OF REPORT R6D PROJECT CARD Pronre s s 1. PROJECT TITLE I 2. SECURITY OF PROJECT I 3. PROJECT NO. U 6-60-13 -017 Internal Medicine 4. INDEX NUMBER S. REPORT DATE I 6. EASIC FIELD OR SUBJECT 7. SUE FIELD OR SUBJECT SUB GROUP 317A. TECH.Dec. OW. 1957 f.!edical Sciences Therapeutics PO-16 I I a. COGNIZANT AGENCY 112. CONTRACTOR AND/OR LABORATORY I CONTRACT~W. 0. NO. Offics of The Surxeon General,DA, B. DIRECTING AGENCY Ras. 8: Dev. Div., OTSG See Item 216(7) 10. REOUESTINO AOENCY

I I I I. PARTICIPATION AND/OR COORDlNATlOW 13. RELATED PROJECTS 17. EST. COMPLLTION DATIS Navy (5) Ais Fmce (c) 1- TEST

io. FY. FISCAL ESTI~ATES I4DATE APPROVED 58 &&7pr 12 July 1954 59 urn II. PRIORITY 16. MAJOR CATEQORY T wcr;lJ 1c 7.23 IB. REPLACED PROJECT CARD AND PROJECT 8TATUI

I I 10. REOUIREYCNT AND/OR JUITIC1CATION There is a requirement to investigata and to dsvelop methods for the prevention and treatnent of a wide array of ,lseasos o5served in soldiers, such as, gastro-intestinal disorders, livsr and renal comglications following infectims diseases, tuberculosis, ,ad diseases of the skin. (Par 1410c CDOC)

11. EllLC OF PROJECT AND OUECnVE a. grief: To investigate and svaluate the causes of secondary or complicating conditions occurring in infectious diseases ?and disorders and to devslop inproved netkads for the prevention and treztmnt of skin diseases.

b. Amroach: Studies we being pursusd regsrding the nature of infectious diseases in order to block coFlicstions in the early stage of the disease. Sfforts -6 being made to determine ths bsr>e -.rtd nunbor of isoniacid resistant, nutants of the.tabercule bacilli, as well as the serum and body fluid con- csntrations of antituberculous drugs necesszry to destroy the causative organisas. A detailed sta?y is being nx€e of the metabolic pathways cmcerned

, R&D PROJECT CARD INTINUATION SHtET I. PROJECT TITLE 1 I SECURITY OF PROJECT I 3. PROJECT NO.

.. U 6-50-13-017 Internal Medicine I 4. 1. REPORT DATE

in skin 4isorders, In addition promising therapeutic agents for prevention Tn5 t,reQt*nsiitof skin disorders are under study and evaluation,

co Tasks: "See Annual Research Task summary" (Pages 95; 84-86 BCl,) *Investigations of Peptic Ulcer, Circulatory and Renal Complications of Infectious Diseases

*Basic Mechanisms Involved in Chronic Skin Diseases Encountered in the Tropics

d. Other information: (1) This project consists entirely of scientific rgsearch, Number of research tasks - 2, Number of research contracts - 14.

(2) Standardization item - Not applicable (3) Enginebrim test - Not applicable (4) Operational availability date - Not applicable (5) Same or related item - Not applicable (6) Specific review points - Not applicable (7) Item 12 - Contractor and/or Laboratom?: Task - Investigations of Peptic Ulcer, Circulatory and Renal Complications of Infectious Diseases

Walter Reed Army Institute of Research, Walter Reed Amw bdical Center USAF Antilles Comrnand National Bureau of Standards, Washington, D. C, Tropical Medical Research Laboratory, San Juan, P. R. Fitzsimons Army Hospital, Denver, Colo. ED-874 - Dr. H, Vasken Aposhian, Vanderbilt University, Nashville, Tenn. FD-601 - Dr. Julius M, Coon, Jefferson Medical College, Philadelphia, Pa. m-676 - Dr, Bernard .M. Wagner, The Children's Hospital, Philadelphia, Pa. R&D PROJECT CARD ONTINUATION SHEET 1. PROJECT TITLE 2 SECURITY OF PROJECT 3. PROJECT NO. U 5-60-13-01? Internal Medicine 1. 5. REPORT DATE 31 Dec. 1957 Task - Basic Mechanisms Involved in C'nronic Skin Diseases Encountered in the Tropics XD-595 - Dr. Herman N, Eisen, Vashington University, St. Louis, €40~ :!D-154 - Dr. Donald E. Pillsburj, University of Pennsylvania, Philadelphia, Pa. KD-694 - Dr. Thomas H, Sternberg, University of klifornia, Los hgeles, Cfiif. PiD-731 - Dr. Harvey Blank, Universit27 of Iliami, Miami, ?la. XD-573 - Dr. Herbert H. Johnson, Western Reserve University, Cleveland, Ohio (Tsrminated 31 December 1957) XD-730 - Dr. Walter C. Lobitz, Jr., Hitchcock Foundation, Hanovsr, N. H. ID-584 - Dr. Herman Pinkus, Wayne State University, Detroit, Nich. MD-411 - Dr. Stephen Rothman, University of Chicago, Chicqgo, Ill- ND-153 - Dr, Maurice Sullivan, Johns Hopkins University, Baltimore, Hd. MD-753 - Dr. Marion B. Sulzberger, N. Y, University-Bellevue Medical Center, New York, 11. Y, ED-640 - Dr, Xerbert Eescon, Boston University, Boston, Nass. (Teminatsd. 31 Kay 1957 1 e. Backwound historr and x)rogress:

(1) Backmound history: These stu.=lies were initizted to investigate on ?. broad front the infectious and degenerative diseases of military significance, Mseases of the skin, the cardiovascular-renal system, snd ths gastro-intestinal tract have been of particular interest in these studiss because of the important rOl9 they play in causing military noneffectiveness.

(2) Promess: It has been established that factors other than high gastric acid production are responsible for the establishment of peptic ulcer condition in soldiers. Streptmycin and isoniacid provide for the first the effective control and treatment of tu'oerculosis. It has been demonstrated that the amount of histamine released from mast cells of t'ne skin, the ability of the skin to metabolize nutrients, hormones and chemical substances vary in different skin areas of the body. These findings ma7 2ccount for the site of predilection of certain skin diseases and skin sensitivifq reactions.

f. Future Dlans: To clinically investigate a wide array of diseases observed in soldiers such as peptic ulcer, circulatxy .md renal coqlications of acute infectious diseases,

2. References: Wee Annual Reseamh Tesk Sunrnary"

h, Xodernization code : Not ap?licable - PAGE 3 OF 3 PAGES DD ,Zk 613-1 WESW FORM 6lS-l. 53 ' mB sa. TYPE OF REPORT RGD PROJECT CARD Pr s yess I. PROJECT TITLE 12. SECURITY OF PROJ rJ 6-51-01-004 A r c L hnt-1 1 '?r~un.x 4. INDEX NUMBER 5. REPORT DATE 31 3eco 1957 (1. .,BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OW. 3,fL:: -1 3clq7(>*~s Invsat iz T.t ion, hthcx-1 zed PO22

(1. COGNIZANT AGENCY 12. CONTRACTOR AND/OR LABORATORY CONTRACT~W.0. NO. C" rice of The Srr? :eon Ceriaral, DA 9. DIRECTING AGENCY ??S, ?: 3?V. 910. OT% 10. REQUESTING AGENCY

11. PARTICIPATION AND/OR COORDlNATlON IS. RELATED PROJECTS 17. .EST. COYPLETlON DATES RES. .,!?,2 (rx) DEV. TJYY (2) TJ,:,', (2) I OP. NAL. 10. FY. CISCAL ESTIMATES

9 July 1951 15. PRIORITY 16. MAJOR CATEOORY . 1c 7 e23 19. REPLACED PROJECT CARD AND PROJECT STATUS

I I 10. REQUIREWENT kND/OR JUSTl?lCATlON Accidental trautna in the services is the major case of man days lost. This study is aimd at eliminating factors which cause accidents wh,prever possible. (Par i410b C3OG)

21. BRIE? OF PROJECT AND OBJECTIVE

ri. - Fais is 2. scisntific projact to evaluate tne rohtive import.ance af vvious C;?'.ISSS of injury to ~Llitarypersonnel, 2nd to develop and test --e...-,- (- ...,..i din-

:,., ,!,>?>? -n o,ch: * 3 Three separate approaches Ire in proqress: (I) Study cf t?..3 :csc'::nriicai factors in mtomotivP design responsi53.s for acci.3ent.s and i,4iJ1iry;(2) spz.ce-t.irne rlistributfon of accidents around representative nilitrj ?,os-ts: w? (3) the psyc:?~~yicaipeculierities of drivers ~hohave frequent

~~ ~~ CN. C. X. 1. C. PAGE 1 OF 3 PAaIs DD i:O,%SlS REPLACES DO FORM 613. 54 RID PROJECT CARD INTINUATION SHEET 1. PROJUT TlTLE 2 SECURITY OF PROJECT 3. PROJECT NO. U 6-61-Ol-OorC Accidental Trauma 4. 5. REPORT DATE 31 Dec, 1957 c* -Tasks: “See Annual Research Task Sutumary” (Page 96) *Factors in Vehicle and Highway Design Responsible for Accidents, . Injury and Death

*Personal and Interpersonal Factors in Driving

d, Other Idormation: (1) This project consists entirely of scientific research. Number of research tasks - 2. Number of research contracts - 6. (2) Standardization item - Not applicable (3) Engineering test - Not applicable (4) herational availability date - Not applicable (5) Same or related itemq - bency Pro.) e ct Number Title Air Force 6361 Development of Survival Equipment

Air Force 7752 Medical Flying Safety Navy Department NM 15 00 00 Aviation Safety, Escape and Rescue

Navy Department NR 118-782 Crash Injury Research (6) Specific review points - Not applicable (7) Item 12 - Contractor and/or Laboratory Task - Factors in Vehicle and Highway Design Responsible for Accidents, Injury and Death

William Beaumont Army Hospital, El Pasor Texas MD-166 - Dr, .Ross A. McFarland, Harvard University, Cambridge, Mass, MD-483 - Dr. Walsh McDernott, Cornell University, New York, Ne Y.

PAGE 2 OF 3 PAGES DD 613-1 I. PROJECT TINE 2. SECURITY OF PROJECT 3. PROJECT NO. U 5-51-01-004 Accidental Trauma 4. S. REPORT DATE 31- Dec 1957

Task - Personal and Interpersonal Factors in Driving ~~-876- Dr. Jack '11. Dunlap,Dunlap & Associates, Inc., Stamford, Conn. YD-502 - Dr. Herbert S. Gzskill, University of Colorado, Denver, Colo. FD-887 - Dr. W. A. Tillmann, St. Joseph's Hospital, London, Ontario, Canada CAA Project No. 53-209 - Dr. Pster J. Sutro, Civil Aeronautics Medical Research Laboratory, Solumbus 10, Ohio - Joint project with BuMed, Air Force, I-, 2nd CAA

e, Bxkaround history and orocress:

(I) Rackaroimd histow: Accidental trauma is a major cause of death and injury in ':ot3 clvilim and militwy personnel. The lzrgest proportion results from land operated aotorized equipmsnt, frequently when the driving personnel ar9 in an off-duty status. A review of accidental. trauma in the services rsvsals tli.at a vaq serious problem exists. Accidents ranked first of the ten leading causes of aan days lost in the U. So Navj during the past four years. Similar trends have been reported by the Army and Air Force. Current statistics indicate that even in combat areas, accidents account for about one-half of ths hospitalized casualSies; this was true of the Korean campaign, vith approximatel;. 70$ of the accidents being vehicular in nature. Research has been directed chiefly toward autmotive zccidents, however, both industrial accidents in milit?y arsenals 2nd aircraft accidents are also receiving attention,

(2) Prozress: Basic concepts of causation have been established in the i zutomotive fisld, and these hgpotheses are being tested by small scale applicatory studies of control methods. As hypotheses me confirmed, the control i aethods are expsctsd to find vide application in the military and the civilian ! accident fields, where correctivs actions have long been based on opinion 2 rather tfic...n fact. ,i f. Future p1,m.s: Continued studies xi11 be made designed to yield resirlts which will assist in the prevention of accidents and thus reduce the toll of dee.th, injury and disability from this cguse. The scope of these studies will include application of the eFidemiologica1 ayproach and the consideration of the environment-host-agent-factors to determine how they c2.n be successful1;r nodified, controlled or nmipulatsd.

g. Rsferznces: "See ilnnual Zesearch Task Smmary" i h Kodernization code : Not a??licable I !

