bioRxiv preprint doi: https://doi.org/10.1101/455709; this version posted October 30, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Coherent Transcription Factor Target Networks Illuminate Epithelial Remodelling and Oncogenic Notch Ian M. Overton1,2,3,4*, Andrew H. Sims1, Jeremy A. Owen2,5, Bret S. E. Heale1,6, Matthew J. Ford1,7, Alexander L. R. Lubbock1,8, Erola Pairo-Castineira1, Abdelkader Essafi1,9 1. MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK 2. Department of Systems Biology, Harvard University, Boston MA 02115, USA 3. Centre for Synthetic and Systems Biology (SynthSys), University of Edinburgh, Edinburgh EH9 3BF, UK 4. Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast BT9 7AE, UK 5. Department of Physics, Massachusetts Institute of Technology, Cambridge MA 02139, USA 6. Current address: Intermountain Healthcare, 3930 River Walk, West Valley City UT 84120, USA 7. Current address: Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal H3A 0G4, Canada 8. Current address: Department of Biochemistry, Vanderbilt University, Nashville TN 37232, USA 9. Current address: School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK *Corresponding author:
[email protected] Running title: Mapping Transcription Factor Networks Subject categories: Network biology; Chromatin, Epigenetics, Genomics & Functional Genomics Manuscript character count: 168,671 1 bioRxiv preprint doi: https://doi.org/10.1101/455709; this version posted October 30, 2018.