The Human Nervous System S Tructure and Function
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Somatosensory Systems
Somatosensory Systems Sue Keirstead, Ph.D. Assistant Professor Dept. of Integrative Biology and Physiology Stem Cell Institute E-mail: [email protected] Tel: 612 626 2290 Class 9: Somatosensory System (p. 292-306) 1. Describe the 3 main types of somatic sensations: 1. tactile: light touch, deep pressure, vibration, cold, hot, etc., 2. pain, 3. Proprioception. 2. List the types of sensory receptors that are found in the skin (Figure 9.11) and explain what determines the optimum type of stimulus that will activate each. 3. Describe the two different modality-specific ascending somatosensory pathways and note which modalities are carried in each (Figure 9.10 and 9.13). 4. Describe how it is possible for us to differentiate between stimuli of different modalities in the same body part (i.e. fingertip). Consider this at the level of 1) the sensory receptors and 2) the neurons onto which they synapse in the ascending sensory systems. 5. Explain how one might determine the location of a spinal cord injury based on the modality of sensation that is lost and the region of the body (both the side of the body and body part) where sensation is lost (Figure 9.18). 6. Describe how incoming sensory inputs from primary sensory axons can be modified at the level of the spinal cord and relate this to the mechanism of action of some common pain medications (Figure 9-18). 7. Describe the homunculus and explain the significance of the size of the region of the somatosensory cortex devoted to a particular body part. Cerebral cortex Interneuron Thalamus Interneuron 4 Integration of sensory Stimulus input in the CNS 1 Stimulation Sensory Axon of sensory of sensory receptor neuron receptor Graded potential Action potentials 2 Transduction 3 Generation of of the stimulus action potentials Copyright © 2016 by John Wiley & Sons, Inc. -
Proprioceptive- Deep Tendon Reflex Dr. Jose Palomar
PROPRIOCEPTIVE- DEEP TENDON REFLEX DR. JOSE PALOMAR PROPRIOCEPTIVE- DEEP TENDON REFLEX DR. JOSE PALOMAR Proprioceptive-Deep Tendon Reflex About the Author Dr. Jose Palomar Lever, M.D. is a native of Guadalajara, the capital city of the state of Jalisco in Mexico. He began his medical school education at the age of 17 at the Universidad Autónoma de Guadalajara (UAG) and received his training in Orthopedic Surgery and Traumatology at the Universidad del Ejercito y Fuerza Aérea (UDEFA). He performed his first orthopedic surgery at the age of 24 and between 1984 and 1988 was an orthopedic surgeon on the staff of the Reconstructive and Plastic Surgery Institute of Jalisco, S.S.A. He went on to receive specialized training in minimally invasive spine surgery at the Texas Back Institute in Dallas, Texas. Pursuing his interest in what he now refers to as the “software” of the human body, a study, which began in earnest for him in 2000, Dr. Palomar became a Diplomate in Applied Kinesiology from the International College of Applied Kinesiology (ICAK). He received the organization's Alan Beardall Memorial Award for Research for 2004-2005 and over the years has had eighteen papers accepted for inclusion in ICAK-USA Proceedings. He also completed the Carrick Institute for Graduate Studies program in Clinical Neurology. Today, in addition to pursuing an ongoing research program, Dr. Palomar conducts regular trainings in Proprioceptive-Deep Tendon Reflex (P-DTR) for medical practitioners in USA, Canada, Australia, Mexico, England, Poland, Latvia and Russia, and continues to practice medicine from his home base in Guadalajara, Mexico. -
Hemispheric Differences in the Mesostriatal Dopaminergic System