DD 613-1 WLACZS 09 FORM 6SS-I. 56 I mm sa. meOF RIPORT RBD PROJECT CARD C pSTROL SYMBOL Progress I rn3-fO . PROJECT TITLE I 2. SECURITY OF PROJECT 13. PROJECT NO. U 6-61-01 -0 06 Gem-Free malStudies 4. INDEX NUMBER s. RamRT DATE 31 Dec. 1957 I. BASIC FIELD OR SUBJECT 7. sun FIELD OR suwecr SUI GROUP 7A. TECH. OW. Prevsntive Wedicine Investigation, Authorized PO-14

I. COGNIZANT AGENCY I2.CONTRACTOR AND/OR LABORATORY CONTRACTIW. 0. NO. Office of The Surgeon General.DA 1. DIRECTING AGLNCY See Item 21d(7) Bes. & Dev. Div.. OTSG 0. REOUESTlNG AGINCY

13. RELATED PROJECTS 17. KIT. COMPLETION DAWS RES. DEV. TLrr OP. WAL. IS. fY. I FISCAL ESTIMATLS 14. DATE ACPROVID 5d 27M 12 July 1954 54 low 18. ?RlORlTY 16. MAIOR CATLWRY -04 1c 7.23 0. RCPLACIO.,tRO.JICT CARD AND PROJECT STATUS

I I 0. RLOUlRCMINT AND/OR JUSTIFICATION

"Germ-free" animals are a unique tool and their usefulness in medical rssearch needs to be thoroughly explored. (Par l4lOc CDOG)

1. BRIEF OF PROJICT AND OUCCllVL a. 2rief: This is a scientific project with an objective to raise gern- free animals. ?fork on this project includes the application of ge-m-free 2xpeAmentaltechniques to current problems in the areas of communicable diseases, acute respiratxy diseases, inmunology, nutrition, surgical shock, and related are2 s . 5. Aunroach: These studies involve the comparison of events in two l;rmFs of mimals; me, gem-free and the other, conventional laboratory stock. Stu?i,?s are being; made to determine whether, ;znd if so to what extent, the process under study is influenced by the normal bacterial, fungal and viral f 7""p-

2. OASD (R gl D) SN. C. X. 1 '. C. PAGES DD i'P,!s613 PAGE 1 OF 3 'cPUCICS DO FORM 01s. 57 JAN 52. I. PROJECT Tina 2 SECURITY OF PROJECT 3. PROJECT NO. U 6-61.0l-Oo6 Germ-free Anixal Studies I 4. 5. REPORT DATE I 31 Dec. 1957

C. Tasks: "See Annual Research Task Summary" (Page 39) *Use of Germ-free Animals in Studies of Diseases

d. Other Information: (I) This project consists entirely of scientific research. Number of research tasks - 1. Number of'research contracts - 3.

(2) Standrirdization item - Not applicable (3) Encineerifia test - Not ag$icable (4) kerztional avai1abilit:r date - Not applicable (5) Same or rehted item - ArrencL Proiect Number -Title

M2.v~ Department NM 63 00 00 Preventive Medicine

(6) Snecific review goints - Not applicable (7) Item 12 - Contractor and/or Laboratory - ! Walter %sed Army Institute of Research, Walter Reed Army Medical Center I MD-3 - Dr, Paul Gyorgy, University of Pennsylvania, Philadelphia, Pa. ND-878 - Dr. Philip C, Trexler, University of Notre Dame, Notre Dame, Ind. 1 Navy Contract - Dr. J. A. Reyniers, University of Notre Dame, Notre Dame, Ind. NR 131-067 - "See pp 346 Annual Research Task Surmnary Om, 1 Jan 1957" 1 e. Backmound histors and sromess: (1) Backmound histow: Since the "germ-free" animal can serve as a very valuable tool in militzry medical research, it was deemed essential that additional facilities be acquired for the production of such animals. Until the past yelrr, studies have been hampered by unpredictable failures in equipment of accessories which have contaninated groups of experimental animals requiring terminstion of experiments before they were completed. The entry of the WRAIR and the University of Pennsylvmia groups into this field has provided a powerfd stimulus to the development of newer and more efficient equipment to prevent i these accidents. i (2) Proeress: Techniques are being developed to make more efficient i 1 use of the equipment available by minimizing the requirements for breeding space. i New, less eqensive plastic germ-free holding tanks are being evaluated for i DD 613-1 PAGE 2 OF 3 d ImAcEa 00 FORM 61s-I, 58 I msa.

I. . .,! . kD PROJECT CARD )NTINUATION SHEET I. PROJECT TITLE 6-61-01-006 Germ-free Animal Studies 5. REPORT DATE

general use. A number of nutritional and infectious disease studies have been completed during the past yaar, and the results have indicated that there are significant differences between germ-free and conventional animals.

f. Future alans: Xork is actively continuing and may be expected to be increasingly more productive now that aost of the major nechanical problems have been solved. Continued research on germ-free animals is essential to the investigztions of many problems of infectious diseases due to various agents, including viruses. This is a unique development which must be exploited,

Q. References: "See Annual Research Task Summary" Reyniers, James A., Am. Jr, of Vet. Res, Vol. XVIII, No. 68, July 1957 and Cincinnati Jr. of Ked. 38:417-424, 1957. h. Modernization code: Not applicable

- PAGE 3 OF 3 PAGES DD 613-1 W FORM 6lS-1, 1-m 59 R&D PROJECT CARD R ogres s 1. PROJECT TITLE 12. SECURITY OF PROJECT IS. PROJECT NO. U 6-61 -0 3 -0 35 Communicable Eseases 4. INDEX NUMBER 5. REPORT DATE I 1.31 Dec. 1957 E. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OBJ. Prevsntive i&di.cine Communicable Disease PO-14

B. COGNIZANT AGENCY 12. CONTRACTOR AND/OR LABORATORY 1 CONTRACT/W. 0. NO. Cfr'ice of The Surgeon Genera1,DA D. DIRECTING AGENCY lies. & Dev. Div., OTSG See Item 21d(?) 10. REQUESTING AGENCY

I I 1. PARTICIPATION AND/OR COORDINATION IS. RELATED PROJECTS 1 17. CST. COMPLmON DATES LIB (C) I RES. I DEV.

14. DATE APPROVED 58 1.020l4 1 August 1955 59 1.080M 11. PRIORITY 16. MAJOR CATEGORY T 1.080:.! 1c 7 a23 IO. REPLACED PROJECT CARD AND PROJECT STATUS

!I. BRIEF OF PROJECT AND OBJECTIVE a, Erief: This is a scientific project and the object is to conduct sfu32es in the fisld, clinic, hospital and laboratory of diseases caused by lnfectiolis agents, under broad programs for specific groups of such agents, to innrsve know~edgeof their epidemiology, etiology, control, prevention and treatment .,

bo Amroach: Studies are conducted by both epidemiologic investigation ,3.nd labc.ratoq7 analysis of viral, rickettsial, enteric, parasitic, and other infectious diseases. Present efforts are being made to svaluate and determine the biochemicd and metabolic pathways of various drugs being utilized in the treatment of these infectious diseases. !2. OASD (R@D) I SN. CN. C. X. 1. I c.

uv PEPLACES DD FORM 813, I JAM 82.

I I R&O PROJECT CARD 3NTINUATlON SHEET 1. PROJECT TITLE 2. SECURITY OF PROJECT 3. PROJECT NO. 6&1~)7-035 Communicable Diseases 4. 5. REPORT DATE 31 Dec. 1957

C. Tasks: "See Annual Research Task summary" (Pages 87; & 97-102 Incl.)

*Prevention and Improved Treatment of Parasitic Infections in Man

*Prevention and Improved Treatment of Viral and Rickettsial Infections in Man

*Prevention and Improved Treatment of Bacterial Infections in VI de Other Infosnation; (1) This project consists entirely of scientific research. Number of research tasks - 3. Number of research contracts - 52. (2) Standardization item - Not applicable (3) Enizineerina test - Not applicable (4) berational availability date - Not applicable (5) Same or related items - Apency Prod ect Number Title

Navy Department NM 52 00 00 Investigation of Epid&ologg Etiology,.Pathology, Diagnosis and Prevention of Communicable Disease

Navy Department EJR 130-225 Concurrent Effect Between Virus and Bacteria in Enteric Infections

Navy Department NR 389-083 Studies in Medical Geography

Air Force 7752 Air Force Preventive Medicine DHEW F'H Grant E-939 (C2) Character of the Formosan Strain of Schistosoma jaDoni cum

Studies of Enterobacterial Antigens and Hemoagglutination

(6) Snecifie review Dointg - Not applicable

DD 613-1 PAGE 2 OF 5 PAGES R&D PROJECT CARD

I. PROJECT TmE I SECURITY OF PROJECT 3. PROJECT NO. U 6-61-03435 Communicable Diseases 5. REPORT DATE I I I 31 Dec. 1957 1 (7) Item 12 - Contractor and/or Laboratom -

Task - Prevention and Improved Treatment of Parasitic Infections in Man 1

Walter 9eed Army Institute of Researchp Walter Reed Army Medical Center Tropical Research Medical Laboratory, San Juan, P, R, Fourth Army Area Medical Laboratory MD-633 - Dr, Paul C, Beaver, Tulane University, New Orleans, La. ED-692 - Dr. Nathan Entner, New York Univsrsity, New York, N. Ye Ya-516 - Dr, Robe+ M, Lewert, University of Chicago, Chicago, Ill. YXl-688 - Dr. Jose F. Mzddonado, University of Puerto Rico, San Juan, P. Re MD-595 - Dr. J. Wister Meigs, Yale University, New Haven, Conn. ED-891 - E&. P'itsura Nakamura, Montana State university, Missoula, Mont. MD-771 - Dr, Morris F, Shaffer, Tulane University, New Orleans, La. MD-604 - Dr, Henry van der Schalie, University of Michigan, Ann Arbor, Mich. MD-530 - Dr. Thomas H, Weller, Xarvard University, Cambridge, Mass. Task - Prevention and Improved Treatment of Viral and Rickettsial Infections in Man

Walter Reed Army Institute of Research, Wdter Reed Army Medical Center MD-566 - Dr, Uf S. Alving, University of Chicago, Chicago, Ill. MD-175 - Dr, Frederik B, Bang, Johns Hopkins University, Baltimore, Md. 1*fE-338 - Dr. Rodney 3. Beard, Leland Stanford Junior University, Stanford, Calif. ID-649 - Dr. R, S, Diaz Rivera, University of herto Rico, San Juan, P. R. KID474 - Dr, John F. Enders, The Children's Hospital, Boston, Mass. ED-602 - Dr, Ross L. Gauld, National Academy of Sciences, Washington, D. C. (Terminated 30 September 1957) XD-705 - Dr. Irving Gordon, University of Southern California, Los Angeles, Calif, XD-OZ9 - Dr, McD. Harmon, University of Pittsburgh, Pittsburgh, Pa, MD-687 - Dr. Robert P. Hanson, University of Xiscansin, Madison, Wisc. 14D-022 - Dr, Albert V. 'aardy, Florida State Board of Health, Jacksonville, Fla, ID-062 - Dr, Paul Havens, Jefferson Xedical College, Philadelphia, Pa. Kl-071 - Dr, Werner Henle, Children's Hospital, Philadslphia, Pa. MD-281 - Dr, Marshall Hertig, Gorgas Memorial Institute of Tropical and Preventive Medicine, Inc., Yashington, D. C. MD-655 - 9.. Car1 M. Johnson, Gorgas Memorial Institute of Tropical and Preventive Medicine, Inc ., Washington, D. C. (Terminated 30 June 1957) MD-792 - Dr. Gerald A, Lo Grippo, Henry Ford Hospital, Detroit, Mich. Navy Contract - Dr. J, No May, American Geographical Society, New York, N. ye ND-243 - Dr, George S. Mrick, Johns Hopkins University, Baltimore, Md. I*XLOjO - Dr. Robert F. Norris, University of Pennsylvania, Philadelphia, Pa. XD-rC3l - Dr. Jean Oliver, Research Foundstion of State University of New York, Albany, hT, (Terminated 30 September 1957) Ye 4 PAGE 3 OF 5 'q DD 8'2- 613-1 ruruQI DO FORM 6lS-1, 62 I rn sa. RELD PROJECT CARD DNTINUATION SHEET 1. PROJECT tm 2. SECURITY OF PROJECT 3. PROJECT NO. U 6-61-03-035 Communicable Diseases 4. 5. REPORT DATE 31 Dec. 1957 XD-065 - Dr. John R. Paul, Yale University, New Haven, Conn. MD-690 & XD-691 - Dr. Winston Price, John Hopkins University, Baltimore, Md. (MD-690 Terminated 31 July 1957) ND-777 - 3r. J. J. Quilligan, Jr., College of Medical. Evangelists, Los Angeles, Calif. KD-059 - Dr. Albert B. Sabin, Children's Hospital Research Foundation, Cincinnati, Ohio MD-055 - Dr. John C. Snyder, Harvard University, Cambridge, Mass. WD-307 - Dr. Zdward De Vagner, College of Medical Evangelists, Los hgeles, &l.if. XD-477 - Dr. Robert Ward, New York University, New York, N. Y. ED-616 & BID-617 - Dr. Francis C. Wood, University of Pennsylvania, Philadelphia, Pi. (Terminated 30 June 1957) ED-751 - 9.. T. E. Woodward, University of MarJland, Baltimore, Md. Task - Prevention and ImFroved Treatment of Bacterial Infections in Man Tropical Research Medical Laboratory, San Juan, P. R. ??alter Reed Army Institute of Research, Walter Reed Army Medical Center KD-776 - Dr. Victor B. Arean, University of Puerto Rico, San Juan, P. R. (Terminated 31 July 1957) MD-711 - Dr, EXgar E. Baker, Boston University, Boston, Mass. MD-515 - Dr. 'dilliun Balamuth, University of California, Berkeley, Calif. ED-202 - Dr. R. S. Benhm, University of Chicago, Chicago, Ill. (Terminated 31 Jmuary 1957) >ID-547 - Dr. Francis S. Cheever, University of Pittsburgh, Pittsburgh, Pa. PiD-603 - Dr. Gustave J. Dammin, Harvard University, Cambridge, Mass. MD-756 - Dr. William W. Frye, Louisiana State University, New Orleans, La. MD-864 - Dr. Paul Fr3mont-SmithI Harvard University, Cambridge , Mass . MD-639 - Dr. Quentin M. Geiman, Leland Stanford University, Stnford, Calif. HD-638 - Dr. Karl F. Meyer, University of California, Berkeley, Calif. HD-321 - Dr. Joseph C. Olson, University of Minnesota, Minneapolis, Minn. ND-280 - Drn Walter D. Tiedeman, University of Michigan, Ann ilrbor, Mich. la-896 - Dr. Ralph H, Weaver, University of Kentucky, Lexington, Ky. e. Backmomd histom and Dromess:

(1) Backaround histom: These studies were initiated to conduct research on viral, rickettsial, enteric, parasitic and infectious diseases of dlitarg importance which are a hazard to troops operating in all areas of the world. These investigations provide information and data on which to base effective aeans of control for prevention and treatment in reducing military noneffectiveness.

