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ISSN 1881-7815 Online ISSN 1881-7823 BST BioScience Trends Volume 8, Number 1 February, 2014 www.biosciencetrends.com ISSN: 1881-7815 Online ISSN: 1881-7823 CODEN: BTIRCZ Issues/Year: 6 Language: English Publisher: IACMHR Co., Ltd. BioScience Trends is one of a series of peer-reviewed journals of the International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA) Group and is published bimonthly by the International Advancement Center for Medicine & Health Research Co., Ltd. (IACMHR Co., Ltd.) and supported by the IRCA-BSSA and Shandong University China-Japan Cooperation Center for Drug Discovery & Screening (SDU- DDSC). BioScience Trends devotes to publishing the latest and most exciting advances in scientific research. Articles cover fields of life science such as biochemistry, molecular biology, clinical research, public health, medical care system, and social science in order to encourage cooperation and exchange among scientists and clinical researchers. BioScience Trends publishes Original Articles, Brief Reports, Reviews, Policy Forum articles, Case Reports, News, and Letters on all aspects of the field of life science. All contributions should seek to promote international collaboration. Editorial Board Editor-in-Chief: Misao MATSUSHITA Tokai University, Hiratsuka, Japan Masatoshi MAKUUCHI Takashi SEKINE Japanese Red Cross Medical Center, Tokyo, Japan The University of Tokyo, Tokyo, Japan Yasuhiko SUGAWARA Co-Editors-in-Chief: The University of Tokyo, Tokyo, Japan Xue-Tao CAO Web Editor: Chinese Academy of Medical Sciences, Beijing, China Rajendra PRASAD Yu CHEN UP Rural Institute of Medical Sciences & Research, Uttar Pradesh, India The University of Tokyo, Tokyo, Japan Arthur D. RIGGS Beckman Research Institute of the City of Hope, Duarte, CA, USA Proofreaders: Chief Director & Executive Editor: Curtis BENTLEY Roswell, GA, USA Wei TANG Christopher HOLMES The University of Tokyo, Tokyo, Japan The University of Tokyo, Tokyo, Japan Thomas R. LEBON Managing Editor: Los Angeles Trade Technical College, Los Angeles, CA, USA Munehiro NAKATA Tokai University, Hiratsuka, Japan Editorial Office Senior Editors: Pearl City Koishikawa 603, 2-4-5 Kasuga, Bunkyo-ku, Xunjia CHENG Tokyo 112-0003, Japan Fudan University, Shanghai, China Tel: +81-3-5840-8764 Yoko FUJITA-YAMAGUCHI Fax: +81-3-5840-8765 Tokai University, Hiratsuka, Japan E-mail: [email protected] Na HE Fudan University, Shanghai, China Kiyoshi KITAMURA The University of Tokyo, Tokyo, Japan www.biosciencetrends.com i BioScience Trends Editorial and Head Office Tel: +81-3-5840-8764, Fax: +81-3-5840-8765 Pearl City Koishikawa 603, 2-4-5 Kasuga, Bunkyo-ku, E-mail: [email protected] Tokyo 112-0003, Japan URL: www.biosciencetrends.com Editorial Board Members Girdhar G. AGARWAL Takahiro HIGASHI Mark MEUTH Koji TANAKA (Lucknow, India) (Tokyo, Japan) (Sheffield, UK) (Tsu, Japan) Hirotsugu AIGA De-Xing HOU Satoko NAGATA John TERMINI (Geneva, Switzerland) (Kagoshima, Japan) (Tokyo, Japan) (Duarte, CA, USA) Hidechika AKASHI Sheng-Tao HOU Miho OBA Usa C. THISYAKORN (Tokyo, Japan) (Ottawa, Canada) (Odawara, Japan) (Bangkok, Thailand) Moazzam