REVIEW ARTICLE published: 11 June 2014 SYSTEMS NEUROSCIENCE doi: 10.3389/fnsys.2014.00110 Hemispheric differences in the mesostriatal dopaminergic system Ilana Molochnikov and Dana Cohen* The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel Edited by: The mesostriatal dopaminergic system, which comprises the mesolimbic and the Ahmed A. Moustafa, University of nigrostriatal pathways, plays a major role in neural processing underlying motor and limbic Western Sydney, Australia functions. Multiple reports suggest that these processes are influenced by hemispheric Reviewed by: differences in striatal dopamine (DA) levels, DA turnover and its receptor activity. Here, Rachel Tomer, University of Haifa, Israel we review studies which measured the concentration of DA and its metabolites to Reuben Ruby Shamir, Case Western examine the relationship between DA imbalance and animal behavior under different Reserve University, USA conditions. Specifically, we assess evidence in support of endogenous, inter-hemispheric *Correspondence: DA imbalance; determine whether the known anatomy provides a suitable substrate for Dana Cohen, The Gonda Brain this imbalance; examine the relationship between DA imbalance and animal behavior; and Research Center, Bar Ilan University, Building number 901, Ramat Gan characterize the symmetry of the observed inter-hemispheric laterality in the nigrostriatal 52900, Israel and the mesolimbic DA systems. We conclude that many studies provide supporting e-mail: [email protected] evidence for the occurrence of experience-dependent endogenous DA imbalance which is controlled by a dedicated regulatory/compensatory mechanism. Additionally, it seems that the link between DA imbalance and animal behavior is better characterized in the nigrostriatal than in the mesolimbic system. -
Tissue Engineered Myelination and the Stretch Reflex Arc Sensory Circuit: Defined Medium Ormulation,F Interface Design and Microfabrication
University of Central Florida STARS Electronic Theses and Dissertations, 2004-2019 2009 Tissue Engineered Myelination And The Stretch Reflex Arc Sensory Circuit: Defined Medium ormulation,F Interface Design And Microfabrication John Rumsey University of Central Florida Part of the Biology Commons Find similar works at: https://stars.library.ucf.edu/etd University of Central Florida Libraries http://library.ucf.edu This Doctoral Dissertation (Open Access) is brought to you for free and open access by STARS. It has been accepted for inclusion in Electronic Theses and Dissertations, 2004-2019 by an authorized administrator of STARS. For more information, please contact [email protected]. STARS Citation Rumsey, John, "Tissue Engineered Myelination And The Stretch Reflex Arc Sensory Circuit: Defined Medium Formulation, Interface Design And Microfabrication" (2009). Electronic Theses and Dissertations, 2004-2019. 3826. https://stars.library.ucf.edu/etd/3826 TISSUE ENGINEERED MYELINATION AND THE STRETCH REFLEX ARC SENSORY CIRCUIT: DEFINED MEDIUM FORMULATION, INTERFACE DESIGN AND MICROFABRICATION by JOHN WAYNE RUMSEY B.S. University of Florida, 2001 M.S. University of Central Florida, 2004 A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Burnett School of Biomedical Sciences in the College of Medicine at the University of Central Florida Orlando, Florida Fall Term 2009 Major Professor: James J. Hickman ABSTRACT The overall focus of this research project was to develop an in vitro tissue- engineered system that accurately reproduced the physiology of the sensory elements of the stretch reflex arc as well as engineer the myelination of neurons in the systems. In order to achieve this goal we hypothesized that myelinating culture systems, intrafusal muscle fibers and the sensory circuit of the stretch reflex arc could be bioengineered using serum-free medium formulations, growth substrate interface design and microfabrication technology. -
BRS Physiology 3Rd Edition