PAGE 4 OF 5 PAGES DD 613-1 00 fORM 6IS-1. I m sa. 63 R&D PROJECT CARP INTINUATION SYET I. PROJECT TlnE I 2. SECURITY OF PROJECT 1 3. PROJECT NO. -61-03-035 5. REPORT DATE Comunicabla Diseases I 4.

(2) Prosress: Vork with Roc& Eountain spotted fsver and its tick vector has fully confirmsd a f.ct thzt 8 blood meal for ths tick significantly increases the virulsncs of the orgmisn. Considerable progress h;?s been mzde in the collzction of lsta on ths protection afforded by a nsw avirulent, live epidemic tl-phus vacclne in volmtesrs. Progress has been macle in selecting chemicals for incorporatim into crea:iis which will afford protection against schistosomiasis, Oral propbykctic medicstion, similsr to malaria prophylaxis with chloroquine is being studied, Dsvelopment of nav tissue culture techniques in the manufacture of po1iom;;elitis vxcine now xj- sake it possi'ole to produce other virzl vaccines in lorse qurmtities by tissue culture. Definite progress has bsen m&e :&thin the last two yeas in in vitro cultivation of the agent of amebic dysentery. Sensitive diagnostic tests for this disease appear to be feasible vithin tha Rext few years.

f. Ynfiuture vluls: It is planned to extend present studies on ~liseasesof grmt im?ort,ance to the Army in world-wide operations. Research will be continue( to st.aa? the cause, epideniolog znd control of diseases of inilitary significance

g, References: "See Annual Research Task Sumnzry" h Nodernization Code : Not applic5ble

PAGE 5 OF 5 PAGU 3D lzw613-1 LMCES DO WRY SlS-1. 54 f€l ss. i I I, TYPE OF REPORT RCD PROJECT CARD Progress . PROJECT TITLE I 2. SECURITY OF PROJECT IS. PROJECT NO. U 6-61-03-035 Acute Reqiratomj Diseases 4. INDEX NUMBER S. REPORT DATE 31 Dec. 1957 1. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OW. Medical Sciences Communicable Diseases PO-14 I I. COGNIZANT AGENCY 12. CONTRACTOR AND/OR UBORATORY CONTRACT1 W. 0. NO. 3ffice of The Surgeon General,DA I. DIRECTINS ASINCY Res. & Dev. Div., OTSG See Item 21d(7) 0. REOUESTING AQEWCY

~~ ~ I. PARTICIPATION AND/OR COORDINATION 13. RELATED PROJLCTS 17. EST. COUPLETION DATES us11 (V?) DE- USAT (c&P) DEV. TEST (c) - DE{ (W) OC. WAL. 18. fY. FISCAL ESTIMAILS 14. DATE APPROVED 58 770M 1 August 1955 59 87OFI IS. PRIORITY 18. MAJOR CATISORY T 870M 1c 7.23 9. REPLACED PROJECT CARD AND PRQlECT STATUS

0. REOUlRCUINT &ND/OR JUITIFICATION Acute respiratory diseases are a continuing major cause of man-days lost. It is essential that aggressive research in this field be conducted to exploit new leads which may provide better contrcll and preventive methods. (Par 1410b CDOO)

I. BRIEF OF PROJECT AND OBJECTIVE a. Brief: To conduct studies in the field, clinics, hospitals, and laboratories of acute respiratory diseases to improve our knowledge of their epidemiology, etiology, control, prevention and trsataent.

b. Amroach: Research studies are being cxcrried on 'oy both eqerhentai studies, frequently utilizing human volunteers, and egidemiologic investigation and laboratory analysis on outbreaks of influenza, acute respiratory, and streptococcal diseases in militwy md othsr personcel. Information md data are being collected and studied on ths mechanisms leading to th4 developnent of the immune state in man and aninals.

ILPUCCS DD CORM 615. 65 JAN 6%. R&D PROJECT CARD DNTINUATION SUEET 1. PROJECT Tin4 2. SECUR!'Y OF PROJECT 3. PROJECT NO. U 6-61-03-036 Acute Respiratory Diseases 4. 5. REPORT DATE 31 Dec. 1957

C. Tasks: "See Annual Research Txsk Summary" (Pages 103-106 IncL)

*Prevention and Improved Treatment of Adenovirus Infections Adenovirus Vaccine

*Prevention and Improved Treatment of Influenza

*Prevention and Improved Treatment of Streptococcal Disease

d. Other Information: (1) This project consists entirely of scientific research. Number of research tasks - 3. Number of research contracts - 31.

(2) Standardization item - Not applicable (3) Emineerinn test - Not applicable (4) Operational availab2lity date - Not applicable (5) Same or related items - 4llWzLY Pro.iect Number

Air Force 7753 Air Force Preventive Medicine Navy Department NM 52 00 00 Investigation of Epidemiology, Etiology, Pathology, Diagnosis and Prevention of Communicable Disease

DHEW 89-T-4 Development of New Materials and Techniques for the Control of Arthropod Vectors of Disease

187 -T -51 Development of Materials, Equipment and Methodology for Control of Communicable Diseases

DHEN 90-~-40 Development of New Materials, Techniques, and Equipment in the Control of Insects Important to Public Health

! RLD PROJECT CARD CONTINUATION SHEET -.-. .._. . ..-.- -.- . .. ’ . ’ OF ! ‘it; :L.Y

U . ..--- .5-51-03 . -. .I -036 Acute ,RespirztorjDiseases I-->. i. Rt’!’Oi?T DATE :1 D9c. 1957 -e.--- ..------..---..---- I

‘dater Reed -4my Institute of Ressgch, ‘dLLt.$r Reed hny Xedical Center >;D-727 - 9ro Fr3d 14. Davenport, UnLversitT of Michiqz, Ann Arbor, Eich. 13LL121 - Dr. EIar~jF. Dovling, UniversitT of Illiiiofs, Chicago, Ill.. EEL067 - I)r. Thomas Frazcis, Jr., Vnivsrsity of Kichig&q, Ann Arbor S“Ucho 1-3-703 - Dr. Edwin 2, Xilbourne, Cornel1 ‘;niversit;r, Ithacap N. Y. W-XD-kS!: & !!I)-898 - Dr. Edwin H. knnette, Calif. State Department of Public R9dt4h, Bsrkeley, Calif. IS)-212 - boClqrtcn 03, Loosli, Uniwrsit:j of Chicago, Chicago, 111, ::3&51 - 3, KDert P, IdcKee, State Univarzit7 of Tcx, Iowa city, Iowa t3-5CS - k. Themas P. Magill, State University of New York, Brooklyn, Ne Y. ( Terminated 31 January 1957 ) ‘9-22’4 -= Er, Gordcr? Xeiklej&n, University af Colorado, Dsnver, Colo . lP-7CL: - Dr, ‘XilliDan J, Xogabgab, Tdane University, New Orleans, La, 3ID-4?3 - ?&.A. F. Ramussen, Jr. , Uniwrsit~rnf California, Los Anzeles, Calif, X3-37 j - Er. Juiius So Youncer, Ucivei.sLtg of PittsSurgh, Pittsburgh, .Pa. Tssk - Preventi-an and Inproved Treatz?nt oP SfreptDcoccal Disease I. PROJECT TITLE 2. SECURITY OF PROJECT 3. PROJECT NO. U 6-61-03-036 Acute Respirztory Diseases 4. 5. REPORT DATE 31 Dec. 1957

e. Ba.ckeround-histom and progress :

(1) Background historv: Research studies were initiated and have been underway for the Fast 15 years to find methods of immunization and control of the occasional outbreaks of influenza in the military causing a considerable nxmber of hospitalized patients, These studies have led to an understanding of the pronounced tendency of t'ne influenza virus to undergo antigenic change from year to year, requiring yearly changes in vaccine composition. Wing periods of mobilization streptococcal disease spreads characteristically by close personal contact and is a major problem, Occasionally during peacetime training this disease appears in ecidenic form in training centers. During the past 15 years effective, although laborious, methods of chemoprophylaxis have been developed and tested, first with the sulfonamides and later with the nore effsctive penicillin, During the past several years a hitherto unrecognized cause of acute respiratory disease,, the adenovirnses, hzs been isolated and identified,

(2) Prozress: In the last quarter of F'Y 1957 a new variant of influenza virus suddenly spread from Hongkong through large portions of the world. This virus was first isolated in the United States by Army rssearch personnel at !4RA.IR and was distributed through the U. S. Public Health Service to manufacturers for vzccine production.

Considerable effort is being expended to develop, from a military point of view, a new ?ad im9roved method of immunization for reducing military non- efftctiveness due to streptococcal. diseases.

,An effective adenovirus vaccine has been developed and field tested.

f. Futurg glans: To investigate and identify various causes, principally viruses, of acute respiratory disease in the military population, and to evaluate respective importance of each as a cause of illness in the military environment. It is planned to complete the final tests of adenovirus vaccines and to continue to provide valuable information on the prevention

DD 613-1 PAGE 4 OF 5 PAGm DO CORY 6lS-t, 68 FU8s. RLD PROJECT CARD INTINUATION SHEET 1. PmlCrTmE I 2. SKURITY OF PROJECT I 3. PROJECT NO. U 6-61-03-036 Acute Respiratory Diseases I 4. 1 5. REPORT DATE

of influenza and streptococcal infections. Intensive search for new agents of respiratory disease will continue because of the great importance of these illnesses in event of mobilization.

g. References: “See Annual Ressarch Task Summary“ h. Modernization code: Not applicable

t TYPE OF REPORT RO. 0 PROJECT CARD Frc)gress REPOEsm:_Ho6. SYMBOL I. PROJECT TITLE 2. SECURITY OF PROJECT IS. PROJECT NO. U 16-61-03-037 Studies in Immunization 4. INDEX NUMBER IS. REPORT DATE 31 Dec. 1957 1. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OW. Fedical Sciences Communicable giseases PO-14

1. COGNIZANT AGENCY 12. CONTRACTOR AND/OR LABORATORY CONTRACTIW. 0. NO. Office of The Surgeon Genera1,DA D. DIRECTING AGENCY Res . 8: 3ev. Div., OTSG See Item Zld(7) IO. REQUESTING AGENCY ...

11. PARTICIPATION AND/OR COORDINATION IS. RELATED PROJECTS 17. EST. COYPLCTlON DATES RES.

DEV.

TEST OP. EVAL. 1B. FY. FISCAL EETIYATIS 14. DATE APPROVED 1 August 1955 IS. PRIORITY I 16. MAJOR CATCQORY 1c I 7.23 ID. REPLACED PROJECT CARD AND PROJECT STATUS e

There is a continuing urgent need for finding new inmizing agents, for improving 9xisting ones, for developing methods and procedures to decrease the number of immunizations and severity of reactions, and for developing agents or nethods to give more lasting and solid protection against specific diseases. (Par 14lOb /=DOG)

a. Brief: This is a scientific project which has as its objective the rsduction of nonmmbat casualtiss in the Armed Forces by providing preventive measures through immunization vhich would assure that maximum manpower is available at all times to accomplish its primary mission despite tactical necessity tc~operate in axas $?hers specific diseases are endemic. be Amroach: The apTroach to this problem involves the improvemsnt of existing vaccines in terns of protective effect or undesirable side-reactions; the development of new vaccines to protect against diseases for which there is no protection at this time; and lastly the simplification of existing techniques

2. OASD (Rbt D) I SN. CN. C. X. 1. C. FORM PAQE 1 OF 4 PAGES 3D 1 APRss 613 IBPLACLS DO FORM 619, JAN 82. 70 R6D PROJECT CARD COIITIWUATION SHEET 1. MQI&T TlTLE L. SECURITY OF PROJECT 3. PROJECT NO. U 6=61-03-037 Studies in Immunization 4. 5. REPORT DATE 31 Dec. 1957

of immunization in terms of total number of injections required for the frequency with w'nich they must be given.

