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Home , Buserelin, Gonadorelin, Leuprorelin, Nafarelin, Peforelin, Zoptarelin doxorubicin

SUPPLEMENTARY DATA

Draft Medline search – PubMed interface

1# ""[Mesh] OR (Puberties) OR (Pubertal Maturation) OR (Early Puberty) OR "Puberty, Precocious"[Mesh] OR () OR "Precocious Puberty, Central" [Supplementary Concept] OR (Central Precocious Puberty) OR "Sexual precocity" [Supplementary Concept] OR (Idiopathic sexual precocity) OR (Familial precocious puberty) OR (Sexual Precocity) OR "Sexual Maturation"[Mesh] OR (Maturation, Sexual) OR (Maturation, Sex) OR (Sex Maturation) OR "Sexual Development"[Mesh] OR (Development, Sexual) OR (Sex Development) OR (Development, Sex) OR (Gonadal Disorder Maturation) OR (Pubertal Onset) OR "Menstruation Disturbances"[Mesh] OR (Precocious Menses) OR (Early Menses) OR (Early Menarche) OR (Precocious Menarche) OR (Disorders of Puberty) OR (-Dependent Precocious Puberty) OR (Gonadotropin-Independent Precocious Puberty) OR (Isolated Precocious Thelarche) OR (Isolated Precocious Pubarche) OR (Isolated Precocious Menarche)

2# "Gonadotropin-Releasing "[Mesh] OR (Gonadotropin Releasing Hormone) OR (-Releasing Hormone) OR (Luteinizing Hormone Releasing Hormone) OR (GnRH) OR (Gonadoliberin) OR () OR (LFRH) OR (LH-FSH Releasing Hormone) OR (LH FSH Releasing Hormone) OR (LH-Releasing Hormone) OR (LH Releasing Hormone) OR (LH-RH) OR (LHFSH Releasing Hormone) OR (Releasing Hormone, LHFSH) OR (LHFSHRH) OR (LHRH) OR (Luliberin) OR (FSH-Releasing Hormone) OR (FSH Releasing Hormone) OR (Gn-RH) OR (Factrel) OR (Gonadorelin ) OR (Kryptocur) OR (Cystorelin) OR (Dirigestran) OR (Gonadorelin Hydrochloride) OR (Luteinizing Hormone Releasing Hormone Analogue) OR (Gonadotropin Releasing Hormone ) OR (GnRH Agonist) OR " Pamoate"[Mesh] OR ""[Mesh] OR "Leuprolide"[Mesh] OR "Triptorelin Pamoate"[Mesh] OR (Pamoate, Triptorelin) OR (CL-118532) OR (CL 118532) OR (CL118532) OR (Decapeptyl) OR (Beaufour Brand of Triptorelin Embonate) OR (Decapeptyl Depot) OR (Ipsen Brand of Triptorelin Embonate) OR (Decapeptyl Trimestral) OR (Trimestral, Decapeptyl) OR (Ferring Brand of Triptorelin Acetate) OR (Ipsen Brand of Triptorelin) OR (Triptorelin Ipsen Brand) OR (Beaufour Brand of Triptorelin) OR (Triptorelin Beaufour Brand) OR (Decapeptyl LP) OR (Triptorelin) OR (LHRH, Tryptophyl(6)-) OR (GnRH, Trp(6)-) OR (LHRH, Trp(6)-) OR

