Comprehensive Characterization of Protein-Protein Interaction Network
bioRxiv preprint doi: https://doi.org/10.1101/2020.09.18.302588; this version posted September 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Comprehensive characterization of protein-protein interaction network perturbations by human disease mutations Feixiong Cheng1-3,#, Junfei Zhao4,5,#, Yang Wang6,7,#, Weiqiang Lu8,#, Zehui Liu9, Yadi Zhou1, William Martin1, Ruisheng Wang10, Jin Huang9, Tong Hao 6,7, Hong Yue6,7, Jing Ma6,7, Yuan Hou1, Jessica Castrillon1, Jiansong Fang1, Justin D. Lathia2,3, Ruth A. Keri3,11, Felice C. Lightstone12, Elliott Marshall Antman13, Raul Rabadan4,5, David E. Hill6,7, Charis Eng1-3,14,15, Marc Vidal6,7, Joseph Loscalzo10,* 1Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA 2Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA 3Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA 4Department of Systems Biology, Herbert Irving Comprehensive Center, Columbia University, New York, NY 10032, USA 5Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA 6Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana- Farber Cancer Institute, Boston, MA 02215, USA. 7Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. 8Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200062, China 9Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China bioRxiv preprint doi: https://doi.org/10.1101/2020.09.18.302588; this version posted September 21, 2020.
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