C. Tasks: "See Annual Research Task Summary" (Pages 107 - XU InCl,) *Development of Modified Dengue Fever Vaccine

*Study of the Basic Phenomena of Natural and Induced Immunity

*Development of New and Improved Vaccines for Immunization of the Soldier d . Other Inf onation : (1) This project includes important scientific research. Number of research tasks - 3. Number of research contracts - 14. (2) Standardization item - Not applicable (3) Ewineerinrt test - Not applicable (4) Omrational availability date - Mot applicable (3) Same or related item - kencg Project Number -Title Eavy Department m 52 00 00 Investigation of Epidemiology, Etiology, Pathology, Diagnosis and Prevention of Communicable Disease

Air Force 7753 Air Force Preventive Medicine (6) Specific review Doints - Not applicable (7) Item 12 - Contractor and/or Laboratom- Task - Development of Modified Dengue Fever Vaccine KD-660 - Dr. Charles L. Wisseman, University of Maryland, Baltimore, Md. Task - Study of the Basic Phenomena of Natural and Induced Irmnunity

Walter Reed Army Institute of Research, Walter Reed AXVI~Medical Center MD-246 - Dr. Albert H, Coons, Harvard University, Cambridge, Mass. PAGE 2 OF 4 PAGES 1 DD lFg'?,,613-1 t i R&O PROJECT CAR0 INTINUATION SHEET

1. PROJECT TlTLa ' 1 2. SECURITY OF PROJECT I 3. PROJECT NO. U 6-61-03-037 Studies in Immuni.z&im 5. REPORT DATE 31 Dec. 1957

?D-558 - Dr, 1. ??.Pappenheimer, Jr., N. Y. University-Bellevue Medical Center, New Por4, N. V. l!D-677 - Dr. Inch H, Lepow, Xsstern Fteserve University, Cleveland, Ohio KD-095 - 9.. Dennis V. Watson, University of Minnesota, Minneapolis, Ninn. (Terninated 30 September 1957) 14D-890 - Dr. A. Go Osler, Johns Hop!cins University, Baltimore, Md. I.!3-650 - Dr. C. V. Seastme, University of Wisconsin, Madison, Wisc. (Terminated 30 June 1957) Task - Development of New and Improved Vaccines for Immunization of the Soldier KD-482 - Dr, Edgar E. Baker, Boston University, Boston, Mass. X3-054 - Dr. Kenneth Goodner, Jefferson Medical College, Philadelphia, Pa. (Terminated 30 Septsmber 1957) lCD-570 - Dr. Werner Henle, Children's Hospital, Philadelphia, Pa. YZ-270 - Dr . Johannes Ipsen , H-mard University, Cambridge, Mass . ,h3D-122 - Dr. Karl Fo Neyer, University of California, Berkeley, Calif. MD-693 - Dr. Theodore E. Woodward, Universibj of Maryland, Baltimore, Md, ID-770 - Dr. John P. Fox, Tulane University, New Orleans, La.

3. Backzround history 2nd ProEress:

(1) Backsround histom: Research was initiated to study the basic phenomena of natural immunity in men and animals against communicable diseases of military importance and to apply these principles in development of new or improved biological products for the immunization of our military forces and the control or preventisn of epidemic disease.

(2) Promess: This project is ona of continuing investigation. Smallpox, typhoid, tetanus, diphtheria, plage and cholera vaccines am the chief agents under investigation with a view toward improving these vaccines. Progress is being made in the collection of data on the protection afforded by a new, avirulent, live epidemic typhus vaccine in volunteers. All data indicate a significantly higher levd of protection than given by a killed vaccine. Progress is also being made >nth hTyposensitization (deallergizing) individuals sensitive to plant products. A vaccine against dengue has been developed, but it has such a short shelf: life that it is impractical to use in its present form. RLD PROJECT CARD 3NTlNUATlON SHEET 1. PROJECT TmE 2, SECURITY Of PROJECT 3. PROJECT NO. U 6-61-09-037 Studies in Immunization 14. 5. REPORT DATE

f. Future Dlans: Investigations will continue to develop means of incrsasing protsction afforded by existing vaccines and to develop new vaccines to protect against dissases for which no vaccines currently exist.

g. References: "See Annual Research Task Summary" h. Modernization Code: Not applicable

PAGE 4 4. PAGES DD lzMm613-1 OF ml.Acm w maw Sla-1. 73 m 8a. TYPE OF REPORT qS0 PROJECT CARD REPORT CONT OL SYMBOL PrOgl*e.SS CSCRD-1%

Ecolog and Control of Disease Vectors 2nd U 6-61-04-007 Xeservoir s 4. INDEX NUMBER 5. REPORT DATE I 31 Dec. 1957 6. BASIC flELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OW. Preventive Yedicins EL tornology PO-14

e. COGNIZANT AGENCY IZ. CONTRACTOR AND/OR LABORATORY CONTRACTlW. 0. NO. Office of The Six,~eo~5enera1,DA 0. DlRLCTlNG AOENCY Res. C: Dev. Tjiv., OTSG Sse Item Zld(7) IO. REOU*ITINO AGENCY I I I. PARTICIPATION AND/OR COORDINATION 13. RELATED PROJKCTS I 17. KST. COYPLKTION DATES I %! Corps (C); Chem.‘ Ccrps (C) RES. Engr Sor!>s (C) ; D/E (T) DLV. I D/.V (C) ; TED4 (S) : A?PS3 (Si ; 3RC (S)

I4DATE APPROVED 4 77m 2 August 1954 --:a 7?&6 IS. PRIORITY 16. MAJOR CATEOORY T 7qQ.7 1c 7.23 IO. REPLACED PROJECT CARD AND PROJECT STATUS

I I LO. REQUIREMINT AND/OR JUSTIFICATION Xany severe and fatal infectious diseases of man are transmitted from aninals to man, znd from mar! to nan by ar, intermediate vector, frequently an insect. The identification of ar,imal hosts 2nd vectorso a knowledge of their ecology, physiolckj and genetics as vel2 as availability of methods for their control are of veat military importance. Historically, even as late as the Korean conflict, such diseases Dften have been cr presented a grester threat of military disaster ; than enemy action. (Par ~10bCDOS) I

If. BRIEF OF PROJECT AND OBJLCTIVE a. Brief: This is a scisntific project for study of vector-bourne diseases It is common ‘mowledge now that nany diseases are transmitted to man by animals advectcrs, usually insectsp an3 certainly malaria and yellow fever are clsssic cmanples. Less zommon is the knowledge as to the variety of diseases that ars transrni%ted in tills fashion. In inany areas of the world the varying disaases, t!ie hosts, the vectors, ad the modes of transmission are unknown. Frequentlj t!iey are not recognized simply becase the indigenous populations am sqosed to the qents early in life, acquire unrecognized or inapparent infections, and if they do not succumb to a “femr ?f unknown origin“ or similar complaint, they ‘cecome immune. Each yezr, as knowledge accumulates, more

!Z. OASD (R b) D) I SN. I CN. C. X. C. FORM PAOC DD I APR 10 613 1CPUCLS OD CORM 61s. JAN UP. 74

4 RaD PROJECT CARD INTINUATION SHEET 1. PmJtcr m 1 t SECURITY OF PROJECT I 3. PROJECT NO. Ecology and Control of Disease Vectors and U 6-61-04-007 Reservoirs I 4. 5. REPORT DATE

examplss of sgidemiologic~lsignificsnce of such diseases are added, The salient fact of the greatest militcay importulce is that when a group of nonimnunes are forced to deploy qnd operate in these are::s, they acquire these diseases,

b. Amroach: This problem is being mproached through the utilization of insect scolog,r and behzvior patterns to provide maximum effect from insecticides already zvciilable. Studies 3re being made thro*Jl-h trz2pin:T and identifying the s?mi:?s of ?rtlwapod or mama1 involusd in the ri,ll md in t:w laboratory. in rsl?tin5 tha yector or reservoir species to human disease,

*Insect iiesistance to Insecticides

*Study of Ecology of Disease Vectors and Rsservoirs

d. Other informstion: (1) This project consists entirely of scientific resex-ch. Nurnbcr of msearch tasks - 2, Niimber of research contrzcts - 19% (2) Standardization iten - Nst 2prlicaLlo (3) Eneineerinp: test - Not mplic.nble (4) Ooeratimal avr,ilcibilityr drte - Not spplicable

(5) Same or rehted items- Title bene? Project Number 7 -termaster Corps 7-65-01-002 Insecticides and Rokmticides

Corps of Sngineers e -65-50-005 Equipnent and Methods for Control of Insects, Rodents, and Other Pests

Navy Department NY 450-030 Marine Borer Protection Navy Deprrtment NY 530-020 Pest Control

Nzvy Department MS 041-021 Insecticides and Fumigants

Ch3mical corps 4-98-05-026-04 Epidemiology & Ecologjj

msmic.1 corps 4-98 -05 -027 Ecology & Epidemiology

DD 613-1 PAGE 3, OF 5 PAGES mLKcs w roam Sls-1. mas. 75 RID PROJECT CARD )NTINUATION *€ET 3. PROJECT NO. I. PROJECT Tm I 7. SECURITY OF PROJECT I 3colqj 2nd Control of Disease Vectors and U 6-61-04-007 Reservoirs 4. 5. REPORT DATE 31 Dec. 1957

Dept. of -Agricltlture --- Protection Against Insects The Quartermaster Genera.l..is responsible for research on and development of measures to protect foods and fabrics against infestation.

The Corps of Engineers is conducting studies for developing equipment and methods for the ground dispersal of insect and rodent control agents.

The Navy is conducting research to develop methods to reduce damage caused to Navy equipment bj the marine borer, insects, rodents adother pests, ind to improve the cmfort -and habitability of ships through improved methods of pest control.

The work on rodenticides .and insacticides is coordinated through the Armed Forces Pest Control Board of the Department of Defense. (6) SDecific review Doints - Not applicable (7) Item 12 - Contractor and/or Lzboratom - Task - Insect Resistance to Insecticides

Walter Reed Army Institute of Research, 14alter Reed Array Msdical Center MI-778 - Dr. Raixon L. Beard, Connecticut Agriculatural Experiment Station, New Haven, Connecticut MD-752 - Dr. Laurence K. Cutkomp, University of Minnesota, St. Pzul,Minn. ED-304 - Dr. W. M. Hoskins, University of California, Berkeley, Calif. MD444 - Dr. Daniel Ludwig, Fordham, University, New Pork, N. Y. FD-492 - Dr. L. P. Miller, Boyce Thompson Institute for Plant Research, Inc. Yonkers, N. Y. MD.426 - Dr. Lemar F, Remmert, Oregon State College, Corvallis, Oregon ID-574 - Dr, Clifford C. Roan, Kansas State College, Nanhattan, Kans. ED-352 & PD-738 - Dr. Robert R, Sokal, University of Eulsas, Lawrence, Kans. MD-478 - Dr. George C, Decker, Universitj of Illinois, Urbana, 111. (Terminated 30 June 1957) BD-327 - Dr, 14. Demerec, Long Island Biological Association, Cold Spring Harbor, Long Islsnd, M. Y. (Terminated 31 May 1957) MD-560 - Dr. Herbert Knutson, Kansas State Collsge, Eanhattan, Kansas (Terminated 31 June 1957) KD-370 - Dr. Jam3s F. Crow, University of ;Jisconsin, Nadison, Xisc I (Terminatsd 31 August 1957)

.- I RAD PROJECT CARD 3NTINUATION SHEET 1. PROJECT TITLE 2 SaURITY OF PROJECT 3. PROJECT NO. Ecolog .and Control of Disease Vsctors and ,u 6-61-04-007 Ileservoirs 4. 1. REPORT DATE 31 Dec. 1957 Task - Study of Ecology of Disease Vectors and Reservoirs. Xalter Reed Army Institute of Research, Walter Reed Army Medical Center Fourth Army Area Medical Laboratory Third Area Laboratory ED-714 - Dr, Villiam E, Sickley, University of Maryland, College Park, Md. 39-744 - Dr. Osmond P. Breland, University of Texas, Austin, Texas ND-308 - Dr, Gottfried S. Fraenkel, University of Illinois, Urbana, Ill. WD-653 - Dr. Don IJ, Micks, University of Texas, Galveston, Texas XD-430 - Dr. T, ililson, Institute of Medical Research, Kuala Lumpur, Malzya ICD-501 - Dr. G, if.Vharton, University of Maryland, CollSge Park, Md.. (Terminated 30 June 1957)

e- SaCkZrQUnd histor? and orogress:

(1) Backmowd history: In many pzrts of the world where troops may be deployed, disease vsctors and reservoirs could become major obstacles to military operations, for example, scrub typhus and malaria in World War Therefore, to m~rcomethese obstacles an understanding of ecology 2nd a rational approach to prevention or elimination of the development of resistance of insects to insecticides is essential. By authority of Department of Defense Directive No. 5154,12, 17 November 1956, the Armed Forces Pest Control Board wzs originated to function as a joint agency of the three milit- departnents under the managenent control of the Secretary of the Army. This Board functions as a coordinating agency in the field of pest control; serves as an sdvisomj bod^ xd provides liaison vith other agencies as required. Research has been carried on to provile data upon which new and improved control nteasures sai be dovelopad adused to combat diseases involving animal, arthropod vectors or hosts of the infectious agent,

(2) Promess; Lrfomation has been collected to indicate that 'in my given insect thsre are multiple mechanisms of development of resistance to even one insecticide, From a biological point of view, the development of resistance should not be an unexpected phenomenon, since any nutation providing increased resistance would immediztely initiate a selection process on tha basis of "survival value," No common denominator has been found in the biochemical or genetic mechanism in t'ne development of resistance between two insects of diffayent speciJs, or, between two,strains of thz sane species3 Basic research continues and diseases being invsstigzted at the present time include yelkw fser, fillziasis, scrub typhus, Japanese encephalitis, Sat-bourne rabiss, nalaria ZAZ the human enteritides which may be transmitted the house fPJa

PAGE 4 OF 5 PAGES DD I="# 613-1 W FORM 613-1. 77 i Fu u. p ,%! ,%! f I RBD PROJECT CARD INTlNUATlO~fHEET 1. PROJECT ll* t SECURITY OF PROJECT Ecology and Control of Disease Vectors and U Rsservoir s 4. 5. REPORT DATE 31 Dec, 1957 f, Future Plans: Studies will continua an groblems connected with insect 2nd animl vectors of disease, and in paticulv problems of the devslopmet2t of resistance ta insecticidss,

g. Referencss: "See Annual Research Task Sumnary"

h, Modernization CO~Q: Not applicable

DD 613-1 PAGE 5 OF 5 pm W VORM OlS-1. m sa. 78

. I t i TYPE OF REPORT R6D PROJ- CARD Progress =m@&iEy+ 1. PROJLCT TITLE 12. SECURITY Or PROJECT I S. PROJECT NO. U 16-61-14-001 Chemicals HealA& Hazards of Witaqj 4. INDZX NUMBER 11. REPORT DATL I 31 Dec. 1957 E. BASIC FILLD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP I 7A. TECH. OW. Preven%iveXedicine ToxLeology PO-14

1. COGNIZANT AGENCY 12. CONTRACTOR AND/OR LABORATORY CONTRACT~W.0. no. chdcal coqs 0. DIRECTING AGENCY See Item 21:1(7) C~EX~C:~~CO~SIkde 'Labs, ID. REQUESTING AGENCY Office of The Surgeon General& I I. PARTICIPATION AND/OR COOROINATION tS, RKLATED ?ROJECTS 17. ESTT.COMPLETION DATES RES. DLV.