ALI Yong HUANG Xianjun QU Toshifumi TSUKAHARA (Geneva, Switzerland) (Ji'ning, China) (Ji'nan, China) (Nomi, Japan) Ping AO Hirofumi INAGAKI John J. ROSSI Kohjiro UEKI (Shanghai, China) (Tokyo, Japan) (Duarte, CA, USA) (Tokyo, Japan) Hisao ASAMURA Masamine JIMBA Carlos SAINZ-FERNANDEZ Masahiro UMEZAKI (Tokyo, Japan) (Tokyo, Japan) (Santander, Spain) (Tokyo, Japan) Michael E. BARISH Kimitaka KAGA Yoshihiro SAKAMOTO Junming WANG (Duarte, CA, USA) (Tokyo, Japan) (Tokyo, Japan) (Jackson, MS, USA) Boon-Huat BAY Ichiro KAI Erin SATO Ling WANG (Singapore, Singapore) (Tokyo, Japan) (Shizuoka, Japan) (Shanghai, China) Yasumasa BESSHO Kazuhiro KAKIMOTO Takehito SATO Xiang-Dong Wang (Nara, Japan) (Osaka, Japan) (Isehara, Japan) (Boston, MA, USA) Generoso BEVILACQUA Kiyoko KAMIBEPPU Akihito SHIMAZU Hisashi WATANABE (Pisa, Italy) (Tokyo, Japan) (Tokyo, Japan) (Tokyo, Japan) Shiuan CHEN Haidong KAN Zhifeng SHAO Lingzhong XU (Duarte, CA, USA) (Shanghai, China) (Shanghai, China) (Ji'nan, China) Yuan CHEN Bok-Luel LEE Ri SHO Masatake YAMAUCHI (Duarte, CA, USA) (Busan, Korea) (Yamagata, Japan) (Chiba, Japan) Naoshi DOHMAE Mingjie LI Judith SINGER-SAM Aitian YIN (Wako, Japan) (St. Louis, MO, USA) (Duarte, CA, USA) (Ji'nan, China) Zhen FAN Shixue LI Raj K. SINGH George W-C. YIP (Houston, TX, USA) (Ji'nan, China) (Dehradun, India) (Singapore, Singapore) Ding-Zhi FANG Ren-Jang LIN Junko SUGAMA Xue-Jie YU (Chengdu, China) (Duarte, CA, USA) (Kanazawa, Japan) (Galveston, TX, USA) Yoshiharu FUKUDA Daru LU Hiroshi TACHIBANA Benny C-Y ZEE (Ube, Japan) (Shanghai, China) (Isehara, Japan) (Hong Kong, China) Rajiv GARG Hongzhou LU Tomoko TAKAMURA Yong ZENG (Lucknow, India) (Shanghai, China) (Tokyo, Japan) (Chengdu, China) Ravindra K. GARG Duan MA Tadatoshi TAKAYAMA Xiaomei ZHU (Lucknow, India) (Shanghai, China) (Tokyo, Japan) (Seattle, WA, USA) Makoto GOTO Francesco MAROTTA Shin'ichi TAKEDA (as of December 2013) (Tokyo, Japan) (Milano, Italy) (Tokyo, Japan) Demin HAN Yutaka MATSUYAMA Sumihito TAMURA (Beijing, China) (Tokyo, Japan) (Tokyo, Japan) David M. HELFMAN Qingyue MENG Puay Hoon TAN (Daejeon, Korea) (Beijing, China) (Singapore, Singapore) ii www.biosciencetrends.com CONTENTS Volume 8, Number 1, 2014 Reviews 1 - 10 Transient receptor potential (TRP) channels, promising potential diagnostic and therapeutic tools for cancer. Jianpeng Chen, Yi Luan, Ruofei Yu, Zheng Zhang, Jinbiao Zhang, Weibo Wang 11 - 23 Prediction of response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer. Xiangjiao Meng, Zhaoqin Huang, Renben Wang, Jinming Yu Original Articles 24 - 31 Purification and refolding of anti-T-antigen single chain antibodies (scFvs) expressed in Escherichia coli as inclusion bodies. Noriyuki Yuasa, Tsubasa Koyama, Yoko Fujita-Yamaguchi 32 - 37 Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L. Yuchen Sheng, Yibo Ma, Zhongping Deng, Zhengtao Wang, Lili Ji 38 - 44 The supercritical CO2 extract from the skin of Bufo bufo gargarizans Cantor blocks hepatitis B virus antigen secretion in HepG2.2.15 cells. Xiaoyan Cui, Yoshinori Inagaki, Dongliang Wang, Jianjun Gao, Fanghua Qi, Bo Gao, Norihiro