Board Review Series • Reflects USMLE changes • Approximately 350 USMLE-type questions with explanations • Numerous illustrations, diagrams, and tables • Easy-to-follow outline covering all USMLE-tested topics • A comprehensive examination V Ah, LIPPINCOTT -"*" WILLIAMS &WILKIN; mum IEEE mows IF 'IMP IMMO MINK I I. Key Physiology Topics for USMLE Step I Cell Physiology Transport mechanisms Ionic basis for action potential Excitation-contraction coupling in skeletal, cardiac, and smooth muscle Neuromuscular transmission Autonomic Physiology Cholinergic receptors Adrenergic receptors Effects of autonomic nervous system on organ system function Cardiovascular Physiology Events of cardiac cycle Pressure, flow, resistance relationships Frank-Starling law of the heart Ventricular pressure-volume loops Ionic basis for cardiac action potentials Starling forces in capillaries Regulation of arterial pressure (baroreceptors and renin-angiotensin II-aldosterone system) Cardiovascular and pulmonary responses to exercise Cardiovascular responses to hemorrhage Cardiovascular responses to changes in posture Respiratory Physiology Lung and chest-wall compliance curves Breathing cycle Hemoglobin-02 dissociation curve Causes of hypoxemia and hypoxia vq, P02, and P00 2 in upright lung V/Q defects Peripheral and central chemoreceptors in control of breathing Responses to high altitude Renal and Acid-Base Physiology Fluid shifts between body fluid compartments Starling forces across glomerular capillaries Transporters in various segments of nephron (Na Cl-, -
Diabetic Ketoacidosis Associated with Guillain-Barre Syndromewith
CASE REPORT Diabetic Ketoacidosis Associated with Guillain-Barre Syndromewith AutonomicDysfunction Setsuko Fujiwara, Hiroyuki Oshika, Kenzo Motoki, Kenji Kubo*, Yukiaki Ryujin*, Masahiro Shinozaki**, Takuzo Hano*** and Ichiro Nishio*** Abstract Case Report A37-year-old womanwas admitted in a comatosestate, In March 1996, a 37-year-old womanwas admitted to Koyo after exhibiting fever and diarrhea. Diabetic ketoacidosis Hospital in a comatose state after fever, diarrhea and vomiting was diagnosed due to an increased blood glucose level (672 of 1-week duration. Diabetes mellitus was diagnosed in 1990, mg/dl), metabolic addosis, and positive urinary ketone bod- and the patient had taken anti-diabetic drugs for five years, but ies. On the fifth hospital day, despite recovery from the criti- follow-up was discontinued in 1995. She had no episodes of cal state of ketoacidosis, the patient suffered from dyspha- neurological deficit or fainting and was workingas a nurse. gia, hypesthesia and motor weakness, followed by respira- On admission, Kussmaul's breathing, blood pressure of 96/ tory failure. Cerebrospinal fluid analysis was suggestive of 56 mmHg,and a heart rate of 122/min were observed. DKA Guillain-Barre syndrome (GBS). Autonomic dysfunction was diagnosed on the basis of an increased blood glucose level was manifested as tachycardia and mild hypertension in (672 mg/dl), severe metabolic acidosis (arterial blood gas analy- the acute stage. Marked orthostatic hypotension persisted sis: pH 6.703, PCO2 13.8 mmHg, PO2 281.4 mmHg, HCO3 1.7 long after paresis was improved, indicating an atypical clini- jjmol//, BE -36.3 jimol//) and urinary ketone bodies. Other labo- cal course of GBS. -
Men's Athlete Profiles 1 49KG – SIMPLICE FOTSALA – CAMEROON
Gold Coast 2018 Commonwealth Games - Men's Athlete Profiles 49KG – SIMPLICE FOTSALA – CAMEROON (CMR) Date Of Birth : 09/05/1989 Place Of Birth : Yaoundé Height : 160cm Residence : Region du Centre 2018 – Indian Open Boxing Tournament (New Delhi, IND) 5th place – 49KG Lost to Amit Panghal (IND) 5:0 in the quarter-final; Won against Muhammad Fuad Bin Mohamed Redzuan (MAS) 5:0 in the first preliminary round 2017 – AFBC African Confederation Boxing Championships (Brazzaville, CGO) 2nd place – 49KG Lost to Matias Hamunyela (NAM) 5:0 in the final; Won against Mohamed Yassine Touareg (ALG) 5:0 in the semi- final; Won against Said Bounkoult (MAR) 3:1 in the quarter-final 2016 – Rio 2016 Olympic Games (Rio de Janeiro, BRA) participant – 49KG Lost to Galal Yafai (ENG) 3:0 in the first preliminary round 2016 – Nikolay Manger Memorial Tournament (Kherson, UKR) 2nd place – 49KG Lost to Ievgen Ovsiannikov (UKR) 2:1 in the final 2016 – AIBA African Olympic Qualification Event (Yaoundé, CMR) 1st place – 49KG Won against Matias Hamunyela (NAM) WO in the final; Won against Peter Mungai Warui (KEN) 2:1 in the semi-final; Won against Zoheir Toudjine (ALG) 3:0 in the quarter-final; Won against David De Pina (CPV) 3:0 in the first preliminary round 2015 – African Zone 3 Championships (Libreville, GAB) 2nd place – 49KG Lost to Marcus Edou Ngoua (GAB) 3:0 in the final 2014 – Dixiades Games (Yaounde, CMR) 3rd place – 49KG Lost to Marcus Edou Ngoua (GAB) 3:0 in the semi- final 2014 – Cameroon Regional Tournament 1st place – 49KG Won against Tchouta Bianda (CMR) -