14. DATL APPROVLD 27 November 1950 1% PRIORITY 16. MAJOR CATCOORY ZC 723 IS. REPLACED PROJECT CARD AND PROJECT STATUS

LO. REQUIREMENT AND/OR JUSTIFICATION 'L'm s project is to su3pl-Y-- - I.IX Ol?lTlat ion perssmcl hmd15.ng iililita-c-c chem!&d.s, such as propellant fuels and ofidizers exhaust gases frm solid propellant charges, hydraulic fluids, firs extinguishents and other chenicals for using agencies. T&cological inforimtion on many ched- cas ?ropcsed for technological use by the DOD is imdequate and preventive ne:~.i*x,ind treatnent for casuaLties irmst be evolved. (P;.r 14.104 XO,?)

L1. BRIEF OF PROJECT AND OBJECTIVE a, BrieC~ This is a scientific project and was initiated .to evaluate tks kaxards frm military chedcds so that a selection of chemicals on LIe basis ai' tozdcity can be iwde by using agenciese Where no suitable less toxic substibrte che,xical can be e-qLopd. by operating groups for techaological reasons,, an apprrec- ktion of hzzard is realized so that suitable measures for protection and thera2y can be derelqed, i?esuli,s of this research trill be used for the preparation of safety directives for bandli-rg military chmicals, b. To accomplish t\e purpose of this projec3, the fcllo%5llg aTproaclies are being used on all co~qoundssubmitted bj operating agencies:

!z. OASD (R~1 D) I SN. CN. C. I x. I. 1 c. PAGE OF 'I PAGES DD i%!E613 1 d PCPLACCS DD CORM 61s. I JAN 52. 73 R&D PROJECT QA#D

. PROJECT Tlfia 2. SECURITY OF PROJECT 3. PROJECT NO. Zealth Hazards of Military Chemicals U 6=61-14-901 S. REPORT DATE

(1) Prcceckx -2ie +initiation or" Zaborztory a thorough search of the literature is made and all available information on the operational use of the compound is collected., (2) Iriit5.d. acxte tczdcity tests are performed on ex- periiiental aximls % the rm5es of a.chL~-Ls';rztf.o~i Lidicttsd by the practical hazards, Coqoumis of &Te;*.i;ncntal tnterest only are not carried beyond the pre- limiiiay scycer-iru2 .;te,a 2. (3) Sibacute mcl ckronic toxicity experiments includ- irq per5m:it. ~b;-siolc.~ic& adpat,koiogical studies I are conducted, (4) Ibchan- ism of ~hysioh~ical&,ion. are investigzted as a basis for the formulation of methods of tilerap>-., (5) Research on the development of simple tests, for the detection of rinimal-toxic effects resulting frcm exposure is being pursu& cr Task: "See Annual Research Task Snnmaq.'' (Page 113) *Health 5zards of Eiilitary Chemicals

de mer Lzom!ti.on; (1) The task of this'project comes under the category of siwficsnt scientific researchc Xmber of research tasks = 1, Number of research cor;i;racts - 9,

(2) Stanc&dieatLon Item; - Not applicable (3) 3xineering Test: - Xot applicable (4) berational Availabilit37 Date: - Xot applicable

(5) Satize QT Related Itens: Lbz!zxx Praject Xumber Project Title

I chacai corps 4-61-14-002 Ee.il.Cn Hazards of Military I Cinmicals

124 53 00 00 Hazards frm Use of I'Lilitarg Chemicals Air Force 7259 Health Hazards of AF Xaterials

Corps of 3ngLneers 8-75-07-214 Removal of CBii Contmknants from Water (6) Specific Review Taints: - Not anlicable (7) Corkractor and/ or Laboratory Chemical Corps Nedhal Laboratories, kmy Chemical Center, Ihryland DD #E"#613-1 PAGE 2 OF 3 PAGP 00 FORM 6lS-1. 80 1 mss. i i i e. i ..-. I I R(CD PROJECT CARD DNflNUATlON SHEET 1. PROJECT TITLE I L- SECURITY-- OF PROJECT 1 3. PROJECT NO. U 6-61-14-091 of Hilitary Chemicals Health Hazards I 1. 5. REPORT DATE

e, Backmumd Histom and Progress: (1) Bac hround &stox: This is essentially an occupational health problem of safe handling, storage, use and disposal of chemkcals-with which man has had little or no previous experience. Unless hckcological data are obtained, widespread use of insecticides, rodenti- tides, hydraulia fluids, missile propellants, fire extingu'shers, etc., can cause disability of &liteJ?personnel thraugh toxic actions. Estimates are applied to the evaluation and selection of nrilitary chemicals from the standpo5nt of toxicity using agencies. When less toxic substitutes are not available, ?roper procedures and devices for handling these chemicals are being studied in order to mini- rrdze the toxic effects in Armed Forces personnel.

(2) Promess: Work is continuing to determine the toxicit7 and mechanism of the action of military chemicals so that an estimate of hazards to man can be made and methods developed for treating poisoned personnel. High priorities have been assigned to tmdcological investigation of high energy propellants.

f, Future : Studies will be conthed to obtain additional information on the toxicity of chemical conq?ounc€s in use by, or potentially useful to, the military in order to prevent non-battle injury to troops.

g. Ref=? cas:. "See Annual.Besearch Task Summary."

h. Ybcbnisation code: m Not agplicable

DD fsG613-1 PAGE 3 OF 3 DO FORM 8IS-1. 81 'ma TYPE OF REPORT R&D PROJECT CARD Progress REL@I#&JfT~OL SYMBOL

1. PROJECT TITLE 2. SECURITY OF PROJECT 3. PROJECT NO. Oral 3iseases U 6-63-01-006 4. INDEX NUMBER 1. REPORT DATL 31 Dec 1957 6. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJaCT SUB GROUP 7A. TECH. OBJ. Xedicsl Sciences Investigations, Authorized PO-14 I I 1. COGNIZANT ACEUCY 1 12. CONTRACTOR AND/OR LABORATORY I CONTRACT/W. 0. NO. Office of The Surgeor! Genera1,DA 8. DIRECTINQ AGENCY Res. & Dev. DiV., OTSG See Item 21d(7) IO. RLOULSTING AOLNCY

I I. PARTICIPATION AND/OR COORDlNAfION 13. RELATED PROJECTS 17. LIT. COYPLITION DATE1 US Department of Commerce, RES. National Bureau of Standards (C) DIV. Mayy ($1 TLIT Air Force (c) OP. WAL.

tI I 20. RfOUIlCYINT AUD/OR JU8TlCICATION To reduce oral disease which affects 955 of the military age group, resulting in loss of tiii for treatraent. This study requires investigation in all fields of the science of dentistry, Studies of the basic causes as well as methods of treatment are essential if any substantial reduction in dental casualties is to be effected. (Par 1410c CI)OG)

21. BRIEF OF PROJCCT AND OBJECTIVE a, T3rief: The objective of this project is to investigate the causes, treatment and epideniology of dental caries, peridontitis, and other oral diseases which affect militqy personnel.

bo broach: To investigate the bacteriologic and biochemical aspects of dental caries; to evaluate laboratorj chemical analysis of dentin and enamel of both carious and noncarious specinens; to investigate the causes and treatment of lesions of the oral tissue; and to conduct research on the physical and chemical properties of dental materials.

REPLACES OD FORM 813, I JAN 52, 82

. - ., ... ..,. . ,. ... -. . R&D PROJECT CARD ONTINUATION SHEET 1. MOJECT TITLE 2. SEtURlTY OF PROJECT 3. PROJECT NO. U 6-63-01-006 Oral Diseases 5. REPORT DATE

c. Tasks: “See Annual Research Task Summary1’ (Pages 69 - 73 fncl,) *Prevention and Treatment of Dental Caries and Periodontal Disease

*Improvement of Dental Haterials d. Other Tneormation: (1) This project consists entirely of scientific research, Number of research tasks - 2. Number of research contracts - 32.

(2) Standardization item - Not applicable \ (3) Enaneerinrr test - Not applicable (4) ODerational availability date - Not applicable (5) Same or related item - Work conducted at the National Bureau of Standards is in cooperation with the Council on Dental Research of the American Dental Association, The Amy Dental Corps, the Air Force Dental Service, the Navy Dental. Corps and the Veterans Mninistration, (6) SDecific review uoints - Not applicable (7) Item 12 - Contractor and/or Laboratorv: Task - Prevention and Treatment of Dental Caries and Periodontal Disease Armed Forces Institute of Pathology, Washington, D, C, Walter Reed Army Institute of Research, Walter Reed Army Ikdical Center MD-390 - Dr, Wallace D, Armstrong, University of Minnesota, MinneapoLis, Rhn. MD-766 & &ID-909 - Dr- James R. Avery, University of Michigan, Ann Arbor, Mich. (KD-766 - Terminated 30 November 1957) &ID-906 - Dr. Baldev R, Bhussry, Georgetmn Univsrsity, Washington, D. C, ID-017 - Dr, Milton Engeli University of Illinois, Urbana, 111, (Terminated 31 Earch 1957) MD-768 - Dr, B, 3, Ershoff, Western Biological Laboratories, Culver City, Calif, ID-238 & ID-769 - Dr, Robert B, Fischer, Indiana University, Bloomington, Ind, . (NIL238 - Terminated 30 June 1957) MD-675 - Dr, John Haldi, Emory University, Ga, KD-556 - Dr, Erling Johansen, University of Rochester, Rochsster, Y= FB-471 - Dr. R. S,.Manly, Tufts College, Medford, Nass, (Terminated 30 June 1957) KD-449 - Dr. FredQrick if, Krauss University of Alabama, Birmingham, Ala. ED-721 - Dre Robert 3. Moyers, University of Nichigan, Ann Arbor, FIic’n, FIB-332 - Dr, J, C, Ku!der, Indiana University, Bloomington, Ind. (Terminated 30 JUm 1957) BID-773 & ND-774 - Dr, Vard Pigman, University of Alabama, Birmingham, Ala. PAGE PAGES 2 OF 3 I. PROJECT mu 2, SECURITY OF PROJECT 3. PROJECT NO. U 6-63-01-006 Oral Diseases 4. 5. REPORT DATE 31 Dec. 1957 MD-460 - Dr. Henry W. Scherp, University of Rochester, Rochester, N. Ye MD-718 - Dr. Harry E. 75apiro, Columbia University, New York, N. Y MD-392 - Dr. James H, Siaw, Harvard University, Cambridge, Mass. (Terminated 30 November 195 7) MD-400 - Dr. John M, Slack, West Virginia University, Morgantm, W, Va. MD-859 - Dr. Richard W. Tiecke, Morthwestern University, Chicago, IUe MD-765 - Dr. Otto R. Rautz, New York University, New York, N. Y. MD.706 - Rra Samuel Turesky, Tufts College, Boston, Mass. MD-622 - Dr. Joseph -P. Weinmann, University of Illinois, Chicago, Ill. MD-857 - Dr. Helmut D, Zander, Eastman Dental Dispensary, Rochester, N. Y. Task - Improvement of Dental Materials

National Bureau of Standards, Washington, De C, MD-557 - Dr. F. R. Eirich, Polytechnic Institute of Brooklyn, Brooklyn, N. Y. MD-867 - Dr, David B. Mahler, University of Oregon, Portland, Ore, MD-860 - Dr. Floyd A. Peyton, University of Michigan, Ann Arbor, Mich, MD-391 - Dr. Ralph W. Phillips, Indiana University, Bloomington, Ind. MD-757 & MD-869 - Dr. Eugene W. Skinner, Northwestern University, Chicago, Ill (HD-284 - Terminated 31 March 1957) MD-330 -. Dr Finn Brudevold, Eastman Dental Dispensary, Rochester, N. Yo (Terminated 30 June 1957) e. Background histom and Drogress: (1) Background histors: This project was initiated to find means of i reducing the incidence of oral diseases and to provide more adequate and efficient methods of treatment, with emphasis on dental caries and periodontal disease, which affscts 95% of military personnel. (2) Progress: Good progress is being made on the effects of high speed cutting on the oral tissues. Progress is also being made in amalgam studies where a method and device for measuring the setting time of dental amalgam have been developed, This, for the first time, enables the manufacture of silver alloys with a predetermined setting time. f. Future plans: Investigations will continue on the development of new dental materials, new instrumentation methods, and methods of preventing and treating oral disease.

g- References: "See Annual Research Task summary" h. Modernization code: Not applicable - PAGE 3 OF 3 PA- I DD 613-1 I nrucD Do 1111-1. 8Lc I 5s. mu m 1 i I TYPE OF REPORT R&D PROJW CARD P:-o;y.,ss REFORT$-UNTFUL SYMBOL ,ad.. -J-: . PROJECT TITLE I 2. SECURITY OI PROJECT I 3. PROJECT NO.