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(6-D-Tryptophan-Luteinizing Hormone-Releasing Factor (Pig)) OR (D-Trp-6-LH-RH) OR (Wy-42462) OR (Wy 42462) OR (Wy42462) OR (AY-25650) OR (AY 25650) OR (AY25650) OR (Trelstar) OR (Watson Brand of Triptorelin Embonate) OR (Triptorelin Embonate) OR (Embonate, Triptorelin) OR "Nafarelin"[Mesh] OR (Synarel) OR (RS-94991- 298) OR (RS 94991 298) OR (RS94991298) OR (Nafarelin Acetate) OR (Nafarelin Acetate, Hydrate) OR (Nafarelin Monoacetate) OR "Leuprolide"[Mesh] OR () OR (Enantone) OR (Leuprolide Acetate) OR (Acetate, Leuprolide) OR (Leuprolide Monoacetate) OR (Monoacetate, Leuprolide) OR (Leuprolide, (L-Leu)-Isomer) OR (Lupron) OR (TAP- 144) OR (TAP 144) OR (TAP144) OR (A-43818) OR (A 43818) OR (A43818) OR (Leuprolide, (DL-Leu)-Isomer) OR ""[Mesh] OR (ICI-118630) OR (ICI 118630) OR (ICI118630) OR (Zoladex) OR (Goserelin Acetate) OR (Acetate, Goserelin) OR ""[Mesh] OR (Buserelin Acetate) OR (Acetate, Buserelin) OR (Suprefact) OR (Profact) OR (Aventis Brand of Buserelin Acetate) OR (Receptal) OR (Intervet Brand of Buserelin Acetate) OR (Tiloryth) OR (Hoechst Brand of Buserelin Acetate) OR (Suprecur) OR (Galenpharma Brand of Buserelin Acetate) OR (Bigonist) OR (-Aventis Brand of Buserelin Acetate) OR (Sanofi Aventis Brand of Buserelin Acetate) OR (HOE-766) OR (HOE 766) OR (HOE766)

3# "Body Height"[Mesh] OR (Body Heights) OR (Height, Body) OR (Heights Body) OR (Final Height) OR (Target Height) OR (Predicted Height) OR (Growth) OR (Skeletal Growth) OR (Bone Maturation) OR (Auxological Anthropometry) OR (Adult Height) OR (Body Size) OR (Body Sizes) OR (Size, Body) OR (Sizes, Body) OR (Vertical Dimension) OR (Height)

#4 (randomized controlled trial [pt] OR controlled [pt] OR randomized controlled trials [mh] OR random allocation [mh] OR double-blind method [mh] OR single-blind method [mh] OR clinical trial [pt] OR clinical trials [mh] OR ("clinical trial" [tw]) OR ((singl* [tw] OR doubl* [tw] OR trebl* [tw] OR tripl* [tw]) AND (mask* [tw] OR blind* [tw])) OR ( placebos [mh] OR placebo* [tw] OR random* [tw] OR research design [mh:noexp] OR comparative study [mh] OR evaluation studies [mh] OR follow-up studies [mh] OR prospective studies [mh] OR control* [tw] OR prospectiv* [tw] OR volunteer* [tw]) NOT (animals [mh] NOT humans [mh])

