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Proceedingsx LINZ 2015 – EUSAAT 2015 Volume 4, No. 2 ISSN 2194-0479 (2015) AlteProceedingsX Horst Spielmann: Skin sensitization Welcome Efficacy and safety testing Multi-Organ-Chips Nanotoxicology Stem Cells Disease Models 3D Models Biobarriers International Progress EU Directive 63/2010/EU in 3Rs Research & on the Protection Global Cooperation of Animals Used for on Implementing Scientific Purposes the 3Rs Ethics & Legal Issues QSAR & Read Across Refinement & Culture Risk Assessment of Care Based on the AOP Concept Replacement Repeated-Dose Toxicity 3Rs in Academia and Other and Education Toxicological Endpoints Young Scientists Inhalation Short Lectures SCIENCE WITHOUT SUFFERING Advancing 21st century toxicology & bioscience research worldwide Humane Society International is present on the ground in the world’s top economies—ending cosmetics animal testing and trade, driving acceptance and use of alternative methods, and boosting investment in human biology-based technologies to ultimately replace animal use. hsi.org/endanimaltesting HSI EUSAAT program insert.indd 1 2015-08-31 6:42 PM LINZ 2015 Welcome address Dear friends and colleagues, On behalf of EUSAAT, the European Society for Alternatives to Animal Testing, I welcome you to the “EUSAAT 2015 - Linz 2015” congress, which is actually the “16th Annual Congress of EUSAAT” and the “19th European Congress on Alternatives to Animal Testing” on 20-23 of September 2015 in Linz. During the past two decades the “Linz-Congress” has emerged in Europe as one of the major scientific events in the field of the 3Rs. EUSAAT 2015 is hosting presentations, discussions and exchange of new ideas for the benefit of alternative methods to animal experiments. The Scientific Committee has identified the most important subjects related to the 3Rs, which are of interest to scientists in Europe. The EUSAAT 2015 conference is focusing in oral and poster sessions on animal-free disease models, non-animal tools for basic biomedical research, -omics-techniques and advanced 3D models including recent progress on developing a “human-on-a-chip”. Thus EUSAAT 2015 is providing a forum for discussing the new EU Directive 2010/63/EU on the protection of animals used for scientific purposes, which is currently being implemented in EU member states. Colleagues from the EU Commission, from member states and from the animal welfare movement will discuss the high expectations that the public at large and the animal welfare movement have for improving the current situation on behalf of the experimental animals. This year we are happy that two satellite meetings will be held right after the EUSAAT 2015 congress on 23-24 September 2015. Taking into account the successful first practical training course at the last EUSAAT congress in 2013 we will hold the second “EUSAAT 2015 Practical Training Course on Alternative Methods” focusing on “Assessment of in vitro eye irritation potential – focusing on methods accepted for the regulatory purposes”. We are grateful to all speakers for contributing to the training course and in particular Helena Kandarova for organizing the training EUSAAT course and also for a financial contribution via MatTek IVLSL. In addition we do appreciate that the German Foundation SET (Stiftung zum Ersatz von Tierversuchen, engl. “Foundation for the Promotion of Alternate and Complementary Methods to Reduce Animal Testing”) will hold the satellite SET Workshop “Translational Aspects of in vitro and in vivo Models for Inflammatory Diseases” on 23-24 September 2015. We want to thank the SET foundation for sponsoring the workshop and in particular for covering the travel expenses of invited experts, several of whom have agreed to give lectures at the EUSAAT 2015 congress in sessions on “disease models”. We are particularly indebted to Manfred Liebsch, chair of the Scientific Advisory Board of the SET Foundation, for organising the workshop and for inviting speakers to our congress. Taking into account the successful program for “Travel grants for students and young scientists” of WC9, the 9th World Congress on Alternatives, which was held last year in Prague, EUSAAT 2015 has this for the first time offered a Young Scientists Travel Award (YSTA) program. Therefore we will for the first time at an EUSAAT conference hold two sessions with “Young Scientists Short Lectures” and also present YSTA Lecture Awards. We want to express our thanks to the organizers of the YSTA program Helena Kandarova, Lucia Lee and Manfred Liebsch, who also organized the students and young scientists program at WC9 in Prague last year. The YSTA program has been quite attractive for young scientists and due to the generous funding by the SET Foundation, MatTek IVLSL and BASF we will be able to offer around 30 travel