1. DIRECTING AGENCY 0- ?. 35- (_' -3'. JL-ie, 3TS"I '0. REOUESTINQ AQLNCY

IS. RELATED PROJECTS 17. EST. COYPLITION DATES RES. DLV.

OP. LYAL. 18. Cy. FISCAL ESTIYATES 14. OAtE APCROYED 12 JAy 1351, IS. PRIORITY 16. YMOR CATEGORY ?C -: 9 P, -9

9. REPLACED PROJECT CARD AND PROJECT STATUS

'I. 8)RIEF OF PRUJLCT AN0 OBJICIIYI

CN. C. X. I. C. 2. OASD (R 6) D) I SN. PAGE 1 OC 3 PAOES 3D iYX613 RLD PROJECT CARD ONTINUATION SbyT 1. PROJECT Tlnk ' I 2 SECURITY OF PROJECT I 3. PROJECT NO. U 6-64-01401 Advisory Skrvices 4. 5. REWRT DATE 31 Dec.1957

C. Tasks:

*Advisory Services of Specialists in Various Fields of Xedicine *Joint Support of Government Agemies in Collection and I)issmi.mti.on of Scienti3.c Information

d. Other Infomation: (1) This project includes jmportant scientific research tasks. Number of research tasks - 2'. Number of research contracts - 5. (2) St=- dization Item: - Not aBlicable (3) Ewineerinz Test: - :Jot applicable (4) Onerational Avaibbility Date: - Not applicable (5) Same or Eekted Item; Pro-iect Mo, Project Title 7158 Ifandbook of Medical aid Biological Data NR 100434. Handbook of Biological Data 183A86 Medical Bdvisory Codttee 100-001 BioSciences Information Exchange 390-020 Bibliographies 1404@ Armed Forces-Sational Research Council Committee on Hearing and Bio~coustics Physiological Acoustics Physiological and Psychological Effects of High Intensity Noise (6) Smcific Review Toints: - Not applicable (7) Item I.Z - Contractor az/or ~aboratory: Task - Advisory Services of Specialists in VarLous Fields of Medicine Navy Contract - Armed Forces-National Research Council Vision Committee Navy Contract - Armed Forces-1Jational Council Cmttee on Eearing and Bio-Acoustics MI-U.8 - National Acadq of Sciences - Advisory Senrices;. A joint program in cooperation with FCDA, Navy and Air Force

DO FORM 615.1. R&D PROJECT CARD CONTlNUATlON SHEET 1. PROJECT T1TLE. 2 SECURITY OF PROJECT 3. PROJECT NO. U ~-0l-OCl Advisory Services 4. 5. REPORT DATE 31 Dec.1957 Task - Joint Support of Govemme~tAgencies in Collectfan and MssearLnnt.ion of Scientific Information

(1) tom: This p-llajact was initiated and is contirming because of the =-as af Medical &search of interest to the m, and the fzequent need for eptpert advice on particular problems, advisorg services are esserrtial to a sound Arqy Medical Service Research Program-. The advisory groups consist of the National Acadq of Sciences-National Research Council, Armed Forces National Resear& Council Cam&ttee on &azzI.ng and BiaAcoustics, the Armed Forces H&iW Retiemch CctuncU Vision Ccnmrittee, Coamnittee on Hetabolism and &trition, and indimhd. ctaum&mta in qme~albedfield& The Amy Hedid. S-ceJs share of mpport of the ao-seiences Infcma*~n &change is carried under this project.Y;

(2) EE-mss : The work done pnder this contract is a continuing type of operation, f, Future3 It is planned to obtain advisory services of recognized and eminent specialists in the various fields of nmdichet and to support joint efforts of Gavenrment agencies in the collections, collation and dissemination of scientific information,

go Reference% See pmgress reports of Agencies listed5

h. Modernization code: Not applicable

PAGE 3 OF 3 PAGES 3D 1'gk 613-1 ULACCS W FORM 613-1. 87 mn SS TYPE OF REPORT R69 PROJECT CARD L Progress I. PROJECT TITLE 12. SECURITY OF PROJECT 11. PROJECT NO.

31 Dec.1957 6. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OBJ. Xedicd Scisnces Internal Medicine PO-13

E. COGNIZANT AQENCY 12. CONTRACTOR AND/OR LABORATORY CONTRACTIW. 0. NO. Cffice of Tne Surgeon Genoral,DA 9. DIRECTING AGENCY See Item Zld(7) Xes. & Dev. Div., OTSG 10. REOUESTINC AGENCY

11. PARTICIPATION AND/OR COORDINATIOM ~~ 13. RELATED PROJECTS 17. EST. COMPLETION DATES RES. DEV. TEST

14. DATE APPROVED 3 December 1951 1s. PRIORITY I 16. MAJOR CATEGORY 1c 7.23

!O. REOUIREYENT AND/OR JUSTlFlCATlON Soldiers have been and wiU be required to exist ad fight in all types CC cnviroments. lhch is yet to be learned concerning the efficiency of the solcbsr Ln various environments or the physiologic mechanisms whereby he may adapt 'himmlf to~environmentalconditions and thereby increase his efficiency. Pressnt !marledge is scantyo particularlj. in relation to cold environments. {Pw 1Q0j CIOG) I

a. BLef: The objectivs is to study aJJ. phases of physiologic reactions of man and experimental animals to various environments and the conditions brought on by these environments in an attempt to advance the knowledge of the phjjsiologic uld 'oimhemi&L alterations that take place under such stresseso be Woach: Utilizing ;InimaLs as subjects, experiments are carried out under a variety of adverse climatic and nutritional situations', Animals and hunan -rolun$eers are studied in hot and cold environmental chambers. Field skuclies to simulate actual operat;ing conditions with volunteers are being initiated to sbtain the final human evaluation.

2. OASD (RBD) I SN. I CN. C. I x. 1. I c. FORM PAQS 1 OF 3 pAac' 2D i APRss 613 .- . EPLACLS DD FORM 013, 90 i JAN 82.

I I R&O PROJECT CARD 3NTINUATION SHEET 1. PROJECT TITLE S#URITY OF PROJECT 3. PROJECT NO. U 6-64-12-028 Environmental Physiology 4. 5. REPORT DATE 31 Dec. 1957 cm' Tasks: "See Annual Research Task suZmnarybll (Page 88) *Studiss of the PtgsiologicalZffects of Cold on 1.kn *Renal and Scdy Fluid Responses to Environxner,tal Variables

de (1) This project consists entirely of scientific research. Number of research tasks -. 2. Number of research contracts - 2, (2) ion Ita: - Not applicable (3) -@rin€? Test:. - Not a-cable (4) Availabilit:r Date: - ?Jot applicable (9 weor ted. Items:

Quartermaster. 7-83-01-003 Effects of Natural and Military Environments on the Soldier (6) as?= 'fLc,Re~euPa : Not applicable (7) Item 12 - Contractor and/or Laboratory: Studies of the PbsiologicalEffects of Cold onTlIan

UnLted States Army Hedical Research Laboratory, Fort Hncpc, Kentucky E.zD-873 - Dr. Frederick A. Fuhnnan, Stanford University, Stanford, California Renal ad Sody Fluid Responses to Erwiromental Variables United States Army Medical Research Laboratory, Fort Knac, Kentucky MD-279 - Dr. Warren S, Eehtn, University of huispille, Louispille, Kentwky e, -0Und btom an d Promess: (1) Ekkraund Histom: In order to elucidate clearly the many phssiologic and biochemical alterations that occur during and folie exposure to various environmental stresses, it is necessary to study these alterations in various animal preparat5ions as weU as in mano (2) pr- : Current research is directed toward obtaining more information concerning the psychological and physiological effects on man of a DD lF$k 613-1 PAGE 2 OF 3 PAGES W fORM 6151. m ss. 91 1. PROJECT TITLE 2 SECURITY OF PROJECT 3. PROJECT NO. U 6-6U2-028 Envisomental Physiology 1. 5. REPORT DATE 31 Dec. 1957 variety of mviroTrmental conditions under which the military can be expected to operate.

f, &twe Plans : Research wiU be continued in order to obtain a more coirrplete and thorough understanding of the controlxechanisns and responses of the soldier following exposure to environmental &rems.

go tw= encesr "See Annual &?search Task Summa?,"a It he Modernization Code: - Not applicable

DD 613-1 PAGE 3 OF 3 92 TYPE OF REPORT REPORT CON OL SYMBOL RQD PROJ~CARD Progre s s I CSrn-lF 3. PROJECT NO. . PROJECT TITLE 2. SECURITY Of PROJECT U 6-78-01-OCl: .2rTtic 2nd Sub,z-cti,c Pisld Yedical ?roblens 4. INDEX NUMBER 1. REPORT DATE 31 Dec. 1957 7A. TECH. OBJ. . BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP ?,sscue md Survival Squi?ment Investigation, Authorized PO-11

CONTRACTIW. 0. NO. I. COGNIZANT AGENCY 17.. CONTRACTOR AND/OR LABORATORY 3ffice of The SursYcn General,DA * I. DIRECTING AGENCY See Item 21d(7) Res. & Dev, Div., OTSG 0. REOUESTING AGENCY

1. PARTICIPATION AND/OR COOROlNATlON 13. RELATED PROJECTS 17. IIST. COMPLITION DATES RES. Am (2): As?~:Sc (c): 0: (c) DEV. 3: (c): sc (c) I:avy (c) Or. KVAL. Air Force (c) la. FY. FISCAL ESTIMATES 14. DATE APPROVED 58 15014 2 June 1952 59 50kr 15. PRIORITY IS. MAJOR CATEGORY T 5014

IS. REPLACED 7ROJECT CARD AND PROJECT STATUS I

I I LO. REOUIREYENT AND/OR JUSTIFICATION There is both a present and a continuing future nsed to maintain the operational efficiency of rnilitary personnel in the arctic and subarctic, and to develop appropriate means of meeting medical. problems which assume Unique importance under arctic cmditions of temperature extremes. (Par 1410b CDOS)

21. BRIEF OF PROJECT AND OBJECTIVE a. 3rfef: This is a scientific project to develop information, techniques, methods, equipment and doctrine which will permit the maintainance of health snd the treatnent of injury and disease under arctic conditions.

5. Amroach: This problem Is approached both by field studies in the arctic area and b3 laboratory investigations in the %!Lted States. Field stuciiss c.m brst be conducted vhers logistic support can be furnished by eAistisg military mits. S-hdies and investigations are being condzcted in Alaska, flJanada, S-reenland and Finland.

22. OASD (RbD) I SN. CN. C. X. I. C. PAGL 1 Of 4 PAGES FORM DD IAPRSS 613 RLPLACCS DO CORM 613, 93 .. I JAN 82. E 1. PROJECT Td.Er 2, SECURITY OF PROJfCT 3. PROJECT NO. I U 6-78-01-004 Arctic & Subarctic Field Medical Problems 4. 5. REPORT DATE 31 Dec. 1957

c. Tasks: "See -4nnual Research Task Summary" (Pages ll4 & 115)

Waste Disposal and Enteric Disease Under Arctic Conditions

'Health and Habitability of Military Shelters for Arctic Use

d. Other Information: (1) This project consists entirely of scientific research. Numbsr of research tasks - 2. Number of research contracts - 2. (2) Standardization item, - Not applicable (3) Enaineerina test - Not applicable (4) hrational availability date - Not applicable (5) Same or relsted item - Arencs Pro-iect Number -Title

Quartermaster Corps 7-83-01-001 Nature and Distribution of Significant Factors

Chemical Corps 4-98-01-003 Environmental. Field Trials

Ordnance Corps 5-98-09-004 Climatic Tests of Ordnance Equipment

Signal Corps 3-91-02-008 Techniques for Operation under all Environmental Conditions

Transportation Corps 9-9849-001 Climatic Tests

Corps of Engineers 8-98-09-002 Environmental Research Testing

Corps of Engineers 8-97-10-004 Military Evaluation of Geographic Areas

Corps of Engineers 8-66-02-004 Snow, Ice, Permafrost and Frozen Ground

Navy Department NY-000-011 Permafrost Field Station

3D 613-1 PAGE OF 4 rM;m WUCCS W TORY #IS-1. 94 m IS. The Teclmical Services as listed above under tile projects as indicated, coiiduct tests of their equipment and materiel to evaluate the effects or“ envir.onmentd. conditions on these items, (6) Specific review pobtr; - Not applicable (7) Jt.m - ~G~~~~-~-~i~~~.~~~~~~~- Task -Waste Dispasdl and Snteric Diseasz Under Arctic Conditions r.;D-S86 - Dr, John E, Gordon, Harvard Ihivsrsity, Cambridge, Nass. Task - Health and Habit&;Jit,y of Xlitary Shelters for Arctic Woz iuD&03 - Dr. Constantin Paglou., Harvard University, Cambridge, ik~ss~ e, Backgpnmd HLg;O -ry and P.?om?s: (1) €Jack d Hist- Preparedness for operations in low hpra= ture is essential tzional security, Adequate medical service, including prevention of diseases through lhqrovzd sanitation, rescue, shelter, evacuathn and treatment of casualties, is necessary to the success of such operationsl Of particular importance is the evaluation of the influence of waste disposal and other epideniological factors in the srread of enteric disease, as well as the potential medical problems of exposum to carbon monoxide and other env2ron- xental hazards. Recent increase or‘ interest -b operatiom in certain amtic areas points to the necessity for continued effort in this area, Tis project is essentially a carrier project to serve as a nucleus for field medical research on arctic problsms, This WGY~is cioseiy coordinated with other medical. projects such as Tslutritior,, Xetabolisnr, Enviromnentd. Physiology, Psychophysiology, Traumatic Surgeq m-d Shock etc,

(2) F-ess: A cansiderable volurrre of valuable infornation on t;:e responses of man to extreme cold has ’wen collected, Studies on the ifluenca of Cbtic factors on human disease +transmission are in progress, chiefly ~Jitlhrespiratory and intestinal diseaseso In general, these diseases are propagated and transmitted in cold climates in ess2xtially t‘ne same manner ;Irld frequency as in temperate. Person to person transmission appears to play the major role in tra,nsIrission.

