Nicotinic Acetylcholine Receptors in the Mesolimbic Pathway
The Journal of Neuroscience, April 14, 2010 • 30(15):5311–5325 • 5311 Behavioral/Systems/Cognitive Nicotinic Acetylcholine Receptors in the Mesolimbic Pathway: Primary Role of Ventral Tegmental Area ␣62* Receptors in Mediating Systemic Nicotine Effects on Dopamine Release, Locomotion, and Reinforcement Cecilia Gotti,1* Stefania Guiducci,2* Vincenzo Tedesco,4 Silvia Corbioli,5 Lara Zanetti,2 Milena Moretti,1 Alessio Zanardi,2 Roberto Rimondini,7 Manolo Mugnaini,6 Francesco Clementi,1 Christian Chiamulera,4 and Michele Zoli2,3 1Consiglio Nazionale delle Ricerche, Institute of Neuroscience, Cellular and Molecular Pharmacology Center, Department of Medical Pharmacology, University of Milan, 20129 Milan, Italy, 2Department of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia, and 3Centro AntiFumo (Interdipartimentale), Azienda Ospedaliero–Universitaria Policlinico di Modena, 41100 Modena, Italy, 4Neuropsychopharmacology Laboratory, Section of Pharmacology, Department of Medicine and Public Health, University of Verona, 37134 Verona, Italy, 5Preclinical Drug Discovery and Enabling Technologies and 6Addiction and Sleep Disorders Discovery Performance Unit, Neurosciences Center of Excellence for Drug Discovery, GlaxoSmithKline Medicines Research Center, 37135 Verona, Italy, and 7Department of Pharmacology, University of Bologna, 40126 Bologna, Italy ␣6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostriatal dopamine (DA) neurons. These neurons are thought to mediate several
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