Cortex Brainstem Spinal Cord Thalamus Cerebellum Basal Ganglia
Harvard-MIT Division of Health Sciences and Technology HST.131: Introduction to Neuroscience Course Director: Dr. David Corey Motor Systems I 1 Emad Eskandar, MD Motor Systems I - Muscles & Spinal Cord Introduction Normal motor function requires the coordination of multiple inter-elated areas of the CNS. Understanding the contributions of these areas to generating movements and the disturbances that arise from their pathology are important challenges for the clinician and the scientist. Despite the importance of diseases that cause disorders of movement, the precise function of many of these areas is not completely clear. The main constituents of the motor system are the cortex, basal ganglia, cerebellum, brainstem, and spinal cord. Cortex Basal Ganglia Cerebellum Thalamus Brainstem Spinal Cord In very broad terms, cortical motor areas initiate voluntary movements. The cortex projects to the spinal cord directly, through the corticospinal tract - also known as the pyramidal tract, or indirectly through relay areas in the brain stem. The cortical output is modified by two parallel but separate re entrant side loops. One loop involves the basal ganglia while the other loop involves the cerebellum. The final outputs for the entire system are the alpha motor neurons of the spinal cord, also called the Lower Motor Neurons. Cortex: Planning and initiation of voluntary movements and integration of inputs from other brain areas. Basal Ganglia: Enforcement of desired movements and suppression of undesired movements. Cerebellum: Timing and precision of fine movements, adjusting ongoing movements, motor learning of skilled tasks Brain Stem: Control of balance and posture, coordination of head, neck and eye movements, motor outflow of cranial nerves Spinal Cord: Spontaneous reflexes, rhythmic movements, motor outflow to body. -
High-Yield Neuroanatomy
LWBK110-3895G-FM[i-xviii].qxd 8/14/08 5:57 AM Page i Aptara Inc. High-Yield TM Neuroanatomy FOURTH EDITION LWBK110-3895G-FM[i-xviii].qxd 8/14/08 5:57 AM Page ii Aptara Inc. LWBK110-3895G-FM[i-xviii].qxd 8/14/08 5:57 AM Page iii Aptara Inc. High-Yield TM Neuroanatomy FOURTH EDITION James D. Fix, PhD Professor Emeritus of Anatomy Marshall University School of Medicine Huntington, West Virginia With Contributions by Jennifer K. Brueckner, PhD Associate Professor Assistant Dean for Student Affairs Department of Anatomy and Neurobiology University of Kentucky College of Medicine Lexington, Kentucky LWBK110-3895G-FM[i-xviii].qxd 8/14/08 5:57 AM Page iv Aptara Inc. Acquisitions Editor: Crystal Taylor Managing Editor: Kelley Squazzo Marketing Manager: Emilie Moyer Designer: Terry Mallon Compositor: Aptara Fourth Edition Copyright © 2009, 2005, 2000, 1995 Lippincott Williams & Wilkins, a Wolters Kluwer business. 351 West Camden Street 530 Walnut Street Baltimore, MD 21201 Philadelphia, PA 19106 Printed in the United States of America. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Lippincott Williams & Wilkins at 530 Walnut Street, Philadelphia, PA 19106, via email at [email protected], or via website at http://www.lww.com (products and services). -
Immobilization and Anaesthesia in Asiatic Lions (Panthera Leo Persica)