PAGE 3 OF 4 PAGP DD I=”# 613-1 V W FORM 6IS-t. I msa 95 '. T 2 SECURITY OF PROJECT 3. PROJECT NO. U 6-78-01-004 Arctic and Subarctic Field Medical Problems 4. S. REPORT DATE 31 Dec. 1957

)D 613-1 PAGE 4 Of 4 PAGm uucw Do muom-1, 96 m u. TYPL OF REPORT Progress -R%§m2t~L 1. PROJLCT TITLE 12. SECURITY OF PROJECT IS. PROJECT NO. U 6-95-~0-001 Psychophysiological Studies 4. INDCX NUMBER 5. REPORT DATE 31 Dec, 195': 6. BASIC flELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OW. Social and Sehavioral Physiological Psychology Sciences Sxperimental Psychology PO-6 8. COGNIZANT AGENCY 12. CONTRACTOR AND/OR LABORATORY CONTRACTIW. Q. NO. Office of The Surgeon General,DP 0. DlRECTlNQ AGENCY Res & Dev. Div.. WS rJ See Itex 21d(7) 10. REQUESTING AGENCY

I 11. PARTICIPATION AND/OR COORDINATION 13. RELATED PROJECTS 1 17. EST. COMPLETION DATES

Other Technical Services, DA DEV. (P&C) TEST Navy (C) OP. IIYAL. Air Force (C) 18. Cy. FlSCAL CSRMATCS 14. DATE APPROVED 58 347y 12 July 1954 59 397pj 15. PRIORITY 16. YAJOR CATEGORY T 7924 1c 7.23 19. REPLACED PROJECT CARD AND PROJECT STATUS

I I 20. REOUIREYENT AND/OR JU6TlFlCATlON The efficient operation of recently developed equipment is placing greater demands upon the users. Basic human sensory and perceptual factors that afzeisct the speed and sfficiency of operation under vzrious conditions nmt be studied in order to determine optimum operating arrangemmts of user and equipment. The immediate physical environment and the climatic environment of operation must be studied in order to determine if working space, work loads, noise, vibration, teqerature, gases, etc., are consfstent with human capabilities and if tnese factors alter speed and efficiency of operation indicating a need for cliages in design of eq?!pment compatible mth logistic requlrsmenLs to reduce my adverse effects. (Par l420j CDCG) 21. Brief of Project and Objective

2. Brief: The objectivss of this project are to determine the basic psychophysiological data required for optinal design and operatim cf mu.-macb-ine systems; to study the interaction effects produced by simultaneous stixnulat,ion of the several. sense departments; and to determine the effects of various physical energies which have an effect on a soldier's performance.

!Z. OASD (RBD) I SN. CN. C. X. C. FORM PAaL 1 OF 4 PAGES DD i APRSS 613 ?LPLICIS DD CORM 61s. 97 JAN 62. 1. PROJECT Tm# 1 I SECURITY OF PROJECT 3. PROJECT NO. , U 6-95-20-001. -_-- Psjchophysiolocical Studies 4. 5. REPORT UA I E 31 Dec. 1957

*Improvement of Control and Coordination in Complex Performance

*Detarmination of Sffects of Physical Snvironmcnt on Performance

"Investigstion of Vision and Perception in Relation to Performance

*Investigztions of Sound arxl Hearing in Relztion to Performance

*fnvestigztions of Hotion 3ncl Balxice in Relatim to Perforrnance

d. Other infonnatioa: (1) 'his project consists entirely of scientific research. Number of research tasks - 5. Huber of research cmtracts - 12. (2) Standardization item - Not applicable (3) Enaineerine test - Xot applicable

(4) Operational availzbility data : Mot applicabla

(5) Sane 3r relatad items: Project Number

7-83-01-004 Operational Effectiveness of the ,ZEI-Equipped Soldier

PAGE 2 OF 4 PAGES DD tfgk 613-1 RBD PROJECT CARD MTIWUATIOW SHEET . PROJECT TmE 7 2 SECURITY OF PROJECT 3. PROJECT NO. 1 u 6-95-20-001 P sy chophysiologid a1 Studies 4. 5. REPORT DATE 31 Dee. 1957

Navy Department NM 17 00 00 Studies on Psychophysiology, Including Sensations and =ius ion s Navy Department NM 18 00 00 Problems in Buman Engineering

(6) S3- Not applicable (7) Item 12 - Contractor and/or Laboratom: Task - Improvement of Control and Coordination of Complex Performance Army Medical Research Laboratory, Ft. Knox, Ky. m-625 - Dr. Edward Girden, Brooklyn College, Brooklyn, N, Y. MD-537 - Dr. Richard H. Henneman, University of Virginia, Charlottesville, Va. ND-877 - Dr. William E. Kappauf, Uniyersity of Illinois, Urbana, Ill. m-626 - Dr. Robert B. Malmo, McGill University, Montreal, Canada MD-719 - Mr. Don Cahalan, National Opinion Research Center, Chicago, Ill. Task - Determination of Effects on Physical Environment on Performance

Army Medical Research Laboratory, Ft. &OX, Ky. MD-683 - Dr. John P. Nafe, Florida State University, Tallahassee, Fla. MD-797 - Mr. A, K, Simons, Bostrom Mfg. CO., Milwaukee, Wisc. Task - Investigation of Vision and Perception in Relation to Performance Arqy Medical Research Laboratory, Ft. Knox, Ky. MD-866 - Dr. Walter Cohen, University of Ehffalo, Buffalo, N. Y. m-536 - Dr. Mason N. Crook, Tufts College, Medford, Mass. MD-871 - Dr. E. Parker Johnson, Colby College, Waterville, Maine HD-722 - Dr. Donald B, Lindsley, University of California, Los Angeles, Calif. Task - Investigations of Sound and Hearing in Relation to Performance Army Medical Research Laboratory, Ft. K~ox, Ky. Dr. Merle Lawrence, University of Michigan, Ann Arbor, Mich. (MD-634) Task - Investigation of Motion and Balance in Relation to Performance Army Medical Research Laboratory, F’t. Knox, Ky.

PAGE 3 OF 4 PAGES DD t‘gk 613-1 YrUwI DO FORM 6lS-1. 99 I m 5s. R&D PROJECT CARD INTINUATION ,SIJEET 1. PROJECT T*q 1 7.. SECURITY OF PROJECT 13. PROJECT NO. U 6-95 -20-001 Psychoph4 siologicd Studies 5. REPORT DATE

e. Background history and rrovresst (1) Backmound history: In accordance with AR 70-8, Personnel and Training, dated 20 Decenber 1955, The Surgeon General was assXgned the responsibility for the conduct of research to determine basic psychophysiological data to satisfy Arm;T requirements for such information. (2) Pronress: Group audiometric procedures have been used to conduct a survey of the hearing losses possibly attributable to noises most common in the military environment. A comparative test of tine sound attenuation characteristic: of four e-ar protective devices was completed. The results of the tests were of use in the design and development of the new helmet for combat vehicle crewmen, A special task investigating the side effects accompanying the administration of motion sichmess preventive drugs produced tests sensitive to those side effects. A special. field trip to the Arctic Icecap further defined the visual problems involved in the "whiteout" phenomenon. Initial phases of the study of the effectz of vibration on human performance have been completed and have pointed the way to new areas for investigation. f. Future plans: Research investigations will continue in an effort to produce data concerning the sensory, perceptual and psychosomotor abilities and limitations of the soldier in relationship to the complex and stress producing equipment and weapons he employs in carrying out his military functions,

g. References: "See budResearch Task Summary" h. Modernization Code: Not applicable

DD CORY 61S-1. m sa. 100

i I t ! I

I* _- . .. . I I I1 TYPE OF REPORT R6D PR!DlECT CARD Progress 1. PROJECT TITLE 12. SECURITY Of PROJECT 1 S. PROJECT NO. U 6-97-85-001 Investigations in Overseas Units 4. INDEX NUMBER 1. REPORT DATE 31 3ec. 1957 6. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OBJ. Applied Studies and Techniques Global Medicine Sib13

6. COGNIZANT AGENCY 12. CONTRACTOR AND/OR LABORATORY CONTRACT/W. 0. NO. Office of The Surgeon General,DA D. DIRECTING AGENCY Res. & Dev. Div., OTSG Sse Item 2ld(?) 10. REQUESTING AGENCY

II. PARTICIPATION AND/OR COORDINATION IS. RELATED PROJECTS 17. EST. COMPLETION DATES IIavy (c) RES. Air Force (C) DEV.

.IOP. KVAL. c la. FY. FISCAL ESTIMATLS 14. DATE APPROVED 58 8-ar 12 July 1954 59 98K IS. PRIORITY 16. MAJOR CATLOORY T 9&i 1c

:O. REQUIREMENT ANDIM JUSTIFICATION I I National commitments require the presence of U. S. Armed Forces in diffarent areas of the world where they are exposed to diseases and trauma nct noAmally encountered in the Continental United States. Certain phases of medical resaarch can only he carfled out in areas where such conditions exist. (Par l4iOb CDOG)

1. BRIEF Of PROJECT AND OBJECTIVE a. grief. This is a scisntific prgject. Personnel serving in various locations of the world ar3 exposed to hazards peculiar to the area, tc their living conditions, and to combat situtions. Xaqy aspects of these hazards cannot be reproduced in the United States nor can theater personnel adequate* investigate all of them in addition to thsir assigned duties.

b. Amroach: Nedical problems of this nature are brought to the attention of the Research and Eevelopment Division, OTSG, on the basis of information reaeived from theater personnel, frcm past experience, and frcm a study of medical statistics, 9 The investigation proper is usually performed

L. OASD (RbD) IN. 1 CN. C. X. I. C. FORM PAGE 1 OF 3 PAGES ID 8 APRSS 613 KPLACCS no CORM em. JAN 82. 101 . PROJECT TITLE' 2. SECURITY OF PROJECT 3. PROJECT NO. U 6-97-85-001 Investigations in Overseas Units 4. 5. REPORT DATE 31 Dee* 1957

d. &her information: (1) This project consists entirely of scientific research. Number of research tasks - 1. Number of research contracts - 0. (2) Standardization item - Not applicable (3) wineerine test - Not applicable (4) Berational availabilitv date - Not applicable (5) same or related item - Not applicable (6) gnecific review looints - Not applicable (7) Item 12 - Contractor znd/or Laborators - U. S. Amgr Medical Research Detachment Unit, 406th Medical General Laboratory

e. Background histom and loromess:

(1) Background histom: Research studies are initiated to identify the causes of "fevers of unlrnawn origin" and to determine military importance of exotic diseases to which U. S. Armed Forces are exposed in different areas of the world. Evaluation of studies are made .and ways established for diagnostic tests, means of isolating etiologic agents, and taxonomic identification of entomological species of medical importance.

(2) Promess: Insect vectors of diseases prevalent in certain oversea areas have been under study both in the United States and in oversea laboratories. A breakthrough has been achieved during the past year in rearing Culex DD I'gG 613-1 PAGE 2 OF 3 PACu nm.Accs w mu6SSl. 102 _-

I I RID PROJECT CARD INTINUATION SHEET . PROJECT TITLE I SECURITY OF PROJECT 3. PROJECT NO. U 6-97-8 5 -001 Investigations in derseas Units 4. 5. REPORT DATE 31 Dec. 1957

tritaeniorhmchus. the biological vector of Japanese encephalitis in most of the Far East. The difficulties that have made rearing this mosquito impossible for the past ten years were suddenly resolved when it was discovered that total light duration was the governing factor regulating reproduction when temperature and humidity were optimal. Colonization of this mosquito enables research studies on Japanese encephalitis to progress on a year round basisS instead of seasonally.

f. Future dam: Research will continue on medical problems of importance in militnry operations in the Far East. The main portion of this work is conducted at the Army Medical Research Detachment Unit, Camp Zama, Japan. Its mission is to plan, coordinate and conduct medical research in various areas of the Tar East. The Army Medical Research Detachment Unit also serves as an operating base for Lll medical research teams or groups sent to the Far East for spscific short term investigations.

h. Modernization code: Not applicable

PAGE 3 OF 3 PAGES DD 613-1 IIDUCCS W WRY 6f3-1. I mu. TYPE OF REPORT PROJECT R&D CARD Progrsss REIpjJS&yNJpL SYMBOL U 6-97-87-001 Hedical Effects of Blast on IIan 4. INDEX NUMBER 5. REPORT DATE 31 bc.1957 a. BASIC FIELD OR SUBJECT 7. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OW.