#1 AND #2 AND #3 AND #4

2

Draft Embase search

#1 'precocious puberty'/exp OR 'precocity, sexual' OR 'premature pubarche' OR 'premature puberty' OR 'premature thelarche' OR 'proeotia' OR 'proiotia' OR 'pubertas praecox' OR 'pubertas precox' OR 'puberty praecox' OR 'puberty, precocious' OR 'sex precocity' OR 'sexual precocity' OR ‘early puberty’ 2# 'gonadorelin'/exp OR '6 leucine 10 deglycine gonadotropin releasing factor ethylamide'/exp OR '[6 leucine 10 deglycine] gonadotropin releasing factor ethylamide'/exp OR 'ay 24, 031'/exp OR 'ay 24031'/exp OR 'ay24, 031'/exp OR 'ay24031'/exp OR 'cryptocur'/exp OR 'factrel'/exp OR 'fertagyl'/exp OR 'fertiral'/exp OR 'gn rh'/exp OR 'gnrh'/exp OR 'gnrh serono'/exp OR 'gonadoliberin'/exp OR 'gonadorelin hydrochloride'/exp OR 'gonadotrophin releasing factor'/exp OR 'gonadotrophin releasing hormone'/exp OR 'gonadotropin release factor'/exp OR 'gonadotropin releasing factor'/exp OR 'gonadotropin releasing hormone'/exp OR 'gonadotropin-releasing hormone'/exp OR 'hoe 471'/exp OR 'hoe471'/exp OR 'hoechst 471'/exp OR 'ici 88262'/exp OR 'ici88262'/exp OR 'kryptocur'/exp OR 'lh releasing hormone'/exp OR 'lrh'/exp OR 'lrh luteinising hormone releasing factor'/exp OR 'lrh luteinizing hormone releasing factor'/exp OR 'luforan'/exp OR 'luliberin'/exp OR 'luliberine'/exp OR 'lutal'/exp OR 'lutamin'/exp OR 'luteinising hormone release factor'/exp OR 'luteinising hormone releasing factor'/exp OR 'luteinising hormone releasing hormone'/exp OR 'luteinizing hormone release factor'/exp OR 'luteinizing hormone releasing factor'/exp OR 'luteinizing hormone releasing hormone'/exp OR 'pulstim'/exp OR 'relisorm'/exp OR 'gonadorelin agonist'/exp OR 'gnrh agonist'/exp OR 'gonadotropin releasing hormone agonist'/exp OR 'lhrh agonist'/exp OR 'luteinising hormone releasing hormone agonist'/exp OR 'luteinizing hormone releasing hormone agonist'/exp OR 'gonadorelin derivative'/exp OR 'gnrh derivative'/exp OR 'gonadoliberin analog'/exp OR 'gonadoliberin derivative'/exp OR 'gonadorelin analog'/exp OR 'gonadotropin releasing factor derivative'/exp OR 'gonadotropin releasing hormone analog'/exp OR 'gonadotropin releasing hormone derivative'/exp OR 'gonadotropin releasing hormone analogs'/exp OR 'lh releasing hormone analog'/exp OR 'lhrh'/exp OR 'hrh analog' OR 'lhrh derivative'/exp OR 'luliberin analog'/exp OR 'luliberin derivative'/exp OR 'luteinising hormone releasing factor derivative'/exp OR 'luteinising hormone releasing hormone analog'/exp OR 'luteinising hormone releasing hormone derivative'/exp OR 'luteinising releasing hormone analog'/exp OR 'luteinizing 3 hormone releasing factor derivative'/exp OR 'luteinizing hormone releasing hormone analog'/exp OR 'luteinizing hormone releasing hormone derivative'/exp OR 'luteinizing releasing hormone analog'/exp OR 'avorelin'/exp OR 'buserelin'/exp OR 'buserelin acetate'/exp OR 'dalarelin'/exp OR ''/exp OR 'folligen'/exp OR 'gonadorelin acetate'/exp OR 'gonadorelin associated '/exp OR 'gonadorelin associated peptide derivative'/exp OR 'gonadorelin[1-9] ethylamide[6 dextro tryptophan]'/exp OR 'gonadorelin[1-9][6 dextro alanine]'/exp OR 'gonadorelin[6 dextro [3 (2 naphthyl)alanine] 10 azaglycine]'/exp OR 'gonadorelin[6 dextro lysine] 2 pyrrolinodoxorubicin'/exp OR 'gonadorelin[6 medphalan]'/exp OR 'goserelin or or leuprorelin' OR 'leuprorelin plus acetate'/exp OR 'lutrelin'/exp OR 'nafarelin'/exp OR 'nafarelin acetate'/exp OR 'ovurelin'/exp OR ''/exp OR 'triptorelin'/exp OR 'zoptarelin '/exp) #3 'height'/exp OR 'body height'/exp OR 'body length'/exp OR 'height, body'/exp OR 'length, body'/exp OR 'stature'/exp) #1 AND #2 AND #3