awards. The EUSAAT Board is quite happy that the number of sponsors of the EUSAAT congresses has increased over the years, since without their continuous support we would not be able to maintain the high scientific standard and to keep the congress fee low. Both elements are equally important in order to attract young scientists from all over Europe and beyond. Therefore, the EUSAAT Board and Scientific Committee want to thank all of the sponsors of EUSAAT 2015 on behalf of the participants. I finally want to thank my colleagues on the EUSAAT Board and in the Scientific Committee for their continuous support in planning EUSAAT 2015. Horst Spielmann President EUSAAT ALTEX Proceedings 4(2), 2015, LINZ 2015 I LINZ 2015 List of Abstracts ID Title Authors Type 1 Analysis of insulin mimetic phytochemicals with Renate Haselgrübler, Verena Stadlbauer, Otmar Poster a complementary chick embryo model Höglinger, Klaus R. Schröder, Peter Lanzerstorfer, Julian Weghuber 2 HTS for screening of selective muscarinic Valerii Tonkopii Lecture cholinergic receptors antagonists 4 Update on 3Rs activities at the EU institutional Francois Busquet Lecture level and beyond the borders. 5 Systematic Assessment of Different Computational Priyanka Banerjee, Vishal B Siramshetty, Lecture Approaches for Prediction of Toxic Effects of New Malgorzata Drwal, Mathias Dunkel, Chemical Structures Robert Preissner 6 A 3D in vitro iPSC derived mini-brain model to David Pamies Lecture study Parkinson’s disease 7 Human intervertebral disc as an efficient source for Tomaz Velnar, Lidija Gradisnik Poster annulus fibrosus and nucleus pulpous cell isolation 8 Isolated human intervertebral disc cells as a useful Lidija Gradisnik, Tomaz Velnar Poster platform for in vitro toxicology tests 9 Modular human biochip-based organoid models in Alexander Mosig, Marko Gröger, Knut Rennert, Lecture sepsis research Benjamin Giszas, Ralf Claus, Otmar Huber 10 Development of Micro-Engineered 3-Dimensional Su Su Htwe, Alan Knox, Amir Ghaemmaghami Poster Biomimetic Hydrogel Culture System by using Gelatin Methacrylate 11 Systems Toxicology-based assessment of Aerosols Julia Hoeng Lecture using Human Organotypic Tissue Cultures of Nasal and Bronchial Epithelium 12 28-day microphysiological monitoring of human Joachim Wiest Lecture hepatocellular cells 16 BoNT Activity Determination by Stimulus- Andrea Pathe-Neuschäfer-Rube, Lecture dependent Release of Neuro-secretory Vesicle- Frank Neuschäfer-Rube, Lara Genz, targeted Luciferase from Neuronal Cell lines Gerhard Püschel 17 In vitro assays for the potency determination of Emina Wild, Heike Behrensdorf-Nicol, Ursula Lecture botulinum neurotoxin serotypes A and B Bonifas, Jolanta Klimek, Beate Krämer, Birgit Kegel 19 A novel human organotypic tumor invasion model Sebastian Konzok, Susann Schindler, Danny Jonigk, Lecture of cell line MDA-MB-231 in Precision-Cut Lung Peter Braubach, Armin Braun, Katherina Sewald Slices (PCLS) to reduce animal experiments in preclinical oncology 20 Legal issues in the work of the German National Justyna Chmielewska, Barbara Grune, Bettina Bert, Lecture Committee: an overview Nora Leich, Gilbert Schönfelder 21 Working together to develop and implement a Kirsty Reid Lecture 'culture of care' II ALTEX Proceedings 4(2), 2015, LINZ 2015 LINZ 2015 ID Title Authors Type 22 Application of in silico methods for predictions of Malgorzata Drwal, Janette Nickel, Lecture different toxicological endpoints Priyanka Banerjee, Vishal Babu Siramshetty, Mathias Dunkel, Robert Preissner 23 Preliminary validation studies of a 3D in vitro Ingeborg Kooter, Mariska Gröllers, Evert Duister- Lecture inhalation model, using cytokine and gene maat, Yvonne Staal, Frederique van Acker, expression responses to metal-oxide particles Eric Schoen, Eugene van Someren, Frieke Kuper 24 Do scientists have an adequate overview of global Adrian Smith, Tim Allen, Karina Smith, Poster 3R resources? Øyvind Wærenskjold, Bente Bergersen, Siri Knudsen, Anton Krag, Anne Ramstad 25 Ending severe suffering: the scientific animal Elliot Lilley, Penny Hawkins Lecture welfare organisation as a catalyst for change 26 Animal Research: Critical, Challenging & Creative Juliet Dukes, Nikki Osborne, Elliot Lilley, Penny Lecture Thinking about the 3Rs Hawkins 27 The Role of the National Committee in Bettina Bert, Barbara Grune, Justyna Chmielewska, Lecture Germany - Severity Assessment of Genetically Nora Leich, Gilbert Schönfelder Altered Animals 28 Towards the prediction of nanoparticle-induced Martin Wiemann, Antje Vennemann, Lan Ma-Hock, Lecture inhalation toxicity: Evaluation of an in vitro mac- Karin Wiench, Robert Landsiedel rophage assay 29 Reboot3R - Design Thinking Workshops for Cecilia Hilmer, Laura Behm, Annemarie Lang Lecture scientists to constructively
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