Advances in Animal and Veterinary Sciences Research Article Immobilization and Anaesthesia in Asiatic Lions (Panthera leo persica) 1 2 1 MURUGAN BHARATHIDASAN , BENJAMIN JUSTIN WILLIAM *, RAMAMURTHY JAYAPRAKASH , THANDAVAN 2 3 1 ARTHANARI KANNAN , RAJARTHANAM THIRUMURUGAN , RAVI SUNDAR GEORGE 1Department of Veterinary Surgery and Radiology, Tamil Nadu Veterinary and Animal Sciences University, India; 2Centre for Stem Cell Research and Regenerative Medicine, Madras Veterinary College, Chennai – 600007, Tamil Nadu, India; 3Veterinary Assistant Surgeon, Arignar Anna Zoological Park, Chennai, India. Abstract | A total of 12 trials were conducted in 8 Asiatic and hybrid lions (Panthera leo persica) for diagnostic and surgical procedures. All the lions were immobilized with a combination of xylazine and ketamine at the rate of 1.00 mg/kg and 2.00 mg/kg body weight, respectively, using darts based on assumed body weight. Ketamine and propofol intravenously were used as induction agents sufficiently to achieve deep plane of anaesthesia and good jaw muscle relaxation in six trials each of treatment I and II. The commercially available large animal endotracheal tubes and cus- tom made silicon medical grade tubes were used for intubation either by direct visualization or by digital palpation of glottis. Anaesthesia was maintained with isoflurane. The study revealed that the young lions required 1.08±0.10 and 2.70±0.26 mg/kg and adult required 1.06±0.30 and 2.64±0.08 mg/kg body weight of xylazine and ketamine, respec- tively for immobilization. Ear flick reflex was taken as an indicator for safe and appropriate time for approaching the lion after immobilization, which was completely abolished only after 1.37 and 2.01 minutes after recumbency in young and adult lions, respectively. -
Sensorimotor Deficits Following Oxaliplatin Chemotherapy
Wright State University CORE Scholar Browse all Theses and Dissertations Theses and Dissertations 2017 Sensorimotor Deficits ollowingF Oxaliplatin Chemotherapy Jacob Adam Vincent Wright State University Follow this and additional works at: https://corescholar.libraries.wright.edu/etd_all Part of the Biomedical Engineering and Bioengineering Commons Repository Citation Vincent, Jacob Adam, "Sensorimotor Deficits ollowingF Oxaliplatin Chemotherapy" (2017). Browse all Theses and Dissertations. 2074. https://corescholar.libraries.wright.edu/etd_all/2074 This Dissertation is brought to you for free and open access by the Theses and Dissertations at CORE Scholar. It has been accepted for inclusion in Browse all Theses and Dissertations by an authorized administrator of CORE Scholar. For more information, please contact [email protected]. SENSORIMOTOR DEFICITS FOLLOWING CHEMOTHERAPY A Dissertation submitted in partial fulfillment of requirements for the degree of Doctor of Philosophy By JACOB ADAM VINCENT B.S. The Ohio State University, 2009 2017 Wright State University WRIGHT STATE UNIVERSITY GRADUATE SCHOOL April, 14 2017 I HEREBY RECOMMEND THAT THE DISSERTATION PREPARED UNDER MY SUPERVISION BY Jacob Adam Vincent ENTITLED Sensorimotor Deficits Following Chemotherapy BE ACCEPTED IN PARTIAL FULFUILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF Doctor of Philosophy. Timothy C. Cope, Ph.D. Dissertation Director Mill W. Miller, Ph.D. Director, Biomedical Sciences Ph.D. Program Robert E.W. Fyffe Ph.D. Vice President for Research and Dean of the Graduate School Committee on Final Examination Timothy C. Cope, Ph.D. Mark M. Rich, M.D.,Ph.D. Mill W. Miller, Ph.D. David Ladle, Ph.D. F. Javier Alvarez-Leefmans, M.D., Ph.D. Abstract Vincent, Jacob Adam. -
A Dictionary of Neurological Signs
FM.qxd 9/28/05 11:10 PM Page i A DICTIONARY OF NEUROLOGICAL SIGNS SECOND EDITION FM.qxd 9/28/05 11:10 PM Page iii A DICTIONARY OF NEUROLOGICAL SIGNS SECOND EDITION A.J. LARNER MA, MD, MRCP(UK), DHMSA Consultant Neurologist Walton Centre for Neurology and Neurosurgery, Liverpool Honorary Lecturer in Neuroscience, University of Liverpool Society of Apothecaries’ Honorary Lecturer in the History of Medicine, University of Liverpool Liverpool, U.K. FM.qxd 9/28/05 11:10 PM Page iv A.J. Larner, MA, MD, MRCP(UK), DHMSA Walton Centre for Neurology and Neurosurgery Liverpool, UK Library of Congress Control Number: 2005927413 ISBN-10: 0-387-26214-8 ISBN-13: 978-0387-26214-7 Printed on acid-free paper. © 2006, 2001 Springer Science+Business Media, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, Inc., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dis- similar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to propri- etary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omis- sions that may be made.