Kokudo, Dingzhi Fang, Wei Tang 45 - 51 Shufeng Jiedu Capsule protect against acute lung injury by suppressing the MAPK/NF-κB pathway. Zhengang Tao, Jingyan Gao, Guoliang Zhang, Mingming Xue, Weiqiang Yang, Caoyang Tong, Ying Yuan 52 - 58 Clinical epidemiology of HIV/AIDS in China from 2004−2011. Min Li, Yinzhong Shen, Xiaofei Jiang, Qi Li, Xiaoming Zhou, Hongzhou Lu 59 - 63 Stroke volume variation fail to predict fluid responsiveness in patients undergoing pulmonary lobectomy with one-lung ventilation using thoracotomy. Qiang Fu, Feng Zhao, Weidong Mi, Hong Zhang www.biosciencetrends.com iii CONTENTS (Continued ) Case Report 64 - 67 A case of psoriasis accompanied by arthritis after delivery. Hisashi Kanemaru, Masatoshi Jinnin, Kae Asao, Asako Ichihara, Katsunari Makino, Ikko Kajihara, Akihiko Fujisawa, Satoshi Fukushima, Hironobu Ihn Guide for Authors Copyright iv www.biosciencetrends.com BioScience Trends. 2014; 8(1):1-10. 1 Review DOI: 10.5582/bst.8.1 Transient receptor potential (TRP) channels, promising potential diagnostic and therapeutic tools for cancer Jianpeng Chen1,*, Yi Luan2,*, Ruofei Yu3, Zheng Zhang1, Jinbiao Zhang4,**, Weibo Wang1,** 1 Department of Oncology, Provincial Hospital Affiliated with Shandong University, Ji'nan, Shandong, China; 2 Center for Disease Control, Ji'nan Command of the People's Liberation Army, Ji'nan, Shandong, China; 3 Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; 4 Department of Oncology, the 148th Hospital of the People's Liberation Army, Zibo, Shandong, China. Summary Despite the advances in detection of and therapies for various tumors, high rates of treatment failure and mortality still exist throughout the world. These high rates are mainly due to the powerful capability of tumor cells to proliferate and migrate. Recent studies regarding the transient receptor potential (TRP) have indicated that TRP channels are associated with tumors and that TRP channels might represent potential targets for cancer treatment. TRP channels are important calcium-selective ion channels in many different tissues and cell types in mammals and are crucial regulators of calcium and sodium. TRP were first discovered in the photoreceptors of Drosophila with gene defects or mutations. TRP channels can be divided into seven subfamilies: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipin), TRPP (polycystin), TRPA (ankyrin transmembrane protein), and TRPN (NomPC-like). TRPC proteins are conserved across organisms since they are most homologous to Drosophila TRP. TRP superfamilies have been linked to many physiological and pathological functions, including cell differentiation, proliferation, apoptosis, and ion homeostasis. This review focuses on the properties of TRP in oncogenesis, cancer proliferation, and cell migration. Keywords: Ion channels, transient receptor potential (TRP), cancer, proliferation, migration 1. Introduction including oncogenesis, basement membrane degradation, matrix permeability, cell adhesion, and vessel formation. Most of life's activities cannot function properly without During these processes, many genetic alterations ion channels (1). Likewise,