*i.ledicalSciences Basic Nedicdi Sciences PO-32. 0. COGNIZANT AGENCY 12. CONTRACTOR AND/OR LABORATORY CONTRACTIW. 0. NO. Office of The Surgeon General& 8. DIRECTING AQENCY Reso & Dev,, Dive, OTSG IO. REQUESTING ACENCY

I I. PARTICIPATION AND/OR COORDINATION 13. RELATED PROJECTS 17. EST. COMPLETION DATES RES. rt-99~2=ooz-o3 l?d DEV. Ballistics of 2Essiles and .TE~ BhSt OP. EVAL. 10. FY. FISCAL EITIMAm 14. DATE APPROVED 58 4%M 12 November 1956 59 38M 15. PRIORITY 16. YAJOR CATEGORY T lC 2.23 IO. REPLACED PROJECT CARD AND PROJECT STATUS

20. REOUIRLWENT AND/OR JUSTICICATION

Insufficient' experimental e~dencsis available on which to base estimates of the pathologic, physiologic and psychologic hazards f:rm blast as a function of Wfdag blast. conditions (8.g. st.atic overpressure, dyxmdc pressure, pulse duration, and pulse shape), A thorough investigation of the significant mechanism of hlast injury is necessary for planning purposes to detenrine: (a) The probarn' ty that personnel will be rendered ineffec'tive (physiologicdly or psycho1ogicW' as a result of particubs Slasf characteristics. (b) The meshold of safety COE- tingent an different blast conditions. (c) Defense cocsiderations or proteeeve mwmammumces r-easiue r or rf?LIUC~~~QJAST~~ZZ!HS. '- placed on principlas pertinent to personnd. 5n the open, in fo,uho%es, and in hastily erested fortificatlonso (Par l422c QOG)

a, arief: The objective of this projest is t.o determine the relationship between the physiologic and/or psychologis effects and the specific combination of blast variables to which these ezfects may be attributed (peak pressureso pressure gradient, &a-ation of overpressure, single or repeated exposure); to detem5n.e the range between lethal dosage and tolerability of air blsst; and to examine into the

22. OASD (RBD) I SN. CN. C. I x. ' I I. C.

RLPUCES DO CORM 01% lOlc 1 JAN 8%. RLD PROJECT CARD 3NTINUATION SHEET 1. PROJECT TITLE I 2. SECURITY OF PROJECT I 3. PROJECT NO. I Hedical Effects of Blast on Ikn I 6-97-87-001 I,. I 5. REPORT DATE 131 Dec. 1957 interferences by blast w%th certain physiological functions, sensorimotor abilities and higher central nervous system capacities. b, werimients will be designed with ar3nal.s as subjects, Laboratory tests will be made of blood pressure, pulse rate, body temperature, basal netaboUsnt, sensory acuity and of any interference to the learning or problem selving capacities of the animal.dter shock due to blast. Studies will also include eDcamlnation of pathologic.and psychophysiologic hazards derived from secondary sourcc)~such as, translational motion, tumbling along open terrafn striking of solid objectives, and the protective measures therefor.

C. Task: "See Annual Research Task -t," (P=e 61) *Psychological and Physiological Aspects of Blast

de Other Information: (1) This project consists entire* of scientuic researcho Number of research tasks - 1, briber of research contracts - O+ (2) s--* .Ite~:- Xot applicable (3) IEQF11Jeerin,c Tat: - Not applicable

(4) 0mratianal-Av * ability: - Not applicable (5) s- or related Iternst - &en% Pro.iect Niunbq.2- project Title

cbenbca corps 4-99 -02402-03 1$ound Ballistics of Missiles & i3last (U)

Navg Im 64 00 00 Protection From 3last (Other man Ataxic)

(6) Saecific Review Points: = Not applicable (7) Item 12 - Contractor and/or Laboratory; Task: Psychological and Thysiolcgical Aspects of Blast

United States Army Ibdical 3esearch Laboratory, Fort Knox, Xentucw Chmficd Warfare La'ooratories ,Army Chefisdl Center, ITkCYlard

PAGE 2 OF 3 PAGES DD l'gMw 613-1 R&D PROJECT CAW ONTlNUATIbN ##ET I. PROJECT TITLEI I 2 SECURITY OF PROJECT 1 3. PROJECT NO. U 6-97-87-001 I 4. 5. REPORT DATE

e. 3ack.zrcxnd Histom and Progress: (1) Backmound Histom: ., In accordance witn instructions contained in DF from Chief, R69, OCS, DA to The Surgeon General dated 21 May 1956, file No, CRD/G 7354, Subject: Requirements for Inforn- ation on ?r* and Secondary Biological. Effects of Air Blast to Aqy Troops from Nuclear Ifeapons (U) , The Surgeon General, D/A is charged with the responsibility for research on tie effects of blast on rmr

(2) aomess; A blast tube has been constructed at Fort box, Kentucky, and instrumentation is being prepared for tests. f, Future Plans "See Annual Research Task

g, Referemes: "See Annual Research Task Sumnary.ll

h. Modemisation Cod= - Not applicable

PAGE 3 OF 3 PAC= DD ,EMM613-1 106

.i i TYPE OF REPORT

2;hysic Standards Research U I 6-97-87-002 .. 4. INDEX NUMBER 15. REPORT DATE 31 Dsc.1957 6. BASIC FlUD OR SUBJECT 17. SUB FIELD OR SUBJECT SUB GROUP 7A. TECH. OBJ. ~idica~Sciences Basic Nedical Sciences I -PO2 ---- Ffidical Standards 6. Ca!3NlUNT AGENCY 12. CONTRACTOR AND/OR LABORATORY 1 CONTRACT~W. 0. NO. Office of The Surgeon General, D. DIRECTING AGENCY See Item 21d(7) Res, SC Dev. 25.v., OTSG 10. REQUESTING AGENCY

11. PARTICIPATION AND/OR COORDINATION 13. RELATED PROJECTS 17. EST. COMPLETION DATES Xavy (c) RES. us= (c) I DEV. DCS Pers (C) I TEST TAG (c) OP. EVAL. JAG (c) 10. FY. I FISCAL ESTIMATES COITARC (c) 14. DATE APPROVED 58 n?I Selective Service (C) 1 April 1947 59 0 15. PRIORITY [ 16. MAJOR CATEGORY I 2 I 7.23 I IS. REPLACED PROJECT CARD AND PROJECT STATUS

I I 10. REQUIREMENT AND/OR JUITlflCATlON Under present conditions, conservation of utilizable manpower has become of paramount importance. This project is designed to investigate methods by which available manpower may be effectively medically evaluated as regards fitness and suitability for the wide variety of assignments within tne military establishment, (iio EKE Xisfereme)

!l.BRIEF OF PROJECT AND OBJECTIVE a. Brief: A critical evaluation triil be made of the physicdl stzndards criteriz which are presently generally accepted, A review of current przctices restilting from presently accepted criteria and the development of dependable system for the medical evaluation of manpower and (2) a new and hitherto untapped source of skilled military manpower in terms of those individuals whose level of fitness is presently thought to limit or prevent their assignment to military duties,

bo &mroach: A critical evaluation and review will be made of the physi- cLL standards critezja which are presently generally accepted and of the current nrclctices which result from these criteria. .2. OASD (RID) I SN. CN. C. I x. 1. I e. PAGE 1 OF 3 PAQES DD iZ!!s613 IlEPUClE5 DD FORM SIS. 107 JAN 5% RBD PROJECT CARD

I.PROJECT TIT& 2. SECURITY OF PROJECT 3. PROJECT NO. Physical btmdards Research U 6-97-87-002 I,. 5. REPORT DATE I 31 Dec,1957

C. Tasks: "See ArmuaL Research Task Sutlrmary." (Page 62)

d. Other Information: (1)This project corries mder the category of significant scientific research, Wtaber of research tasks - 1, Iiunber of research contracts 0. &!€lda.r dization Item - Not applicable

EJgiIle=€J inp Test: - ITot applicable ODeratioU AvaiLbilitv Date:- - Mot applicable

Same OT Related Items:

Pro-iect Ihmber Project Title

M.Z 32 00 00 Psychologiczl Standards and Testing of Personnel for Efficient 14ilitmj Service

Air Force 7755 ltedical Standards in Aviation (6) Snecific Review Point,.: - Not zqplicable (7) Contractor and/or Labcratory

Walter Reed Anrsy Institute of Research, Walter Reed Amy Kedical Center Vashingtcn, D, C. e. Background Histom and Promess: (1) Sackmound Xistow: In connec-' tion with the present mission of The Surgeon General which is essentially the preservation and maintenance of pbsical and mental health of the Army, it is necessaq that a series of investigations be carried out relating to standards and criteria of mental and physical health. (2) Progress: This project was initiated in Apil L9;57.+ To date a review of sever& forms for reporting of medical casualties has been made, and an initial proposal for a modification of the Pm3fEs system has been drawn up. f, Future Plans: Investigations will continue,

PUCU OD FORM 6lLl. m IS. 108 i I ’ 11

R&O PROJECT CARD ONTINUATION SHEET I 1. PROJECT TlTLE I 2. SECURITY OF PROJECT 3. PROJECT NO. U 6-97-07-002 Physical Standards Research 4. 5. REPORT DATE I 31 bc.1957

Not applicable

I .. 1 d i I ii

1 PAGE 3 OF 3 PACES

DD lrgk 613-1 ~ [ mm.Acm 00 FURY OI11. I m sa. 109

I TYPE OF REPORT RIG D PROJECT CARD i Progress 1. PROJECT TITLE [ 2. SECURITY OF PROJECT 1.3. PROJECT NO. U 6-99-02-001. 4. INDEX NUMBER 3. REPORT DATE 31 Dec.1957 6. BASIC FIELD OR SUBJECT 7. sua FIELD OR SURIECT SUB GROUP 7A. TECH. OW. P@-u, 3asi.r: hsearch Eallistics iJouncl

8. COGNIZANT AGINCY 12. CONTRACTOR AND1 OR LAaORATORY CONTRACT/W. 0. NO. C?l"z'~eol' Tile SW~~OIIGeilei.&.,DA 9. OlRECTlNC AGENCY See Iten 21ci(7) Xes, & 30-J. Div., OTSG 10. REQUESTING AGENCY t 1. PARTICIPATION AND/OR COORDlNATlON 13. RELATED PROJECTS 17. BST. COUILETlON DATES kwi Fmces Inst.Path,(P) RES. laAl3 (PI om. W. C; kd, Labs. (P) TEST Ord. C, (C) OP. SVAL. Ar'srclp (P) 18. FY. FISCAL KITIMATES Y2yy (e) 14. DATE APPROVID 58 ?9 Air 9'orcs (c) Ax5, 19-57 :: 9 73< 13. PRIORITY 18. YAJOR CATKGORY T -7C;.* 1c 7.23 10. REPLACED PROJECT CARD AND PROJECT STATUS

I I 20. REQUIREMINT AND/OR JUSTIFICATION Cetailed information concerning the location, freqx.enc7, a&(? severiG7 cf wounds from missiles ar,d blast is needed in order thzt trea%iaeiit of the tsovzded may be Lxproved and conpetemt advice on protective devices provj-c'd development agencies. (Par 14x0~cI)SG)

:2. OASD (R 6) D) SN. CN. C. X. I '. C.

UV ?EPLACIIS DD FORM 813. JAN S2. R&D PROJECT CARD JNTINUATION SHEET I. PROJECT TmE I L SECURITY OF PROJECT I 3. PROJECT NO. Wound Ballistics U 6-99 lc)~001 I 4. S. REPORT DATE

C. Tasks; "See Annual Research Task Summary." Wound Ballistics ?kIedical Aspects of Protective Armor

d. 0nna;ticm: (1) All the tasks of this project cone under the category of significant scientific research. Number of research tasks - 2, Number of resear& contracts - 0, (2) n Itenr: - Mot applicable (3) Test: - Not applicable

(4) t : I) Not ayplicable

dkzazac Pro-iect %mber Project Title cheEd.cical corps 4-99-02-0024. Biophysical Mecka~sn~sin CW Wounds (U) 4-99-02-QO2-02 Antipersonnel Effectiveness of Incendiary Weapons (0)

4-9g-OZ-OO2-03 I?md Sallistics of Missiles h BWt (u> O;.dnance 5B93-08-OZO( TN-10) Deformation Qaracteestics SR-13 (5967 ' of Armored Vests 7-80-0~&01( 6)POIS Physiological and Wqd (5865) Ballistic Aspects of Personnel Amor

m 64 00 00 Protection &am 3last (Other Than At0nXi.c) (6) Not applicable (7) Item 12 - Contractor and/or Laboratory:

PAGE 2 OF 3 PAGES DD 613-1 DO FORM 6151. m sa. 111 R&D PROJECT CARD JNTlNUATlON SHEET I I. PROJECT TlTLE 12. SECURITY W PROJECT 11. PROJECT NO. 6-9y*02-0cl Wound Ballistics i3 I 4. 5. REPORT OATE I I 33, Dgc. 1957 Task - Wmd Ustics - Hedical Aspects of Protective Armor Corps lbdical Laboratories - (See Chexdcal Corps Projects 4-99-02-002-01; 02; sc 03)

e, dIfigtmand Progress: (1) &&gg ound ELsu- This joint program on the design of body armor, including helmets, is of interest to the various teebid. serxices. Advice on the medical ramifications is Zurnished an a cdtative basis whenrequested by interested agencies..

(2) pr9ctress: Data on effects of missiles on biological tissue* witk and without armor are obtained, Frum these studies reemendations an adequcy of armor iteats ipTe This program is bei- condwted bjr the Che:nical Corps and is supported the Array I

f. Future. : Research stcdies will. cont4inue on the aedicnl aspects of wounding and o%h, missiles in order to develop metho& of protection.

go References : See Chenical Corps Project Reports.

h. ModeMlization code: Not applicable

~~- 3D lg'&613-1 PAGE 2 OF 3 PAGES PUCE8 00 FORM 6IS-1. m u. 112