Draft Lilacs search – Virtual Health Library interface

1# MH:"Puberdade Precoce" OR (Early Puberty) OR MH:C19.391.693$ 2# MH:"Hormônio Liberador de Gonadotropina" OR (Hormônio Liberador do FSH) OR GnRH OR Gonadoliberina OR Gonadorrelina OR (Hormônio Liberador de LH-FSH) OR LHRH OR Luliberina OR (Hormônio Liberador de Hormônio Luteinizante) OR MH:D06.472.699.327.740.320$ OR MH:D12.644.400.400.740.320$ OR MH:D12.644.456.460$ OR MH:D12.644.548.365.740.320$ OR MH:D12.776.641.650.405.740.320$ OR MH:"Busserrelina" OR MH:D06.472.699.327.740.320.100$ OR MH:D12.644.400.400.740.320.100$ OR MH:D12.644.456.460.150$ OR MH:D12.644.548.365.740.320.100$ OR MH:D12.776.641.650.405.740.320.100$ OR MH:"Gosserrelina" OR MH:D06.472.699.327.740.320.340$ OR MH:D12.644.400.400.740.320.340$ OR MH:D12.644.456.460.315$ OR MH:D12.644.548.365.740.320.340$ OR MH:D12.776.641.650.405.740.320.340$ OR MH:"Leuprolida" OR MH:D06.472.699.327.740.320.400$ OR MH:D12.644.400.400.740.320.400$ OR MH:D12.644.456.460.480$ OR MH:D12.644.548.365.740.320.400$ OR MH:D12.776.641.650.405.740.320.400$ OR MH:"Nafarelina" OR MH:D06.472.699.327.740.320.580$ OR MH:D12.644.400.400.740.320.580$ OR 4

MH:D12.644.456.460.600$ OR MH:D12.644.548.365.740.320.580$ OR MH:D12.776.641.650.405.740.320.580$ OR MH:"Pamoato de Triptorrelina" OR (D-Trp-6- LH-RH) OR (Trp(6)-LHRH) OR (Pamoato de Triptorelina) OR Triptorrelina OR Triptorelina OR MH:D06.472.699.327.740.320.790$ OR MH:D12.644.400.400.740.320.790$ OR MH:D12.644.456.460.800$ OR MH:D12.644.548.365.740.320.790$ OR MH:D12.776.641.650.405.740.320.790$ 3# MH:"Estatura" OR Altura OR (Altura do Corpo) OR (Altura Corporal) OR MH:E01.370.600.115.100.160.100$ OR MH:E05.041.124.160.500$ OR MH:G07.100.100.160.100$ OR MH:G07.700.320.249.314.100$ OR MH:SP6.011.042.048.019$

#1 AND #2 AND #3

Draft CENTRAL Cochrane search

#1 MeSH descriptor: [Puberty, Precocious] explode all trees 65 #2 Precocious Puberty 135 #3 Early Puberty 326 #4 MeSH descriptor: [Gonadotropin-Releasing Hormone] explode all trees 2236 #5 gonadorelin 1255 #6 Precocious Thelarche 1 #7 MeSH descriptor: [Nafarelin] explode all trees 78 #8 Nafarelin Acetate 95 #9 MeSH descriptor: [Leuprolide] explode all trees 519 #10 MeSH descriptor: [Triptorelin Pamoate] explode all trees 311 #11 MeSH descriptor: [Nafarelin] explode all trees 78 #12 MeSH descriptor: [Goserelin] explode all trees 408 #13 Goserelin Acetate 201 #14 Acetate, Goserelin 201 #15 MeSH descriptor: [Buserelin] explode all trees 275 #16 Buserelin Acetate 166 #17 (Gonadotropin Releasing Hormone) or (LHFSH Releasing Hormone) or (Releasing Hormone) or LHFSH or (LH-Releasing Hormone) or (LH Releasing Hormone) or (LH-FSH Releasing Hormone) or (LH FSH Releasing Hormon) or (Luteinizing Hormone-Releasing

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Hormone) or (Luteinizing Hormone Releasing Hormone) or (FSH-Releasing Hormone) or (FSH Releasing Hormone) 4201 #18 #4 or #17 4772 #19 Leuprolide Acetate or Acetate, Leuprolide or Leuprolide Monoacetate or Monoacetate, Leuprolide or Leuprolide, (L-Leu) -Isomer or Leuprolide, (DL-Leu) -Isomer 468 #20 #9 or #19 694 #21 Pamoate, Triptorelin or Triptorelin or Triptorelin Embonate or Embonate, Triptorelin 656 #22 #10 or #21 656 #23 MeSH descriptor: [Body Height] explode all trees 1400 #24 Body Heights or Height, Body or Heights, Body 6639 #25 #23 or #24 6644 #26 #1 or #2 or #3 409 #27 #5 or #7 or #8 or #11 or #12 or #13 or #14 or #15 or #16 or #20 or #22 2916 #28 #23 or #24 6644 #29 #26 and #27 85

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